Repair of DNA double-strand breaks after low radiation doses in childhood cancer survivors and matched cancer-free individuals https://www.biorxiv.org/content/10.64898/2025.12.22.695953v1

Is NHEJ truly a double-strand break repair pathway...repairing both strands, at the same time?

Great piece of work - congratulations, all!

Very cool! Figs 2 and 3 are especially cool!

So cool. And hey, its a good thing NHEJ doesnt slow down when you get sleepy.

New study from the lab on genetic relationship between 53BP1-RIF1 and DNA-PKcs on DSB repair outcomes. Led by PhD student @kaelamakins.bsky.social www.nature.com/articles/s41...

🎉 Joint paper from the Freudenthal and @tmweaver.bsky.social Labs! Abbey Vito’s first publication discusses a tug-of-war between BER enzymes and chromatin for access to damaged DNA, a battle central to genome stability. Built on Tyler's foundational work! tinyurl.com/ywkt2bt5

H2B ubiquitination by RNF20/40 safeguards replication fork dynamics in human cells, by facilitating fork reversal and recruiting RNF169 that protects from excessive degradation of nascent DNA @penengolab.bsky.social and collaborators www.embopress.org/doi/full/10....

Great scientist. "One of the most influential" - definitely.

R.I.P Hamilton Smith, 1978 Nobel Laureate for the discovery of type II restriction-modification systems (HindII).

Pol delta's exo at it again!

See our paper “Mechanism of trinucleotide repeat expansion by MutSβ-MutLγ and contraction by FAN1”. Using biochemistry, we show how DNA incisions by the MutLγ nuclease can lead to expansions, and how expansion is prevented by FAN1. Well done Issam and Valentina! www.nature.com/articles/s41...

Registration is open for the 2025 SoCal Genome Stability Symposium. Free registration. All talks by trainees. www.cityofhope.org/genome-stabi...

Kickstarting our Bluesky🦋 account with great news! Our REPAIRome study finally out today in @science.org www.science.org/doi/10.1126/...

Also available in the Ramsden lab....Lab manager (gap year, temp employee) OR research tech/lab manager (longer term, SHRA).

Also: Research positions in the Ramsden lab. Post doctoral position - 5 years funding available. Cross-country collaborative, working closely with the groups of Gupta, Rothenberg, Wood, and Doublie. Some example pubs from the last two post docs: PMIDs 37968395,35927262, 2963245, 30213916, 26240371

Good news for Adam, Kishore, and the Ramsden lab - their paper describing how each strand of a DSB is repaired has been accepted for pub in principle for Nature Communications. More to come on this soon...