Hypoxia-activated PROTACs (HAP-TACs) are online in @jacs.acspublications.org (pubs.acs.org/doi/10.1021/...)! Collborative work with Ester Hammond (@hammond-lab.bsky.social). Congrats to Marta Serafini, Sophie Twigger, George Delfas, Max Mallerman, Elliot Bailey & Ewen Calder (@ecalder.bsky.social).

Great end to the week! Thank you to @sophietwigger.bsky.social for aiming high and getting us the Gold award. @oncology.ox.ac.uk

Join us for our DPhil in Cancer Science Open Day on Tuesday 2nd September at 12:30pm to find out how a DPhil can be the next step in your cancer research career development! Register via our Eventbrite link before 1st Sept⬇️ @oncology.ox.ac.uk @medsci.ox.ac.uk www.eventbrite.co.uk/e/university...

Our pre-print on the development of bivalent ligands for the TRIM24 bromodomain & PHD is now online chemrxiv.org/engage/chemr... Congratulations to the authors: Michael Platt, Ekaterina Kot, Louise Martin, Antoine Wallabrègue, Liwen Song, Alistair Boyd, Lizbé Koekemoer, & @hammond-lab.bsky.social

As the active PROTAC is revealed selectively in hypoxia, POI (BRD4) degradation occurs mainly in hypoxia. This technology has the potential to give PROTACs that degrade selectively in hypoxic tumors. This is collaborative work with @hammond-lab.bsky.social - congratulations to all of the authors.

Our pre-print on hypoxia-activated PROTACs (HAP-TACs) is now on ChemRvix: chemrxiv.org/engage/chemr... We used the indolequinone bioreductive group to protect VHL- or CRBN-recruiting BRD4 degraders rendering them inactive. This group is removed selectively in hypoxia, revealing the active PROTAC.

Exciting news!!! We are recruiting a RA to join my lab at ‪@oncology.ox.ac.uk‬ to study epigenetic reprogramming in stem cells and within the TME using colon organoids www.oncology.ox.ac.uk/team/giulia-... Deadline 2nd of July (my.corehr.com/pls/uoxrecru...) Re-post are very welcome!

We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms. Please get in touch with your CV if you are interested; closing date: 27th June 2025. More details here: candidate.hr-manager.net/ApplicationI...

We really are fans of cross-disciplinary projects! Delighted to have contributed to some #PlantScience

I highly recommend working with @kleszczynsk.bsky.social If you're looking for a postdoc and interested in hypoxia and epigenetics take a look at nencki.edu.pl/job/the-nenc...

Meet @halaestephan.bsky.social 👩‍🔬🔬🧪 Hala is a postdoctoral researcher here at the oncology department, working on cancer immunology. To mark #IWD25, Hala shares her STEM journey & her advice on how to thrive as a woman in academia. @medsci.ox.ac.uk @hammond-lab.bsky.social #InternationalWomensDay

Great opportunity for anyone looking for a post doc in Oxford - highly recommend!

Great to see this collaborative work with @emilyflashman.bsky.social and @hammond-lab.bsky.social on @biorxivpreprint.bsky.social. Using our previously developed hypoxia probes (pubs.acs.org/doi/full/10....) to image hypoxia in plants.

Curious about doing a PhD? 🤔 Join Oxford's research community and work with academic staff on projects in a range of subject areas. UNIQ+ research internships are now open for applications from UK undergraduates from under-represented and disadvantaged backgrounds. More info ⬇️

The MSc in Medical Physics with Radiobiology at @oncology.ox.ac.uk welcomes students looking to kickstart a career in medical physics research, clinical practice, or industry. Find out more: tinyurl.com/4a4km74v

ICYMI We are recruiting a new Associate Professor in cell and molecular biology, with a preference for immunology, inflammation and/or infection - all defined broadly Come and be our colleague! Deadline 28 Feb, please spread the word! www.path.ox.ac.uk/vacancy/asso...

Congratulations to the new Dr Twigger @sophietwigger.bsky.social and many thanks to Angie Russell and Navita Somaiah for examining. Let the celebrations commence

Great start to 2025. Tumor hypoxia promotes immune evasion by autophagy-mediated downregulation of MHC class I expression leading to reduced antigen presentation. Great work from @halaestephan.bsky.social www.embopress.org/doi/full/10....

Are you full of ideas, thinking about applying for fellowships and looking for a home i.e. junior group leader position? We're recruiting! my.corehr.com/pls/uoxrecru...

We enjoyed a great holiday celebration, throwing some darts (some better than others) and eating lots. Happy holidays to all @sophietwigger.bsky.social @katroseworth.bsky.social @olivierzanier.bsky.social @brightw.bsky.social @halaestephan.bsky.social @edpetrosyan.bsky.social @chuminz.bsky.social

Exciting opportunity to establish your own research group in the Department of Oncology at Oxford. Please spread the word my.corehr.com/pls/uoxrecru...

Still a month left to apply for one of our fully funded PhD positions in Birmingham, UK. EU / International students welcomed. DNA replication, biochemistry, structural biology. Supportive, multinational team. Please RT (not just ❤️). Thank you!

Dear all, my first post! I have postdoc positions available if you would like to join my lab in beautiful Sussex by the Sea! Please contact me on [email protected]

Ok first post on Bluesky and it’s a science one… New paper out from the lab! APOBEC genes protect us from viral infection but go rogue in cancer. Here we shed new light on how these important genes are regulated, offering clues as to what goes wrong in cancer. www.embopress.org/doi/full/10....