High level overview of some of the things that have happened at NIH over the past 16 months from @jenna-m-norton.bsky.social www.youtube.com/watch?v=Q4iY... Worth the 15 minutes if you want a clear insider's perspective.

Units of the NIH, you can f*** all the way off on this one.

#RIP Pierre Chambon (1931-2026) via @alainberetz.bsky.social one of the last giants in biology: PARP, nuclear receptors, RNA Pol II, nucleosome, promoters, split genes

How to be a Super Ager @npr.org www.npr.org/programs/ted...

How to detect a single case of measles in a population of >1 million people? Wastewater sequencing picked it up from 0.000005% of ~1 billion sequencing reads! evidence.nejm.org/doi/full/10....

In its 2025 PhD survey, Nature asked more than 3,700 doctoral candidates around the world a simple question: what is the best thing your supervisor has done for you during your studies? Nature highlights several moments when good supervision made the difference. #Academicsky 🧪

Spain PM Pedro Sánchez: "We cannot depend on the electoral cycles of the U.S. to know whether we will be protected or not — that is why the creation of a common European army must become a reality. Not in 10 years, not in 2 years, but tomorrow”

An in-press version of our latest paper in @natcomms.nature.com on phospho-activated protein-protein interactions with ssDNA-binding protein RPA during BIR. If your favorite pathway involves RPA, this may be for you! Thanks to the lab, collaborators & @ukri.org! www.nature.com/articles/s41...

… that the Trump regime IS PROPOSING to terminate. This is up to Congress. They need to hear from their constituents who value these programs. When we fight, we win!

The multitude of ways that jack up American healthcare costs (without improving outcomes) gift link wsj.com/health/healt...

Do you want to be my boss? We are looking for a new Head of Department Our Department covers biology broadly, from molecular biophysics 🧬 to ecology 🌱 & biodiversity 🐋, and coordinates teaching in several BSc and MSc programmes🧑‍🎓 Located in Copenhagen, one of the world's most liveable cites 🚲 🌞 🌥️

Dear all, please see link below for Milano et al, describing a role for BRCA2 (& BRCA1) in the maturation of nascent DNA strand gaps during DNA replication in the presence of PARP inhibitor. Congratulations Larissa and all ! authors.elsevier.com/a/1mtQe3vVUP...

Another great opportunity for genome integrity / replication stress aficionados to attend two excellent seminars with a simple click. Join us in a few days (Tue April 7th)! 👇

New Online! STING signalling as a mediator between lipid metabolism and innate immunity

When you need a multiomic view to see the bigger picture, P2i is the fully integrated sequencer you can count on for greater insights into human health and disease. Ask more of your sequencing. Find out more: https://bit.ly/4sACA51

No earth scientists, no astronomers, no one with expertise in biotechnology or medicine, no climate scientists, no materials scientists, no field biologists, no ocean scientists, no atmospheric scientists, no biochemists, no developmental biologists, no evolutionary biologists.

A high-affinity split-HaloTag for live-cell protein labeling. And much more. www.nature.com/articles/s41...

Circulating to all..Please register and attend! One of the best platforms to meet all mutagenesis enthusiasts!

It is good to see that AAU is aware of and sharing information about the slowdown in NIH grantmaking. www.aau.edu/newsroom/lea...

Transcriptomic atlas of premalignant oral squamous cell carcinoma in an aging mouse model reveals an enhanced immune response and dysregulation of head and neck tissue stem cells https://www.biorxiv.org/content/10.64898/2026.03.20.713236v1

This is a striking result. While this is unusual paper and set of circumstances, the linear relationship between citations and the journal impact factor certainly seems to indicate that journal impact factor is measuring something other than purely paper quality (Duh).

Apply now! The 2026 call for the EMBO Young Investigator Programme is now open with a deadline of 1 April 12:00 midday CEST. 🧪 More info here: https://www.embo.org/funding/fellowships-grants-and-career-support/young-investigator-programme/ #LifeSciences #research #funding

Action Item...Action Item...Action Item Time to comment on the Framework for the NIH-Wide Strategic Plan grants.nih.gov/grants/guide... Comments due by May 16, 2026

new out in Nature www.nature.com/articles/s41...

new out in Nature (well, last week) www.nature.com/articles/s41...

and the Research Briefing to go with it www.nature.com/articles/d41...

Several people from our team are going to the 3R meeting this year (unfortunately, I cannot). I still have very fond memories of one of the previous editions.

PRMT5 inhibition triggers functional ATM deficiency and sensitizes pancreatic cancer to CHK1 blockade www.frontiersin.org/journals/cel...

I am focused on the Stand Up for Science events today, but I will dig into these data early next week. I was continuously funded from when I started my independent career in 1988 until I move to NIH in 2003, usually with multiple grants. 1/2

No, really. This is one of those moments in life where you see an event, and it tells you something about your future. The midterms in November will tell us if this is to be possibly recoverable. But the damage that is being done now is generational.

Sequence effects on patterns of variation and DNA strand asymmetries observed from whole-genome sequenced UK Biobank participants https://www.biorxiv.org/content/10.64898/2026.03.06.710079v1

Buon 8 marzo. Che la Forza sia con voi.

Non c'è distinzione in termini di potenziale e capacità cognitive tra cervelli maschili e femminili. Eppure, nel mondo accademico/ricerca, la strada è ancora in salita. Non serve un "laboratorio rosa", serve un laboratorio equo: la scienza non si basa sul sesso ma ha solo bisogno di menti curiose.

Distinct mutational landscapes when comparing germline and somatic cancer variants in forty tumor suppressor genes. https://www.biorxiv.org/content/10.64898/2026.02.26.707048v1

For free access t.co/ymJY2l0eGP

For reasons, I was just thinking about what I’ve said on the blog about NIH’s Center for Scientific Review over the years. From the Archive: drugmonkey.wordpress.com/page/3/?s=CS...

We are looking for Postdoctoral Fellows with expertise in Structural Biology. Expertise in CryoEM/CryoET is required. Come join us in St. Louis to work on some amazing enzyme complexes. www.antonylab.org/positions.html APPLY HERE: slu.wd5.myworkdayjobs.com/en-US/Career...

Stiamo discutendo civilmente da ieri sera sul referendum costituzionale. Due correnti di pensiero opposte si confrontano senza insulti, senza eccessi, con argomenti e con rispetto. Evviva Bluesky.

Nearly 40% of new cancer cases worldwide are potentially preventable, according to one of the first investigations of its kind go.nature.com/3ZmJluH

Happy to share our perspective on the DNA translocation mechanism by the CMG helicase. DNA translocation by the CMG helicase: the helical inchworm model url: portlandpress.com/biochemsoctr...

Follow our research and lab here: www.ircan.org/research/tea... If you are interested in joining the lab, we are looking for our future labmates and for future students, at all levels.

If you are interested in chromosomal instability, micronuclei and more, I suggest reading this book: link.springer.com/book/10.1007... We wrote chapter on transcription-replication conflicts and micronuclei with my mentor @paserolab.bsky.social @ircan.bsky.social @univcotedazur.bsky.social

Happy to share our deep characterization of #LLPS events modulating the DNA damage response (#DDR) through #53BP1 condensation promoted by #dincRNA www.biorxiv.org/content/10.6...

Long post from me at the Good Science Project on success rates including the effects of multiyear funding. goodscience.substack.com/p/understand... 1/2

Dear Colleagues, Delighted to share that our first lab paper is now published in Nature.!!! 😊😊😊 We identify a previously concealed “safety limit” in DNA replication program: cells intrinsically rate-limit PCNA via PAF15, shaping strand-specific and global replication dynamics. 👉 rdcu.be/e1bBt

Institut Pasteur (@pasteur.fr) is recruiting new young PIs to open new groups in the Institute. Deadline is February 9th! Don't miss the opportunity!

Si riempiono la bocca di militari, carabinieri, i nostri angeli, sto con la polizia, poi quando un bavoso pedofilo USA con la sua manica di nazisti e fenomeni da baraccone, insulta i nostri caduti in Iraq e Afghanistan, balbettano. La vergogna assoluta Il peggior governo della storia repubblicana.

🔔 Register now and send an abstract! Lots of opportunities to talk! 👉 www.eventsforce.net/biochemsoc/f...

“A student joining a lab is often presented with a hypothesis to work on and may see science as a hypothesis-testing endeavor. Many young postdocs have been told that as a PhD student their job was to answer questions—now they have to discover their own unknown unknowns.”