Sarah Shammas
@sarahshammas.bsky.social
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Biophysicist who loves disordered proteins and transcription. PI at Univ of Oxford, UK. She/her.
pinned post!
Why are transcription factors disordered? Come join us in Oxford as a postdoc and we'll find out together! Help publish 3 mature projects, AND develop cool new single molecule fluorescence binding assays! biophysics transcription protein:DNA interactions
my.corehr.com/pls/uoxrecru...
about 1 month ago
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One week left to apply!
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19 days ago
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Why are transcription factors disordered? Come join us in Oxford as a postdoc and we'll find out together! Help publish 3 mature projects, AND develop cool new single molecule fluorescence binding assays! biophysics transcription protein:DNA interactions
my.corehr.com/pls/uoxrecru...
about 1 month ago
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Over 10% of human transcription factors are oligomeric. Stoichiometry might be dialled to modulate transcription. We show CREB searches in DNA mixtures as a dimer, and suggest this might be common amongst other members of the bZIP family which fold on binding DNA.
www.biorxiv.org/content/10.1...
2 months ago
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I'm excited to be invited alongside the fabulous Sonia Longhi to present at IDPseminars this Thursday. I will talk about some of our work with disordered DNA binding domains.
add a skeleton here at some point
5 months ago
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Sarah Shammas
Andrew Bowman
9 months ago
Just one stop.
www.nature.com/articles/s41...
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Engineering a genomically recoded organism with one stop codon - Nature
Ochre, a strain of Escherichia coli engineered to have a single stop codon, enables reassignment of four codons for non-degenerate functions, such as incorporation of non-standard amino acids into pro...
https://www.nature.com/articles/s41586-024-08501-x
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Sarah Shammas
IDPSeminars
9 months ago
Announcing the Biophysics Week IDP Trainee Symposium on March 27 at 12pm CT hosted by
@idpseminars.bsky.social
& The BPS IDP Subgroup! Join via Zoom for talks by talented grad students & postdocs. Abstract submissions are open! See flyer for more details!
#BiophysicsWeek
@biophysicalsoc.bsky.social
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Sarah Shammas
Romain Koszul
9 months ago
Our latest work: how can compartmentalization emerge in a eukaryotic genome lacking canonical heterochromatin? By investigating bacterial genomes put in yeast, we show that the presence or absence of transcription is sufficient!
#chromatin
#3Dgenome
#generegulation
www.science.org/doi/10.1126/...
👇
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Sequence-dependent activity and compartmentalization of foreign DNA in a eukaryotic nucleus
In eukaryotes, DNA-associated protein complexes coevolve with genomic sequences to orchestrate chromatin folding. We investigate the relationship between DNA sequence and the spontaneous loading and a...
https://www.science.org/doi/10.1126/science.adm9466
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Sarah Shammas
Tom Ellis
9 months ago
What happens to bacterial genomes when they're cloned into yeast? Do they transcribe, do they get silenced, do they get packaged away from the rest of the DNA? This cool study congrats to the Koszul lab team at Pasteur for this great work.
www.science.org/doi/10.1126/...
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Sequence-dependent activity and compartmentalization of foreign DNA in a eukaryotic nucleus
In eukaryotes, DNA-associated protein complexes coevolve with genomic sequences to orchestrate chromatin folding. We investigate the relationship between DNA sequence and the spontaneous loading and a...
https://www.science.org/doi/10.1126/science.adm9466
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Sarah Shammas
Magnus Kjærgaard
10 months ago
PhD opportunities (yes, plural!) We will launch a center of excellence “Plat-PATH” with
@bjornppedersen.bsky.social
this summer. We have an opening for some PhD students to work on plant hormone transporter mechanism. - Details and application link:
tinyurl.com/44hf9zkd
Please repost 💚
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Structural and biophysical analysis of plant hormone transmembrane transport
https://tinyurl.com/44hf9zkd
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Sarah Shammas
Samrat Mukhopadhyay
11 months ago
Attn. Intrinsically Disordered Proteins Subgroup members: We are excited to host our IDP subgroup dinner on Feb 15 after the IDP symposium at a Mexican restaurant in Los Angeles: Sol Agave L.A. LIVE.
www.solagave.com/los-angeles
You can purchase a dinner ticket:
www.biophysics.org/store/produc...
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Opportunity for postdocs in IDP related biophysics research! The deadline is coming up quite soon.
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11 months ago
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A paper to cite!
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12 months ago
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Sarah Shammas
Kresten Lindorff-Larsen
12 months ago
If you are a PhD student and like protein disorder (or want to learn more), Birthe Kragelund
@bbkrage.bsky.social
and Kristian Strømgaard are organizing a PhD course on How IDPs work 🧶🧬🧪 Note the cost if you are not at a Danish university. Details:
phdcourses.ku.dk/DetailKursus...
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Sarah Shammas
amelie-iska
12 months ago
www.biorxiv.org/content/10.1...
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Improved protein binder design using ꞵ-pairing targeted RFdiffusion
Despite recent advances in the computational design of protein binders, designing proteins that bind with high affinity to polar protein targets remains an outstanding problem. Here we show that RFdif...
https://www.biorxiv.org/content/10.1101/2024.10.11.617496v2
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Sarah Shammas
Altmetric
12 months ago
We strongly suggest that academic publishers and other platforms that host research rapidly implement a Share to Bluesky button for their articles. Here's how:
docs.bsky.app/docs/advance...
#AcademicSky
#HigherEd
#Altmetrics
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Action Intent Links | Bluesky
Authors, websites, and apps can use action intent links to implement "Share on Bluesky" buttons, or similar in-app actions. Logged-in users will be directed to the corresponding action view in the Blu...
https://docs.bsky.app/docs/advanced-guides/intent-links
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Sarah Shammas
Eileen Furlong
12 months ago
My first post on Blue Sky - moving over ! For all post-docs out there - fantastic opportunity @EMBL. Independent group leader position: Core funding, state-of-the-art core facilities, access to fantastic Ph.D. students, and of course amazing colleagues. Please apply
www.embl.org/jobs/positio...
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EMBL Jobs
We offer a wide range of challenging scientific and non-scientific positions at all of our European locations and encourage applications from international candidates at all career levels.
https://www.embl.org/jobs/position/HD02741
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Sarah Shammas
Rohit V. Pappu
12 months ago
New collaborative work in collaboration with the labs of Robert Best & Tanja Mittag driven by Ben Schuler. Identifying Sequence Effects on Chain Dimensions of Disordered Proteins by Integrating Experiments and Simulations.
pubs.acs.org/doi/10.1021/...
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Identifying Sequence Effects on Chain Dimensions of Disordered Proteins by Integrating Experiments and Simulations
It has become increasingly evident that the conformational distributions of intrinsically disordered proteins or regions are strongly dependent on their amino acid compositions and sequence. To facili...
https://pubs.acs.org/doi/10.1021/jacsau.4c00673
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Sarah Shammas
Alex Holehouse
12 months ago
BONUS! If IDPs are your jam, check out an ever-expanding starter pack!
go.bsky.app/J23B51L
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Sarah Shammas
Black In Biophysics
12 months ago
Register for the upcoming JUST-B Seminar on Nov. 19th at 11am PST / 2pm EST to learn about the science of two amazing PhD students❗️❗️❗️ Register here:
biophysics.org/store/products…
@blackinx.bsky.soci
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Sarah Shammas
Denis Wirtz
12 months ago
Download our database of 313 different postdoctoral fellowships. For each entry, we provide link to funder, description, amount, deadline, and eligibility criteria (e.g. citizenship). Download our database here:
research.jhu.edu/rdt/funding-...
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