Pleased to share the final version of this behemoth of a paper, now finally published. I guess I can retire now? www.nature.com/articles/s41... More functional data, many thousands of words removed, and a few other updates from last year's preprint.

It was a pleasure to write the review on the role of phase separation in transcription together with you, @bsabari.bsky.social, Mikayla and Ambuja. I learnt a lot!

Faculty retreat of @stjuderesearch.bsky.social today. We see evidence everywhere of how Jim Downing shaped the vision for St. Jude over the last twenty years. The results are cutting edge fundamental science, St. Jude Global and important new initiatives. Inspiring!

New preprint with work led by @asrauh.bsky.social in which we explore how double mutant cycles could be used to study molecular interactions in condensates, and highlight difficulties in extracting information about interactions from mutational experiments www.biorxiv.org/content/10.6...

Does targeting enzymes and substrates in a condensate lead to rate enhancement? No. Here, we investigate how the condensate environment can inhibit an enzyme reaction. Spoiler: Mass-transport limitations. We find a strong correlation between diffusion and reaction rates. doi.org/10.64898/202...

I am recruiting postdoctoral fellows to develop new research directions in the lab. We study transcriptional regulation through biomolecular condensates in development and disease, with an emphasis on first-principles and mechanistic discovery. Please repost or share with colleagues.

Second preprint of the year in which @sarahgersing.bsky.social from @rhp-lab.bsky.social mapped the effects of >7500 variants in glucokinase (GCK) on the interaction with the glucokinase regulatory protein so that we now have a 3D GCK scan (abundance, interaction, activity) doi.org/10.64898/202...

Are you a junior scientist working in theoretical biophysics? @zamakany.bsky.social and I are organizing another workshop this fall here at @hhmijanelia.bsky.social. Travel and the workshop expenses are all covered! tinyurl.com/yc66fawc

IDPSeminars is BACK THIS WEEK! Talks from Andrea Soranno and @bokaizhulab.bsky.social on Thursday! 1 pm EST / 7 PM European time! Sign up here: forms.gle/3yCHeYvuuqLh... And check out the full Spring 2026 schedule at idpseminars.com!

Nuclear speckle associated RRM-containing proteins are block copolymers. They make size-limited, ordered microphases, tens of nm in size comprising tens of molecules. Speckles are likely clusters or emulsions of distinct microphases and not macrophases www.sciencedirect.com/science/arti...

🚨New preprint(1/2)! We show that RTK fusion oncoproteins broadly suppress EGFR signaling. How? Sequestration of adapters as the shared principle. Led by superb PhD student Carol Gao. www.biorxiv.org/content/10.1... Implications for drug tolerance/resistance, and includes one big surprise🫧.👇

Hey that’s us 🎉

Our review on Integrative modelling of biomolecular dynamics 💃 is now live at COSB We discuss approaches to integrate computational methods with time-dependent & time-resolved experiments to study protein dynamics With @dariagusew.bsky.social & Carl G. Henning Hansen doi.org/10.1016/j.sb...

Iowa State Dept of Molecular Biology is hiring for biomolecular solution NMR facility staff #NMRchat #Chemjobs #Chemsky (I am NOT the hiring manager for this position, but I will refer any questions you have to the appropriate person.) isu.wd1.myworkdayjobs.com/IowaStateJob...

New preprint! We measured temperature- and pH-induced aggregation for over 18,000 natural and de novo designed protein domains!

Help me spread the word about an opening for the Furino Chair in Bioengineering in the Department of Bioengineering at McGill University. We seek candidates focused on developing biotherapeutic approaches to cancer, including but not limited to mRNA vaccines, CAR-T, and immunotherapy. (1/3)

Re-boosting! The Dept. of Microbiology 🧫 at the University of Tennessee is hiring two 9-month faculty! Come join a vibrant and growing department located in the foothills of the Smoky Mountains! #microsky

📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu

We (@sobuelow.bsky.social) developed AF-CALVADOS to integrate AlphaFold and CALVADOS to simulate flexible multidomain proteins at scale See preprint for: — Ensembles of >12000 full-length human proteins — Analysis of IDRs in >1500 TFs 📜 doi.org/10.1101/2025... 💾 github.com/KULL-Centre/...

During these uncertain times, I’m very happy to see that my institution, @scripps.edu has an open tenure-track Assistant Professor position. Any field in Chemistry or Biology is welcome. I’d especially love to see fellow neuroscientists apply. Please repost! apply.interfolio.com/174756

JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto. www.nature.com/naturecareer... Please repost!

🚨The 2026 IDP GRC Program is LIVE! 📣 Check it out: www.grc.org/intrinsicall... We’ve got an incredible speaker lineup! 🌟 Over the next few weeks, we’ll be highlighting some of them and giving you a sneak peek at the exciting topics they’ll be covering. Stay tuned!

Open faculty position! We're seeking applicants for a tenure-track faculty position at the junior level (Assistant or untenured Associate Professor) with research programs that exist at the interface between molecular science and computation. Apply here: stanford.io/45MF3Qa

🚨🚨The GRC on Intrinsically Disordered Proteins #IDPs is back!! 🍝🧵🏔️Join us for cutting-edge IDP science, great discussions, and mountain views 🌄🍝 📅 June 21-26, 2026 | Les Diablerets, Switzerland 👉 Details & registration: grc.org/intrinsicall...

Why are transcription factors disordered? Come join us in Oxford as a postdoc and we'll find out together! Help publish 3 mature projects, AND develop cool new single molecule fluorescence binding assays! biophysics transcription protein:DNA interactions my.corehr.com/pls/uoxrecru...

Come work with me. Excellent startup package. su.varbi.com/en/what:job/...

We are hiring an Assistant Professor of Biochemistry and Biophysics at Weill Cornell Medicine. Come join our collaborative research environment with state-of-the-art facilities in NYC! Application review starts Oct 22. biochem.weill.cornell.edu/join-our-fac...

We are looking for a new colleague to join the vibrant and fast-growing biophysics community at CMU and in Pittsburgh! The City of Bridges also offers a unique combination of affordability, innovative ecosystems, and rich cultures. Please spread the word!

Feeling awed and a bit starstruck that @science.org chose to run a book review on #LabworkToLeadership!! www.science.org/doi/10.1126/...

Did you know about the BPS Bridging Funds Program? If you're a biophysicist navigating a difficult time, this program is for you to defray costs for attending the BPS Annual Meeting! I am grateful to the @biophysicalsoc.bsky.social for supporting our members! www.biophysics.org/2026meeting/...

Wow Karolinska Institutet is recruiting 20 outstanding early-career researchers for assistant professor positions ki.se/en/about-ki/...

Direct binding of TDP-43 and Tau drives their co-condensation, but suppresses Tau fibril formation and seeding www.biorxiv.org/content/10.1...

New paper on transcription factor phase separation published from my colleague Aseem Ansari's and my lab: Reconciling competing models on the roles of condensates and soluble complexes in transcription factor function authors.elsevier.com/sd/article/S...

Karolinska is looking for 20 (!!) assistant professors and offering 6 year appointments with ~1M USD startup packages. ki.se/en/about-ki/...

It’s been a weird, unproductive week at the lab and I’m feeling a little down. So here are 10 cool facts about vision:

New paper out from the Mittag lab: www.biorxiv.org/content/10.1... New adventures in understanding structure and function of SPOP, which involve donuts! 🍩 Congratulations to first authors Matt Cuneo, Ömer Güllülü and Mohamed-Raafet Ammar, and all other authors!

I spoke with Jade Hindmon, host of @kpbssandiego.bsky.social Midday Edition, about the consequences of the current administration’s cuts to science funding. Please share to help spread the word and raise awareness. www.kpbs.org/podcasts/kpb...

Welcome to the Biological Physics of Biomolecular Condensates: Bridging Theory and Experiment (#biomol-c25) Conference at #KITP Learn more at: buff.ly/HHQAdGh If you are unable to attend in person or want to revisit any talks, recorded sessions are available to watch at: buff.ly/ufXjSxG 🧪

Lively poster session after a day full of talks (😅) by @drummondlab.bsky.social, Allie Obermeyer, @albertilab-tud.bsky.social, Sam Safran, and @tanjamittag.bsky.social at the #KITP biomol25 conference on biomolecular condensates. Great conversations between theorists and experimentalists!

"TENURE-TRACK FACULTY POSITIONS INSTITUTE OF PLANT AND MICROBIAL BIOLOGY at Academia Sinica, Taipei, Taiwan *Application Deadline: 8/31/2025" Read more here: https://arabidopsis.org/news/jobs/view?file=Tu_6-13-25.pdf #PlantSciJobs

Thank you, @philipcball.bsky.social ! It was a pleasure to meet you in person!

Are you looking for a faculty job? We are hiring in my department at Roswell Park NOW. Contact me for details as I await the formal ad. (Please RT.)

Wonderful example of thermodynamics vs kinetics. This is def gonna change the way I think about phase separation and condensates from now on!

Biomolecular condensates are shape shifting bits of DNA, RNA and proteins that “condense” molecules to key locations inside our cells. I call em "power blobs" cuz I'm fun like that. 🧪 🩺 Research from @rohitpappu68.bsky.social with @stjuderesearch.bsky.social source.washu.edu/2025/05/rese...

Scientists at St. Jude Children’s Research Hospital and Washington University in St. Louis demonstrated that neurodegenerative disease-causing fibrils could form with or without condensates. Their research lays the groundwork for developing therapeutics for such diseases. ow.ly/CtKM50W0ajN

Are stress granules crucibles or protective against amyloid fibril formation? Read about our work at Mol Cell: "Tunable metastability of condensates reconciles their dual roles in amyloid fibril formation". Wonderful collaboration with @rohitpappu68.bsky.social and other colleagues (see next post)!

Gemma Solomon and I are looking for a postdoc to work across the two groups on modelling biological systems with a view to applications for quantum computing More details about the project including how to apply in the link below. Deadline April 9 2025 candidate.hr-manager.net/ApplicationI...

Circulate this widely! We need to know which NIH grants have been terminated. It goes beyond the list that HHS has released. Send to every scientist you know. @scott-delaney.bsky.social @noamross.net