Interested in inherited chromosomal instability syndromes and DNA repair? We are looking for an enthusiastic person to join the Stewart lab at the University of Birmingham as a senior technician. Please checkout the job advert: www.jobs.ac.uk/job/DPH515/senior-research-technician

Fascinating work from @raychaudhurilab.bsky.social and @cejkalab.bsky.social! Challenges the idea that HR defects in BRCA2-deficient cells stem from poor RAD51 loading, shows instead that unchecked RAD51 removal by FIGNL1 drives the defect. Great read!

Have a look at this Tools of the Trade Article I wrote for @natrevmcb.nature.com on decoding #ubiquitin signals inside cells using UbiREAD! Many thanks to @lisaheinke.bsky.social for the opportunity to write this TotT!

Neat trick if you polycolonal ab's suck. Incubate them with fixed cells with a KO of your protein of interest, then spin. Protocol here: www.med.upenn.edu/markslab/ass... I was amazed how well it worked on first try (I'm sure that I can completely eliminate unspecific bands) #WesternBlot #cellsky

Required reading for cell biologists to get a sense of basic statistical principles! www.nature.com/articles/s41...

SUMO interactions: the 1st of two reviews which Aanchal (@origichals.bsky.social), El Hadji, and I have recently written on non-covalent interactions of SUMO is now out. The 1st covers interactions with E1, E2, and deSUMOylating enzymes; the 2nd - on interactions with SIMs etc. - will appear soon.

Excited to share our latest publication, out in @science.org! We define a key role for the CST complex in double-strand break repair pathway choice. This study was conducted in close collaboration with the Sung lab at UT Health San Antonio. Congrats to @michelleswift.bsky.social and all authors!

Proud to present our work identifying a role for DIAPH1 and gamma-actin in regulating DSB repair and how defects in this pathway give rise to human disease. Big thanks to everyone involved, especially Beth Woodward, Sudipta Lahiri and @anoopsinghchauhan.bsky.social. www.nature.com/articles/s41...

Thrilled to see this “veritable tour de force” led by John_C_Fielden from Jacob Corn lab out @nature.com, rdcu.be/ehd4E. This @erc.europa.eu funded project uses #CRISPRi to systematically scan 548 DDR genes for synthetic lethal interactions, ~150,000 pairwise combinations!

📢 Just published! Excited to share my latest research, now published in Nature Communications! Grateful to my collaborators and mentors who made this work possible. @profstewartlab.bsky.social @Jo Morris, @Aneika C. Leney, @drjhujh.bsky.social www.nature.com/articles/s41...

We are looking for a senior administrator to take care of the Structural Studies Division at @mrclmb.bsky.social. Come and work for the benefit of human health in a fantastic environment. Happy to chat! www.jobs.ac.uk/job/DLY086/s...

Join the first Keystone conference dedicated to DNA replication gaps and cancer! Send an abstract to be selected for a talk. www.keystonesymposia.org/conferences/...

Fascinating paper! No G2/M checkpoint for under-replicated cells! academic.oup.com/nar/article/...

Excited to see the final published form of this amazing @drewberry.bsky.social‬ animation of DNA repair go live! Watch your favourite friends BRCA1/2, RPA, RAD51, Exo1, BLM, PCNA, MRN, primase and DNA polymerase perform their recombination magic. Cool educational & scientific tool for our community.

DNA nicks in either the leading or lagging strand templates can trigger break-induced replication (although nicks are introduced with Cas9n, Flp or gp2 that also create an R-loop or covalent protein barrier). In yeast. www.cell.com/molecular-ce...

Glucose limitation protects cancer cells from apoptosis induced by pyrimidine restriction and replication inhibition 🧪 Congrats @richpossemato.bsky.social & team for the very cool work! www.nature.com/articles/s42...

My first post on BlueSky. Our latest review delves into the critical roles of ubiquitin E3 ligases in safeguarding genome integrity and their implications in human diseases. @drjhujh.bsky.social @profstewartlab.bsky.social portlandpress.com/biochemj/art...

Hi BlueSky! It's great to be here. Here's a handy Starter Pack of DNA repair & genome stability groups that I found so far go.bsky.app/NvFWKvL