Greetings! I decided to make a YouTube video of my AlphaFold workshop that I've given a few times in the past year. Caveats aside, people seem to find this useful for thinking about how to model protein interactions and how to interpret various AF outputs 1/2 www.youtube.com/watch?v=u63o...

Magic Johnson was the grand marshal of the Rose Parade today, and as someone who remembers his November 1991 HIV announcement: if you had told anybody that day that he would be alive and healthy 34+ years later, I don't think they would have believed you. Medicine and research—they work.

New post! There was a lot of innovation in medicine and biomedical research this year, and I've tried to summarize the biggest ones in this blogpost. Medical breakthroughs in 2025. Plus a serious note at the end. www.scientificdiscovery.dev/p/medical-br...

What Do Oral Drugs Really Look Like? Dose Regimen, Pharmacokinetics, and Safety of Recently Approved Small-Molecule Oral Drugs

Congratulations former postdoc @jfhevler.bsky.social (in transit to Roche) and the team on their work using thermal proteome profiling along with glycosylation perturbagens to discover glycan-dependent protein functions at the proteome scale 👏 www.biorxiv.org/content/10.6...

Excessive vigorous exercise impairs cognitive function through a muscle-derived mitochondrial pretender: Cell Metabolism www.cell.com/cell-metabol...

My wife, who designed our card, completely shares my sense of humor. Happy holidays!

It’s the most wonderful time of the year…

😬

This “major update to ProteomicsDB” is definitely worth a look. academic.oup.com/nar/advance-...

Pilot just came on and said that in addition to turbulence, “We are flying today with an unusually large number of tubes. Please make sure you exit the plane with the correct tube.” Non #SFN25 passengers very confused 😂

For solving a 50-year mystery by uncovering the machinery behind BMP, a molecule with protective effects against various disorders, Uche Medoh is the winner of the 2025 Science & SciLifeLab Prize for Young Scientists. 🎉 Learn more about the work: https://scim.ag/4qVpK1a

Current group mood 🚀 🚀

Every time I open a Capri Sun:

Reading this, it truly resonates how fortunate we were that Jim Watson never took an interest in social media.

Huge congratulations to @craigmcrews.bsky.social on being awarded the #Havinga medal at the #Reedijk Symposium of the Leiden Institute of Chemistry for his groundbreaking work on induced proximity, including targeted protein degradation, as a new paradigm for #DrugDiscovery. #ChemSky #ChemBio #TPD

I think about this post every day 🧪

We have wondered what a complex archaeal cell might look like ever since 2014. It’s been a long road (and the journey is far from over), but it’s a good time to pause for breath and look. These Asgard archaeal cells are a surprise! And that is the joy of being a cell biologist.

Beautiful discovery by the Huber and Kubicek labs and a wonderful example of using targeted protein degradation to probe novel non-catalytic functions.

Bronsted-basic small molecules activate GTP hydrolysis in Ras Q61 mutants https://www.biorxiv.org/content/10.1101/2025.11.04.686643v1

Flying Squirrel Loves It Every Time

Excited to share our latest work in collaboration with the @edreznik.bsky.social lab @mskcancercenter.bsky.social, where we describe functionally dominant mitochondrial DNA mutations in patient tumors. So, what is functional dominance in mitochondrial genetics, I hear you ask? rdcu.be/eN1jm

Required reading for cell biologists to get a sense of basic statistical principles! www.nature.com/articles/s41...

Every scientist’s secret aspiration is to make it into this Pubmed alert:

If you’re the parent of two trick-or-treaters who want to trade candy, it’s your job to act as commissioner to oversee any trades to avoid any Nico Harrison situations.

Science brings us new miracles every day. Update from a mother whose son was the first patient dosed with Grace Science's gene therapy for NGly1 deficiency (GS-100). Video can be seen on YouTube. #glycotime www.youtube.com/watch?v=tdNn...

Chemoproteomics v. Boltz-2: "These cases...point to the need to re-train ML co-folding tools on datasets enriched in more diverse types of small molecule-protein interactions...to avoid biased predictions derived from memorization of common orthosteric ligand poses" www.biorxiv.org/content/10.1...

Review @natrevcancer.nature.com @stjuderesearch.bsky.social Epigenetic regulation of T cell exhaustion in cancer www.nature.com/articles/s41...

This graph is jaw-dropping and tracks anecdotal academic experience so well.

Fed employee mood this weekend:

Our photoswitchable HaloTag is out in Angewandte Chemie @angewandtechemie.bsky.social ! We now also show that this system can be used to control emitter density in SMLM. Congrats to Franzi, Bego, and our amazing collaborators. Check it out: onlinelibrary.wiley.com/doi/full/10....

Reading 'The Witches' to my girls and the point near the end when the boy who has been turned into a mouse asks, "Grandma, how long do mice live?" has got to be one of the most emotionally destroying segues ever in a children's book.

Amazing paper from collaborators Schraga Schwartz and Moran Shalev-Benami at Weizmann. Nucleotide resolution sequencing of 16 RNA modifications from diverse organisms cultured under basal and 'extreme' conditions + enzymology, structure, synthesis, and biophysics. www.cell.com/cell/fulltex...

So excited to see this out in @natgenet.nature.com! An amazing collaboration with @gagneurlab.bsky.social, I am happy I was (a small) part of. Nucleotide dependencies can capture regulatory elements, including #RNA structures! Congrats to the whole team! Check it out: www.nature.com/articles/s41...

new preprint: Ubiquitin is a protein modification linked with degradation but known to regulate other functions. Over 100k ubiquitination sites have been discovered and here we (@julianvangerwen.bsky.social + others) try to prioritize those most critical to the cell www.biorxiv.org/content/10.1...

Spotted in the wild: the perfect license plate for our moment.

Check out the symposium organized by our CoE, excited to have Marcia Haigis, @lydiafinley.bsky.social, Matthias Hebrok and Tom MacVicar over in Helsinki in November. Sign up by October 22nd 👇

TIL "Come Out and Play"/'Keep 'Em Separated' by "The Offspring" was inspired by a grad student experiment with autoclave broth: www.asbmb.org/asbmb-today/... (article from 2014) #chemsky ⚗️🧪

New week, new tool: Find our Protein Domain Designer tool to generate publication-ready protein domain diagrams here: domaindesigner.farnunglab.com

This comic is becoming increasingly realistic. m.xkcd.com/3056/

Full circle moment! While visiting ASBMB for a Maximizing Access Committee meeting, @garcialabms.bsky.social spotted one of his early JBC papers. www.jbc.org/article/S002... Do you remember the thrill of your early publications? Share below! @asbmbjournals.bsky.social #asbmbJBC #TeamMassSpec

Seven years. Over 400 pages. About 750 references. Over 40 figures. Finally I get to hold the finished book. It’s a big day. #EpigeneticsBook @cshlpress.bsky.social

Exclusive: Anthony Letai, a cancer researcher and oncologist at the Dana-Farber Cancer Institute and Harvard University, has emerged as a leading candidate to be the next director of the National Cancer Institute. www.statnews.com/2025/09/24/n...

🚀 Our new paper is out @natmethods.nature.com! Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells. 🔗 www.nature.com/articles/s41... 🧬 www.addgene.org/John_Ngo/

don't release preprints without a Methods section don't release preprints with a Supplementary Materials section don't release preprints without data don't release preprints without code use preprint servers to share your science, not advertisements

I loved this! Read it if you have time. Read it even if you don’t….

Cool feature of Shana Kelley’s work.

To evoke a famous Warren Zevon quote: “Enjoy every burrito.” Memorializing our final Friday 🌯 lunch with @fjoreilly.bsky.social who will move his group to St. Jude in October. A real one! I wish we had more time.

To evoke a famous Warren Zevon quote: “Enjoy every burrito.” Memorializing our final Friday 🌯 lunch with @fjoreilly.bsky.social who will move his group to St. Jude in October. A real one! I wish we had more time.

Sad to hear that David Baltimore died. I am one of hundreds of scientists that David generously mentored, supported, and inspired. His influence on each of us was deep and lasting, and his impact on the world immeasurable. Arguably David Baltimore is one of the greatest scientists of any generation.