Curious about where, how and when #extracellularvesicles fuse with target cells? A new methodology developed in our group, spearheaded by Jasper van den Ende, provides insight in this process. EV-FUSIM: an EV-Fusion Spatiotemporal Imaging Method. www.biorxiv.org/content/10.1...

The Hubrecht Institute has an open call for it's PhD program. It's a great place to work and do research, so apply!

Really nice paper on a new sensor for double-stranded RNA: Prkra dimer senses double-stranded RNAs to dictate global translation efficiency: Molecular Cell www.cell.com/molecular-ce...

Can anyone recommend good mRNA therapeutics conferences that are coming up? Ideally conferences that are attended by both industrial and academic researchers?

It's possible to apply for the Hubrecht Talent Program again! The HTP aims to promote scientific excellence in the Netherlands by supporting talented minority students in pursuing a career in scientific research. Read more in the flyer and on www.hubrecht.eu/about-us/hub...

Very honored to receive the Ammodo Science Award for fundamental research! Great recognition for the amazing work done by all our group members, both past and present, over the past 10 years! Also a huge congrats to my co-awardee Leila Akkari! www.ammodo-science.org/researches/m...

Very excited to share a new paper from the lab! We visualize RSV infection with single-vRNP resolution and show how the virus coordinates transcription and replication with the formation of viral factories, biomolecular condensates that act as sites of viral genome control. doi.org/10.1101/2025...

Save the date for the next edition of this wonderful meeting. We look forward to seeing you in Portugal!!

Check out the latest paper from our collaboration with the Kuppeveld lab where we use a combination of virology and single-molecule imaging assays to reveal the role of the enterovirus 2A protein: www.biorxiv.org/content/10.1...

Super happy to receive a VICI grant from NWO! 5 more years of studying mRNA translation using single-molecule imaging

Wow, very nice!

Our paper on Stopless-ORF Circular RNAs (socRNAs) is now out in Cell. By high-res tracking and comparing translation by either single or multiple ribosomes, we find that ribosomes cooperate to overcome pausing to ensure fast and efficient translation www.cell.com/cell/fulltex...

Wow, mindblowing!

Very happy to share our preprint on visualizing the life cycle of Influenza viruses using single-molecule imaging! 🥳 We developed two techniques to visualize infections of unmodified influenza viruses in live cells from endosomal release to budding of new viruses. For more details&videos see below ⬇️

Our new paper is out: "Mapping the complete influenza A virus infection cycle through single vRNP imaging". Combining newly-developed single-molecule imaging approaches with in situ viral transcriptomics, we identify numerous non-canonical infection pathways. www.biorxiv.org/content/10.1...

This is really interesting. Have other people observed NGD outside of yeast? We haven't seen much evidence of mRNA decay caused by ribosome stalling or collisions in human cells