New preprint from the lab! A frontal motor circuit for economic decisions and actions: www.biorxiv.org/content/10.6... We use a novel task in mice, cortex-wide imaging and optogenetics, NPX recording and modelling to reveal a circuit mechanism that transforms abstract decisions to spatial actions.

Congrats to Ella for her new paper! She asked a really interesting question about how the brain represents uncertainty during hidden state inference, and in a lovely crossover with theoretical work, she shows that in mice, acetylcholine dynamics play a crucial role. www.biorxiv.org/content/10.1...

come join our dept as a fellow - and join a fantastic crew of people using interdisciplinary approaches to investigate the brain across scales - from molecules to behaviour. reach out if you have any Qs!

Today is the 89th anniversary of The Battle of Cable Street when the people of the East End of London halted the march of Oswald Mosley’s Blackshirts through Stepney.

In London, hate will never win.

True. Current Biology on the other hand...

This had me laughing to tears. The person sitting next to me on the flight must have thought I was nuts. A must read for the FEP curious. www.researchgate.net/publication/...

We're looking for a research assistant to work in our neuroscience lab at @princetonneuro.bsky.social @hhmi.org where we study learning and decision-making circuitry. Apply here: research-princeton.icims.com/jobs/21001/r... Pls share w/ anyone who might be interested!

🚨Amazing opportunity: position available for a new associate/full professor at the FIL @imagingneuroucl.bsky.social @uclbrainscience.bsky.social! Do you have a neuroimaging-focused research program? Get applying! 🚨 www.ucl.ac.uk/work-at-ucl/...

The story — written by journalist @emmaanne.bsky.social — raises tough questions about the perverse incentives at play in mine action. Emma reached out @thehalotrust.bsky.social for comment. They declined. Read the full story: spoileralerts.substack.com/p/questionab...

🚨🚨Job Alert🚨🚨!! Neuroscience, Physiology and Pharmacology are recruiting a new lecturer/associate professor! an amazing opportunity to join our fantastic dept! @ucl.ac.uk @ucllifesciences.bsky.social @uclnpp.bsky.social post here: www.nature.com/naturecareer...

Our work, out at Cell, shows that the brain’s dopamine signals teach each individual a unique learning trajectory. Collaborative experiment-theory effort, led by Sam Liebana in the lab. The first experiment my lab started just shy of 6y ago & v excited to see it out: www.cell.com/cell/fulltex...

This is a nice paper which applies and refines some of the ideas we put forward in our Psych Review paper. Our model combined multiple Successor Representations which it switches between based on uncertainty. Jess's model adds reward outcomes to this process and captures splitter cells and more!

How does in-context learning emerge in attention models during gradient descent training? Sharing our new Spotlight paper @icmlconf.bsky.social: Training Dynamics of In-Context Learning in Linear Attention arxiv.org/abs/2501.16265 Led by Yedi Zhang with @aaditya6284.bsky.social and Peter Latham

Really interesting stuff here!! Looking forward to digging in

We just pushed “Memory by a 1000 rules” onto bioRxiv, where we use clever #ML to find #plasticity quadruplets (EE, EI, IE, II) that learn basic stability in spiking nets. Why is it cool? We find 1000s!! of solutions, and they don’t just stabilise. They #memorise! www.biorxiv.org/content/10.1...

Finishing your undergraduate and interested in neuroscience research? The Neuroscience streams of our Biosciences MRes degree provide a unique opportunity to conduct a year-long research project in any UCL neuro lab, plus taught modules to prepare you for a PhD. 🧪🧠📈 www.ucl.ac.uk/biosciences/...

Congrats to the fantastic Jess P for her new paper! She compared how feature Vs outcome focussed agents learn to solve contextual inference problems. She found that you need a balance of both to learn these tasks - and that this mix recapitulates pfc and hippocampal activity in rodent tasks!

Sharing a new paper from the lab. This paper, led by Sangyoon Ko, represents a merging of two longstanding research themes in the lab-- adult neurogenesis and systems consolidation. rdcu.be/el18q A short thread follows for those interested. 1/n

*** Come join us !! We are recruiting !! *** How does the brain generate beliefs that go beyond direct experience? How do these mechanisms go awry in psychosis? The Barron lab tinyurl.com/bdf4drjf @MRCBNDU @NDCNOxford are recruiting a new postdoc tinyurl.com/ut4vbwt4 to work in mouse models

Reward-based prosocial choices in mice https://www.biorxiv.org/content/10.1101/2025.02.21.639526v1

🥺

Inspired by recent posts, here is my Christmas gift for you: the worst postdoc interview ever.

If you haven’t read this yet, drop everything and do it. Thought provoking, based on fantastic & insightful examples (how much info do you need to solve Rubik’s cube?) In PhD, while training rats on a Y-maze, I could not help thinking that the outcome was just 1 bit (left/right). I now have answers

Our preprint of my PhD’s work in @gisellavetere.bsky.social lab is finally out on BiorXiv: doi.org/10.1101/2024..., and I’m so excited to share it! If you’ve ever wondered about reconciling engram manipulation experiments and neuronal activity during encoding, you’re on the right thread! 1/14

Jake has been busy in Klosterneuburg. Many interesting insights from the intact Hp of TLE patients. Mind (or at least, CA3) blown. 🤯 Congrats @jakefwatson.bsky.social and the team. #synapses #humanNeuroscience

Everyone knows that failure is bad. We devote a lot of time to trying to avoid it. But sometimes failure is good. A brief story: ~11 yrs ago, when my friends were all starting their own labs, I was starting my 2nd postdoc. My 1st postdoc (w/ Gord Fishell at NYU) had ended in disaster when 1/

I am excited that my first Bluesky post is to share our new paper in @natureportfolio.bsky.social - "Understanding the neural code of stress to control anhedonia." With @fxia.bsky.social , @valeriafascianelli.bsky.social and @stefanofusi.bsky.social. www.nature.com/articles/s41...

Excited to share our new paper out now @natureportfolio.bsky.social, where we identified neural signatures of stress susceptibility and resilience in the amygdala-ventral hippocampal network to enable control of anhedonia! <https://www.nature.com/articles/s41586-024-08241-y> Thread below:

New Year, New Challenge? About to finish your PhD or recently graduated? Ready to tackle brain circuits & mouse behavior using Neuropixels/2P imaging, and live in London? We’ve got the postdoc position for you. Apply by Dec 18th before it’s gone! 🧠 #PostdocLife #ScienceJobs

So excited to see this preprint out - the cumulation of an ambitious project lead by the very talented @sjshipley.bsky.social Alzheimers models are a new direction for the lab and we'll be doing more in this direction. TLDR: AD > disordered HPC reactivations > less stable PCs > memory defects

"There’s a great lot of countries that want to see the betterment of this planet.” Fiji's Sivendra Michael on the 100+ nations who now want curbs on plastic production to be included in a global #plasticstreaty being debated in Busan www.google.com/amp/s/amp.th...

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New position at UCL!! Lecturer in Neuroscience in the Department of Imaging Neuroscience, home to the internationally renowned Functional Imaging Laboratory (FIL). Details are here: www.ucl.ac.uk/work-at-ucl/.... 70% research, 30% teaching on a new BSc Neuroscience course.

Lets start with something exciting! Applications are now open to join our fantastic department as a group leader fellow! Come start your independent group at (in our opinion) the best neuroscience department! reach out here or @macaskillaf.bsky.social for more info! www.ucl.ac.uk/work-at-ucl/...

The Trapp Lab has moved to BlueSky. No better way to start this than with a new paper. We are excited to alert you to the latest study on the involvement of brain GLP-1 in stress responses led by our @CCMN_London and Trapp Lab alumni @MKBHolt Read the details at doi.org/10.1016/j.mo....

Our dept has an account! follow for all things neuroscience from UCL! including our new faculty search! #neuroskyence #jobs

My paper is out!! 🎉 "Opponent control of reinforcement by striatal dopamine and serotonin", @Nature Here, we show that dopamine and serotonin signals form a gas-brake system for reward in the mammalian brain THREAD ⬇️ 1/n

i highly recommend @ruedigersarah.bsky.social‬ lab - asking really exciting and important qs about how we convert sensation to decision making - using all the most fun tech! I did both PhD and postdoc in a 'new' lab - its an amazing environment to do great science with amazing mentorship. apply!!

Huge congrats to @karyna-mi.bsky.social for her paper published today in Science! She found that the hippocampus is really important for a key strategy we use to make decisions called hidden state inference! 🧪 🧠https://www.science.org/doi/10.1126/science.adq5874 1/7

Join us at #BNA2025 in Liverpool in April 25 by registering/submitting your abstract now. Very glad our symposium on "Motivation and reward pursuit - from cues to adaptative decision making" with @katepeters3.bsky.social, @shaunaparkes.bsky.social and @macaskillaf.bsky.social has been accepted. 🧠

Excited to share our new publication, out today in @currentbiology.bsky.social . Project lead by the amazing @sophiepeterson.bsky.social 🧠 🔬🐀 www.cell.com/current-biol...

I recently wrote a primer on UMAP for Nature Reviews Primers. If you are looking for an overview of the method, a getting started primer, or best practices it is a good place to start. rdcu.be/d0YZT

The BNA scholars programme is now open for applications - this is a great scheme, instigated by @landreae.bsky.social (I can't tag the BNA as they aren't here yet I don't think) www.bna.org.uk/mediacentre/...

Excited to share our new publication out today in Nature Communications! Congrats to the team! @craggasap.bsky.social #dopamine #astrocytes #acetylcholine #openscience Supported by @ukri.org and @asapresearch.bsky.social rdcu.be/d0Knj

Exciting new study from @alexatompary.bsky.social and Lila Davachi: consolidation-related restructuring and integration doi.org/10.7554/eLif...

The plot thickens

🦋 Intro time! I’m a systems neuroscientist working to understand *how* the brain prioritizes *what* to remember. As a postdoc in the Giocomo lab at Stanford, I currently use 2P imaging and ephys to study reward memory in the hippocampus and its partners. 🧠🐀🐭 www.nature.com/articles/s41...

Can I ask you to share a PhD advert at Bristol Uni please? Rhomboid proteases play a role in neurons that is essential for life- but it is not characterised. Got a student interested in cell biology, electrophysiology and neurobiology? Send them our way! tinyurl.com/56f24f7c

xcited to share our new results! We (huge team effort led by post-doc extraordinaire Sylvie Lesuis) examined the effects of acute stress on threat memory generalization and engram ensemble architecture. www.sciencedirect.com/science/arti...