⚡ What do you get when you combine a meaningful mission, innovative solutions, and an epic group of people? Something extremely Exciting 😉 We're looking for brilliant people to fill these roles & more > excitinginstruments.com/careers/ #lifesciencejobs #startupjobs #sheffieldjobs #hiring #scaleup

🤔 Who is familiar with the traditional structure–function paradigm that a protein’s atomic structure determines its function? 🧵 1/4

🇨🇭 Meet Roman at #PSDI2025 (poster PO21) to see how our tools reveal drug-induced conformational changes, bringing static structures to life. Then 🇦🇹 join him & Tim at the 8th Austrian Cryo-EM Symposium. DM us to connect! #cryoem #drugdiscovery #structuralbiology

📢 Our Exciting Seminars are back! Join @timcraggs.bsky.social & @shenk0128.bsky.social on Nov 20 for 'Mapping the global conformation of the Rag GTPase heterodimer with single-molecule FRET' > us06web.zoom.us/meeting/regi... #biophysics #lifescienceevent #molecularmedicine #biochemistry #smfret

✨ Watch Dr Erin Cutts use the EI-FLEX and imagine the discoveries you could make yourself! We’re offering labs and core facilities a 2 month EI-FLEX trial at no cost. Run your own samples and see the data for yourself. Apply by Dec 15 → bit.ly/4ojRDhF #singlemolecule #biophysics #lifescience

What happens when fluorescence detection reaches nanosecond precision? Recent work in time-resolved single-molecule FRET from Howard et al. using the EI-FLEX reveals fast, transient conformations and connects photon-level observables with structural and dynamic models - biorxiv.org/content/10.1...

🚀 Exciting news! Submit a short proposal on how you'd use the EI-FLEX in your lab for a chance at a 2-month, no-obligation trial! Plus: see smFRET in action, upcoming seminars and more 👉 www.linkedin.com/pulse/octobe... #biophysics #lifescience #moleculardynamics #singlemolecule

How can our stable, compact, and easy-to-use single-molecule tools bring your static models to life? Check out the poster our Senior Application Scientist shared at last week’s Advances in Structural Analysis of Biomolecules conference👇 #structuralbiology #singlemolecule #molecularbiology

Cut prep time, skip immobilisation, and get real-time molecular insights with Fluorescence Correlation Spectroscopy (FCS). ✓ In-solution, label–mix–measure ✓ Setup in a day ✓ First results in minutes Spend less time prepping, more time discovering. Find out more > bit.ly/47pRqm1 #fcs #kinetics

Average doesn't really exist... so why measure it? Our compact and easy-to-use instrument has been designed to help researchers access dynamic single-molecule insights from their own lab benchtops. Find out more about the EI-FLEX and book a demo bit.ly/3KZK3Ku #singlemolecule #smfret #fcs

🚀 Join our mission to democratise single-molecule analysis! We’re hiring: Scientific Creative Writer Product Manager – Assay Kits Field Application Scientists Apply now 👉 excitinginstruments.com/careers?utm_... #sheffieldjobs #startupjobs #lifescience #hiring

Great chatting dynamic single-molecule data with brilliant scientists at the Crick yesterday! 🇩🇪 Next stop: Advances in Structural Analysis of Biomolecules at Charité Berlin, Oct 23–24. Don’t miss our Senior Application Scientist Mahmoud’s poster - P017! #structuralbiology #chembiochem #chemphyschem

Join Tim Craggs, Paul Wheeler & the single-molecule community at The Francis Crick Institute, London - this Monday! ⚡ Dive into the latest single-molecule research, techniques & discoveries. Free to attend - reserve your spot: www.eventbrite.co.uk/e/single-mol... #biophysics #molecularbiology

Can smFRET deliver reproducible, absolute distance measurements? Yes! Check out Hellenkamp et al.'s (2018) paper to learn more > www.nature.com/articles/s41... #singlemolecule #smfret #biophyics #biochemistry

🚀 Since spinning out in 2021, our journey has been an Exciting one! Thrilled to see our CEO & founder @timcraggs.bsky.social named Entrepreneur of the Month by Insider Magazine. Read Tim’s comment below and the article here 👉 flickread.com/edition/html... #entrepreneur #singlemolecule #sheffield

🚀 Our 'professor in a box', a quick-watch smFRET explainer video, a very exciting Chair appointment and more... see what we've been up to in September in the latest edition of our newsletter - buff.ly/EDA6U5s #structuralbiology #moleculardynamics #singlemolecule #smfret #fcs #deeptech #startups

“Absolutely gorgeous!" That's how Edwin Antony describes the data from our EI-FLEX in his Exciting Seminar, where he discusses how DNA context regulates the myriad roles of RPA. Watch the seminar in full to learn more: youtu.be/r0yowVKdXUI #DNA #singlemolecule #molecularbiology #structuralbiology

🚀 Here comes the next big step in our Exciting journey! Thrilled to announce the appointment of Jonathan Rigby as the Chairman of our Board. Find out more about what it means for Exciting Instruments in the press release below. #innovation #startups #biophysics #Sheffield #pressrelease

🤔 How did Groves et al. use the FLEX to reveal insights about SARS-CoV-2’s RNA polymerase? Find out here > doi.org/10.1093/nar/... Want to know more about the FLEX? Learn more, request a tech spec or book a demo on our website: excitinginstruments.com/ei-flex/?utm... #smfret #RNA #nucleicacids

👋 At the Midlands Biophysics Network meeting today? So are we! Visit our stand to chat about how we're bringing solution-based single-molecule techniques right to your benchtop - no extensive training required. #midlandsbiophysicsnetworkmeeting #biophysics #singlemolecule #smfret #fcs

Thrilled to see long-time #FRET experts moving into single-molecule work with our technology at McMaster University! Plus, our instrument now also supports University at Albany's core facility with #smFRET & #FCS! A very Exciting week! 🙌 #biophysics #singlemolecule #structuralbiology

Tim and Paul are ready and waiting at the Biology and Physics of Prokaryotic Chromosomes conference to show you how in-solution, single-molecule fluorescence spectroscopy can help visualise structural dynamics of prokaryotic protein/DNA interactions. Visit our stand for a chat! #prokaryoticproteins

Missing biomolecular dynamics at picomolar levels? The EI-FLEX makes single-molecule research quick and easy with precision and stability. Watch Dr. Quinn below and book a demo: excitinginstruments.com/contact-us/?... #singlemolecule #structuralbiology #moleculardynamics #smFRET #FCS

Heading to the Austrian Cryo-EM Symposium in November? Let's catch up! We'll be on hand to share how freely diffusing smFRET can complement this already exquisitely detailed technique #cryoEM #smfret #singlemolecule

Discover how single-molecule fluorescence reveals transient DNA–protein interactions, kinetics and conformational changes, and more. Meet @timcraggs.bsky.social & Paul Wheeler at next week’s events - email [email protected] to schedule! #biophysics #smfret #fcs

What is single-molecule FRET? Watch @timcraggs.bsky.social explain how this technique measures nanometer-scale distances and captures single-molecule conformations - youtu.be/BpCsTVJkQyE #structuralbiology #moleculardynamics #discovery #smFRET

X-ray crystallography gives static molecular snapshots with atomic precision. Freely diffusing smFRET adds dynamics, revealing alternative states, transition rates, and validating models. See how Craggs et al. (2019) used it to reveal hidden structures: bit.ly/45Vznoh #smfret #structuralbiology

💡 Measure fleeting protein encounters with ease - no dark rooms, bulky equipment, or extensive training. Our compact instrument delivers fast, publication-ready results from the bench in ambient light. 👉 bit.ly/4683zLQ #smFRET #FCS #biophysics #science

🚀 Hear ALEX and smFRET pioneer Shimon Weiss talk on origins, breakthroughs, and the future 👀 Watch the Exciting Seminar in full > youtu.be/MBI82_QKAnk #smFRET #ALEX #biophysics #structuralbiology #moleculardynamics

⚡Discovery moves faster when your software keeps up. The EI-FLEX lets you visualise data in real time, validate assays with ease & share results. Publication-ready plots + full metadata for confidence in every experiment. Book a demo 👉 bit.ly/3JzwYXE #smFRET #FCS #structuralbiology #singlemolecule

Want the latest single-molecule spectroscopy news and research, groundbreaking smFRET and FCS applications, exciting updates about our products and team, and more straight into your inbox?🚀 Subscribe > fwfh6.share-eu1.hsforms.com/2tB-S9AikSdG... #singlemolecule #smfret #fcs #biophysics

Single-molecule measurements in solution expose heterogeneity, rare events, and real-time dynamics without immobilisation, yielding precise kinetic and mechanistic insights. Learn more: excitinginstruments.com?utm_source=b... #proteindynamics #DNAproteininteractions #structuralbiology #biophysics

Curious how FCS applies to stem cells, CRISPR/Cas9 models & isolated receptors at physiologically relevant protein levels? Watch Joelle Goulding’s Exciting Seminar on FCS in biological systems 👀 youtu.be/YzFw-TLG1Bk?... #fcs #biophysics

💡Heading to #MAF2025? Check out @dr-mahmoud.bsky.social presenting at the FRET Satellite workshop, or visit him and @robertbell.bsky.social at stand 14 to see EI-FLEX single-molecule and FCS data in action! Not in Montréal? Book a demo anytime 👉 excitinginstruments.com #singlemolecule #fluorescence

🔬 Running smFRET with TIRF or just getting started? Traditional barriers holding you back? 👉 See how EI-FLEX is redefining smFRET. Watch the video + book a demo: bit.ly/474aeZA #smFRET #TIRF #singlemolecule #biophysics #molecularbiology

🙌 Excited to share that our CEO @timcraggs.bsky.social has been elected to @biophysicalsoc.bsky.social alongside Robert Best, Tanja Mittag & Kandice Levental. Congrats also to Enrique M. De La Cruz, elected President-elect! #biophysics #lifescience #biophysicalsociety

See biomolecules in action at the single-molecule level without the complexity. Meet us at #MAF2025 in Montréal (23–27 Aug) for demos of our compact, powerful smFRET instrument. Book a chat: meetings-eu1.hubspot.com/robert-bell1

💡 Find out how Professor Rhoades used FCS to investigate the cellular internalisation of disordered proteins linked to neurodegeneration in this episode of our Exciting Seminars! #fcs #biophysics #neurodegeneration #fluorescencecorrelationspectroscopy #singlemolecules youtu.be/Z7nbpW1xBpg?...

Single-molecule data reveals tiny fluctuations, rare events, and fleeting states that ensemble averages often overlook. Bring this precision to your lab. Learn more: bit.ly/4makHar #molecularbiology #structuralbiology

🚀 We're on a mission to make single-molecule fluorescence spectroscopy simple and accessible - no specialist facilities, darkrooms, or complex training needed👇 Subscribe to our newsletter for updates: www.linkedin.com/build-relati... #biophysics #singlemolecules #moleculardynamics #structuralbiology

Move beyond averages. smFRET and FCS reveal real-time, single-molecule dynamics - conformational changes, binding, diffusion - missed by bulk methods. Discover more in the 2024 NAR paper on RPA-DNA interactions: academic.oup.com/nar/article/...? #biophysics #moleculardynamics #singlemolecules

🤔 What if we could detect disease from a single molecule before symptoms even appear? This isn’t just innovation. It’s a shift in how we understand, detect, and prevent illness. Molecular insights are unlocking a new era in human health. #innovation #lifescience #biophysics

🙌 We're still on a high from opening our new office & lab at Pennine Five, alongside FourJaw & Phlux Technology, right on Sheffield’s innovation spine. Huge thanks to COGO Interiors and RBH Properties! Here’s to advancing smFRET & FCS from our new home! #deeptech #sheffield #startups

Frustrated by static structures? Single-molecule fluorescence reveals real-time dynamics, binding kinetics and molecular heterogeneity, offering true mechanistic insight. See how biology truly works. Learn more: bit.ly/3H1H1nf #singlemolecule #biophysics #moleculardynamics #smFRET #structuralbiology

Are you a @biophysicalsoc.bsky.social member? Vote in the 2025 election by 01/08! @timcraggs.bsky.social is nominated as Industry Rep. We encourage everyone to vote for this important cause, regardless of who you're voting for 🙂 www.biophysics.org/elections/bp... #biophysics #lifescience

New preprint alert! 🚨👇 I'm delighted to share the latest research from @jemmabetts.bsky.social in our group: ‘A new protein-dependent riboswitch activates ribosomal frameshifting’. Huge congratulations to Jemma for the first manuscript of her PhD! ✨ www.biorxiv.org/content/10.1...

🙌 Check out this brilliant example of our benchtop single-molecule fluorescence spectrometer in action! www.linkedin.com/posts/chris-... Great work from Chris Hill and his team in York 👏 #smfret #biophysics #singlemolecules #innovation #lifescience

Is picomolar sensitivity critical to your work? Hear Dr. Steve Quinn (Univ. of York) on how EI-FLEX revolutionised his smFRET, FCS & FCCS experiments. Learn more & get the tech spec: excitinginstruments.com/ei-flex/ Watch the seminar: youtu.be/9eq-EE70PgQ #biophysics #smFRET #FCS #FCCS

We're thrilled to be a finalist in this year's KPMG UK Tech Innovator competition! 🚀 Support UK innovation - cast your vote and help us shine! app.sli.do/event/dkwYDn... #techinnovatoruk #innovation #startup #biophysics

🇩🇪 Heading to EMBL’s Gene Regulation: One Molecule at a Time? Come chat with us about how smFRET, FCS & FCCS are transforming molecular research—and see our accessible benchtop system in action. #EMBL #EMBLSingleMolecule #singlemolecules #biophysics