RESEARCH PAPER: B-lineage commitment is dependent on a reversible epigenetic switch By Tingvall-Gustafsson et al., and Mikael Sigvardsson ➡️ https://genesdev.cshlp.org/content/40/3-4/233.full Linköping University @lunduniversity.bsky.social #hematopoiesis #Bcell #transcriptionfactor #epigenetics

RESEARCH PAPER: Hunchback functions in the postmitotic larval MDN to restrict axon outgrowth, synapse formation, and backward locomotion By Lee et al., and Chris Doe ➡️ https://genesdev.cshlp.org/content/40/3-4/255.abstract HHMI University of Oregon #neuron #drosophila #locomotion #hunchback

RESEARCH PAPER: Plagl1 and Lrrc58 control mammalian body size by triggering target-directed microRNA degradation of miR-322 and miR-503 By LaVigne et al., and Joshua Mendell ➡️ https://genesdev.cshlp.org/content/40/3-4/215.full Josh Mendell HHMI #TDMD #RNAdecay #miRNA #triggerRNA #development

REVIEW: Nuclear receptor coregulator interactions: beyond the switch By F. Nafrisha Cassim Bawa and Mitchell Lazar ➡️ https://genesdev.cshlp.org/content/40/3-4/146.full University of Pennsylvania #nuclearreceptor #transcription #ligand #coactivator #corepressor

RESEARCH PAPER: Mutant p53 binds and controls estrogen receptor activity to drive endocrine resistance in ovarian cancer By Shao et al., and Maureen Murphy ➡️ https://genesdev.cshlp.org/content/40/3-4/199.full The Wistar Institute #ovariancancer #p53 #cancertherapy #endocrineresistance

G&D's Editor-In-Chief, Andrew Dillin, will be at the Keystone Symposia on Mitochondria Signaling in Physiology and Disease. #KSMitochondria26 If you’d like to chat about publishing your work with #genesdev, feel free to reach out to [email protected]

RESEARCH PAPER: SOX2 phosphorylation during mitosis limits genomic damage By Williams et al., and Steven Pollard ➡️ https://genesdev.cshlp.org/content/40/3-4/185.full Edinburgh University #sox2 #chromatin #neural #mitosis #stemcells #phosphorylation

RESEARCH PAPER: ERRγ impedes neuroendocrine prostate cancer development By Li et al., and Vincent Giguère ➡️ https://genesdev.cshlp.org/content/40/3-4/160.abstract Vincent Giguère #prostatecancer #neuroendocrine #cancertherapeutics #nuclearreceptor

🚨 NEW ISSUE ALERT!!! 🚨 New Outlook, Review, and Research articles online now at Genes & Development. Click on the link to learn more: ➡️ https://genesdev.cshlp.org/content/40/3-4.toc

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Hunchback functions in the post-mitotic larval MDN to restrict axon outgrowth, synapse formation, and backward locomotion By Lee et al., and Chris Doe ➡️ https://genesdev.cshlp.org/content/early/2025/11/20/gad.353223.125.abstract #neuron #drosophila #locomotion

🎙️ G&D Voices: Author Lori Sussel 🎙️ From submission to publication, our authors’ experiences matter. Here’s what one of our authors had to say about publishing with G&D. Learn more about publishing with G&D here: ➡️ https://genesdev.cshlp.org

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Potent synthetic lethality between PLK1 and EYA family inhibitors in tumors of the central and peripheral nervous systems By Nelson et al., and Hilda Pickett ➡️https://genesdev.cshlp.org/content/early/2025/11/20/gad.353271.125.abstract #cancertherapy #glioblastoma

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: B-lineage commitment is dependent on a reversible epigenetic switch By Tingvall-Gustafsson et al., and Mikael Sigvardsson ➡️ https://genesdev.cshlp.org/content/early/2025/11/20/gad.353002.125.abstract #hematopoiesis #Bcell #transcriptionfactor #epigenetics

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Plagl1 and Lrrc58 control mammalian body size by triggering target-directed microRNA degradation of miR-322 and miR-503 By LaVigne et al., and Joshua Mendell ➡️ https://genesdev.cshlp.org/content/early/2025/11/10/gad.353138.125.abstract Josh Mendell HHMI

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: SOX2 phosphorylation during mitosis limits genomic damage By Williams et al., and Steven Pollard ➡️ https://genesdev.cshlp.org/content/early/2025/11/10/gad.352664.125.abstract #sox2 #chromatin #neural #mitosis #stemcells #phosphorylation

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Mutant p53 binds and controls estrogen receptor activity to drive endocrine resistance in ovarian cancer By Shao et al., and Maureen Murphy The Wistar Institute ➡️ https://genesdev.cshlp.org/content/early/2025/11/05/gad.352953.125.abstract #ovariancancer #p53

Explore emerging research with field leaders Keystone Symposia #IsletBiology & #Diabetes : #BetaCell Compensation, Failure & Recovery, this March in Breckenridge! #KSDiabetes26 For more info: ➡️ https://hubs.la/Q03X7Ckz0

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: ERRγ impedes neuroendocrine prostate cancer development By Li et al., and Vincent Giguère ➡️ https://genesdev.cshlp.org/content/early/2025/10/29/gad.353024.125.abstract #prostatecancer #neuroendocrine #cancertherapeutics #nuclearreceptor

Explore emerging research with field leaders at Keystone Symposia RNA Modifications: Bridging Biological Function and Therapeutic Potential, this March in Keystone! #KSRNAMod26 For more info: ➡️ https://hubs.la/Q03-NnlC0#KSRNAMod26

OUTLOOK: Rewiring gene circuits to dissect oscillatory signaling dynamics By Marek van Oostrom and Katharina Sonnen ➡️ https://genesdev.cshlp.org/content/40/1-2/1.full Read the full story: ➡️ https://genesdev.cshlp.org/content/40/1-2/124.full Ina Sonnen Hubrecht Institute ##optogenetic #segmentation

RESOURCE/METHODOLOGY: Synchronization of the segmentation clock using synthetic cell–cell signaling By Akihiro Isomura, Daisuke Asanuma, and Ryoichiro Kageyama ➡️ https://genesdev.cshlp.org/content/40/1-2/124.full #optogenetic #signaling #segmentation #notch

RESEARCH PAPER: Longevity-promoting mitochondrial unfolded protein response activation requires elements of the PeBoW complex By Adedoja et al., Armen Yerevanian, and Alexander Soukas ➡️ https://genesdev.cshlp.org/content/40/1-2/110.abstract #mitochondria #longevity #Celegans #EJC

RESEARCH PAPER: Dorsal determinant Hwa stabilizes β-catenin through direct inhibition of GSK3 By Ji et al., and Feng Cong ➡️ https://genesdev.cshlp.org/content/40/1-2/56.abstract #development #signaling #kinase #WNT

RESEARCH PAPER: An intrinsically disordered region of Drosha selectively promotes miRNA biogenesis independent of tissue-specific Microprocessor condensates By Yang et al., and Katherine McJunkin ➡️ https://genesdev.cshlp.org/content/40/1-2/26.abstract #IDR #miRNA #Microprocessor #smallRNA

REVIEW: Mutant p53: evolving perspectives By Gizem Efe, Katherine Cunningham, Anil K. Rustgi, Carol Prives, James J. Manfredi, and Francisco J. Sánchez-Rivera ➡️ https://genesdev.cshlp.org/content/40/1-2/43.full #cancer #mutation #p53

📽 G&D Tapes 📽 G&D Author, Alexandra Bergfort, tells us about their new study in #genesdev showing how the EJC coordinates splicing of exon blocks Learn more: ➡️ https://genesdev.cshlp.org/content/40/1-2/94.full Karla Neugebauer Alexandra Bergfort Yale Center for RNA Science and Medicine#genesdev#splicing

RESEARCH PAPER: The exon junction complex coordinates the cotranscriptional inclusion of blocks of neighboring exons By Bergfort et al., and Karla Neugebauer ➡️ https://genesdev.cshlp.org/content/40/1-2/94.full Karla Neugebauer Alexandra Bergfort Yale Center for RNA Science and Medicine #splicing

G+D together with JHU worked to put together this cool video describing our latest work! Check it out!

📽 G&D Tapes 📽 G&D Author, Christina McNerney, tells us about their new study in #genesdev showing how enzyme DIO3 coordinates photoreceptor development. Read the full story here: ➡️ https://genesdev.cshlp.org/content/40/1-2/70.full Christina McNerney Bob Johnston Johns Hopkins University#genesdev#vision

RESEARCH PAPER: DIO3 coordinates photoreceptor development timing and fate stability in human retinal organoids By McNerney et al., and Robert Johnston, Jr. ➡️ https://genesdev.cshlp.org/content/40/1-2/70.full Bob Johnston Christina McNerney Johns Hopkins University #photoreceptor #hormone #neurons

RESEARCH PAPER: Histone modification cross-talk and protein complex diversification confer plasticity to Polycomb repression By Bonnet et al., and Jürg Müller ➡️ https://genesdev.cshlp.org/content/40/1-2/43.full Max Planck Institute of Biochemistry #polycomb #histone #chromatin #drosophila

🚨 NEW ISSUE ALERT!!! 🚨 New Outlook, Review, and Research articles online now at Genes & Development. Click on the link to learn more: ➡️ https://genesdev.cshlp.org/content/40/1-2.toc

Wrapping up G&D 2025 on a high note!!! Stay tuned for another great year of exciting research. HAPPY NEW YEAR!!!

⏪ G&D RECAP ⏪ 🗓️ December 2025 RESEARCH PAPER: Multiple human enhancer RNAs contain long translated open reading frames By Vlasov et al. and James Manley ➡️ https://genesdev.cshlp.org/content/39/23-24/1468.full #protein #translation #enhancerRNA #chromatin #DNAdamage #RNAprocessing #nucleus

⏪ G&D RECAP ⏪ 🗓️ November 2025 OUTLOOK: End of the line: a kinetic ruler model for poly(A) tail termination By Anita Corbett ➡️ https://genesdev.cshlp.org/content/39/21-22/1267.full Learn more here: ➡️ https://genesdev.cshlp.org/content/39/21-22/1377.full #RNAprocessing #mRNA #ribonucleoprotein

⏪ G&D RECAP ⏪ 🗓️ November 2025 RESEARCH PAPER: A kinetic ruler controls mRNA poly(A) tail length By Gabs et al. and Matti Turtola ➡️ https://genesdev.cshlp.org/content/39/21-22/1377.full #RNAprocessing #mRNA #polyadenylation #ribonucleoprotein #CPAC

⏪ G&D RECAP ⏪ 🗓️ October 2025 RESEARCH COMMUNICATION: Structural basis of nucleosome recognition by the conserved Dsup & HMGN nucleosome-binding motif By Alegrio-Louro et al. and Andres Leschziner ➡️ https://genesdev.cshlp.org/content/39/19-20/1155.full #proteininteractions #proteinstructure #cryoEM

Best wishes and holiday cheer to our amazing G&D community...

⏪ G&D RECAP ⏪ 🗓️ September 2025 RESEARCH PAPER: Bystander activation across a #TAD boundary supports a cohesin-dependent #transcription cluster model for #enhancer function By Williamson et al., Wendy Bickmore, and Laura Lettice ➡️ https://genesdev.cshlp.org/content/39/17-18/1012.full Wendy Bickmore

⏪ G&D RECAP ⏪ 🗓️ August 2025 REVIEW: Studying ovarian aging and its health impacts: modern tools and approaches By Bérénice Benayoun, Alison Kochersberger, and Jennifer Garrison ➡️ https://genesdev.cshlp.org/content/39/15-16/975.full Bérénice A. Benayoun, PhD Jennifer Garrison #aging #womenshealth

⏪ G&D RECAP ⏪ 🗓️ July 2025 RESEARCH PAPER: Ribosome association inhibits stress-induced gene mRNA localization to stress granules By Noah Helton, Benjamin Dodd, and Stephanie Moon ➡️ https://genesdev.cshlp.org/content/39/13-14/826.full Stephanie Moon #ribosome #stressgranule #translation

📽 G&D Tapes 📽 G&D Author, Jon Muncie-Vasic tells us about their new study in #genesdev that defines the role of MEF2C in cardiac tract development. Read the full story here: ➡️ https://genesdev.cshlp.org/content/39/23-24/1451.abstract Jon Muncie-Vasic Benoit Bruneau Gladstone Institutes#genesdev

⏪ G&D RECAP ⏪ 🗓️ June 2025 RESEARCH PAPER: Aneuploidy generates enhanced nucleotide dependency and sensitivity to metabolic perturbation By Magesh et al., Stephen Elledge, and Emma Watson ➡️ https://genesdev.cshlp.org/content/39/11-12/770.full #aneuploidy #cancer #metabolism #chemotherapy

⏪ G&D RECAP ⏪ 🗓️ May 2025 RESEARCH PAPER: MRN–CtIP, EXO1, and DNA2–WRN/BLM act bidirectionally to process DNA gaps in PARPi-treated cells without strand cleavage By Seppa et al., and Alessandro Vindigni ➡️ https://genesdev.cshlp.org/content/39/9-10/582.full #DNArepair #BRCA1 #nucleases #PARP #cancer

⏪ G&D RECAP ⏪ 🗓️ April 2025 OUTLOOK: Where and why have so many metabolic enzymes gone from developing spores of Bacillus subtilis? By Peter Setlow ➡️ https://genesdev.cshlp.org/content/39/7-8/426.full #bacteria #sporulation #protease #metabolism #dormancy

⏪ G&D RECAP ⏪ 🗓️ April 2025 RESEARCH PAPER: MdfA is a novel ClpC adaptor protein that functions in the developing Bacillus subtilis spore By Massoni et al., Rivka Isaacson, and Amy Camp ➡️ https://genesdev.cshlp.org/content/39/7-8/510.full #bacteria #sporulation #protease #metabolism #dormancy

⏪ G&D RECAP ⏪ 🗓️ April 2025 RESEARCH PAPER: Developmentally regulated proteolysis by MdfA & ClpCP mediates metabolic differentiation during B. subtilis sporulation By Riley et al., Javier Lopez-Garrido and Kit Pogliano ➡️ https://genesdev.cshlp.org/content/39/7-8/524.full #bacteria #spore #dormancy

⏪ G&D RECAP ⏪ 🗓️ March 2025 RESEARCH PAPER: Two unrelated distal genes activated by a shared enhancer benefit from localizing inside the same small topological domain By Huang et al. and Wouter de Laat ➡️ https://genesdev.cshlp.org/content/39/5-6/348.full #enhancer #3Dgenome #CTCF #TADs #chromatin

⏪ G&D RECAP ⏪ 🗓️ February 2025 RESEARCH PAPER: LINE1 elements at distal junctions of rDNA repeats regulate nucleolar organization in human embryonic stem cells By Ataei et al. and Miguel Ramalho-Santos ➡️ https://genesdev.cshlp.org/content/39/3-4/280.full #retrotransposons #genome #chromosome

⏪ G&D RECAP ⏪ 🗓️ January 2025 REVIEW: Genetics and biology of pancreatic ductal adenocarcinoma By Ying et al. and Ronald DePinho ➡️ https://genesdev.cshlp.org/content/39/1-2/36.full #pancreaticcancer #PDAC #tumor #genetics #tumormicroenvironment #cancertherapy