WE'RE HIRING: Cornell University’s Weill Institute for Cell & Molecular Biology and the Department of Molecular Biology & Genetics are seeking a tenure-track Assistant Professor whose research integrates cell and molecular biology with an evolutionary perspective. apps.hr.cornell.edu/recruiting/f...

🌟 Congratulations to @weillinstitute.bsky.social founding director Scott Emr, on winning the prestigious World Laureate Association Prize! His landmark work on the ESCRT pathway reshapes our understanding of infection, cancer & neurodegeneration. 🌟 news.cornell.edu/stories/2025...

Just throwing this out there as a significant conceptual advance in the field www.biorxiv.org/content/10.1...

I couldn’t be more proud of this tremendous work by Dr @awood2.bsky.social in my lab, co-led by myself and @idwolff.bsky.social. Anna worked tirelessly to conduct a comprehensive analysis of female meiosis, showing that CNTD1 plays role in crossover designation and checkpoint regulation in females.

Co-organizing a one day FREE conference on Genome Instability- Discovery to Personalized Medicine 11/1/25. Please join us! Short talks available. https//noncredit.t...

Here is a link to a new pre-print that is a collaborative effort between our lab and the lab of Michelle Wang here at Cornell. We use single-molecule techniques to investigate how the combination of Rad51 and Rad54 remodels donor DNA during the homology search www.biorxiv.org/cgi/content/...

Here we show that >90% of Paenibacillus encode a unique Spo0B with a transmembrane domain! TM domain helps it interact with its phosphorelay partners. Congrats to @isabellalin.bsky.social who left for grad school this week and her mentor @cassidyprints.bsky.social! www.biorxiv.org/content/10.1...

De novo engineered guide RNA-directed transposition with TnpB-family proteins reveals features of naturally evolved systems www.biorxiv.org/content/10.1...

Things seen today on campus: A coyote leading a slow speed chase of police

Transcription and recombination are two universal DNA-dependent processes, but how they are coordinated remains largely unknown. Here we characterized transcription-recombination priority rules in yeast. 🧵 www.embopress.org/doi/full/10....

We've reached wild animals roaming campus unchecked level of dystopia...

New preprint from the lab: Dr. Daniela James led an effort to improve the ChIP-exo protocol for high-res protein-DNA interactions. Particularly focused on optimizing for use in mammalian cells and making the protocol compatible with newer Illumina sequencers. www.biorxiv.org/content/10.1...

I am delighted to share that I have started my lab in the Dept. of Biochemistry @uofubiochem.bsky.social at the University of Utah @utah.edu. My laboratory will study key aspects of protein synthesis and translational control in healthy and diseased states. #RNAsky sinha.biochem.utah.edu

New publication from our lab! It was really fun writing this review @jcb.org with my postdoc Dr. Chris Mellor and graduate student Elisabeth Larson. We explore how folate deficiency trigger DNA damage that disrupt genome stability.

Latest from the lab! Analysis of everyone’s favorite regulatory mechanism in bacteria — the RF2 programmed frameshift! Likely present in the ancestor of bacteria, use of this mechanism is influenced by stop codon usage! Big congrats to @cassidyprints.bsky.social journals.asm.org/doi/10.1128/...

Check out our new preprint on the discovery of a molecular switch in NAC that mediates nascent chain sorting on the ribosome and prevents mitochondrial protein mistargeting by SRP. A great collaboration with the Shan Lab @Caltech and the Qi Lab @UVA: www.biorxiv.org/content/10.1...

New from our lab in @narjournal.bsky.social: We dissect the folding dynamics of a fundamental element of RNA secondary structure—a stem-loop—at single-molecule and microsecond resolution. doi.org/10.1093/nar/... 1/5

South Park has never disappointed

I've reached a new level of success in my academic career. Things are simultaneously amazing and awful at the same time.

Penn says there are five lights

Maybe a little Guns N Roses to lift my spirits

New preprint from the lab: ATM controls fork processing and restart, and the PPM1D phosphatase is needed to properly balance this action of ATM. Congratulations to @yitingcao.bsky.social @yingzhengwang.bsky.social and Jumana Badar. www.biorxiv.org/content/10.1...

There are four lights

What I wouldn't give for a simple teapot dome right now

Happy to share our DNA Repair special issue on the replication stress response curated with @vindignilab.bsky.social. www.sciencedirect.com/special-issu...

The university refused to make changes it said would "dictate what private universities can teach" and "whom they can admit and hire," among other things.

Harvard currently

Latest work from the lab - we identify a translation factor, YebC2, that reduces ribosome stalling in B. subtilis! Congrats to co-first authors: grad students Hye-Rim Hong & Cassidy Prince & undergrad Dennis Wu @denniswu02.bsky.social journals.plos.org/plosgenetics...

An important lesson from Jean-Luc Picard that I’m still sharing all these years later.

If you give a mouse a cookie, He's gonna ask for a glass of milk.

Excited to share our new pre-print. Direct, ensemble FRET assays developed by our lab reveal that assembly of Rad51 filaments at stalled replication sites via RPA/Rad51 exchange causes complete & irreversible PCNA unloading. Big implications for interplay between human DNA damage tolerance pathways

Bryce Brownfield's review on the structural biology of Golgi trafficking has been published! authors.elsevier.com/a/1kqrY3PA3s... Bryce is now a postdoc in the @buzbarstow.bsky.social lab, we miss him dearly!

How do replisomes walk on DNA? And what happens when they run into a G-quadruplex? @sahilbatra.bsky.social and @benallwein.bsky.social provide unexpected insight in our latest paper with Richard Hite @mskcancercenter.bsky.social @science.org www.science.org/doi/10.1126/.... Congrats to all authors!

A great pleasure to share our newest paper out this morning @cp-molcell.bsky.social. We show that damage to nascent RNAs should not be ignored, and under certain conditions, these can turn into DNA breaks. We call this phenomena RDIBs (RNA Damage Induced Breaks). www.cell.com/molecular-ce...

Excuse me what? Their NIH regulations to track funds

NIH rebutting various arguments now. Re the difficulty of indirect cost oversight: yes, there are a lot of reporting reqs, but the mere presence of so much regulation proves how difficult it is. It's "certainly rationale" to conclude it's burdensome to oversee indirect costs.

Well, we tried to do something www.biorxiv.org/content/10.1...

America is so drunk right now

My first-author paper on uncovering a non-canonical Tel1 motif using phosphoproteomics has been published in JBC! Amazing to work with @rainshj.bsky.social using both untargeted and targeted mass spectrometry. Check it out: doi.org/10.1016/j.jb...

It's not waste its the F*cking American economy dumbass!

On changes to #NIH indirect rates, there is a law in place that prohibits NIH from making such changes without the approval of Congress. See Division D, Title II Section 224 of The Further Consolidated Appropriations Act, 2024 (Public Law No: 118-47) grants.nih.gov/grants/guide...

so there is a black market for egg now abc7ny.com/post/egg-hei...

I guess I should have had another trillion dollar war in the middle east on my bingo card

We did a thing... We purified native transcriptional complexes from Drosophila embryos, obtaining +/- stalk Pol II elongation complexes, native nucleosomes, as well as a nucleosome elongation complex. For more details please check out: doi.org/10.1101/2025...

Isn't this the plot to every die hard movie. International terrorists hack into a computer system to steal money? In this scenario the tariffs are the distraction.

We are up to -3 F˚ and the sun is out a heat wave is forming