How do SMC complexes capture DNA? 🧪 Led by Frank Bürmann, Jan Löwe’s & Mark Dillingham’s groups have identified the directional loading mechanism the bacterial SMC complex MukBEF uses to capture & ingest DNA, & found a phage inhibitor to this pathway. Read more: tinyurl.com/4s8nrrkk #LMBResearch

Excited to share our discovery of the RAD51 filament cap, built by a newly identified RAD51 paralog complex 🔬🧬

New preprint from the lab for any DNA repair or replication stress geeks out there! www.biorxiv.org/content/10.1...

Now out in Science! Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle. In @vcushing.bsky.social's magnum opus, we use #cryoEM to figure out how the CDK-activating kinase recognises CDKs to fully activate them - a key step in cell cycle control. www.science.org/doi/10.1126/...

🧬 Preprint alert! "Distinct ATRX functions cooperate with 9-1-1 and CST complexes to safeguard replication and telomere integrity." Read the manuscript here 👉 www.biorxiv.org/content/10.1...

"… as I helped this bright young scholar rediscover hope in her journey, I rediscovered my own." #ScienceWorkingLife https://scim.ag/473CI43

Our preprint on Pol-η usage during genome replication has been uploaded. It addresses the biased use of Pol-η in the lagging strand and late-replicating regions, which may be correlated with cancer mutagenesis. www.biorxiv.org/content/10.1...

DDIAS is a single-stranded DNA-binding effector of the TOPBP1-CIP2A complex in mitosis https://www.biorxiv.org/content/10.1101/2025.09.09.675193v1

New preprint with @gfudenberg.bsky.social We find the rate of cohesin loop extrusion in cells is set by NIPBL dosage and tunes many aspects of chromosome folding. This provides a molecular basis for NIPBL haploinsufficiency in humans. 🧵👇 www.biorxiv.org/content/10.1...

My first post on bsky to share our latest research in @nature.com: “DNA2 enables growth by restricting recombination-restarted replication” - defines DNA2’s essential function & elucidates links with primordial dwarfism and cancer. Thanks to the lab, collaborators & @ukri.org @acmedsci.bsky.social

Some seriously nice biochemistry and cryo-EM of FAN1-PCNA-flapDNA complexes! www.nature.com/articles/s41...

Slow RNAPII elongation enhances naive-pluripotency rewiring while preserving replication fork speed https://www.biorxiv.org/content/10.1101/2025.05.12.653265v1

3rd edition of the fantastic UK DNA replication meeting is happening next September in Edinburgh. Don't miss out 🧬🏴󠁧󠁢󠁳󠁣󠁴󠁿 www.biochemistry.org/events-and-t...

🎉 Congratulations! Great to see this out in print! 👏

Pls repost. Postdoc role on post-replicative ssDNA gap processing. Interesting models that should float replication aficionados boats. DM or [email protected] for info. Until Dec26 but will strive for funding to provide continuity. Fantastic place to live+work www.jobs.ac.uk/job/DMG682/r...

How are chromosome breaks repaired and how is their repair influenced and facilitated by nuclear and genome dynamics? Fantastic initiative and collaboration with @karimmekhail.bsky.social, @chiololab.bsky.social, and @lablegube.bsky.social. @natrevmcb.bsky.social Link to article: rdcu.be/edViW

🧬⛓️‍ Our latest preprint examines the fate of collapsed forks in vertebrates 🐸 and our colleagues in @heathmurraylab.bsky.social asked similar questions in bacteria 🦠 to reveal how evolution shapes the response to fork collapse (see🧵) www.biorxiv.org/content/10.1... www.biorxiv.org/content/10.1...

TRIP13 protects pancreatic cancer cells against intrinsic and therapy-induced DNA replication stress https://www.biorxiv.org/content/10.1101/2025.01.26.634889v1

Telomeric SUMO level influences the choices of APB formation pathways and ALT efficiency https://www.biorxiv.org/content/10.1101/2025.01.16.633463v1

Okay, the list is far from complete, but it is a first attempt.☺️Here you can find our starter pack on #research organizations and #academies, in #Germany and worldwide. Who else do you think should be included? go.bsky.app/DGGtVu6

New discovery from our #CDlab reported in Cell @cp-cell.bsky.social today: SMC motor proteins have a left-right ‘gearbox’ and can switch direction in DNA loop extrusion! www.sciencedirect.com/science/arti... 1/

The PST repeat region of MDC1 is a tunable multivalent chromatin tethering domain https://www.biorxiv.org/content/10.1101/2025.01.10.632395v1

Identification of critical factors of the replication stress response in human cells https://www.biorxiv.org/content/10.1101/2025.01.12.632149v1

Fascinating paper! No G2/M checkpoint for under-replicated cells! academic.oup.com/nar/article/...

Great start to 2025. Tumor hypoxia promotes immune evasion by autophagy-mediated downregulation of MHC class I expression leading to reduced antigen presentation. Great work from @halaestephan.bsky.social www.embopress.org/doi/full/10....

Great paper about p38 and endometrial cancer from a long-term collaborator and friend, Cyrus Vaziri, just published in Cell Reports: www.cell.com/cell-reports...

Our last article about ssDNA gaps and BRCA1 👇🏻👇🏻 doi.org/10.1093/nar/...

Delighted to publish my new molecular animation: DNA Break Repair by Homologous Recombination youtu.be/Xe-83tBcxhs

Happy to share a review written with the wonderful @jstingele.bsky.social on transcription-coupled DPC repair, featuring an overview of new methods, close comparison with TC-NER, comments on clinical implications and plenty of discussion of the unknowns. www.cell.com/trends/cell-...

Not sure if there are PhG applicants on here, but if there are there is an information event for UKRI funded PhD projects at northwest Bio here. Please sign up if interested. t.co/yIgIyelZFP

Re posting this as there's been a lot of updates since I originally posted the starter pack!

ok, Genome Stability people. Here are our two starter packs - since I can't pin them both independently to my profile, have to make a new post. Still adding new people to the second pack. As usual, please reach out if you would like to be added! bsky.app/starter-pack... bsky.app/starter-pack...

BlueSky: A Guide for Scientists by @jacoates.bsky.social #AcademicSky #EduSky 🧪

The lab 2024 article is out! BRCA1/BARD1 ubiquitinates PCNA to promote continuous, ssDNA-free, DNA synthesis in a RAD18-independent pathway. www.nature.com/articles/s41...

go.bsky.app/KxWyLE4 Trying to put together a starter pack for journals!

Let's get this site started. I'm excited to share that our work on transcription-coupled DNA repair is now published! We recapitulated TC-NER in Xenopus egg extract and identified STK19 as a core repair factor that couples lesion-stalled RNA Pol II to TFIIH. 🧬🐸 ➡️ cell.com/cell/fulltex...

We said hello to our new followers last week, but there's many more of you now! Welcome! We've created a starter pack for you, which is a work in progress. We'd also love to hear from you about your work we've published or what kind of things you want us to post.

The peer-reviewed version of our paper is out! Thanks to all co-authors, editor and reviewers for the smooth process 🤓🎉 And don’t miss the chromatin haiku! www.cell.com/molecular-ce...

Nice to see the number of people on here increasing over the last few days. 🎉

ok, I tried to make a starter pack on genome stability/DNA replication/DNA repair etc. Sorry if I couldn't find someone, please nominate yourself and your colleagues in comments or DMs, looking forward to connecting with everyone! go.bsky.app/9jdDNxG

Reminder for newcomers that bioRxiv has Bluesky accounts in every subject category - great way to keep up (please re-skeet) connect.biorxiv.org/news/2023/09...

Maiden BlueSky post to rep a collaborative paper I'm a co-author from the Stewart and Vazri lab showing that RNF168 has roles in both DSB repair and DNA replication! Really glad to have been part of this and super excited for people to read it! 😅