🚨 NEW ISSUE ALERT!!! 🚨 New Research articles and Outlook online now at Genes & Development. Also in this issue, a detailed Review on the molecular and structural mechanisms of non-homologous end joining. Click on the link to learn more: ➡️ https://genesdev.cshlp.org/content/40/7-8.toc

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Multiomic analysis of clonal development reveals new regulators of leukemic cell growth By Bonilla et al. and Ruslan Sadreyev ➡️ https://ow.ly/Apg850YAPw7 @gracia-b.bsky.social Harvard Medical School #leukemia #AML #evolution

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Bypass of blocking lesions by RNAPII reveals a novel stress induced by DNA damage By Bañuelos et al. and Ramiro Verdun ➡️ https://ow.ly/ZfMy50YAOS1 #chromatin #histone #epigenetics #cellstress #chemotherapy

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Separable roles for Microprocessor and its cofactors, ERH and SAFB1/2, during microRNA cluster assistance By Shang et al. and Eric Lai ➡️ https://ow.ly/XzBb50YyUjb Memorial Sloan Kettering Cancer Center eric lai #miRNA #Microprocessor #RNAi

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: A brain-specific microRNA, miR-1000, regulates lipid homeostasis via neuropeptide-like precursor 1 in Drosophila melanogaster By Verma et al. and David Van Vactor ➡️ https://ow.ly/sCFM50YyTsG Harvard Medical School #Drosophila #lipid #metabolism #lifespan #miRNA

Register now for On Demand Access to Keystone Symposia #IsletBiology & #Diabetes : #BetaCell Compensation, Failure & Recovery, this March to explore emerging research! #KSDiabetes26 For more info: ➡️ https://hubs.la/Q03X7Ckz0

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Exosome-mediated decay of unstable long extended precursors of human telomerase RNA is dependent on 5′-cap trimethylation By Samajdar et al. and Luis Batista ➡️ https://ow.ly/Ko1u50YyStI Huntsman Cancer Institute #transcription #telomerase #telomere

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: The LINC complex component Kms1 & CENP-B protein Cbp1 cooperate to enforce faithful homology-directed DNA repair at the nuclear periphery in S. pombe By Laffitte et al. & Megan King ➡️ https://ow.ly/BRKE50Ywy23 Yale School of Medicine #yeast #DNArepair

📽️ G&D Tapes 📽️ G&D Author, Jamie Alegrio-Louro, tells us about their work defining conserved nucleosome-binding mechanisms for invertebrate protein Dsup and the vertebrate protein HMGN. Learn more here: ➡️ https://genesdev.cshlp.org/content/39/19-20/1155.full @jaimealegriolouro.bsky.social

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: tRNA synthetase activity is required for stress granule and P-body assembly By Baymiller et al. and Stephanie Moon ➡️ https://genesdev.cshlp.org/content/early/2026/01/13/gad.353535.125.full.pdf+html Stephanie Moon #translation #ribosome #granule #stress

🆕 ADVANCE ONLINE 🆕 RESEARCH COMMUNICATION: Chromatin architecture reprogramming reveals novel epigenetic dependencies in breast cancer By Garcia-Martinez et al. and Lluis Morey ➡️ https://genesdev.cshlp.org/content/early/2025/12/18/gad.352982.125.full.pdf+html Lluis Morey #chromatin #transcription

📽️ G&D Tapes 📽️ G&D Author, Chiara Nicoletti, tells us about how MYOD’s context-dependent role as a transcriptional repressor during skeletal muscle development. Learn more here: ➡️ https://genesdev.cshlp.org/content/39/21-22/1299.abstract Luca Caputo

I made a short video talking about our most recent research article published in Genes & Development where we characterised the cytosolic localisation and role of the conserved RNA binding protein Mei2. You can read all about it here: genesdev.cshlp.org/content/40/5...

OUTLOOK: Making order from disorder in the nucleolus By Susan J. Baserga ➡️ https://genesdev.cshlp.org/content/40/5-6/285.full Also read: ➡️ https://genesdev.cshlp.org/content/40/5-6/351.full @susanbaserga.bsky.social ##ribonucleoproteins #biocondensates #Cajalbodies #proteininteractions

Register now for On Demand Access to Keystone Symposia RNA Modifications: Bridging Biological Function and Therapeutic Potential, this March to explore emerging research! #KSRNAMod26 For more info: ➡️ https://hubs.la/Q03-NnlC0#KSRNAMod26

📽 G&D Tapes 📽 G&D Author, Christina McNerney, tells us about their new study in #genesdev showing how enzyme DIO3 coordinates photoreceptor development. Read the full story here: ➡️ https://genesdev.cshlp.org/content/40/1-2/70.full Christina McNerney Bob Johnston Johns Hopkins University#genesdev#vision

🎙️ G&D Voices: Author Robert J. Johnston Jr. 🎙️ At G&D, we publish rigorous, mechanism-focussed research while embracing cutting-edge model systems. Here’s what Bob Johnston had to say about publishing in G&D. Learn more here: ➡️ https://genesdev.cshlp.org

📽️ G&D Tapes 📽️ G&D Author, Ayokunle Araoyinbo, tells us about the compartment-specific roles of Mei2 in yeast RNA regulation and zygotic development. In this issue of #genesdev: ➡️ https://genesdev.cshlp.org/content/40/5-6/328.abstract Ayokunle Araoyinbo @vjesticalab.bsky.social#genesdev#translation #yeast

RESEARCH PAPER: Gamete fusion triggers cytosolic functions & P-body recruitment of the RNA-binding protein Mei2 to drive fission yeast zygotic development By Araoyinbo et al., & Aleksandar Vještica ➡️ https://genesdev.cshlp.org/content/40/5-6/328.abstract Ayokunle Araoyinbo @vjesticalab.bsky.social

RESEARCH PAPER: Retrotransposon activation during spermatogenesis achieves massive ecDNA biogenesis but rare integration By Tracy, Chen and ZZ Zhao Zhang ➡️ https://genesdev.cshlp.org/content/40/5-6/396.abstract @zz-zhang.bsky.social Duke University School of Medicine #retrotransposon #Drosophila

RESEARCH PAPER: PHA-4/FoxA controls the function of pharyngeal and extrapharyngeal enteric neurons in C. elegans By Walker et al., and Oliver Hobert ➡️ https://genesdev.cshlp.org/content/40/5-6/366.full Columbia University HHMI #transcriptionfactor #Celegans #neuron #gut

Really proud of our stellar lab manager, Kirti Mittal! 1st author in a paper out in @genesdev.bsky.social. From chromatin-bound RNA to functional studies in human ESCs, she discovered a new role for alpha-satellite repeats in nuclear compartmentalization. Congrats! pubmed.ncbi.nlm.nih.gov/41730687/

RESEARCH PAPER: Independent control of neurogenesis and dorsoventral patterning by NKX2-2 By Jang et al., and Hynek Wichterle ➡️ https://genesdev.cshlp.org/content/40/5-6/384.full Columbia University #transcriptionfactor #motorneuron #neurogenesis #spinalpatterning #Tinman

G&D's Executive Editor, Eric Sawey, is attending #IsletBiology & #Diabetes : #BetaCell Compensation, Failure & Recovery in Breckenridge! #KSDiabetes26 Keystone Symposia Want to share your work with us or learn about the journal? Stop by or reach out at [email protected] ➡️ https://hubs.la/Q03X7Ckz0#IsletBiology

RESEARCH PAPER: Intrinsically disordered regions stimulate concentration of small nucleolar ribonucleoproteins and formation of Cajal bodies & nucleoli By Meznad et al., and U. Thomas Meier ➡️ https://genesdev.cshlp.org/content/40/5-6/351.full Albert Einstein College of Medicine #ribonucleoprotein

📽️ G&D Tapes 📽️ G&D Author, Tuo Zhang, tells us about their new study showing how embryonic stem cells attain a diapause-like state, and can maintain their pluripotency and metabolic dormancy. Read more here: ➡️ https://genesdev.cshlp.org/content/40/5-6/319.full The Rockefeller University

RESEARCH PAPER: Transcriptional derepression of negative regulators of MAP kinase supports maintenance of diapause ES cells in the pluripotent state By Zhang et al., and Alexander Tarakhovsky ➡️ https://genesdev.cshlp.org/content/40/5-6/319.full The Rockefeller University #embryo #stemcell

RESEARCH PAPER: Combinatorial use of VHL and KEAP1 PROTACs reveals unexpected synergy and hook effect relief By Islam et al., and Luca Busino ➡️ https://genesdev.cshlp.org/content/40/5-6/308.abstract Penn Medicine #PROTAC #KRAS #cancer #cancertherapy

CANCER METABOLISM REVIEW: Metabolic permissiveness: how tissue context shapes cancer By Chrysanthi Moschandrea and Christian Frezza ➡️ https://genesdev.cshlp.org/content/40/5-6/287.full Christian Frezza CECAD Cologne Universität zu Köln #cancermetabolism #tumormicroenvironment

🚨 NEW ISSUE ALERT!!! 🚨 New Research articles and Outlook online now at Genes & Development. Also in this issue, the first in a series of Review articles on Cancer Metabolism. Click on the link to learn more: ➡️ https://genesdev.cshlp.org/content/40/5-6.toc

G&D Editor, Samantha Cyrill, is attending RNA Modifications: Bridging Biological Function & Therapeutic Potential next week in Keystone! #KSRNAMod26 Keystone Symposia Happy to chat about your work and the journal. Stop by or reach out at [email protected] For more info: ➡️ https://hubs.la/Q03-NnlC0#KSRNAMod26

🆕 ADVANCE ONLINE 🆕 OUTLOOK: Making order from disorder in the nucleolus By Susan J. Baserga @susanbaserga.bsky.social ➡️ https://genesdev.cshlp.org/content/early/2025/12/11/gad.353467.125.abstract Also read: ➡️ https://genesdev.cshlp.org/content/early/2025/11/26/gad.353180.125.abstract

🆕 ADVANCE ONLINE 🆕 CANCER METABOLISM REVIEW: Metabolic permissiveness: how tissue context shapes cancer By Chrysanthi Moschandrea and Christian Frezza ➡️ https://genesdev.cshlp.org/content/early/2026/02/09/gad.353516.125.abstract #cancermetabolism #oncogene #tumorsuppressor #mutation #TCAcycle

🎙️ G&D Voices: Author and Editorial Board Member Maria-Elena Torres-Padilla 🎙️ At G&D, we aim to provide a thoughtful and supportive publishing experience. Here’s what one author had to say about G&D's editorial process. Learn more about publishing with G&D here: ➡️ https://genesdev.cshlp.org

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Independent control of neurogenesis and dorsoventral patterning by NKX2-2 By Jang et al., and Hynek Wichterle ➡️ https://genesdev.cshlp.org/content/early/2026/01/12/gad.352886.125.abstract #transcriptionfactor #motorneuron #neurogenesis #spinalpatterning #Tinman

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Retrotransposon activation during spermatogenesis achieves massive ecDNA biogenesis but rare integration By Tracy, Chen and ZZ Zhao Zhang ➡️ https://genesdev.cshlp.org/content/early/2026/01/22/gad.353011.125.abstract #retrotransposon #Drosophila #genomestability

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Transcriptional derepression of negative regulators of MAP kinase supports maintenance of diapause ES cells in the pluripotent state By Zhang et al., and Alexander Tarakhovsky ➡️ https://genesdev.cshlp.org/content/early/2025/12/11/gad.353143.125.abstract

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: PHA-4/FoxA controls the function of pharyngeal and extrapharyngeal enteric neurons in C. elegans By Walker et al., and Oliver Hobert ➡️ https://genesdev.cshlp.org/content/early/2025/12/04/gad.353265.125.abstract Columbia University HHMI #Celegans #neuron #gut

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Intrinsically disordered regions stimulate concentration of small nucleolar ribonucleoproteins and formation of Cajal bodies and nucleoli By Meznad et al., and U. Thomas Meier ➡️ https://genesdev.cshlp.org/content/early/2025/11/26/gad.353180.125.abstract

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Combinatorial use of VHL and KEAP1 PROTACs reveals unexpected synergy and hook effect relief By Islam et al., and Luca Busino ➡️ https://genesdev.cshlp.org/content/early/2025/12/08/gad.352916.125.abstract #PROTAC #KRAS #cancer #cancertherapy

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Gamete fusion triggers cytosolic functions and P-body recruitment of the RNA-binding protein Mei2 to drive fission yeast zygotic development By Araoyinbo et al., and Aleksandar Vještica ➡️ https://ow.ly/99UX50Ye5KZ Ayokunle Araoyinbo @vjesticalab.bsky.social

OUTLOOK: Flicking the switch for B cell development By Ashley Ng and Stephen Nutt ➡️ https://genesdev.cshlp.org/content/40/3-4/143.full Also read: ➡️ https://genesdev.cshlp.org/content/40/3-4/233.full WEHI (The Walter and Eliza Hall Institute of Medical Research) University of Melbourne ##Bcell

RESEARCH PAPER: Potent synthetic lethality between PLK1 and EYA family inhibitors in tumors of the central and peripheral nervous systems By Nelson et al., and Hilda Pickett ➡️ https://genesdev.cshlp.org/content/40/3-4/267.full Children's Medical Research Institute #cancertherapy #glioblastoma

RESEARCH PAPER: B-lineage commitment is dependent on a reversible epigenetic switch By Tingvall-Gustafsson et al., and Mikael Sigvardsson ➡️ https://genesdev.cshlp.org/content/40/3-4/233.full Linköping University @lunduniversity.bsky.social #hematopoiesis #Bcell #transcriptionfactor #epigenetics

RESEARCH PAPER: Hunchback functions in the postmitotic larval MDN to restrict axon outgrowth, synapse formation, and backward locomotion By Lee et al., and Chris Doe ➡️ https://genesdev.cshlp.org/content/40/3-4/255.abstract HHMI University of Oregon #neuron #drosophila #locomotion #hunchback

RESEARCH PAPER: Plagl1 and Lrrc58 control mammalian body size by triggering target-directed microRNA degradation of miR-322 and miR-503 By LaVigne et al., and Joshua Mendell ➡️ https://genesdev.cshlp.org/content/40/3-4/215.full Josh Mendell HHMI #TDMD #RNAdecay #miRNA #triggerRNA #development

REVIEW: Nuclear receptor coregulator interactions: beyond the switch By F. Nafrisha Cassim Bawa and Mitchell Lazar ➡️ https://genesdev.cshlp.org/content/40/3-4/146.full University of Pennsylvania #nuclearreceptor #transcription #ligand #coactivator #corepressor

RESEARCH PAPER: Mutant p53 binds and controls estrogen receptor activity to drive endocrine resistance in ovarian cancer By Shao et al., and Maureen Murphy ➡️ https://genesdev.cshlp.org/content/40/3-4/199.full The Wistar Institute #ovariancancer #p53 #cancertherapy #endocrineresistance

G&D's Editor-In-Chief, Andrew Dillin, will be at the Keystone Symposia on Mitochondria Signaling in Physiology and Disease. #KSMitochondria26 If you’d like to chat about publishing your work with #genesdev, feel free to reach out to [email protected]

RESEARCH PAPER: SOX2 phosphorylation during mitosis limits genomic damage By Williams et al., and Steven Pollard ➡️ https://genesdev.cshlp.org/content/40/3-4/185.full Edinburgh University #sox2 #chromatin #neural #mitosis #stemcells #phosphorylation