Yasu Daigaku
@yasudaigaku.bsky.social
📤 57
📥 23
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Scientist, Field: DNA replication, Mutagenesis, Genome stability
Our preprint on Pol-η usage during genome replication has been uploaded. It addresses the biased use of Pol-η in the lagging strand and late-replicating regions, which may be correlated with cancer mutagenesis.
www.biorxiv.org/content/10.1...
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Strand- and replication timing-dependent functions of DNA polymerase η in human DNA replication and mutagenesis.
Efficient eukaryotic DNA replication relies on the coordinated actions of replicative and error-prone polymerases, with the latter providing flexibility at the cost of mutagenesis. DNA polymerase η (P...
https://www.biorxiv.org/content/10.1101/2025.09.10.675280v1
4 months ago
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Thanks to Gideon
@costerlab.bsky.social
for visiting JFCR and for a very inspiring seminar. We learned a lot about the impact of many DNA structures on genome replication/stability!
about 1 year ago
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