Hypoxia-activated PROTACs (HAP-TACs) are online in @jacs.acspublications.org (pubs.acs.org/doi/10.1021/...)! Collborative work with Ester Hammond (@hammond-lab.bsky.social). Congrats to Marta Serafini, Sophie Twigger, George Delfas, Max Mallerman, Elliot Bailey & Ewen Calder (@ecalder.bsky.social).

Great to see you today @sebvidalchem.bsky.social ! And great to welcome you home to UCLA Chemistry & Biochemistry (@uclacb.bsky.social)

Where am I? #ChemSky

Our pre-print on the development of bivalent ligands for the TRIM24 bromodomain & PHD is now online chemrxiv.org/engage/chemr... Congratulations to the authors: Michael Platt, Ekaterina Kot, Louise Martin, Antoine Wallabrègue, Liwen Song, Alistair Boyd, Lizbé Koekemoer, & @hammond-lab.bsky.social

Hello #ChemSky! We're the open preprint server for the global chemistry community and we're glad to be here. Follow along as we share exciting preprints and engage with the community. Learn more about us: chemrxiv.org

Many congratulations to Sarah Singleton for passing her qualifying exams @uclacb.bsky.social and officially becoming a PhD candidate! Many thanks to her committee members, Profs Backus, Clarke, and Mikkola for their advice and wisdom.

Our pre-print on hypoxia-activated PROTACs (HAP-TACs) is now on ChemRvix: chemrxiv.org/engage/chemr... We used the indolequinone bioreductive group to protect VHL- or CRBN-recruiting BRD4 degraders rendering them inactive. This group is removed selectively in hypoxia, revealing the active PROTAC.

The UCLA Department of Chemistry & Biochemistry is excited to welcome Dr. Antonio Tinoco Valencia (Harvard), who will join the @ucla faculty as an Assistant Professor on July 1, 2025. www.chemistry.ucla.edu/news/welcomi...

#Hypoxia-activated fluorescent probes as markers of oxygen levels in plant cells and tissues #PlantScience by Monica Perri, et al. 📖 nph.onlinelibrary.wiley.com/doi/10.1111/... @emilyflashman.bsky.social @daanweits.bsky.social @conway-group.bsky.social @hammond-lab.bsky.social

Thank you to the Editors of ACS Bio & Med Chem Au & @conway-group.bsky.social for nominating me. I appreciate the support so early in my career. My lab has some very exciting things in the works I can’t wait to share! 🌟

Everyone please read and act! 👇

Many congratulations to Tanya D'Souza, an undergraduate researcher in our lab, who has been awarded a Summer Undergraduate Research Fellowship to continue her research across the summer! Many thanks to the ACS @organicdivision.org for the award of this fellowship and to Genentech for sponsorship.

The Division of Organic Chemistry (DOC) congratulates the sixteen 2025 DOC Summer Undergraduate Research Fellowship (SURF) awardees and gratefully acknowledges the generous sponsors. zurl.co/x1kZh

In a recent blog, Prof. Osvaldo Gutierrez shares his journey from undocumented UCLA student to chemistry professor and offers advice to a new generation of Bruins. chemistry.ucla.edu/news/rancho-...

Was very pleased to get in a couple of early morning #ChemistsWhoRun runs at #ACSSpring2025 , one with Andrew Scholte and John Gavenonis, and one with Will Pomerantz (@fewill26.bsky.social) catching up on all things epigenetics!

Today there are two symposia at the ACS in honor of Peter Dervan (11AM & 5PM). Although I can't be there to celebrate, I wanted to share a few reflections on my time in his lab (2009-2012) and the impact he's had on me as a scientist.

A novel photoaffinity probe for analysing the phosphatdylinositol 5-phosphate interactome Authors: Glen Brodie, Ahmed Sayed, Sarah Kreuz, Wolfgang Fischle, Stuart Conway DOI: 10.26434/chemrxiv-2025-llnc4

New report shows that NIH grants fueled $95 billion in economic activity and 407,782 jobs in 2024. That's not to mention the countless lives that biomedical research has saved. Show me a better investment than that. www.forbes.com/sites/michae...

The NIH "Fellowships: Topics in biochemistry and chemical biology" Study Section scheduled for March 20th/21st has just been postponed...

We now have a Twitter account, to reach people who are not on bluesky—and to help get them here. If you still have a Twitter account please follow us there, and ask others to follow too. x.com/altnih4science

The mood was defiant at many of the rallies, where chants of “Scientists will not be silenced”, “Facts over fear” and “What do we want? Peer review! When do we want it? Now!” were heard. https://go.nature.com/3F8T6FX

Great crowd at the UCLA/Westwood #StandUpForScience gathering.

BREAKING: Federal judge issues a nationwide preliminary injunction blocking NIH from implementing its "Rate Change Notice" that would dramatically cut payments under grants. Judge Angel Kelley had previously issued a TRO blocking the change. storage.courtlistener.com/recap/gov.us...

Great to see this collaborative work with @emilyflashman.bsky.social and @hammond-lab.bsky.social on @biorxivpreprint.bsky.social. Using our previously developed hypoxia probes (pubs.acs.org/doi/full/10....) to image hypoxia in plants.

If you are attending the Spring ACS Meeting in San Diego, please come and join us on Monday night for a showcase of UCLA research and to meet UCLA students, postdocs, faculty, alumni, and friends! All ACS attendees are welcome! #ChemSky

Join us for the UCLA Research Showcase on 3/24, 5-7 pm at the Spring ACS Meeting in San Diego. Meet UCLA community members, explore posters, discuss science, and enjoy refreshments. All ACS attendees welcome! Please pass this along! RSVP: bit.ly/UCLAACSShowc...

Had a blast writing this piece celebrating the latest paper in @pubs.acs.org from @ellensletten.bsky.social and Ellen’s general awesomeness. My 11-year old daughter was my coauthor! (try to find all the Easter Eggs) pubs.acs.org/doi/10.1021/...

Petition to Reverse the NIH Indirect Cost Cap initiated by Tom Maniatis. Please amplify Sign the Petition: chng.it/kK2HMP5pGk "Share with Leadership & Faculty. Reach out to professional societies, biotech and pharma leaders, and philanthropic organizations to raise awareness and mobilize support."

@papersapp.com What is the easiest way to fund a manuscript that I have just imported (by dragging in a PDF) when it doesn't immediately sync to have the correct title, authors names etc? I think there used to be a just imported tab...that would be useful!

📢 Announcing the 2025 EFMC-YSN Leadership Election! We are glad to introduce Sean McKenna, Laia Josa-Culleré, and Etienne Donckele as the new leaders of the Young Scientists Network. Congratulations! Reach out for future collaborations! @seanmckenna.bsky.social @laiajosacullere.bsky.social

There's still time to register for #ACSSpring2025! Members save: www.acs.org/membership.h... Registration: www.acs.org/meetings/acs... ACS hotels: www.acs.org/meetings/acs... Travel: www.acs.org/meetings/acs... @acsbiol.bsky.social awards: www.divbiolchem.org/awards-at-a-...

Bil Clemons: Following Scientific Curiosity biobeat.nigms.nih.go...

Congratulations to Prof. Yi Tang @yitangucla.bsky.social for being named the winner of the 2025 Marvin J. Johnson Award in Microbial and Biochemical Technology by the American Chemical Society (ACS) Division of Biochemical Technology! chemistry.ucla.edu/news/yi-tang...

NSF has created an Executive Order Implementation webpage to ensure the widest dissemination of information and updates. We will continue to communicate with you as we receive additional guidance. new.nsf.gov/executive-or...

Obituary: James Fraser Stoddart (1942-2024) chemist and nanotechnology pioneer who built molecular machines https://go.nature.com/40MvkI9

We are pleased to announce UCLA’s new Master of Applied Chemical Sciences (MACS) Program. We are accepting & reviewing applications on a rolling basis for the 2nd round deadline. Application deadline: 6/1/25. Learn more: macsucla.com. Questions? Email [email protected]

🎉 Congratulations to our recent awardees: • William Greenlee: 2025 Patrick Woster Award for Service to the Division of Medicinal Chemistry • Sheila DeWitt: 2025 Gertrude Elion Medicinal Chemistry Award • Michael Jung: 2025 Edward E. Smissman Award

Congratulations to Michael E. Jung, winner of the 2025 NAS Award for Chemistry in Service to Society for his key contributions to synthetic medicinal chemistry and drug discovery! Learn more about his research: nasonline.org/award/nas-aw... #NASaward #chemistry

Congrats to Prof. Osvaldo Gutierrez on receiving the Presidential Early Career Award for Scientists & Engineers (PECASE) from Pres. Biden! The highest honor for early-career scientists & engineers. bit.ly/4htM2l0

Now that 2025 is here, just wanted to highlight the opening we have for an Organic Chemistry Lectureship at St Andrews again. Applications close in about two weeks on 22nd January. All the details in the link. www.vacancies.st-andrews.ac.uk/V2/ViewVacan...

RIP J. Fraser Stoddart and Martin Karplus.

Deeply saddened to hear yesterday about Sir Fraser Stoddart passing away. For me, from Sheffield to the streets of Chicago, across 35 years, it was always an adventure (though mostly with much less snow). Fraser was a force of nature and leaves an enormous legacy. He will be sorely missed.

I’m sorry to hear that Sir Fraser Stoddart has passed away. I had the privilege of meeting him at St Andrews, Oxford, and most recently @uclacb.bsky.social. He was kind enough to spend some time with me and provide some very insightful advice. Condolences to his family, coworkers, and collaborators.

RIP friend, colleague, & collaborator Sir Fraser Stoddart @nobelprize.bsky.social @uclacb.bsky.social @nupress.bsky.social #nano

Colleagues, Students, Postdocs, Collaborators and Friends of Sir Fraser Stoddart: I am writing with the sad news that Fraser passed away suddenly on 31 Dec (Australia time) while on holiday with family. No details yet on any services. He is irreplaceable.

Scientists to Follow! As my "Scientists to Follow" list (go.bsky.app/3SyoVNw) reached capacity and I did not want to extend the short list (go.bsky.app/C4URhFa), I made a part 2 with plenty more scientists that post exciting content here: go.bsky.app/9keb2TP Please share this post! (1/n)

Happy holidays from the Conway Group!

We enjoyed a great holiday celebration, throwing some darts (some better than others) and eating lots. Happy holidays to all @sophietwigger.bsky.social @katroseworth.bsky.social @olivierzanier.bsky.social @brightw.bsky.social @halaestephan.bsky.social @edpetrosyan.bsky.social @chuminz.bsky.social