How does the brain connect with each muscle to control the body? Check out new videos from @columbiamed.bsky.social & @zuckermanbrain.bsky.social that reveal two key molecules behind this vital process in fruit flies. @genesdev.bsky.social zuckermaninstitute.columbia.edu/microscopic-... 🧠💪🪰

Our study on the biogenesis of neuronal circular RNAs is out in Genes&Development @genesdev.bsky.social ! genesdev.cshlp.org/content/earl... Our celebration picture features first authors @carlosalfonsog.bsky.social and @shimengjin.bsky.social holding the fabulous circular cake, and most co-authors.

G&D will be at Biology of Cancer 2025 #cshlcancer this week. Come find us in Grace Lobby or schedule an appointment below if you'd like to chat about your work or learn more about publishing with us. @cshlmeetings.bsky.social @genesdev.bsky.social#cshlcancer ➡️ https://tinyurl.com/GenesDev-MeetTheEditors

RESEARCH PAPER: Bystander activation across a TAD boundary supports a cohesin-dependent transcription cluster model for enhancer function By Williamson et al. ➡️ https://tinyurl.com/gd352648 #chromatin #enhancer #transcription #sonichedgehog #TAD #cohesin #genomics #3Dgenome #loopextrusion

OUTLOOK: Lineage rewiring in lung adenocarcinoma via HNF4α and NKX2-1 dynamics By Alice Feng, Alena Yermalovich, and Matthew Meyerson ➡️ https://tinyurl.com/gd353142 Read the paper: ➡️ https://tinyurl.com/gd352742 #KRAS #hybrididentity #lineage #plasticity #lungcancer #cancertherapy

G&D's Editor-in-Chief, Andrew Dillin will be at the 2025 Frontiers in Metabolism – Mechanisms of Metabolic Disease meeting at the Morgridge Institute for Research @uwmadison.bsky.social. If you’d like to chat about publishing your work with us, feel free to reach out to dillin@berkeley.edu

RESEARCH PAPER: Opposing lineage specifiers induce a pro-tumor hybrid identity state in lung adenocarcinoma By Fort et al. ➡️ https://tinyurl.com/gd352742 #cancer #gastrointestinal #lung #transcriptionfactor #tumorigenesis #RAS/MEK #signaling #lineage #plasticity #cancertherapy

OUTLOOK: Speed of life: tuning the ticktock of the segmentation clock By Sally Lowell ➡️ https://tinyurl.com/gd353096 Read the paper: ➡️ https://tinyurl.com/gd352909 #Notch #E3ligase #segmentationclock #somitogenesis #somitoid

RESEARCH PAPER: ELAV mediates circular RNA biogenesis in neurons By Alfonso-Gonzalez et al. ➡️ https://tinyurl.com/gd352670 #circRNA #neuroscience #RNAbindingprotein #Drosophila #embryos #neurons #mRNA #introns #splicing

REVIEW: Timing is everything: transcription bursting in development By Jee Min Kim and Daniel Larson ➡️ https://tinyurl.com/gd352465 #transcription #molecularbiology #transcriptionbursting #embryonicdevelopment #stemcell #differentiation #mRNA #development #molecularmechanism

📽️ G&D Tapes 📽️ G&D Author, Edel McCrea tells us about their new study in #genesdev reporting a role for tyrosine phosphatase PTNP14 in the sexually dimorphic regulation of Hippo pathway function. Learn more here: ➡️ https://tinyurl.com/gd352620

RESEARCH PAPER: Analysis of knockout mice reveals critical female-specific roles for the Hippo pathway component PTPN14 By McCrea et al. ➡️ https://tinyurl.com/gd352620 #Hippo #Development #SexDifferences #YAPTAZ #signaling #WoundHealing #PTPN14 #CornealDisease #uterus #WomensHealth

Excited to share that our manuscript “MEF2C controls segment-specific gene regulatory networks that direct heart tube morphogenesis” is now online @genesdev.bsky.social ! genesdev.cshlp.org/content/earl... (1/n)

📽️ G&D Tapes 📽️ G&D Author, Hedda Meijer tells us about their recent study in #genesdev that demonstrates the functional significance of the interaction between NOTCH1/NICD and the F-box protein FBXW7 during somitogenesis. Learn more here: ➡️ https://tinyurl.com/gd352909

RESEARCH PAPER: NOTCH1 S2513 is critical for the regulation of NICD levels impacting the segmentation clock in hiPSC-derived PSM cells and somitoids By Meijer et. al ➡️ https://tinyurl.com/gd352909 #segmentationclock #NOTCH #NICD #somite #somitoid #embryo #patterning

🚨 NEW ISSUE ALERT!!! 🚨 New Outlooks, Review and Research Papers online now at Genes & Development. Click on the link for more: ➡️ genesdev.cshlp.org/content/39/1...

REVIEW: Studying ovarian aging and its health impacts: modern tools and approaches By Bérénice A. Benayoun, Alison Kochersberger, and Jennifer L. Garrison ➡️ genesdev.cshlp.org/content/39/1... @bbparis1984.bsky.social @jennifergarrison.bsky.social #reproductiveaging #ovary #aging #womenshealth

SYMPOSIUM OUTLOOK: C. elegans cognitive decline with age: more than just wiggling forward and backward By Coleen T. Murphy ➡️ genesdev.cshlp.org/content/39/1... #animalmodels #elegans #behavior #cognition #memory #aging #cognitiveaging

SYMPOSIUM OUTLOOK: The interplay between senescence, inflammation, and the immune system By Jesús Gil ➡️ genesdev.cshlp.org/content/39/1... #senescence #aging #immune #SASP #nucleicacid #inflammation #therapy #openaccess

SYMPOSIUM OUTLOOK: Beyond the usual suspects: expanding aging research from classic models to really cool critters By Amy Walker @akw-lab.bsky.social ➡️ genesdev.cshlp.org/content/39/1... #animalmodels #aging #longevity #allometry #immune #metabolism #environment #openaccess #lifespan #genomics

SYMPOSIUM OUTLOOK: Scaling life as an interspecies hallmark of aging By Itamar Harel ➡️ genesdev.cshlp.org/content/39/1... #aging #evolution #naturalselection #temporalscaling #mortalityrisk #lifespan #reproduction #environment #molecularbiology

SYMPOSIUM OUTLOOK: #Telomeres at the nexus of #aging, #tumor suppression, and #inflammation: toward an understanding beyond #senescence By Samuel Bloom & Jan Karlseder ➡️ https://bit.ly/410dJwg ##cshlsymp25 #DNAdamage #replicativesenescence #DNAreplication #crisis #cancer

SYMPOSIUM OUTLOOK: Mitochondria dysfunction: cause or consequence of physiologic aging? By G.R. Scott Budinger & Navdeep Chandel ➡️ https://bit.ly/41H1W65 ##cshlsymp25 #mitochondria #aging #signaling #ATP #organelles #healthspan #metabolism #DNAdamage #oxidativestress

SYMPOSIUM OUTLOOK: Cancer mortality and senescence: Is redox therapy an option? By Shan Kuang, Manojit Swamynathan, & Lloyd C. Trotman ➡️ https://bit.ly/4fFk3zg ##cshlsymp25 #senescence #cancer #metastasis #prostatecancer #pro-oxidants #redox #lysosome #senolytic #cancertherapy #aging #biomarkers

📽️ G&D Tapes 📽️ G&D Author, Marion Solbach Mouginot tells us about their recent study in #genesdev describing how meta-domains control neuronal gene expression. Learn more here: ➡️ bit.ly/45wGi5M #TAD #chromatin #transcription #neuron #drosophila #3Dgenome

SYMPOSIUM OUTLOOK: Killing wisely: precision senolytics in the age of frailty By Valentin Barthet & Scott Lowe ➡️ https://bit.ly/415me9d ##cshlsymp25 #senescence #senolytics #aging #disease #cancer #immunotherapy #precisionmedicine #uPAR #CARTcells #openaccess

G&D is pleased to present a collection of Outlooks inspired by the recent CSHL Symposium on #Aging and #Senescence. Online now: ➡️ https://bit.ly/47vDGHV

REVIEW: Aging and immunity: the age-old tango by Fernández Maestre et al. @corina-amor.bsky.social‬ @cshlaboratory.bsky.social‬ ➡️ https://tinyurl.com/gd352644 ##aging #senescence #cancer #immuneregulation #antiaging #immunotherapy #CancerImmunotherapy #Inflammaging #CARTCellTherapy #CART

Perspective: Zhu et al. discuss the rise of RAS: how gradual oncogene activation shapes the OIS spectrum @narita-lab.bsky.social ➡️ tinyurl.com/gd352761 #oncogene #cancer #senescence #SASP #physiology #tumorigenesis #tumor #RAS #NOTCH #dose #cellstate #inflammation #replicativestress #openaccess

NEW ISSUE ALERT!!! Inspired by the 2025 CSHL Symposium on Aging & Senescence, this issue features a collection of Outlook, Perspective, and Review articles on the impact of aging on metabolism, immunity, reproductive health & cancer. Online now: ➡️ genesdev.cshlp.org/content/39/1...

In this study, Tran et al. show that Notch signaling controls the switch from neuronal fates to oligodendrocyte fates—in response to Sonic hedgehog signaling—during late embryogenesis. Learn more here: ➡️ tinyurl.com/gd352555

Excited to share that our latest story on Restrictor is out now in @genesdev.bsky.social!! Big thank you to my fellow co-first author Hanneke, Karen @adelmanlab.bsky.social and co-authors Nathalie and Allison!

Happy to share this paper! We uncovered that good 5' splice sites protect against ZC3H4/Restrictor's promiscuous role, and that its role is to suppress elongation and indirectly cause termination. Looking forward to learning more about this protein in the future!

In this study, Perry et al. report that TEAD performs YAP/TAZ-dependent and -independent functions by switching interacting partners during brain development and neuronal lineage progression. Learn more here: ➡️ tinyurl.com/gd352632

Excited to see this new review piece that we wrote together with Jennifer Garrison and Alison Kochersberger on the modern tools and approaches to study #ovarian #aging out this week at @genesdev.bsky.social! genesdev.cshlp.org/content/earl... #GeroSky #WomensHealth 🧪🧬 A 🧵1/3

In this study, Mimoso et al. show that Restrictor serves as a transcriptional safeguard that suppresses the spurious transcription of non-coding RNAs, while preserving mRNA transcription. Learn more here: ➡️ tinyurl.com/gd352654

In this Outlook, Rodeheffer discusses this study and highlights the functional importance of the ETS family of transcription factors in lineage decisions and cell function. #OpenAccess Read the Outlook: ➡️ tinyurl.com/gd352966

In this study, Xue et al. identify a distal enhancer that interacts with transcription factor ETV4 to control brown adipose thermogenesis, with implications for metabolic diseases like obesity and diabetes. #OpenAccess Learn more here: ➡️ tinyurl.com/gd352748

📽️ G&D Tapes 📽️ G&D author, Noah Helton tells us about their new study in #genesdev, revealing an intriguing link between stress granule formation and the integrated stress response. #OpenAccess @smslmoon.bsky.social Read the full story here: ➡️ tinyurl.com/gd352899

In this study, Helton et al. explore the link between stress-induced gene expression and mRNA condensation into stress granules. #OpenAccess @smslmoon.bsky.social Learn more here: ➡️ tinyurl.com/gd352899

G&D’s Editor-In-Chief, Professor Andy Dillin is attending the #GLIA2025 in Marseille. If you’d like to share your work with us or learn about the journal, feel free to drop by or reach out to [email protected] @genesdev.bsky.social @dillinlab.bsky.social

In this Review, Bodur et al. discuss the intricacies of neural control of leptin signaling and its implications for food intake, body weight, metabolism, and disease. #OpenAccess Learn more here: ➡️ tinyurl.com/gd352550

📽️ G&D Tapes 📽️ G&D authors tell us about the recent study by Chocarro-Calvo et al. in #genesdev describing the metabolic cross-talk between melanoma and adipose, and the influence of nutrients on melanoma progression. @achocarro-calvo.bsky.social Learn more here: ➡️ tinyurl.com/gd351985

NEW ISSUE ALERT!!! Check out the new Outlook, Review and Research Papers online now at Genes & Development. Click on the link for more: ➡️ genesdev.cshlp.org/content/curr...

In this study, Magesh et al. describe the metabolic consequences of breast cancer-associated, net gain aneuploidy on mammary epithelial cells, identifying dependencies to improve chemotherapeutic response. #OpenAccess Learn more here: ➡️ tinyurl.com/gd352512

In this Outlook, Huang et al. highlight the heterogeneity of pineoblastoma's pathogenic mechanisms with implications for therapeutic interventions. #OpenAccess Read the Outlook: ➡️ tinyurl.com/gd352932

In this study, Fraire et al. elucidate the impact of the loss of microRNA processing on pineoblastoma formation, illustrating parallel mechanisms that can be leveraged into combinatorial anti-tumor therapies. Learn more here: ➡️ tinyurl.com/gd352485

📽️ G&D Tapes 📽️ G&D author Aitana Verdu Schlie tells us about their new work in #GenesDev about CDK4's role during development, with mutations causing microcephaly and growth defects. #OpenAccess @lukastamayo.bsky.social @aitanavs.bsky.social Read the full story here: ➡️ tinyurl.com/gd352311

In this study, Dehmer et al. show that the USP11/TCEAL1 complex buffers TFIIS's function in RNAPII backtracking, promoting transcription elongation and oncogenic transcription in neuroblastoma. Learn more here: ➡️ tinyurl.com/gd352166

In this study, Mouginot et al. describe the formation and function of meta-domains−megabase-range chromatin contacts−that underpin the complexity and specificity of neuron-specific genome architecture and gene expression. Learn more here: ➡️ tinyurl.com/gd352646