IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇

RESEARCH COMMUNICATION: H3K4me3 amplifies transcription at intergenic active regulatory elements By Yu et. al and Bluma Lesch ➡️ https://genesdev.cshlp.org/content/39/21-22/1290.full Bluma Lesch @haomingyu.bsky.social #transcription #epigenetics #histones #histonePTMs #methylation #enhancers

#QEDscience has been great! We’ve used it for a few manuscripts and it helped us really improve them before submission. Definitely recommend!

💡 Cancer cells don’t just mutate—they reorganize their DNA in 3D space. Our new study shows how the genome’s folding pattern shifts as tumors progress, cell by cell 🧩🧬. It’s the first 3D genome atlas of cancer progression. Thread 👇

New paper on the role of H3K4me3 at enhancers! We (led by Haoming Yu) used dCas9 epigenome editing to add H3K4me3 to intergenic enhancers. This was (1) sufficient to turn up transcription at open, active regions and (2) has no effect on target gene transcription. genesdev.cshlp.org/content/earl...

Agreed, truly a team effort - but a huge amount of credit to @kataruka.bsky.social for her leadership. Smarca5 is important for chromatin remodeling in DNA damage repair during male meiosis (among other things!)

It seems that only the science community is noticing that NIH and NSF budgets are cut 40% and 55% in the budget bill, respectively. If you live in Maine, West Va, Pennsylvania, Alabama, or Louisiana, CALL YOUR SENATOR as they could make a difference. See below. prospect.org/politics/202...

I am heartbroken about the loss of many labs at the Weizmann Institute yesterday in the missile attack. Dear scientists there: please know that you are not alone. Like many many others, I support you and am standing by to help you in any way I can.

Serious science #TCTeAC

Happy to be here!

Starting fresh! With the best kind of post: congrats to (social media-free) grad student Kira Marshall on an awesome paper comparing opossum and placental mammal transcriptomes: www.cell.com/developmenta...