Now online in Cancer Discovery @aacrjournals.bsky.social: LINE-1 Locus Transcription Nucleates Oncogenic Chromatin Architecture - by Michael Lee, Yuannyu Zhang, Jian Xu, and colleagues doi.org/10.1158/2159... @stjuderesearch.bsky.social

Two recent Reviews describe how to select optimal cell migration assays and how to analyze this data. www.nature.com/articles/s41... www.nature.com/articles/s41...

Excited to announce a new review article that Andreas Villunger @villungerlab.bsky.social, Dario Rizzotto (not on bsky) and I wrote. In this article, we discuss mitosis as a central cell cycle stage for integrating DNA damage, cell death and inflammatory responses. www.nature.com/articles/s41...

Researchers are targeting dormant tumour cells that might explain why some cancers reappear long after successful treatment go.nature.com/3NgcKDT

🐭 In vivo veritas 🐭 Now out in Nature Genetics: @josjonkers.bsky.social and I describe currently available mouse models of BRCA1/2 and their roles in understanding BRCA1/2 biology, particularly in normal development, tumor suppression and therapy response. www.nature.com/articles/s41...

Lewy body dementia (LBD) promotion by air pollutants "PM2.5 exposure was associated with an increased risk of developing LBD." www.science.org/doi/10.1126/...

SMC and recombination enthusiasts: we updated our work describing the loop extrusion properties of budding yeast condensin and its function in biasing donor usage for mating-type switching. Lots of cool new data, check it out! www.biorxiv.org/content/10.1...

The gut<->brain axis impact on health and disease is far more important than anticipated, as reflected by GLP-1 effects, modulating the immune system, direct neural circuits, the microbiome, and more. A stellar new, open-access review www.jci.org/articles/vie...

Right. If you want a good explanation of why the American system of government worked well enough for 200 years and then suddenly stopped, it's because Republicans in Congress suddenly started letting their partisan interests COMPLETELY override their institutional interests

A year ago, I went to Copenhagen to write about the political crisis sparked by Trump over Greenland. Danes told me that the US can already do whatever it wants on the island. Their conclusion: Trump just wants the U.S. to look larger on a map www.theatlantic.com/internationa...

New online! Mapping the disease interactome

My quote of the day Every time you tear a leaf off a calendar, you present a new place for new ideas and progress. Charles F. Kettering

Just to simplify what we think happens: Blue light hits pigments in the retina of migratory birds that become 'little magnets' that respond to magnetic fields as light & dark patterns on their visual field. In gamer terms, it's a 'compass on their HUD', merged in with visual data.

Breast cancer stem cells drive resistance to standard therapies in triple-negative breast cancer. Here, Qing Zhang & team show targeting kinesin family member KIF20A in vitro and in mice sensitizes stem-like TNBC cells to standard chemotherapy: doi.org/10.1172/JCI1...

Pope Leo said in a Christmas Eve sermon that the story of Jesus being born in a stable because there was no room at an inn should remind Christians that refusing to help the poor and strangers today is tantamount to rejecting God himself. www.reuters.com/world/pope-l...

Meet the speakers!🎤 Session 6 "Replication Stress" Chunlong Chen (Institut Curie) and Nynke Dekker (@nynkedekkerlab.bsky.social, Univ. of Oxford). Registration via www.sfb1361.de/dnarepairconf2026 is ongoing! See you in March at @imbmainz.bsky.social! #ISC26DNArepair #SFB1361 #IMBMainz

the double bind (not limited to public health, of course — all institutions of trust are caught in it)

Il 'Canto di Natale per la Ricerca' alla Camera dei deputati | Live tv https://video.corriere.it/il-canto-di-natale-per-la-ricerca-della-camera-dei-deputati-la-diretta-video/3551c89f-59d2-4341-9d1f-b0ca9a734xlk

Out now: We present antibody-lectin chimeras (AbLecs) as a molecular platform to target sugars, or glycans, for cancer immunotherapy. www.nature.com/articles/s41... www.nature.com/articles/s41... @mitkochinstitute.bsky.social @mitdeptofbe.bsky.social @mitcheme.bsky.social @stanford-chemh.bsky.social

"Watching my students who didn’t really know if they wanted to do research turn around & fall in love with research … that’s been the most meaningful." — HHMI Postdoc Scientist Brea Manuel, '25 program mentor. 🧪 Rising junior or senior? *Applications close 11:59pm EST Dec. 22* ⏰❗bit.ly/CechFellows

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In case any other Early-career scientist is interested in the call, I am based in Italy and we work on Transcription Factors cooperativity and their activation domains, co-translational assembly, promoter architecture (human cells). Very open to ideas! #HFSP #EarlyCareer

Happy holiday, everyone! 2026 Social DNAing Schedule is now online. Here is a sneak peek. Check it out and sign up at www.cancer.columbia.edu/research/pro...

AlphaFold predictions are valuable hypotheses and accelerate but do not replace experimental structure determination www.nature.com/articles/s41...

NIGMS R35 Maximizing Investigator's Research Award (MIRA) for Outstanding Investigators new NOFO is available!! Submission dates starting in January 2026 through May 2028. See link below: simpler.grants.gov/opportunity/...

Minor problem here: we DON’T have anything like this. Most of the mechanisms we have for ‘researchers and R&D spending’ are massively oversubscribed as funding levels have lagged behind inflation and/or %age gdp. We simply don’t *have* this largesse sufficient that it might fail to produce results.

Can one map the genome-wide binding (1) and its protein partners (2) simultaneously from the same sample? Yes, one can. with CUT&ID ✂️🪪 Spearheaded — singlehandedly — by @annanordin.bsky.social No need of transgenesis, cloning and overexpression. Check it out, it's fast and its works.

There isn’t much for our Supreme Court to hear, the Constitution is already clear. And just to be absolutely clear: the Supreme Court does not have the power to overrule or rewrite our Constitution.

Join us next Tuesday, December 2 at 5pm (Rome) / 11am (NYC) for an exciting GIIN webinar featuring @peterlylab.bsky.social and @alebrambati.bsky.social! Zoom link: uniroma1.zoom.us/j/95149984403 Register here to become part of our community: docs.google.com/forms/d/e/1F...

💥 Working with iPSCs? We’ve got you covered , culture, neuronal & muscle differentiation, organ-on-chip, training, and ready-to-use progenitors. Happy to support your projects! 📩 [email protected] IPSC-neuron platform (POM-biocampus, Montpellier)

Placebo effect is more psychologically complex than previously thought.

Work published today in @natbiotech.nature.com from Arc’s Luke Gilbert and Patrick Hsu labs presents a new way to insert large DNA sequences into the genome using engineered recombinases that don’t require DNA cutting or rely on the cell's repair machinery.

Basta con questo bla bla inconcludente e disinformato sull’IRPEF. Le tasse le paga chi ha redditi medi e alti. Se abbassi le aliquote il beneficio va a chi paga le tasse, non va ai poveri che non le pagano. Per sostenere i redditi bassi ci sono altre misure.

Excited to share: NAR Cancer Editor's Choice review article from Kyungjae Myung and colleagues provides a snapshot of the blossoming field of DNA damage response- and repair-targeted therapeutics. Focus is on small molecules currently in clnical trials. academic.oup.com/narcancer/ar...

DirectRM: integrated detection of landscape and crosstalk between multiple RNA modifications using direct RNA sequencing. #DirectRNAseq #RNAmodifications @nanoporetech.com #Sequencing @natcomms.nature.com 🧪🧬 🖥️ www.nature.com/articles/s41...

"...researchers who invest time in their students tend to lead more-productive, more-collaborative groups and attract stronger future students than those who do not." "Time spent with the next generation of scientists is an investment." www.nature.com/articles/d41...

Read it guys; it is very nice. Kudos to the @stapleslab.bsky.social lab

My quote of the day It is not the young people that degenerate; they are not spoiled till those of mature age are already sunk into corruption. Charles Louis de Secondat, baron de La Brède et de Montesquieu (Montesquieu)

Il cosiddetto turbocancro non esiste, è un’invenzione di ciarlatani senza scrupoli. Se un tumore viene diagnosticato 2 mesi fa in fase avanzata non significa che 3 mesi fa non ci fosse. La diagnosi precoce è molto importante, fate gli screening.

Great point. It it possible to attribute grants in myncbi if your co-author “forgot”, or you were young and foolish and didn’t realize it matters.

Draghi: «Tutti i nostri principi sotto attacco, quanto deve aggravarsi una crisi perché i leader uniscano le forze e agiscano?» https://www.corriere.it/economia/finanza/25_ottobre_24/draghi-discorso-asturias-24635e06-0b27-4a2c-8873-c0dcf5bf8xlk.shtml

I love AlphaFold—but please include PAE (Predicted Aligned Error) plots for every “interaction.” Pretty PDBs ≠ proof. If the PAE doesn’t show an interface, it ain’t one. Show the plots. Structural biology's reputation is on the line.

The data is from April but holy moly