Excited to start 2026 out with a new manuscript from our lab, please check out this thread from superstar postdoc @rvig.bsky.social about how he discovered the function of a conserved secretory protein, and how this also led him to the identification of a new family of GAP proteins!

Alessandro Costa @costalaboratory.bsky.social, Dana Branzei and myself are co-organising the 2026 Machines on Genes meeting in beautiful Crete as the 94th Harden Conference hosted by @biochemsoc.bsky.social Register now - lots of opportunities for selected talks www.eventsforce.net/biochemsoc/f...

The sporulation phosphorelay protein Spo0B is membrane localized in Paenibacillus! The transmembrane domain appears to increase interaction with relay partners. Congrats to former lab undergrad @isabellalin.bsky.social and her grad mentor @cassidyprints.bsky.social journals.asm.org/doi/10.1128/...

Jingyi is harnessing the awesome power of yeast genetics...

To top off the end of 2025, a new preprint from our lab! We find an unanticipated new answer to an old question in DNA repair. www.biorxiv.org/cgi/content/...

We are hiring! We are looking for a motivated and enthusiastic postdoc to study mammalian DSB repair using innovative genomic approaches. Our lab is at the Curie Institute in Paris and offers vibrant scientific environnement and cutting edge platforms. Please repost or apply here: lnkd.in/eJ9q3QrR

Aaron Rodgers is doing a perfect 40-year-old impression right now. I can empathize so hard.

🤡

Congrats to Jingyi Hu the first PhD thesis defender of the Crickard lab

Harry Potter hits differently when you realize it's the revenge tale of Severus Snape

Interested in analyzing kinase activity with subcellular spatial resolution? Want to learn more about peptide barcoding? @smolka-lab.bsky.social and @wjcomstock.bsky.social have something just for you!

Delighted to see our study finally out in "print". Thanks to all the (many) contributors, collaborators and reviewers! Mismatch repair disturbs meiotic crossover control in S. cerevisiae academic.oup.com/nar/article/...

Happy to share our @narjournal.bsky.social paper on the mechanism of Dmc1 filament stabilization by Mei5-Sae3! We show that Mei5-Sae3 can stabilize both active and inactive Dmc1 filaments, and that this is independent of the ATP hydrolytic cycle. doi.org/10.1093/nar/...

Be careful the gates of hell are temporarily open

Members of @acsbiol.bsky.social, the Fall 2025 Election is occurring now & will run until 11/28. To ensure you receive your ballot, be sure that your ACS membership is up to date & your email filters are set to receive from [email protected].

in the crucible

I'm happy to post this recent work from our lab. Trying to keep things going under challenging times. www.biorxiv.org/cgi/content/...

remember when data not shown and personal communication would appear at least once or twice in a paper, and error bars were optional...

What is the over/under they end up in the wrong Portland...

WE'RE HIRING: Cornell University’s Weill Institute for Cell & Molecular Biology and the Department of Molecular Biology & Genetics are seeking a tenure-track Assistant Professor whose research integrates cell and molecular biology with an evolutionary perspective. apps.hr.cornell.edu/recruiting/f...

🌟 Congratulations to @weillinstitute.bsky.social founding director Scott Emr, on winning the prestigious World Laureate Association Prize! His landmark work on the ESCRT pathway reshapes our understanding of infection, cancer & neurodegeneration. 🌟 news.cornell.edu/stories/2025...

Just throwing this out there as a significant conceptual advance in the field www.biorxiv.org/content/10.1...

I couldn’t be more proud of this tremendous work by Dr @awood2.bsky.social in my lab, co-led by myself and @idwolff.bsky.social. Anna worked tirelessly to conduct a comprehensive analysis of female meiosis, showing that CNTD1 plays role in crossover designation and checkpoint regulation in females.

Co-organizing a one day FREE conference on Genome Instability- Discovery to Personalized Medicine 11/1/25. Please join us! Short talks available. https//noncredit.t...

Here is a link to a new pre-print that is a collaborative effort between our lab and the lab of Michelle Wang here at Cornell. We use single-molecule techniques to investigate how the combination of Rad51 and Rad54 remodels donor DNA during the homology search www.biorxiv.org/cgi/content/...

Here we show that >90% of Paenibacillus encode a unique Spo0B with a transmembrane domain! TM domain helps it interact with its phosphorelay partners. Congrats to @isabellalin.bsky.social who left for grad school this week and her mentor @cassidyprints.bsky.social! www.biorxiv.org/content/10.1...

De novo engineered guide RNA-directed transposition with TnpB-family proteins reveals features of naturally evolved systems www.biorxiv.org/content/10.1...

Things seen today on campus: A coyote leading a slow speed chase of police

Transcription and recombination are two universal DNA-dependent processes, but how they are coordinated remains largely unknown. Here we characterized transcription-recombination priority rules in yeast. 🧵 www.embopress.org/doi/full/10....

We've reached wild animals roaming campus unchecked level of dystopia...

New preprint from the lab: Dr. Daniela James led an effort to improve the ChIP-exo protocol for high-res protein-DNA interactions. Particularly focused on optimizing for use in mammalian cells and making the protocol compatible with newer Illumina sequencers. www.biorxiv.org/content/10.1...

I am delighted to share that I have started my lab in the Dept. of Biochemistry @uofubiochem.bsky.social at the University of Utah @utah.edu. My laboratory will study key aspects of protein synthesis and translational control in healthy and diseased states. #RNAsky sinha.biochem.utah.edu

New publication from our lab! It was really fun writing this review @jcb.org with my postdoc Dr. Chris Mellor and graduate student Elisabeth Larson. We explore how folate deficiency trigger DNA damage that disrupt genome stability.

Latest from the lab! Analysis of everyone’s favorite regulatory mechanism in bacteria — the RF2 programmed frameshift! Likely present in the ancestor of bacteria, use of this mechanism is influenced by stop codon usage! Big congrats to @cassidyprints.bsky.social journals.asm.org/doi/10.1128/...

Check out our new preprint on the discovery of a molecular switch in NAC that mediates nascent chain sorting on the ribosome and prevents mitochondrial protein mistargeting by SRP. A great collaboration with the Shan Lab @Caltech and the Qi Lab @UVA: www.biorxiv.org/content/10.1...

New from our lab in @narjournal.bsky.social: We dissect the folding dynamics of a fundamental element of RNA secondary structure—a stem-loop—at single-molecule and microsecond resolution. doi.org/10.1093/nar/... 1/5

South Park has never disappointed

I've reached a new level of success in my academic career. Things are simultaneously amazing and awful at the same time.

Penn says there are five lights

Maybe a little Guns N Roses to lift my spirits

New preprint from the lab: ATM controls fork processing and restart, and the PPM1D phosphatase is needed to properly balance this action of ATM. Congratulations to @yitingcao.bsky.social @yingzhengwang.bsky.social and Jumana Badar. www.biorxiv.org/content/10.1...

There are four lights

What I wouldn't give for a simple teapot dome right now

Happy to share our DNA Repair special issue on the replication stress response curated with @vindignilab.bsky.social. www.sciencedirect.com/special-issu...

The university refused to make changes it said would "dictate what private universities can teach" and "whom they can admit and hire," among other things.

Harvard currently