Just Published! Our new study in Mol Cancer reveals a CRISPR strategy that turns oncogene amplifications into an Achilles' heel for tumors. Proud of our collaboration with Sandra Rodríguez! Targeting amplicons triggers immunogenic cell death and tumor remodeling. 🧪 link.springer.com/article/10.1...

🦠 El investigador #HealthResearch Ezequiel Ruiz-Mateos (@ibis-investigacion.bsky.social#HealthResearch busca desvelar por qué un grupo reducido de personas puede controlar el VIH sin necesidad de medicación. ¿Podría su sistema inmunitario tener las claves para combatir el virus?

www.biorxiv.org/content/10.6... MetaPaCS: A novel meta-learning framework for #PancreaticCancer subtype identification 🧪🧬🖥️

ENO1-mediated deoxycytidine synthesis and gemcitabine resistance by stabilizing RRM2 in #PancreaticCancer 🧪 www.nature.com/articles/s41...

STING Agonist‐Modified Tumor Targeting Photosensitizer Remodels Cancer‐Associated Fibroblasts to Potentiate Photoimmunotherapy in #PancreaticCancer 🧪 advanced.onlinelibrary.wiley.com/doi/10.1002/...

SLC6A14-mediated glutamine promotes SYTL4–CXCL8 axis activation to drive gemcitabine resistance and immune evasion in #PancreaticCancer www.nature.com/articles/s12... 🧪

Still under consideration! ⏳ We’re moving forward and can’t wait to share more soon. #AcademicSky

Simultaneous targeting of KRAS and CDK4 synergistically induces durable growth arrest in #PancreaticCancer cells www.nature.com/articles/s41... 🧪

FUT2 enhances anti-tumor immunity in #PancreaticCancer radiotherapy by driving FBXO2-mediated degradation of NR2F2 www.nature.com/articles/s41... 🧪

Discover CCCdb: a comprehensive resource for cell-cell communication with 2451 human & 917 mouse interactions. Explore at licpathway.net/cccdb. PMID:41188068, Nucleic Acids Res 2025, @NAR_Open https://doi.org/10.1093/nar/gkaf1105 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Randomized Spatial PCA (RASP): A computationally efficient method for dimensionality reduction of high-resolution spatial transcriptomics data 🧬🖥️ journals.plos.org/ploscompbiol...

MAGNET: Multi-view graph autoencoder with cell-gene attention for cell interaction network reconstruction from spatial transcriptomics 🧬🖥️ journals.plos.org/ploscompbiol...

ULK1 knockout suppresses #PancreaticCancer progression by inhibiting autophagy and enhancing antitumor immunity 🧪 www.nature.com/articles/s12...

Aspartate Transaminases Are Dispensable for Pancreatic Development and #PancreaticCancer Progression 🧪 www.biorxiv.org/content/10.6...

Almost on holiday break, just finishing uploading the Molecular Genetics grades and wrapping up my thesis to qualify as a full professor! #AcademicSky

If you’ve felt safer sending a message because you sent it on Signal, please support our work. As a nonprofit, Signal exists because of your donations. In the app: Settings > Donate On the web: Signal.org/donate

My lab is recruiting postdocs in AI/ML for genetics & genomics through the Malone Postdoctoral Fellows program. Apply by Jan 30! Lots of other great labs across the Malone Center as well.

ULK1 knockout suppresses pancreatic cancer progression by inhibiting autophagy and enhancing antitumor immunity 🧪 #PancreaticCancer www.nature.com/articles/s12...

NRG1 fusion-positive solid tumors: clinical detection, genomic landscape, and real-world data in #PancreaticCancer 🧪 academic.oup.com/jnci/advance...

A window trial in metastatic pancreatic ductal adenocarcinoma reveals resistance mechanisms to targeting the KRAS-MEK pathway 🧪 #PancreaticCancer www.biorxiv.org/content/10.6...

p53 and YAP/TAZ-TEAD activities determine metaplastic heterogeneity in #PancreaticCancer 🧪 www.biorxiv.org/content/10.6...

USP10 promotes cell proliferation and gemcitabine resistance in #PancreaticCancer by the regulation of IGF2BP3-STEAP3 www.nature.com/articles/s41... 🧪

NRG1 fusion-positive solid tumors: clinical detection, genomic landscape, and real-world data in 🧪 #PancreaticCancer academic.oup.com/jnci/advance...

#Pancreaticcancer metastasis is regulated by an eleven amino-acid sequence 🧪 www.biorxiv.org/content/10.6...

PCNA Inhibition Enhances the Antitumor Activity of KRAS-Targeted Therapies in #PancreaticCancer 🧪 www.biorxiv.org/content/10.6...

TMEM Doorway Mediated Metastasis in Pancreatic Ductal Adenocarcinoma by Tie2 Signaling #PancreaticCancer 🧪 www.biorxiv.org/content/10.6...

Loss of CD44 re-educates pancreatic cancer-associated fibroblasts modulating their fibrotic and immunosuppressive functions #PancreaticCancer 🧪 www.biorxiv.org/content/10.6...

Multi-stromal organoid co-cultures model pancreatic cancer and pancreatitis epithelial cell-fibroblast heterogeneity #PancreatiCancer 🧪 www.biorxiv.org/content/10.6...

Unraveling miRNA-Driven DNA Damage Response Networks in Pancreatic Adenocarcinoma: A Multi-Omics and Machine Learning Approach 🧪 #PancreaticCancer www.biorxiv.org/content/10.6...

End of my Molecular Genetics classes and now fully focused on lab work. Time to wrap up manuscripts and hit the books! #academicsky

Students use one paper as the basis for a "research grant application" that they will write. So papers that are cool but also open doors to future study are ideal! Do you know one? It can be your own, I don't mind! Last year's selection: quantixed.org/2025/01/06/p... 2/2

HELP! Please suggest a cool paper/preprint in your field in the last year or so. For a course I teach, I am collecting papers on: cell/dev bio, microbio, neuro, maths/stats/CS/chem/phys applied to biology. 1/2

Targeting CREB remodels the immune microenvironment to enhance immunotherapy responses in #PancreaticCancer www.biorxiv.org/content/10.6...

Yesterday, I made my first donation to @signal.org . I’m happy to support #open-source apps that prioritize privacy and security.

We are hiring! We are looking for a Postdoc to drive our efforts on using tissue clearing for 3D histopathology. @erturklab.bsky.social #Histopathology #TissueClearing #PostDoc www.linkedin.com/feed/update/...

🚨 Want to do a #Phd using high-throughput mutagenesis and CRISPR screens to understand how gene body methylation impacts transcription in collaboration with Greg Kudla's group? Do apply, deadline in a week! www.findaphd.com/phds/project... Deadline 15th December 2025 #epigenetics Please share 🙏

The subclonal footprint of pervasive early dissemination in #PancreaticCancer Yuanchang Fang, et al bioRxiv 2025.11.27.690823; doi: doi.org/10.1101/2025...

Silylation of hydroxychloroquine enhances autophagy inhibition and antiproliferative activity in breast and pancreatic cancer cells Michael J. Williams, Anuj K. Singh, Matthew D. Wittmer, Grant W. Anderson, Conor T. Ronayne, Venkatram R. Mereddy bioRxiv 2025.11.26.690890; doi.org/10.1101/2025...

Predicting Benefit of Neoadjuvant Chemotherapy and Elective Nodal Irradiation in Pancreatic Adenocarcinoma: A Supervised Machine Learning Approach - Harada - 2025 - Cancer Medicine - Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/...

#Planify is an excellent app for task organization and project management. It is open-source and available via #Flatpak on #Linux. Congratulations to the developers! github.com/alainm23/pla...

Circulating tumor cell and oncosome subtypes in portal and peripheral venous circulations may be used for diagnosis and prognostication of #PancreaticCancer 🧪 www.nature.com/articles/s41...

Longitudinal Analysis of Matched Patient Biospecimens Reveals Neural Reprogramming of Cancer-Associated Fibroblasts Following Chemotherapy in Pancreatic Ductal Adenocarcinoma 🧪 #PancreaticCancer www.biorxiv.org/content/10.6...

Tissue-specific tolerance mechanisms and lymph node co-drainage converge to shape T cell immunity in the upper digestive system and regulate pancreatic cancer progression 🧪 #PancreaticCancer www.biorxiv.org/content/10.6...

Rotational migration in human pancreatic ductal organoids depends on actin and myosin activity #PancreaticCancer 🧪 www.nature.com/articles/s42...

Glycaemic control is a modifiable risk factor for #PancreaticCancer development in patients with diabetes: a population-based cohort study 🧪 gut.bmj.com/cgi/content/...

Targeting TNK2/ACK1 reverses the immunosuppressive tumor microenvironment and synergizes with immunochemotherapy in #PancreaticCancer 🧪 www.nature.com/articles/s41...

Que contrates una cuenta on line con unas condiciones de interés al 2% con el @bancosabadell.bsky.social y a los 4 meses cambien unilateralmente las condiciones al 1% dice muy poco de su seriedad y compromiso con el cliente. #banca #BancoSabadell

Ok, this is a first. I have a fastq file with an accession that I *can not find anywhere*. That is, the file has an SRR#, that is embedded in the read headers (and matches the file name), but I can't find this file anywhere (ENA/SRA/etc.). Has anyone ever encountered this?

A guide to transcriptomic deconvolution in cancer 🧬🖥️ www.nature.com/articles/s41...

AGR2 suppresses ferroptosis via the p53/FPN1 regulatory axis and drives therapeutic vulnerabilities in #PancreaticCancer 🧪 www.nature.com/articles/s41...