Our Molecular Genetics course is officially underway! 🧬 This week: prokaryotic replication. Next up? Eukaryotes! Ready to unravel the mysteries of DNA? #Genetics #Science #MolecularBiology

hey bluesky 👋 visa hurdles mean I’m looking for opportunities outside the US. I’m a computational biologist (bacterial + phage genomics, postdoc in Koonin’s group @ NIH). I am interested in teaming up on funding apps. reach out if this resonates!

Pancreatic tumor microenvironment reprogramming via alloantigen-expressing virotherapy elicits tumor rejection and improves immunotherapy response www.biorxiv.org/content/10.1... #PancreaticCancer 🧪

Exploiting TGF-β-mediated Stromal Programming in Homologous Recombination-Deficient #PancreaticCancer www.biorxiv.org/content/10.1... 🧪

#PancreaticCancer risk prediction using deep sequential modeling of longitudinal diagnostic and medication records www.sciencedirect.com/science/arti... 🧬🖥️🧪

FOLFIRINOX Combined with GPX4 Inhibition Induces Ferroptosis and Defines Redox-Based Therapeutic Subgroups in #PancreaticCancer 🧪 www.biorxiv.org/content/10.1...

Flexynesis: A deep learning toolkit for bulk multi-omics data integration for precision oncology and beyond | Nature Communications www.nature.com/articles/s41... 🧪🧬🖥️

Biomedical Research Seminars @UFV are back! Top scientists from CNIO, IRB, CIEMAT & more will share cutting-edge insights on cancer, immunotherapy, AI in biomedicine & aging. Monthly talks, Sept–June. Open to all! #Biomedicine #UFV #Science 🧪 @ufvmadrid.bsky.social

Vitamin D Binding Protein, a Ligand of Integrin beta 1, Motivates Both Tumor Cells and Schwann Cells to Promote Perineural Invasion in Pancreatic Ductal Adenocarcinoma 🧪 #PancreaticCancer advanced.onlinelibrary.wiley.com/doi/10.1002/...

A novel FAP-targeting antibody-exatecan conjugate improves immune checkpoint blockade by reversing immunosuppressive microenvironment in #PancreaticCancer 🧪 www.nature.com/articles/s41...

Durotaxis is a driver and potential therapeutic target in lung fibrosis and metastatic #PancreaticCancer 🧪 www.nature.com/articles/s41...

Tumor nutrient stress gives rise to a drug tolerant cell state in #PancreaticCancer 🧪 www.biorxiv.org/content/10.1...

MondoA mediates transcriptional coordination between the MYC network and the integrated stress response in pancreatic ductal adenocarcinoma 🧪 #PancreaticCancer www.biorxiv.org/content/10.1...

🌍 #MWGlobalOnc Prognosis & biology of ER-low metastatic breast cancer – TONIC & multicenter cohort 🔑 Key Messages: ✅ ER-low (1–9%) behaves biologically closer to TNBC than ER+/HER2− ✅ Worse OS vs ER+/HER2−; prognosis similar to TNBC ✅ Phenotypic switch from ER+ → ER-low at relapse = poor outcomes

✨ ER-low & TNBC showed comparable response to nivolumab (TONIC trial) ➡️ Transcriptomics: ER-low tumors enriched in immune activation & DNA repair genes

🎯 Clinical impact: ER-low BC should be managed more like TNBC, with inclusion in immunotherapy & ADC trials. Re-biopsy at relapse is crucial to detect phenotype switch. #BreastCancer #ERlow #TNBC #Immunotherapy #Medicalwatch aacrjournals.org/clincancerre...

⏰ ¡Última semana para inscribirse en el Máster de Bioinformática del ISCIII! ¡Aún estas a tiempo! ℹ️ masterbioinformatica.com 📌 Organizado por el @saludisciii.bsky.social @cniostopcancer.bsky.social @bsc-cns.bsky.social 🏅 Acreditación oficial @iscb.bsky.social 🤝 Colaboran SEBiot e Instituto Roche

The absence of IL17A favours cytotoxic cell function and improves antigen‐specific immunotherapies in pancreatic adenocarcinoma 🧪 #PancreaticCancer onlinelibrary.wiley.com/doi/10.1002/...

An allele-agnostic mutant-KRAS inhibitor suppresses tumor maintenance signals and reprograms tumor immunity in #PancreaticCancer | Science Translational Medicine 🧪https://www.science.org/doi/10.1126/scitranslmed.adt5511

The kinase ERK plays a conserved dominant role in the heterogeneity of epithelial-mesenchymal transition in #PancreaticCancer cells | Science Signaling 🧪 www.science.org/doi/10.1126/...

Targeting cancer-associated fibroblast-driven LIF/LIFR axis improves the therapeutic efficacy of gemcitabine and nab-paclitaxel in #PancreaticCancer 🧪 www.nature.com/articles/s41...

Molecular characterization and prognostic implications of KRAS mutations in pancreatic cancer patients: insights from multi-cohort analysis 🧪 www.nature.com/articles/s41...

Functional tumor-reactive CD8 + T cells in #PancreaticCancer 🧪 jeccr.biomedcentral.com/articles/10....

Endothelial-like cancer-associated fibroblasts facilitate pancreatic cancer metastasis via vasculogenic mimicry and paracrine signalling 🧪 #PancreaticCancer gut.bmj.com/content/74/9...

Synthetic data generation method improves risk prediction model for early tumor recurrence after surgery in patients with #PancreaticCancer 🧪🧬🖥️ www.nature.com/articles/s41...

A #PancreaticCancer organoid biobank links multi-omics signatures to therapeutic response and clinical evaluation of statin combination therapy 🧪 www.cell.com/cell-stem-ce...

Hypoxia-induced metastatic heterogeneity in pancreatic cancer 🧪 #PancreaticCancer www.biorxiv.org/content/10.1...

Integrated spatial proteomics of human PDAC uncovers an expanded tumour-immune-stroma spectrum with genomic associations 🧪 #PancreaticCancer www.biorxiv.org/content/10.1...

Tumour genotype shapes blood biomarker expression for use in pancreatic cancer detection and diagnosis. 🧪 #PancreaticCancer www.biorxiv.org/content/10.1...

In-depth proteomic profiling of the extracellular matrix of pancreatic ductal adenocarcinomas identifies signatures correlating with lymphocyte infiltration 🧪 #PancreaticCancer www.biorxiv.org/content/10.1...

MYC-Driven Activation of USP39 Enhances SRSF1 Stability and Promotes PDAC Progression 🧪 #PancreaticCancer www.biorxiv.org/content/10.1...

The Pdgfd-Pdgfrb axis orchestrates tumor-nerve crosstalk in #PancreaticCancer 🧪 www.biorxiv.org/content/10.1...

Meet Planify—an elegant, open-source task manager for #Linux. Supports Todoist & Nextcloud syncing (even offline), visual drag-and-order UI, project sections, reminders, dark mode, and sleek progress indicators. A must-try for #GNOME fans! github.com/alainm23/pla... 🧪🧬🖥️

Dear Bluesky, some good news to brighten your day! We are recruiting for the Director of the Centre for Population and Disease Genomics!! I would be grateful if you could share across your networks! uq.wd3.myworkdayjobs.com/uqcareers/jo...

🚨 𝗝𝗼𝗯 𝗢𝗳𝗳𝗲𝗿 🚨 🧫🫁 PhD on innovative therapeutic and diagnostic strategies for pulmonary diseases. 📅 Deadline: 15th Sep 2025 🔬 Envisaged start date: Nov 2025 to Jan 2026 📍 Location: San Sebastian (Spain) 👉https://www.cicbiomagune.es/job-offer-detail?id=42944

We’re hiring! 🥳fully funded PhD and postdoc positions in human cognitive neuroscience @mpicybernetics.bsky.social M/EEG and brain stimulation methods to study timing/ prediction/ attention/ oscillations tinyurl.com/5dku4du9 @timingresforum.bsky.social @gtc-tuebingen.bsky.social please repost 🙏

SpheroMap Cytometry: a novel spatial flow cytometry approach to evaluate immune response in PDAC spheroids 🧪 #PancreaticCancer www.biorxiv.org/content/10.1...

Unraveling the spatial distribution of CAF subsets in PDAC spheroids through a novel spatial flow cytometry approach 🧪 #PancreaticCancer www.biorxiv.org/content/10.1...

Inhibition of AXL dependent non-professional efferocytosis sensitizes #PancreaticCancer to immune checkpoint blockade 🧪 www.biorxiv.org/content/10.1...

Reprogramming Immunosuppressive Bone Marrow Derived Cells via CD44 Targeting Impacts #PancreaticCancer Metastasis 🧪 www.biorxiv.org/content/10.1...

Unraveling the glyco-immunity nexus in #PancreaticCancer molecular-cancer.biomedcentral.com/articles/10.... 🧪

ALERTA de EMPLEO!! Ofrecemos un contrato predoctoral para realizar la tesis doctoral en el estudio de la heterogeneidad funcional de los fibroblastos asociados a cáncer (CAFs) y su papel en resistencia terapéutica en cáncer de vejiga, asociado a nuestro proyecto (PID2024-157801OB-I00). Más detalles👇

📢 We have an open position at University of Geneva for a PhD student with CS/Math/Physics background to study adaptive immune responses using deep learning. If interested please contact me directly!

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma 🧪 #PancreaticCancer febs.onlinelibrary.wiley.com/doi/10.1002/...

Analysis of hepatitis B virus integration identifies KMT2B as a novel cancer‐related gene in #PancreaticCancer 🧪 onlinelibrary.wiley.com/doi/10.1002/...

CTHRC1 Derived From Cancer‐Associated Fibroblasts Promotes Pancreatic Cancer Progression and Metastasis via the LIF‐STAT3 Pathway #PancreaticCancer onlinelibrary.wiley.com/doi/10.1002/... 🧪

Bacteria and tumor debris induced #PancreaticCancer progression via the NF-κB signaling pathway 🧪 www.sciencedirect.com/science/arti...

A technical review of multi-omics data integration methods: from classical statistical to deep generative approaches 🧬🖥️🧪 academic.oup.com/bib/article/...

Have you compared PyDESeq2 with InMoose? I am quite impressed that InMoose allows interactions in model design that are not yet implemented in PyDESeq2. 🧬🖥️ inmoose.readthedocs.io/en/stable/de... pydeseq2.readthedocs.io/en/stable/

To all post-docs: The Genome Biology dept ‪@embl.org has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th embl.wd103.myworkdayjobs.com/en-US/EMBL/j...