So excited to share this manuscript led by the inimitable Cara Brand, who discovered that Topoisomerase II evolution causes hybrid female lethality in Drosophila. Congrats to Cara, @nickbr0wn.bsky.social, Anirban, and @buszczaklab.bsky.social! www.biorxiv.org/content/10.6...

A stepwise route to polyploidy in yeast https://www.biorxiv.org/content/10.64898/2026.02.20.706944v1

NAR Cancer presents a curated collection of 17 articles on how advances in understanding the DNA damage response are reshaping cancer therapy. Explore the collection and read the editorial from guest editors Li Lan and Elise Fouquerel. New targets and new tools. academic.oup.com/narcancer/pa...

LINE-1 retrotransposition is a recurrent cause of MET exon 14 skipping in cancer https://www.biorxiv.org/content/10.64898/2026.02.19.706876v1

Now live on Find-A-PhD-dot-com: Joint project between @labneale.bsky.social and @drjonbaxter.bsky.social @gdsc-sussex.bsky.social Get in touch if you are interested in any and all of: Chromosomes, Genome Stability, Chromatin and DNA Topology in Mitosis and Meiosis. www.findaphd.com/phds/project...

Happy to share our new pre-print on the dependency of ALT-positive tumors on the DNA translocase SMARCAL1. Outstanding work of @angelotaglialatela.bsky.social in collaboration with the Min, Lazzerini Denchi and @cejkalab.bsky.social laboratories! www.biorxiv.org/content/10.6...

Aspergillus fumigatus - 29.9 crossovers per homologous chromosome pair! That makes about 1500 recombination map units per chromosome....

We are looking for Postdoctoral Fellows with expertise in Structural Biology. Expertise in CryoEM/CryoET is required. Come join us in St. Louis to work on some amazing enzyme complexes. www.antonylab.org/positions.html APPLY HERE: slu.wd5.myworkdayjobs.com/en-US/Career...

A structural analysis of #Ecoli RecBCD enzyme reveals a new RecB tether–RecC groove crosspoint interactions required for Chi recombination hotspot sequence regulation. buff.ly/pT611mK

How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller? Excited to share our latest work in @science.org on a new small polymerase. 1/n

Nice to see some yeast genetics in a Cell paper, where the authors test models based on single-molecule in vitro analysis. The combination of genetics and biochemistry often addresses questions most effectively. www.cell.com/cell/fulltex...

📣 The 2026 Midwest DNA Repair Symposium is coming to Kansas City (registration is open) 🗓 May 30–31, 2026 ✨ Talks will be selected from abstracts, with a strong focus on trainees and new investigators. Please RT & share with your labs! 🔗 sites.google.com/view/kumc-mi...

Thank you to @doksanilab.bsky.social, @nitikataneja.bsky.social, and everyone who joined us for such a great discussion today! We’re excited to invite you to our next webinar on March 3rd with @centromellone.bsky.social and Michele Pagano.

In this @cp-cell.bsky.social review, Doug Hanahan shows how the Hallmarks of cancer framework has evolved over the last 25 years: http://dlvr.it/TQkrlH We'll discuss this in depth @CellSymposia #CSHallmarks2026 http://dlvr.it/TQkrlK

Dear Colleagues, Delighted to share that our first lab paper is now published in Nature.!!! 😊😊😊 We identify a previously concealed “safety limit” in DNA replication program: cells intrinsically rate-limit PCNA via PAF15, shaping strand-specific and global replication dynamics. 👉 rdcu.be/e1bBt

Anticipating on-target resistance to WRN inhibitors in microsatellite unstable cancers https://www.biorxiv.org/content/10.64898/2026.01.22.700152v1

Outreach events with the @ucdaviscancer.bsky.social have been extremely fulfilling! Having benefited from NIH funding and resources offered by the Cancer Center and School of Medicine, I am grateful to share my experience with the next generation health.ucdavis.edu/news/headlin...

Repair of DNA double-strand breaks after low radiation doses in childhood cancer survivors and matched cancer-free individuals https://www.biorxiv.org/content/10.64898/2025.12.22.695953v1

So excited to finally share my recent work on sex differences in crossing over using mice from diverse genetic backgrounds! www.biorxiv.org/content/10.6...

Are you ready for 2026? Social DNAing is! See who is coming. Sign up at www.cancer.columbia.edu/research/pro...

Nek family members regulate Rad54 during homologous recombination in developing mice https://www.biorxiv.org/content/10.64898/2025.12.19.695536v1

Happy to highlight an essay I wrote together with @marcdemanuel.bsky.social, @natanaels.bsky.social and Anastasia Stolyarova, trying to think through what sets the mutation rate of a cell type in an animal species: www.biorxiv.org/content/10.6... 1/n

Hi all! We developed CAD-C to map chromatin organization at high res in yeast. It revealed an unexpected tight alignment: nucleosomes covering the same sequence tend to be associated across sister chromatids. www.biorxiv.org/content/10.6... #3DGenome #chromatin #Cohesin #centromere

Happy holiday, everyone! 2026 Social DNAing Schedule is now online. Here is a sneak peek. Check it out and sign up at www.cancer.columbia.edu/research/pro...

Faculty position at the department of medicine, University of Chicago. Please share.

Adam Luthman says: it depends. Some answers here: rdcu.be/eUVBj

We are hiring! We are looking for a motivated and enthusiastic postdoc to study mammalian DSB repair using innovative genomic approaches. Our lab is at the Curie Institute in Paris and offers vibrant scientific environnement and cutting edge platforms. Please repost or apply here: lnkd.in/eJ9q3QrR

Celebrating the retirement of my wonderful mentor and PhD advisor Doug Bishop @biz3000.bsky.social after more than 30 years at the University of Chicago studying homologous recombination! An incredible mentor to more than 50 grad students, postdocs, and other trainees

A global view of human centromere variation and evolution https://www.biorxiv.org/content/10.64898/2025.12.09.693231v1

What does phosphorylation do to RPA? This has been a long-standing question in the field of genome integrity. In our newest publication in Nature Communications rdcu.be/eT4z3 with @proforiganti.bsky.social , we reveal the answer. Thanks to funding from NIGMS to our groups.

📢 Read this timely review in #NARCancer! 🧬 Gueble and Menon highlight the critical role of #DNAhelicases in linking #DNAdamage recognition with #repair. The review includes a curated table of #clinicaltrials on #helicaseinhibitors. Read it here: doi.org/10.1093/narc... @yalepress.bsky.social

#Yeast RNase H1 responds to unscheduled, stress-inducing #RNA-DNAhybrids. Overexpressed Rnh1 leaves wt cells unaffected, but clears dysregulated RNA–DNA hybrids in mutants and promotes #DNAreplication at transcription-replication conflict sites. Read more: www.yeastgenome.org/reference/S1...

🚨 New Science paper from the Gerlich lab! The team shows how cohesin helps broken DNA find the right template: by opening local DNA loops to shrink the search area and by keeping the damaged strand close to its sister copy: science.org/doi/10.1126/science.adw0566

Thrilled to share that my postdoc research is published today in @science.org! We found that DNA repair uses cohesin complexes to build new chromatin loops that guide the homology search and boost accurate repair! 1/n www.science.org/doi/10.1126/...

I am very pleased to see our work, in which we describe a mutational hotspot at transcription start sites in the human germline, out: www.nature.com/articles/s41... Great work from @castellanoed.bsky.social, @vseplyarskiy.bsky.social, Miguel Cortés Guzmán and Clàudia Serrano Colomé!

What controls expansion & contraction of DNA repeats (e.g. Huntington's)? We were thrilled to collaborate w/ the lab of Marta Olejniczak to find out. Check out the cool screen from @sebasiegner.bsky.social and @matthiasmuhar.bsky.social that reads out repeat sequence. www.biorxiv.org/content/10.1...

Diagnostic yield of colonoscopy in Lynch Syndrome We demonstrate a high adenoma burden with distinct phenotypic and gene-specific characteristics in a UK LS population undergoing high quality surveillance fg.bmj.com/content/earl...

New study from the lab on genetic relationship between 53BP1-RIF1 and DNA-PKcs on DSB repair outcomes. Led by PhD student @kaelamakins.bsky.social www.nature.com/articles/s41...

Looking forward to reading this recent Mol Cell paper from Maria Jasin’s lab on the role of homologous recombination in loss of heterozygosity (LOH) after hearing her talk about it at the @ucdaviscancer.bsky.social Annual Symposium as the Basic Science Keynote address! www.cell.com/molecular-ce...

A new pre-print with some cool results from my PhD! www.medrxiv.org/content/10.1...

Long-read genome sequencing is new first-tier generic test in diagnostics of rare diseases So satisfying to see a long journey end in best-possible diagnostic test for patients with rare diseases @radboudumc.bsky.social. www.radboudumc.nl/en/news-item... (1/n)

Finally! We have a FANCM:RMI inhibitor that is cell active and specifically kills ALT+ cancer cells 🎯 @yuhenglau.bsky.social + my labs just published the first cell-active peptide inhibitors of this critical target in 10-15% of cancers. doi.org/10.1021/acs....

Using #yeast, Yu et al show templated insertions at double-strand breaks in cancers arise from foldback mechanism involving microhomologies. Lack of RPA may drive this process, shedding light on cancer's genetic instability #CancerResearch #Genetics #DNARepair www.yeastgenome.org/reference/39...

Delighted to see our study finally out in "print". Thanks to all the (many) contributors, collaborators and reviewers! Mismatch repair disturbs meiotic crossover control in S. cerevisiae academic.oup.com/nar/article/...

‼️ Excited to share our new paper out now in @science.org ‼️ We describe a new tetrameric RAD51 paralog complex – XRCC3-RAD51C-RAD51D-XRCC2 – which caps the end of RAD51 filaments. Link: www.science.org/doi/epdf/10.... Thread ⬇️ (1/8)

Happy to share our @narjournal.bsky.social paper on the mechanism of Dmc1 filament stabilization by Mei5-Sae3! We show that Mei5-Sae3 can stabilize both active and inactive Dmc1 filaments, and that this is independent of the ATP hydrolytic cycle. doi.org/10.1093/nar/...

Excited to share: NAR Cancer Editor's Choice review article from Kyungjae Myung and colleagues provides a snapshot of the blossoming field of DNA damage response- and repair-targeted therapeutics. Focus is on small molecules currently in clnical trials. academic.oup.com/narcancer/ar...

Our latest collaboration with the talented Susi @sbantele.bsky.social and Jiri Lukas is out now @science.org 🤩. We reveal the hidden price for DNA repair, with potential implications for genome function, gene therapy and ageing👇

We thank Evi Soutoglou and @rubenvanboxtel.bsky.social for sharing their exciting data with the GIIN community yesterday! Our next webinar is on December 2nd, featuring @peterlylab.bsky.social and @alebrambati.bsky.social. Do not miss it! Sign up for updates: docs.google.com/forms/d/e/1F...

Want to know how homologous recombination defects are caused upon loss of BRCA2? Check out our recent efforts in uncovering this phenomenon just out in Science! www.science.org/doi/10.1126/...