Cassidy Prince
@cassidyprints.bsky.social
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📥 32
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Cornell Microbiology PhD Candidate in the Feaga Lab | PSU Microbiology ‘21 | big fan of big data 🤩🥰🧬
pinned post!
Just published the first chapter of my thesis! 🥰 E. coli regulates the levels of a translation release factor (RF2) via a *purposeful* frameshift during translation. We found that most other bacteria do this too and it's likely an ancient mechanism!
journals.asm.org/doi/10.1128/...
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Conservation and evolution of the programmed ribosomal frameshift in prfB across the bacterial domain | mBio
Translation termination is catalyzed by one of two release factors in bacteria, RF1 or RF2. It has been known for decades that RF2 levels in Escherichia coli are regulated by a programmed ribosomal frameshift within the prfB gene that encodes RF2. We ...
https://journals.asm.org/doi/10.1128/mbio.01055-25
7 months ago
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reposted by
Cassidy Prince
George O'Toole (he/him/his)
about 1 month ago
rince & JB Editor's Choice: Lin, Prince & Feaga identified sporulation genes via analyzing almost 1500 genomes. They show that that an unusual membrane-localized variant of Spo0B is found throughout Paenibacillaceae.
journals.asm.org/doi/10.1128/...
@asm.org
#JBacteriology
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reposted by
Cassidy Prince
Heather Feaga
2 months ago
The sporulation phosphorelay protein Spo0B is membrane localized in Paenibacillus! The transmembrane domain appears to increase interaction with relay partners. Congrats to former lab undergrad
@isabellalin.bsky.social
and her grad mentor
@cassidyprints.bsky.social
journals.asm.org/doi/10.1128/...
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https://journals.asm.org/doi/10.1128/jb.00367-25
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the thing about a yarn festival is people want me soooo bad it makes them look stupid
5 months ago
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reposted by
Cassidy Prince
ASM
6 months ago
As national medical, scientific, public health and patient organizations, we call for the resignation of HHS Secretary Robert F. Kennedy Jr. to ensure the health of the American people. Read our statement:
asm.org/press-releas...
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Joint Statement Calling for Secretary Kennedy Resignation
The American Society for Microbiology released a joint statement calling for the resignation of HHS Secretary Robert F. Kennedy Jr.
https://asm.org/press-releases/2025/september/joint-statement-calling-for-secretary-kennedy-resi
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reposted by
Cassidy Prince
Heather Feaga
6 months ago
Here we show that >90% of Paenibacillus encode a unique Spo0B with a transmembrane domain! TM domain helps it interact with its phosphorelay partners. Congrats to
@isabellalin.bsky.social
who left for grad school this week and her mentor
@cassidyprints.bsky.social
!
www.biorxiv.org/content/10.1...
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Conservation of sporulation genes and a transmembrane-containing Spo0B variant in Paenibacillus
Sporulation is a strategy employed by many bacteria to survive harsh environmental conditions. The genus Paenibacillus includes spore-forming species notorious for spoiling pasteurized dairy products ...
https://www.biorxiv.org/content/10.1101/2025.08.24.672004v1
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Awesome work from my mentee
@isabellalin.bsky.social
on sporulation in non-model Bacilli!!
add a skeleton here at some point
6 months ago
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reposted by
Cassidy Prince
Heather Feaga
7 months ago
Latest from the lab! Analysis of everyone’s favorite regulatory mechanism in bacteria — the RF2 programmed frameshift! Likely present in the ancestor of bacteria, use of this mechanism is influenced by stop codon usage! Big congrats to
@cassidyprints.bsky.social
journals.asm.org/doi/10.1128/...
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Conservation and evolution of the programmed ribosomal frameshift in prfB across the bacterial domain | mBio
Translation termination is catalyzed by one of two release factors in bacteria, RF1 or RF2. It has been known for decades that RF2 levels in Escherichia coli are regulated by a programmed ribosomal frameshift within the prfB gene that encodes RF2. We ...
https://journals.asm.org/doi/10.1128/mbio.01055-25
3
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Just published the first chapter of my thesis! 🥰 E. coli regulates the levels of a translation release factor (RF2) via a *purposeful* frameshift during translation. We found that most other bacteria do this too and it's likely an ancient mechanism!
journals.asm.org/doi/10.1128/...
loading . . .
Conservation and evolution of the programmed ribosomal frameshift in prfB across the bacterial domain | mBio
Translation termination is catalyzed by one of two release factors in bacteria, RF1 or RF2. It has been known for decades that RF2 levels in Escherichia coli are regulated by a programmed ribosomal frameshift within the prfB gene that encodes RF2. We ...
https://journals.asm.org/doi/10.1128/mbio.01055-25
7 months ago
2
26
3
reposted by
Cassidy Prince
Heather Feaga
11 months ago
Latest work from the lab - we identify a translation factor, YebC2, that reduces ribosome stalling in B. subtilis! Congrats to co-first authors: grad students Hye-Rim Hong & Cassidy Prince & undergrad Dennis Wu
@denniswu02.bsky.social
journals.plos.org/plosgenetics...
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YebC2 resolves ribosome stalling and increases fitness of cells lacking EF-P and the ABCF ATPase YfmR
Author summary Polyproline motifs are essential structural features of many proteins but are difficult for the ribosome to synthesize. EF-P reduces ribosome pausing at polyproline motifs. Here, we sho...
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1011633
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