Dear Colleagues, Delighted to share that our first lab paper is now published in Nature.!!! 😊😊😊 We identify a previously concealed “safety limit” in DNA replication program: cells intrinsically rate-limit PCNA via PAF15, shaping strand-specific and global replication dynamics. 👉 rdcu.be/e1bBt

Cells possess a built-in limit for DNA replication, controlled by the protein PAF15, which may offer a new approach to targeting rapidly dividing cancer cells.

@science.org Deep contrastive learning enables genome-wide virtual screening | Science www.science.org/doi/10.1126/...

🌍Open call: Junior Group Leader positions! Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery. Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...

𝗖𝗮𝗻 𝗰𝗲𝗹𝗹𝘀 𝗲𝘃𝗲𝗿 𝘁𝗿𝘂𝗹𝘆 𝗿𝗲𝗰𝗼𝘃𝗲𝗿 𝗳𝗿𝗼𝗺 𝗗𝗡𝗔 𝗱𝗮𝗺𝗮𝗴𝗲?Excited to share our new study “Repair of DNA double-strand breaks leaves heritable impairment to genome function”, revealing DNA repair’s hidden cost, out now @science.org tinyurl.com/5n6zw3ye. Led by @sbantele.bsky.social and Jiri Lukas.🧵👇1/n

Now out in Science! Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle. In @vcushing.bsky.social's magnum opus, we use #cryoEM to figure out how the CDK-activating kinase recognises CDKs to fully activate them - a key step in cell cycle control. www.science.org/doi/10.1126/...

9 days to go: * 2 x open positions! * Exceptional environment, competitive start-up package * University of Toronto appointments * Toronto has great (and peaceful) quality of life!

@mariasecrier.bsky.social & I are looking for an enthusiastic & excellent data scientist for a 4-year postdoc to understand cell cycle dysregulation in cancer. Deadline 15th October. Get in touch if you have any questions. Please repost! More details: www.imperial.ac.uk/jobs/search-...

My first post on bsky to share our latest research in @nature.com: “DNA2 enables growth by restricting recombination-restarted replication” - defines DNA2’s essential function & elucidates links with primordial dwarfism and cancer. Thanks to the lab, collaborators & @ukri.org @acmedsci.bsky.social

new out in Nature www.nature.com/articles/s41...

So utterly honoured to have been recruited, mentored and supported by this incredibly influential individual. Long may he happily retire. @gdsc-sussex.bsky.social

new out in Nature: cell cycle meets metabolism www.nature.com/articles/s41...

Tillykke til alle nye SDU-studerende Den 28. juli er 4.415 blevet tilbudt en studieplads på Syddansk Universitet. Stort tillykke og husk at takke ja til pladsen senest den 4. august. Der er fortsat få ledige studiepladser - få et overblik her: ledigepladser.sdu.dk #studiestart #uddpol

Yadav, Jadhav, @hanasedlackova.bsky.social et al present a novel cell-permeable biotin-HaloTag ligand. The reported ligand expands the HaloTag toolbox by enabling in vivo labeling & providing capabilities for efficient affinity capture of protein variants from live cells rupress.org/jcb/article/...

Our new non-denaturing nanoscale 3D DNA tracing technology provides single-cell (and sister-chromatid specific!) readout of chromatin structure with 10kb genomic resolution - Check it out! www.nature.com/articles/s41... Congratulations to Kai and Oyvind!!

new out in Nature, the latest on the cell cycle in fission yeast, lovely basic biology www.nature.com/articles/s41...

Cytarabine has been the mainstay for AML treatment for over 50 years. This chemotherapy can lead to problems with movement and balance. Here we explain this neurotoxic side-effect. www.nature.com/articles/s41... Work led by Jia-Cheng Liu, Donpeng Wang and Elsa Callen and terrific collaborators!

Delighted to share that the results of my main postdoc project are now published in @nature.com 🔗 doi.org/10.1038/s415...

Proud to present our work identifying a role for DIAPH1 and gamma-actin in regulating DSB repair and how defects in this pathway give rise to human disease. Big thanks to everyone involved, especially Beth Woodward, Sudipta Lahiri and @anoopsinghchauhan.bsky.social. www.nature.com/articles/s41...

(1/n) Thread @matteomazzocca.bsky.social @domenicnarducci.bsky.social Simon Grosse-Holz @jessematthias.bsky.social preprint Q: how does chromatin move? Using MINFLUX, SPT & SRLCI, we track chromatin dynamics across 7 orders of magnitude in time to provide answers www.biorxiv.org/content/10.1...

Exciting PhD project available in our lab (time sensitive)! 👇

I am overjoyed to share that I have been selected as a Lundbeck Fellow 2025. Thank you to @lundbeckfonden.bsky.social for their trust in me - My lab and I cannot wait to get started on this important work.

Want to learn more about chromatin and its dynamics? Read this review by Charlotte and Jolijn in our lab, aimed at giving an overview on this and the ways this is dealt with during transcription, replication and damage repair. Thanks to Biochemistry for inviting us! doi.org/10.1021/acs....

this week 20 years ago, Nature published two seminal papers showing for the first time that BRCA-mutant cells were selectively sensitive to PARP inhibitors, paving the way for clinical trials and approval of PARP inhibitors for patients with BRCA-mutant ovarian and breast cancers, and beyond.

A beautiful News & Views by @unterholznerlab.bsky.social highlighting our latest paper in @natsmb.nature.com, where we show that transcription stress triggers an inflammatory response through the release of IL-1α. rdcu.be/ehkTV

Excited to share our new pre-print. Direct, ensemble FRET assays developed by our lab reveal that assembly of Rad51 filaments at stalled replication sites via RPA/Rad51 exchange causes complete & irreversible PCNA unloading. Big implications for interplay between human DNA damage tolerance pathways

An insightful preview by Scott Friedman highlighting our recent findings on the role of hepatic stellate cells in metabolic regulation 🙌🏻 Out today in Cell Metabolism @cp-cellmetabolism.bsky.social www.sciencedirect.com/science/arti...

📢 For all DNA fiber enthusiasts! 🟥🟩 We are thrilled to announce the release of our long-awaited AI-based workflow for the automated and quantitative analysis of DNA fibers. It's an exciting step forward—check it out on bioRxiv! lnkd.in/dQWUPtsP

PAF15-PCNA assembly exhaustion governs lagging strand replication and replisome integrity https://www.biorxiv.org/content/10.1101/2025.03.15.641049v1

Thrilled to share our lab's first preprint, led by an exceptional PhD student Gita Chhetri and with the support of wonderful collaborators, we find that replisome function is rate-limited by strand-specific PCNA dynamics. Hope you will enjoy reading. www.biorxiv.org/content/10.1... Brief teaser:

Very excited to share that my thesis work is out in Molecular Cell! We trained a Structure and Omics informed Classifier (SPOC) to score binary AlphaFold multimer (AF-M) predictions by structural quality and consistency with experimental omics datasets. www.cell.com/molecular-ce...

Check out our latest paper now online at Cell Metabolism: Hepatic stellate cells regulate liver fatty acid utilization via plasmalemma vesicle-associated protein. Amazing work by Daniel, Jasmin, Christian, Peter, Oliver from @ravnskjaer_lab, and many more 🏆💐♥️ www.cell.com/cell-metabol...

Wasting a writing session on the paper's title

Metabolic control of replisome plasticity in genome surveillance

🚨𝐌𝐚𝐣𝐨𝐫 𝐉𝐨𝐛 𝐀𝐥𝐞𝐫𝐭!🚨The Groth @groth-anja.bsky.social, Mailand, Nilsson @nilssonlab.bsky.social & Krietenstein @nilskrietenstein.bsky.social labs are hiring 𝟔 𝐏𝐡𝐃&𝐩𝐨𝐬𝐭𝐝𝐨𝐜𝐬 to join the new Center for Epigenetic Cell Memory (EpiC) in Copenhagen, Denmark. Apply here: tinyurl.com/yvd93na2 & please share!

1/6 🧫 Introduction: We recently explored how glucose metabolism rates influence cell morphology across various yeast species. Our findings underscore the intricate connections between metabolism and cell size. #YeastResearch #Metabolism

Let’s stop treating "leaving academia" as negative. Scientists train for academia, industry, or what suits them. Industry isn’t an alternative; it’s a choice. In fields like engineering, most PhDs go to industry, and no one calls it "leaving academia." We should train scientists for diverse paths.

Congratulations to Jenna Whalen on her Nature Cancer paper out today-a distinct take on nicks and their toxicity! rdcu.be/d60Td

When someone says epigenetics but means gene expression

1/2 We’re hiring a Postdoc to join us at the University of Copenhagen. Are you fascinated by 3D chromatin function and super-resolution microscopy? Then this might be the job for you. Start date 1st of April 2025, starting salary 4700 Euro/month. Apply here: candidate.hr-manager.net/ApplicationI...

Happy Holidays！💐 Credit to: Dario Brunetti

Hello Bluesky! Wishing all happy holidays with this festive display of cells lit up with qTAG, a new tool developed by the Pelletier lab at #LTRI! It enables endogenous fluorescent tagging to illuminate protein dynamics in living cells @embojournal.bsky.social www.embopress.org/doi/full/10....

I applaud this, and I had to do something similar recently. Don't forget, we are only humans I took a break from work to protect my health. This should be more accepted in academia www.science.org/content/arti...

We are looking for a motivated Postdoc to join our lab at the University of Copenhagen. Please reach out if you have any questions regarding the position. Deadline for application is the 2nd of February 2026. candidate.hr-manager.net/ApplicationI...

Dear network, we are looking for skilled technician to join our fun and dynamic team at the Novo Holdings Seedlab in Copenhagen. We support the development of biotech startups spanning multiple areas of interest. Check the ad here: job.jobnet.dk/CV/FindWork/...

I have received a Wellcome Discovery Award to study the initiation of eukaryotic DNA replication, with 8 years of funding at the Francis Crick Institute. Looking for a postdoc in molecular mechanisms, cryo-EM, cryo-FIB and in situ structure? Contact me now! 3 postdoc positions advertised soon.

New pre-print! To support a CDK-cyclin docking motif discovery and characterisation project led by Norman Davey and colleagues, @natalia-mg.bsky.social in my lab determined the #cryoEM structures of three peptide-bound CDK2-cyclin A complexes. Check it out! www.biorxiv.org/content/10.1...

Delighted to publish my new molecular animation: DNA Break Repair by Homologous Recombination youtu.be/Xe-83tBcxhs

📢 Happy to share our bioRxiv preprint on how CRL4-DCAF12 regulates the cellular level of MCMBP, a chaperone of nascent MCM2-7 complexes, to ensure error-free genome duplication. The full story can be found here: lnkd.in/eCjVNQks