NealeLab
@labneale.bsky.social
๐ค 1691
๐ฅ 209
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Recombination, Meiosis, Chromosomes, DNA Break Repair
https://twitter.com/LabNeale
pinned post!
NOW LIVE!: PhD opening joint with
@drjonbaxter.bsky.social
at
@gdsc-sussex.bsky.social
Get in touch and apply if you are interested in any and all of: Chromosomes, Genome Stability, Chromatin and DNA Topology in Mitosis and Meiosis.
www.sussex.ac.uk/study/fees-f...
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20 days ago
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NealeLab
Rajiv McCoy
about 1 month ago
Pregnancy loss is common in humans, and chromosomal abnormalities are the leading cause. Using genetic data from ~140,000 IVF embryos, we show that maternal variation in meiosis genes influences recombination and aneuploidy risk. First authors:
@saracarioscia.bsky.social
&
@aabiddanda.github.io
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Common variation in meiosis genes shapes human recombination and aneuploidy - Nature
Analysis of data from pre-implantation genetic testing sheds light on the genetic basis of meiotic-origin aneuploidy, the leading cause of human pregnancy loss, identifying common genetic variants ass...
https://www.nature.com/articles/s41586-025-09964-2
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After a long incubation, it is a huge pleasure to finally share the work of
@luzmlopez.bsky.social
, Jon Harper and their coauthors: "Localised negative feedback shapes genome-wide patterning of meiotic DNA breaks".
@gdsc-sussex.bsky.social
www.biorxiv.org/content/10.6...
8 days ago
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Now live on Find-A-PhD-dot-com: Joint project between
@labneale.bsky.social
and
@drjonbaxter.bsky.social
@gdsc-sussex.bsky.social
Get in touch if you are interested in any and all of: Chromosomes, Genome Stability, Chromatin and DNA Topology in Mitosis and Meiosis.
www.findaphd.com/phds/project...
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15 days ago
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NealeLab
Di Jiang
18 days ago
@science.org
A small polymerase ribozyme that can synthesize itself and its complementary strand | Science
www.science.org/doi/10.1126/...
#RNA
#ribozyme
#evolution
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Indeed! And this depiction is just of one...
www.nature.com/articles/sre...
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20 days ago
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NOW LIVE!: PhD opening joint with
@drjonbaxter.bsky.social
at
@gdsc-sussex.bsky.social
Get in touch and apply if you are interested in any and all of: Chromosomes, Genome Stability, Chromatin and DNA Topology in Mitosis and Meiosis.
www.sussex.ac.uk/study/fees-f...
add a skeleton here at some point
20 days ago
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NealeLab
Biochemistry & Biomedicine @ University of Sussex
26 days ago
Super strong representation from our department in SussexRNA at the RNA UK meeting in Windermere this week. Many congrats to Jake, Courtney and Hope from the Ben Towler group, and Leandro Castellano, Lidia Vasilieva, Ben and Nikos for having abstracts accepted for presentation. ๐
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Beautiful! Is this in real time (20 seconds?) (Speed also seem to slow over time?)
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27 days ago
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Changes in the UK R&I funding landscape - doing fewer things better. An open letter from Ian Chapman to research and innovation community:
www.ukri.org/news/open-le...
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Open letter from Ian Chapman to research and innovation community
UKRI Chief Executive outlines changes to UKRI investment approach, addressing concerns about research funding and the financial position of STFC.
https://www.ukri.org/news/open-letter-from-ian-chapman-to-research-and-innovation-community/
28 days ago
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NealeLab
Richard Sever
28 days ago
"Writing papers is rarely (probably never) the rate-limiting step in scientific research" Important to remember this. However painful writing is, however much more efficient we can make it, for experimental work it's the research that takes the time.
www.linkedin.com/feed/update/...
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๐ข๐ฝ๐ฒ๐ป๐๐ ๐ท๐๐๐ ๐น๐ฎ๐๐ป๐ฐ๐ต๐ฒ๐ฑ ๐ฃ๐ฟ๐ถ๐๐บโ๐ฎ ๐ณ๐ฟ๐ฒ๐ฒ ๐๐ฎ๐ง๐ฒ๐ซ ๐ฒ๐ฑ๐ถ๐๐ผ๐ฟ ๐ณ๐ผ๐ฟ ๐๐ฐ๐ถ๐ฒ๐ป๐๐ถ๐๐๐. But this isn't about LaTeX. And it's not about training data. They could getโฆ | Adam Hyde | 25 comments
๐ข๐ฝ๐ฒ๐ป๐๐ ๐ท๐๐๐ ๐น๐ฎ๐๐ป๐ฐ๐ต๐ฒ๐ฑ ๐ฃ๐ฟ๐ถ๐๐บโ๐ฎ ๐ณ๐ฟ๐ฒ๐ฒ ๐๐ฎ๐ง๐ฒ๐ซ ๐ฒ๐ฑ๐ถ๐๐ผ๐ฟ ๐ณ๐ผ๐ฟ ๐๐ฐ๐ถ๐ฒ๐ป๐๐ถ๐๐๐. But this isn't about LaTeX. And it's not about training data. They could get papers from arXiv or partner with Overleaf for that. So w...
https://www.linkedin.com/feed/update/urn:li:activity:7422280971141701632?commentUrn=urn%3Ali%3Acomment%3A%28activity%3A7422280971141701632%2C7422298984083353600%29&dashCommentUrn=urn%3Ali%3Afsd_comment%3A%287422298984083353600%2Curn%3Ali%3Aactivity%3A7422280971141701632%29
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Coming soon! PhD opening joint with
@drjonbaxter.bsky.social
at
@gdsc-sussex.bsky.social
Keep a look out and get in touch if you are interested in any and all of: Chromosomes, Genome Stability, Chromatin and DNA Topology in Mitosis and Meiosis.
29 days ago
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reposted by
NealeLab
about 1 month ago
Still some time to register to this great meeting! Great science and great location for a very affordable registration cost!
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Itโs a massive problem across the sector, and Iโm not sure what is the solution isโฆ
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about 1 month ago
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NealeLab
Schuh Lab
about 2 months ago
Human eggs must segregate their chromosomes with exquisite precision โ yet errors rise with maternal age, causing miscarriage & infertility. Our new article on
@biorxivpreprint.bsky.social
shows why chromosome cohesion fails in aging eggs & how to improve it.
www.biorxiv.org/content/10.6...
(1/10)
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Skip to 1m 39s for my current coding hobby project ๐
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about 2 months ago
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NealeLab
Simon Fisher
2 months ago
30 years ago today, December 31st 1995, the last ever Calvin & Hobbes comic strip was published. Even now, I still find it so poignant & moving.
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NealeLab
Aurele Piazza
about 2 months ago
SMC and recombination enthusiasts: we updated our work describing the loop extrusion properties of budding yeast condensin and its function in biasing donor usage for mating-type switching. Lots of cool new data, check it out!
www.biorxiv.org/content/10.1...
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NealeLab
Saccharomyces Genome Database
about 2 months ago
Do
#hybrids
handle heat, cold better? โ๏ธ๐ฅ Over 140 generations at 5C and 31C,
#yeast
#F2
hybrids adapted fast, were ~4ร fitter in cold, more resilient to sudden flips.
#Hybridization
could turbocharge
#adaptation
, impacting
#conservation
&
#agriculture
.
#Evolution
www.yeastgenome.org/reference/41...
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NealeLab
RCSB Protein Data Bank
about 2 months ago
Large and intricate naturally occurring structures composed exclusively of RNA... ROOL! More at Molecule of the Month:
pdb101.rcsb.org/motm...
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NealeLab
Journal of Cell Science
3 months ago
Leanna Owen, Margot Riggi , David Drubin, Janet Iwasa and Yidi Sun use molecular animation to depict the full progression of CME in budding yeast, with an accompanying Cell Science at a Glance article and poster.
journals.biologists.com/jcs/article/...
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NealeLab
H. B. Beryl Rappaport
3 months ago
While ๐. ๐ท๐ฆ๐ณ๐ฎ๐ช๐ง๐ฐ๐ณ๐ฎ๐ช๐ด max temp is around 45ยฐC, we found ๐. ๐ค๐ข๐ด๐ค๐ข๐ฅ๐ฆ๐ฏ๐ด๐ช๐ด grows up to 63ยฐC with optimal growth at 55-57ยฐC๐ฅต. We showed cellular replication via Ultrastructure Expansion Microscopy at 63ยฐC. The previous limit for euks is 60ยฐC!
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Bye bye Edinburgh - such a lovely trip! Thanks to
@marstonlab.bsky.social
@owendavi77.bsky.social
!
3 months ago
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Successful change at Euston. Train is standing room only though due to a prior cancellation ๐ฑ Very glad I booked a seat and it is still reserved!
3 months ago
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Departure: Brighton 13:40 (Due Edinburgh 20:24) ๐
3 months ago
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New research from Valerie Garcia and colleagues: Tel1 is recruited at chromosomal loop/axis contact sites to modulate meiotic DNA double-strand breaks interference
journals.plos.org/plosgenetics..
.
3 months ago
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NealeLab
3 months ago
Happy to share the โInternational Symposium on Chromosome Dynamics: from Structure to Cellular Functionโ that will be held in Japan 31st of May 2026
www.fbs.osaka-u.ac.jp/labs/fukagaw...
. Registrations will open on December 1st! Plenty of opportunities to present your work! Hope to seeing you
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International Symposium on Chromosome Dynamics from Structure to Cellular Function
https://www.fbs.osaka-u.ac.jp/labs/fukagawa/symposium/index.html
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NealeLab
Saccharomyces Genome Database
4 months ago
Using
#yeast
, Yu et al show templated insertions at double-strand breaks in cancers arise from foldback mechanism involving microhomologies. Lack of RPA may drive this process, shedding light on cancer's genetic instability
#CancerResearch
#Genetics
#DNARepair
www.yeastgenome.org/reference/39...
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Delighted to see our study finally out in "print". Thanks to all the (many) contributors, collaborators and reviewers! Mismatch repair disturbs meiotic crossover control in S. cerevisiae
academic.oup.com/nar/article/...
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Mismatch repair disturbs meiotic crossover control in S. cerevisiae
Abstract. Crossover formation during meiosis generates genetic diversity. In many species most crossovers display interference, meaning they are spaced mor
https://academic.oup.com/nar/article/53/21/gkaf1136/8322495
4 months ago
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Matching T-shirt and slide
@gdsc-sussex.bsky.social
from Sir Paul Nurse
4 months ago
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Fantastic celebration of Tony Carrโs scientific career at the
@gdsc-sussex.bsky.social
retreat 2025
4 months ago
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NealeLab
Ian Dunt
4 months ago
Vital piece of investigative reporting from Sky. They've uncovered the X algorithm which feeds users extremist right wing material from the moment they join the site. It is a far-right radicalisation engine, by design.
news.sky.com/story/the-x-...
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Elon Musk is boosting the British right - and this shows how
Elon Musk is boosting the British right - and this shows how
https://news.sky.com/story/the-x-effect-how-elon-musk-is-boosting-the-british-right-13464487#
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NealeLab
Petr Cejka
4 months ago
Among the anti-recombinases, FIGNL1 rules them all. So much that inactivating it brings BRCA2-deficient cells to life. Who is responsible for RAD51 loading without BRCA2/FIGNL1, check out the paper to find out! Great collaboration with
@raychaudhurilab.bsky.social
www.science.org/doi/10.1126/...
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Good old
@nathanwpyle.bsky.social
๐
4 months ago
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NealeLab
Oded Rechavi
5 months ago
BIG ANNOUNCEMENT๐ฃ: I havenโt been this excited to be part of something new in 15 yearsโฆ Thrilled to reveal the passion project Iโve been working on for the past year and a half!๐๐ฅณ (thread ๐)
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NealeLab
Richard Sever
5 months ago
I'm always reminded of Tim Hunt's description of going to the library: "flipping through tables of contents of all the latest issues, hoping there isn't something relevant to your work..." 3/n
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NealeLab
Laurence Pearl ๐ฅ
5 months ago
Excited to announce that our PearlAI DependANT tool for identifying targeted treatments for patients with Cancer of Unknown Primary is one of the 48 projects funded by the UKRI Proof of Concept programme !!
www.ukri.org/news/48-proj...
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48 projects backed to turn cutting-edge research into businesses
UKRI backs cutting-edge projects, from home tests for endometriosis to AI for accessible travel, to grow into market-leading products and services.
https://www.ukri.org/news/48-projects-backed-to-turn-cutting-edge-research-into-businesses/
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Slowly recovering after just briefly visiting that "other" place we used to hang out in and Tweet. So much hate and misinformation...๐
6 months ago
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NealeLab
Sussex Cancer Research Centre
6 months ago
๐ฉโ๐ฌ Weโre hiring! Join a dynamic team driving innovation in blood cancer research at the University of Sussex. Collaborate with experts, grow your skills in protein biochemistry, and contribute to vital discoveries. ๐ Apply here:
www.jobs.ac.uk/job/DOP599/r...
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Research Technician โ Protein Biochemistry at University of Sussex
Discover Research Technician โ Protein Biochemistry jobs and more in higher education on jobs.ac.uk. Apply for further details on the top job board.
https://www.jobs.ac.uk/job/DOP599/research-technician-protein-biochemistry
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NealeLab
Uli Rass
6 months ago
Looking forward to contributing to Social DNAing
@columbiauniversity.bsky.social
@columbiacancer.bsky.social
later today!
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NealeLab
Katy Stoddard
6 months ago
Yesterdayโs
#EasternArc
session on HE in Palestine felt like a direct call to action - so much can be achieved if we put effort into working with/round clunky university processes - pooling open resources, giving Gaza students honorary fellowships to enable library accessโฆ 1/2
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For everyone
6 months ago
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Banksy = Genius
6 months ago
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The irony
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6 months ago
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NealeLab
Genome Damage and Stability Centre (GDSC)
6 months ago
#NEW_PAPER
In this study, the Chan Lab uncover the molecular mechanisms by which human cells safeguard centromeric chromatin during mitosis, via tight dynamic control of the Bloom Syndrome complex (BTRR).
rdcu.be/eCGxF
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Centromere protection requires strict mitotic inactivation of the Bloom syndrome helicase complex
Nature Communications - Centromeres play an essential function in faithful chromosome segregation. Here, the authors demonstrate the mechanism by which human cells dynamically modulate the activity...
https://rdcu.be/eCGxF
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NealeLab
Genome Damage and Stability Centre (GDSC)
6 months ago
#NEW_PAPER
The Hochegger laboratory + collaborators investigate the sensitivity of cancer cells to a highly selective inhibitor of human Greatwall kinase (GWL) + the BB5alpha-to-GWL expression ratio is a predictive biomarker for the cellular reponse to Greatwall-targeted therapeutics.
rdcu.be/eC4Hf
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The balance between B55ฮฑ and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells
Nature Communications - The authors develop and characterise a selective Greatwall inhibitor, C-604, and show that its cytotoxicity stems from PP2A-B55ฮฑ hyperactivation. They identify...
https://rdcu.be/eC4Hf
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NealeLab
Genome Damage and Stability Centre (GDSC)
6 months ago
#New-Paper
Rass laboratory reveal DNA2 to be a gatekeeper to homologous recombination at stalled DNA replication forks, rrequired to stave off cellular senescence. Their findings provide a molecular explanation for the association of DNA2 with primordial dwarfism and cancer.
doi.org/10.1038/s415...
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DNA2 enables growth by restricting recombination-restarted replication - Nature
DNA2 suppresses recombination-restarted replication and checkpoint activation at stalled forks, and its loss triggers recombination-dependent synthesis, checkpoint signalling and cell-cycle exit, high...
https://doi.org/10.1038/s41586-025-09470-5
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Interested in the nucleaseโhelicase DNA2? Fantastic new recombination-replication-checkpoint mechanics uncovered by Jessica Hudson et al:
@u-rass.bsky.social
@gdsc-sussex.bsky.social
www.nature.com/articles/s41...
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DNA2 enables growth by restricting recombination-restarted replication - Nature
DNA2 suppresses recombination-restarted replication and checkpoint activation at stalled forks, and its loss triggers recombination-dependent synthesis, checkpoint signalling and cell-cycle exit, high...
https://www.nature.com/articles/s41586-025-09470-5
6 months ago
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NealeLab
Scott Keeney
7 months ago
New review about DNA double-strand break resection during meiosis, with
@alhajijoker.bsky.social
and Soonjoung Kim. Please check it out:
www.sciencedirect.com/science/arti...
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Insight into Meiotic DNA End Resection: Mechanisms and Regulation
Meiosis generates reproductive cells with a reduced genome complement, with most species using homologous recombination to promote accurate meiotic chโฆ
https://www.sciencedirect.com/science/article/pii/S1568786425000825
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NealeLab
Dr Matt Pope
6 months ago
The floating museum Galeรณn Andalucรญa looking spectacular and formidable in harbour at Shoreham-by-Sea today.
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NealeLab
Helfrid Hochegger
6 months ago
Excited to share our new @NatureComms paper! We developed C-604, a selective inhibitor of Greatwall kinase, and discovered that cancer cells' sensitivity to it depends on a simple ratio: B55ฮฑ/Greatwall expression levels.
www.nature.com/articles/s41...
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The balance between B55ฮฑ and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells - Nature Communications
The authors develop and characterise a selective Greatwall inhibitor, C-604, and show that its cytotoxicity stems from PP2A-B55ฮฑ hyperactivation. They identify B55ฮฑ and Greatwall levels as biomarkersโฆ
https://www.nature.com/articles/s41467-025-62943-z
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