Happy to share that I will be joining the Biology Department and Holden Comprehensive Cancer Center at University of Iowa as an assistant professor in summer 2027! My lab will study how recombination is regulated to prevent non-allelic repair and genome rearrangements, and their relation to cancer.

Carolyn started this as a whole-genome revisit of the classic 1996 papers on spontaneous nondisjunction from Hawley (Dros X) and Sherman (human 21) labs. She looked at a metacentric (Dros 2) and found that the rules are different - no obvious relationship between ndj and crossovers. Shape matters!

Happy to share our collaborative project with Stephane Marcand, on the protective role of Rap1 at telomeres. It turned out that our favorite protein, MRX, has the ability to measure telomere length, and activate response pathways when telomeres become too short. www.nature.com/articles/s41...

Interesting paper from Virginie Ropars and collegues about the architecture of WRN and KU interaction. Interestingly, WRN binds on the internal (end-distal) side of KU. Thanks for this interesting collaboration! @pietropichierri.bsky.social www.nature.com/articles/s41...

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Big congrats to Spencer Thompson on defending his thesis today! Beautiful @lumicks.bsky.social C-Trap single-molecule work and a major MD/PhD milestone. Proud PI! BioRxiv coming soon.

Come work with us! Please share with anyone who might be a good fit!

Our lab at the UC Irvine is currently hiring a postdoctoral researcher. We have a thriving and growing biomedical research campus and are looking for candidates with a strong interest in DNA damage and repair, cancer etiology, and cancer health disparities. Apply at recruit.ap.uci.edu/JPF09440

As a child, @phosphotig.bsky.social dreamed of being an astronaut, but her curiosity led her to scientific research. Now, she leads her own lab at UNC-Chapel Hill, & studies oxidative stress to find better therapies for triple-negative breast cancer. #WomensHistoryMonth www.asbmb.org/asbmb-today/...

Pleased to share our paper. We found surprising widespread glycogen accumulation in A-T due to mitochondrial impairment that can be improved by targeting the unexpected FNIP2-SERCA2b-axis. #AtaxiaTelangiectasia #ATM #RareDisease #Metabolism #Mitochondria www.nature.com/articles/s41...

The Sfeir Lab at MSKCC is hiring a Research Assistant! We are looking for a motivated scientist with at least 2 years of research experience and a two-year commitment. Learn more about our work here www.sfeirlab.com, and message me your CV and cover letter if interested

Just in time for my grad school lecture on NER!

Great conference!!

RNAseH2 is super picky...which is not always a good thing?

100% agree. would definitely recommend.

Very cool!

Repair of DNA double-strand breaks after low radiation doses in childhood cancer survivors and matched cancer-free individuals https://www.biorxiv.org/content/10.64898/2025.12.22.695953v1

Is NHEJ truly a double-strand break repair pathway...repairing both strands, at the same time?

Great piece of work - congratulations, all!

Very cool! Figs 2 and 3 are especially cool!

So cool. And hey, its a good thing NHEJ doesnt slow down when you get sleepy.

New study from the lab on genetic relationship between 53BP1-RIF1 and DNA-PKcs on DSB repair outcomes. Led by PhD student @kaelamakins.bsky.social www.nature.com/articles/s41...

🎉 Joint paper from the Freudenthal and @tmweaver.bsky.social Labs! Abbey Vito’s first publication discusses a tug-of-war between BER enzymes and chromatin for access to damaged DNA, a battle central to genome stability. Built on Tyler's foundational work! tinyurl.com/ywkt2bt5

H2B ubiquitination by RNF20/40 safeguards replication fork dynamics in human cells, by facilitating fork reversal and recruiting RNF169 that protects from excessive degradation of nascent DNA @penengolab.bsky.social and collaborators www.embopress.org/doi/full/10....

Great scientist. "One of the most influential" - definitely.

R.I.P Hamilton Smith, 1978 Nobel Laureate for the discovery of type II restriction-modification systems (HindII).

Pol delta's exo at it again!

See our paper “Mechanism of trinucleotide repeat expansion by MutSβ-MutLγ and contraction by FAN1”. Using biochemistry, we show how DNA incisions by the MutLγ nuclease can lead to expansions, and how expansion is prevented by FAN1. Well done Issam and Valentina! www.nature.com/articles/s41...

Registration is open for the 2025 SoCal Genome Stability Symposium. Free registration. All talks by trainees. www.cityofhope.org/genome-stabi...

Kickstarting our Bluesky🦋 account with great news! Our REPAIRome study finally out today in @science.org www.science.org/doi/10.1126/...

Also available in the Ramsden lab....Lab manager (gap year, temp employee) OR research tech/lab manager (longer term, SHRA).

Also: Research positions in the Ramsden lab. Post doctoral position - 5 years funding available. Cross-country collaborative, working closely with the groups of Gupta, Rothenberg, Wood, and Doublie. Some example pubs from the last two post docs: PMIDs 37968395,35927262, 2963245, 30213916, 26240371

Good news for Adam, Kishore, and the Ramsden lab - their paper describing how each strand of a DSB is repaired has been accepted for pub in principle for Nature Communications. More to come on this soon...