I am excited to share a new review @cp-molcell.bsky.social written in collaboration with @tanjamittag.bsky.social , Mikayla Eppert, and Ambuja Navalkar where we review the current evidence for and against the role of density transitions in regulating transcription www.cell.com/molecular-ce...

Finally comms from UKRI - on a Sunday evening. No mention of the hundreds of ECRs who will see their careers ended by these decisions and notably no explanation for MRC retrospectively applying cuts and wasting all the work that went into writing, reviewing and scoring applications - £millions

At a time when the UK should be capitalising on its global reputation as a great place to do science, this is an enormous own goal. I am so sorry for all those who jobs are going to be impacted.

Spot on. Even if the changes are for the good (I doubt, but await the data) - implementing them like this is curtains for the careers of a bunch of postdoctoral scientists, and probably a final dissuasion for a bunch more. And they talk and TALK about how much they want to support junior careers..

So much depressing news for UK science #funding at the moment; jobs lost, opportunities for future postdoc career development going up in smoke.

I had intended to post something about this new Google DeepMind paper that appeared yesterday in Nature, but the press coverage has added to what there is to say. So this is a long 🧵 www.nature.com/articles/s41...

CaSE: “UKRI need to explain how the cuts detailed in this letter are consistent with the commitment to protect curiosity-led research […] “The information we have had so far is a failure in communication and transparency” www.sciencecampaign.org.uk/press/detail...

Quite timely that Sir Ian Chapman, UKRI CEO, will be in front of the House of Commons Science, Innovation and Technology Committee on Tuesday next week… 👀

Full story by @isaacbarbosa1.bsky.social and me in today's Research Fortnight www.researchprofessionalnews.com/rr-news-uk-r...

Launching soon! R for Biochemists 101 begins on Monday 2 February 2026. Don’t miss your chance to boost your data skills and gain confidence in R. 🧪Secure your place today: https://ow.ly/f48R50XZXh2

I'm not a #cryoET person, but what it's capable of now is incredible!

Announcing the 2026 edition of the EMBO workshop on RNA localization and local translation! This meeting will be held June 30 - July 4 near Porto, Portugal. Come for exciting updates in the field from both established investigators and trainees. See the link below for details!

Unpause! I'm super happy to now be able to share the published version of our paper at Science Advances showing that: 1) active histone mods occur independently of transcription 2) transcription coordinates histone deacetylation at active promoters www.science.org/doi/10.1126/...

IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇

Amazing work from the team at Oxford to pull apart how chromatin structure is organised at enhancers.

This is a super resource - looking forward to having a good poke around

Awesome work looking inside #RNA structural ensembles during folding- congrats!

I’m a fair-weather poster on here to say the least. However, I'm pleased to present our latest paper. A great effort from all authors and an interesting insight into transcriptional regulation (we think!). www.cell.com/molecular-ce...

This is super cool!

What is a promoter? And how does it work? We very happy to share our latest work trying to understand enhancer-promoter compatibility. I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters www.biorxiv.org/content/10.1...

Great review of the super #NeuroBioUK2025 meeting in September. Well done to everyone who organised it @exdrososcientia.bsky.social @alexfellows1.bsky.social and @dozenoaks.bsky.social for putting together such a great meeting for the community! 👏🧠🔬 tinyurl.com/4jn7yrmt roll on next year!

Collective challenges need collective solutions. Happy to share the insights we've gained from the way our cells handle this: www.nature.com/articles/s41... and its summary www.crick.ac.uk/news/2025-09....

We have space for two postdoctoral fellows in the Taipale Lab at the @sangerinstitute.bsky.social. This is a core-funded open position! Come with your ideas and interests and we can develop a project together. sanger.wd103.myworkdayjobs.com/en-US/Wellco...

Our study on the role of LTR5HS and SVAs in regulation of human neural crest migration is now published as peer-reviewed paper on @molsystbiol.org! Congrats to first author brilliant postdoc Laura Deelen, and all the authors involved! @imperialsci.bsky.social www.embopress.org/doi/full/10....

Come and hear about our latest story! It's a really nice series as well- sign up for the mailing list for updates #condensates #UKcondensates

This looks super useful!

Such a cool story- great to see it finally out in the wild #enhancers #geneRegulation

✨Exciting news: the main story of my PhD is out in Science! Together with Christine Moene @cmoene.bsky.social, we explored what happens when you scramble the genome—revealing how Sox2’s position shapes enhancer activation. 📖 Read the full story here: www.science.org/doi/10.1126/...

New review on computational design of intrinsically disordered proteins 🖥️🍝 by @giuliotesei.bsky.social @fpesce.bsky.social & 👴 doi.org/10.48550/arX...

We (and many!) have been thinking a lot about how to quantifiably measure the material properties of biomolecular condensates inside cells. Chris (my final year PhD student) wrote this great review article about microscopy-based techniques link.springer.com/article/10.1... @phar.cam.ac.uk

Looking forward to catching up with everyone at the @biochemsoc.bsky.social #transcription and #chromatin UK #TCUK meeting today in sunny Manchester! #BiochemEvent 🧬🔬☔️ www.eventsforce.net/biochemsoc/f...

New online! Is enhancer-driven gene regulation all wrapped up?

Nice use of #smFRET to study #idr #dynamics

👀 Multiple human enhancer RNAs contain long translated open reading frames genesdev.cshlp.org/content/earl...

Really excited to get our seminars back up and running. @gracebower.bsky.social is going 1st and if you haven't read her range extender story, you're in for a treat! + @creminslab.bsky.social has the 2nd talk and will tell us about the amazing work happening in her lab!

www.nature.com/articles/s41...?

Great news, no more grant deadlines 😀 MRC applicant-led funding – UKRI share.google/lP742F01GmuK...

The emerging roles of long non-coding RNAs in the nervous system www.nature.com/articles/s41...

Cracking lineup of @fnucleosome.bsky.social seminars over the next few months!

Last day to register for the awesome #NeuroBioUK25! Everything #molecular #neurobiology to kick off you autumn!

Just dropped: Super exciting lineup this year for NeuroBio UK! There's still time to register if you haven't done so yet!

Ooh, look. When we covered the climate impacts of machine learning (“AI”) on Rare Earth in June we found it really frustrating that none of the tech companies would tell anyone the water and energy costs. Now Google has made at least some of it public. More of this! (and preferably raw data too).

Are you a @biophysicalsoc.bsky.social member? Vote in the 2025 election by 01/08! @timcraggs.bsky.social is nominated as Industry Rep. We encourage everyone to vote for this important cause, regardless of who you're voting for 🙂 www.biophysics.org/elections/bp... #biophysics #lifescience

Had a super day at the inaugural Nucleic Acids Institute 🧬🧬🧬summer symposium at The University of Sheffield. Loads of fantastic talks and posters and discussion from across all of our faculties and research themes, and two inspiring keynotes Congratulations also to all our prize winners!🥇🎖️🥈

Super new work from Chris and the team, including some cool #smFRET showing changes to n #RNAstructure- have a read!

New preprint alert! 🚨👇 I'm delighted to share the latest research from @jemmabetts.bsky.social in our group: ‘A new protein-dependent riboswitch activates ribosomal frameshifting’. Huge congratulations to Jemma for the first manuscript of her PhD! ✨ www.biorxiv.org/content/10.1...

Do viruses control protein translation using riboswitches? Via protein-mediated regulation of -1 programmed ribosomal frameshifting? We think the do. Very happy to have played a (small) part in this epic paper by @jemmabetts.bsky.social, @chillzaa.bsky.social and colleagues. See 👇for bluetorial.

New preprint. ATF4 activation is thought to lead to longer lifespans. However, our study shows that suppression rather than activation extends lifespan in the fly. New Qs: how we can target ATF4 or its downstream targets to gain targeted longevity benefits. www.biorxiv.org/content/10.1...

This is incredible, and going to be amazingly useful for so many things. I'm already thinking of experiments 🤔 www.science.org/doi/10.1126/... #IDRs #IDPs #ensembles

The Baker lab @uwproteindesign.bsky.social did it again 😱 Protein design of IDPs binders www.ipd.uw.edu/2025/07/hitt...