Bowchro
@bowchro.bsky.social
š¤ 875
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Bowchro
FragileNucleosome
13 days ago
Join us this Wednesday to hear about fascinating research from
@kashyapchhatbar.bsky.social
and
@a-radzisheuskaya.bsky.social
! If you're not already registered, click here to sign up:
us06web.zoom.us/webinar/regi...
you can also join the conversation at our discord:
discord.com/invite/dXqT89r
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Bowchro
FragileNucleosome
about 1 month ago
We have another exciting
#FragileNucleosome
seminar for you next week!
@sunil-k-pradhan.bsky.social
and Genevieve Fourel will share their fascinating stories on chromatin and genome organization. Click here to register:
us06web.zoom.us/webinar/regi...
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Bowchro
Rob Klose
about 1 month ago
We are excited to be recruiting into 3 Associate Professorship's in
@oxfordbiochemistry.bsky.social
. Come join us as a colleague and benefit from our vibrant and multidisciplinary environment. Reach out to me if you have any questions. Please repost! (
tinyurl.com/48deybuu
) (
tinyurl.com/4pdvjaft
).
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I'll never look at my mollies in the same way again, though I think mine are the boring sexual type.
add a skeleton here at some point
about 1 month ago
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I fully agree!
www.bbc.co.uk/news/article...
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Wildlife to replace historical figures on banknotes
The public will help choose which animals and birds will appear on the Bank of England's new notes.
https://www.bbc.co.uk/news/articles/c4geyyg9en6o
about 1 month ago
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Hadas Weiss
about 1 month ago
the most annoying shift in my academic career
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That time of year again when I make my Mendel impression. I suppose these are peaches and not peas, and will be furry not wrinkled, and I'm a biochemist not a geneticist, but I'm claiming it anyway.
about 1 month ago
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āWe need this information. Itās part of the beauty and complexity thatās out there on Earth. Humans hardly know anything.ā
www.theguardian.com/environment/...
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āI love midges because I know what their hearts look likeā: is the passion for taxonomy in danger of dying out?
Insect taxonomist Art Borkent has described and named more than 300 species of midges but fears his field of science is dying out, despite millions of insects, fungi and other organisms waiting to be ...
https://www.theguardian.com/environment/2026/mar/02/identify-species-taxonomists-crisis-art-borkent
about 2 months ago
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Baby guppy update.
2 months ago
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Baby guppies! Did you know: guppies have 23 chromosomes, the same as humans.
2 months ago
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Bowchro
FragileNucleosome
2 months ago
We've got two exciting chromatin talks coming up on Wednesday next week:
@epijenatics.bsky.social
from
@jbuenrostro.bsky.social
's lab and
@ambystoma22.bsky.social
! register and join us:
us06web.zoom.us/webinar/regi...
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Spring vibes
2 months ago
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@cmcbcakeclub.bsky.social
has had a fitness push.
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2 months ago
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"When I contacted OpenAIās support, the first responses came from an AI agent." - Kind of expected, no?
www.nature.com/articles/d41...
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When two years of academic work vanished with a single click
After turning off ChatGPTās ādata consentā option, Marcel Bucher lost the work behind grant applications, teaching materials and publication drafts. Hereās what happened next.
https://www.nature.com/articles/d41586-025-04064-7?utm_source=bluesky&utm_medium=social&utm_campaign=nature&linkId=41682922
3 months ago
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Join us in Warwick for a fun two-day symposium and celebrate the career of Prof Rob Cross!
add a skeleton here at some point
3 months ago
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warwick.ac.uk/fac/sci/med/...
3 months ago
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This term in my lab we are trialling a chalk-talk journal club format with emphasis on concepts and implications: no Powerpoint, no presentation of data.
3 months ago
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The word 'leverage' in biomedical literature (as search by Pubmed trends). I wonder what is behind it. Every other abstract I read now seems to be leveraging.
3 months ago
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Bowchro
Stephan Hacker
4 months ago
Great news in the fight against antimicrobial resistance! Two oral antibiotics have been approved by the FDA for uncomplicated urogenital gonorrhea. As Neisseria gonorrhoeae is becoming resistant to all known antibiotics, such breakthroughs were urgently needed. (1/4)
www.fda.gov/news-events/...
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Bowchro
FragileNucleosome
4 months ago
š§¬šJoin us on Dec 17th for our last session of 2025! šš§¬Two fantastic talks on transcriptional regulation: š¬JB Lalanne on developmental enhancers (and starting a lab in 2025?) š¬
@rberrens.bsky.social
on transposable elements in development šRegister here:
us06web.zoom.us/webinar/regi...
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Sometimes sense does prevail.
add a skeleton here at some point
4 months ago
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Ursula von der Leyen
4 months ago
Today, we make further steps in our renewed EU-UK strategic partnership. We have concluded the negotiations for the UKās association to Erasmus+ in 2027. Bringing back Erasmus+ for our young people, opening the door to new shared experiences and lasting friendships.
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Bowchro
Al-Sady lab
4 months ago
Took us a bit, but proud of this published version. We now examine the genetic interaction of phosphorylation with oligomerization and where bulk and phospho-Swi6 localize. Wonder if chromatin affinity tuning to enable Suv39 H3K9me3 spreading is a conserved mechanism ?
doi.org/10.1093/nar/...
add a skeleton here at some point
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Potato or DNA polymerase?
7 months ago
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Bowchro
Hisham Zerriffi
7 months ago
Oh ffs. No, I do not want to "Chat with the PDF" of this interesting looking academic journal article I just came across. I would like to read it. With my own eyeballs. And think about it. You know, with that grey matter sitting between my ears. Just make it stop.
#AcademicChatter
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āTo consult the statistician after an experiment is finished is often merely to ask him to conduct a post mortem examination. He can perhaps say what the experiment died of.ā ā Ronald A. Fisher Yeah, but, I just wanted a quick look...
share.google/jo0NIT24BKmS...
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How thoughtful experimental design can empower biologists in the omics era - Nature Communications
Here, the authors discuss principles of experimental design that are relevant for all biology research, along with special considerations for projects using -omics approaches, highlighting common expe...
https://share.google/jo0NIT24BKmSI5Mw5
8 months ago
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Bowchro
Molly Gale (Gale-Hammell Lab)
10 months ago
š§¬š½ Happy Transposon Day! š½š§¬ Today we celebrate the birthday of Barbara McClintock - scientist extraordinaire and discoverer of jumping genes. Still the only woman to have an unshared Nobel Prize in the biomedical sciences
#TransposonDay2025
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Back in the lab!
10 months ago
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Bowchro
Posit
10 months ago
ggplot2 is turning 18! š For nearly two decades, itās helped data scientists turn complex data into clear, beautiful insights. Weāre throwing a birthday party at Data+AI Summit, with treats and limited-edition swag. Come celebrate with us and
@hadley.nz
! š Posit Lounge (402) š June 10, 6ā8pm
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reposted by
Bowchro
11 months ago
We have another postdoc position available to work on interplay between ADP-ribosylation and ubiquitination in regulation of genome stability. For this post expertise in cell biology is required.
my.corehr.com/pls/uoxrecru...
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'
https://my.corehr.com/pls/uoxrecruit/erq_jobspec_details_form.jobspec?p_id=180153
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Bowchro
Ed Boyden
11 months ago
Just published, expansion in situ genome sequencing, where you can sequence DNA while still inside the cell, mapping its organization relative to proteins and other markers, with the help of expansion microscopy! Led by @jbuenrostro.bksy.social.
www.science.org/doi/10.1126/...
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Bowchro
Alfonso Martinez Arias
12 months ago
Just published the new edition of āPrinciples of Developmentā from now called āWolpertās Principles of Developmentā to honour his memory and the origin of this textbooks that aims at distilling the, sometimes elusive, principles underlying animal and plant development
shorturl.at/LrOxn
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Bowchro
Rebecca Boyle š
12 months ago
I do not think enough people know about the Campaign for Real Ale (1/2)
add a skeleton here at some point
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Very good
add a skeleton here at some point
about 1 year ago
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Spring has arrived and yes, the two bunnies we got in Autumn were a boy and a girl.
about 1 year ago
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Step aside AlphaFold.
www.nature.com/articles/d41...
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AI masters Minecraft: DeepMind program finds diamonds without being taught
The Dreamer system reached the milestone by āimaginingā the future impact of possible decisions.
https://www.nature.com/articles/d41586-025-01019-w
about 1 year ago
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Alejandro came to Warwick last year and gave an excellent talk on life as a scientific editor. Highly recommend.
add a skeleton here at some point
about 1 year ago
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They say life becomes boring in middle age, but I recorded both a Eurasian Green Woodpecker AND a Rose-ringed Parakeet on my lunch break today. So there.
about 1 year ago
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Seeds in a PCR tube? This is combining work and play.
about 1 year ago
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Bowchro
Mary Goll
about 1 year ago
Epigenetics Folks, Science must go on! Please consider joining us for the Epigenetics Gordon Research Conference to be held August 10-15 in Barcelona. Please spread the word and apply early, as this meeting always oversubscribes!
www.grc.org/epigenetics-...
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2025 Epigenetics Conference GRC
The 2025 Gordon Research Conference on Epigenetics will be held in Castelldefels, Barcelona Spain. Apply today to reserve your spot.
https://www.grc.org/epigenetics-conference/2025/
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www.theguardian.com/technology/2...
"Henceforth, they could speak to machines like the Duke of Devonshire spoke to his gardener, and the machines would do their bidding."
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You don't need code to be a programmer. But you do need expertise | John Naughton
AI is so good at writing software that one father asked it to organise his kidsā school lunches. But that doesnāt mean itās taking over
https://www.theguardian.com/technology/2025/mar/16/ai-software-coding-programmer-expertise-jobs-threat
about 1 year ago
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Polyclonal>monoclonal>phage display>AlphaFold The evolution of antobodies.
www.biorxiv.org/content/10.1...
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In silico discovery of nanobody binders to a G-protein coupled receptor using AlphaFold-Multimer
Antibodies are central mediators of the adaptive immune response, and they are powerful research tools and therapeutics. Antibody discovery requires substantial experimental effort, such as immunization campaigns or in vitro library screening. Predicting antibody-antigen binding a priori remains challenging. However, recent machine learning methods raise the possibility of in silico antibody discovery, bypassing or reducing initial experimental bottlenecks. Here, we report a virtual screen using AlphaFold-Multimer (AF-M) that prospectively identified nanobody binders to MRGPRX2, a G protein-coupled receptor (GPCR) and therapeutic target for the treatment of pseudoallergic inflammation and itch. Using previously reported nanobody-GPCR structures, we identified a set of AF-M outputs that effectively discriminate between interacting and non-interacting nanobody-GPCR pairs. We used these outputs to perform a prospective in silico screen, identified nanobodies that bind MRGPRX2 with high affinity, and confirmed activity in signaling and functional cellular assays. Our results provide a proof of concept for fully computational antibody discovery pipelines that can circumvent laboratory experiments. ### Competing Interest Statement E.P.H., J.S.S., J.D.H., K.J.S., and A.C.K. are co-inventors on a patent application for MRGPRX2 antagonist nanobodies. D.S.M. is an advisor for Dyno Therapeutics, Octant, Jura Bio, Tectonic Therapeutic, and Genentech, and is a co-founder of Seismic Therapeutic. J.C.W. is a co-founder of MOMA therapeutics, a company in which he has a financial interest. A.C.K. is a co-founder and consultant for biotechnology companies Tectonic Therapeutic and Seismic Therapeutic, and for the Institute for Protein Innovation, a non-profit research institute. J.S.S. is an advisor / investigator for Biogen. The remaining authors declare no competing interests.
https://www.biorxiv.org/content/10.1101/2025.03.05.640882v1
about 1 year ago
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Mendel vibes in the greenhouse this morning.
about 1 year ago
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Bowchro
Chris Toseland
about 1 year ago
We are so proud of how Thalia has handled the past two years and continues to approach every day! Brain tumours are devastating and we desperately need more treatments to provide options for families!
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Bowchro
Florian Jug
about 1 year ago
For whatever reason it was hard to find the original letter of Lech Walesa, the Polish president. (And Iām increasingly fond of full context and āzero moderationā raw materials and videos⦠almost like I want to form MY OWN opinion⦠š) If you are in a similar situation, here you goā¦
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Bowchro
Gal Haimovich ā£ š§Ŗš¬š
about 1 year ago
m.xkcd.com/3056/
This is true
#RNASky
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āThey dance around the subject,ā said one student. āItās not banned but not advised, itās academic misconduct if you use it, but lecturers tell us they use it. Very mixed messages.ā
www.theguardian.com/education/20...
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UK universities warned to āstress-testā assessments as 92% of students use AI
Survey of 1,000 students shows āexplosive increaseā in use of generative AI in particular over past 12 months
https://www.theguardian.com/education/2025/feb/26/uk-universities-warned-to-stress-test-assessments-as-92-of-students-use-ai
about 1 year ago
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Bowchro
Krassensteins
about 1 year ago
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