It is strange sometimes that some apps do barely any personalised advertising. The food delivery apps I've used for many years still don't seem to know I'm vegetarian, and I often have to scroll through a whole page "for the carnivores" before I get to stuff I might like.

This seems like a highly unfortunate misspelling of funeral.

It's surprising how long it took for people to accept the theory of continental drift, considering:

Write for us! Here are 26 ideas of articles we'd like to commission. www.worksinprogress.news/p/more-artic...

Saw this in a book and I hope the author didn't have other children not listed here

Reading Rosalind Franklin's Wikipedia page when suddenly

"There is simply no sign of a fiscal catastrophe from the 'Boriswave'. Recent migrants are very likely to be employed, paying tax and seem to be contributing to British society..it will help, rather than hurt, Britain’s fiscal position." Analysis by @lgilbert.co ukandeu.ac.uk/lower-migrat...

happy 11th anniversary to this email sent to all staff at the School of Mathematics and Statistics

I really like the feeling of waking up early and realising it's so early that I can go back and sleep some more. Makes me think I should go to bed earlier so I can feel that even more 😂

The print edition of Works in Progress is now available in: • Canada 🇨🇦 • Australia 🇦🇺 • the European Union 🇪🇺 🇮🇪 🇩🇪 Subscribe today for 6 beautiful issues a year. The first edition ships in 2 weeks! 🥳 worksinprogress.co/print/

I've changed my mind about LinkedIn - it's good now.

The print edition of Works in Progress is now available in: • Canada 🇨🇦 • Australia 🇦🇺 • the European Union 🇪🇺 🇮🇪 🇩🇪 Subscribe today for 6 beautiful issues a year. The first edition ships in 2 weeks! 🥳 worksinprogress.co/print/

"A good way to learn German is to read children's books to familiarise yourself with basic grammar and vocabulary" German children's book:

Slowly listening my way through this episode, which is great overall, except there is a major error in it which I think requires a correction as well as reconsideration of their fact checking process:

I'm not lazy, I'm just convenience maxxing.

Almost fell for a scam call today, and realised that if I simply never picked up the phone, I'd easily avoid loads of potential scammers

Really cool study: a fully recombinant antivenom made not from horse serum but from nanobodies i.e. tiny, single-chain antibodies derived from alpacas and llamas. These molecules are smaller, more stable, cheaper to produce, and less likely to trigger immune reactions. www.nature.com/articles/s41...

Can you take a quarter cup of composite sewage, simply ask ‘what’s in there?’, and find out all of the pathogens circulating in that community? That is the question we asked in our latest pre-print. Turns out you can. 1/ www.medrxiv.org/content/10.1...

There still seems to be a lot of confusion about significance testing in psych. No, p-values *don’t* become useless at large N. This flawed point also used to be framed as "too much power". But power isn't the problem – it's 1) unbalanced error rates and 2) the (lack of a) SESOI. 1/ >

🤦‍♀️

>In a new 4hr episode of the Hard Drugs podcast, The sudden appearance of this podcast is going to ruin my schedule in the best possible way

The reviews of our new podcast episode are in:

This year Demis Hassabis predicted AI could cure all disease in a decade. But other scientists like Claus Wilke & Derek Lowe say biology is far more complex, or progress will be limited by clinical trials & economics. In a new 4hr podcast episode of *Hard Drugs*, we answer: Will AI solve medicine?

Will AI solve medicine? We decided to be as definitive as is possible in 2025. That meant going long, through the drug development process Sections 1. Clashing worldviews 2. Drug discovery 3. Models 4. Efficacy 5. Safety 6. Manufacturing & healthcare 7. Funding 8. Trust & ambition Hope you enjoy!

MFW my co-host @jacobtref.bsky.social is telling me all about the drug development pipeline.

Welp @scientificdiscovery.dev and Jacob are back again, Will AI Cure Disease? By the end of the 4.5 hours you'll be significantly older and might find out! www.worksinprogress.news/p/will-ai-so...?

This year Demis Hassabis predicted AI could cure all disease in a decade. But other scientists like Claus Wilke & Derek Lowe say biology is far more complex, or progress will be limited by clinical trials & economics. In a new 4hr podcast episode of *Hard Drugs*, we answer: Will AI solve medicine?

I love telling people I got a new dog, watching the start of their reaction, and then showing them this

Playing catch with my new dog

Found a tiny joke book at home

Folks, it is the year 2025 and Word's grammar checker is suggesting that I should change "fewer" to "less few".

I just found the virus version of Labubu

Damn, Duolingo being down because of the AWS outage means I can't talk to Lily today 😞 I miss her already. Wonder what she's up to

Apparently some people think I'm AI generated, because... I don't blink enough

I laughed about Huel being “spiritually bad.” I also wish one could just trust media outlets that break news about supposedly troubling contamination to not lean into the story at the cost of scientific accuracy.

Tune in to find out: - how to go from hallucinated cat pictures to hallucinated proteins - whether @jacobtref.bsky.social can do photosynthesis - whether we can make tiny protein straws for tardigrades to drink from

Got my flu shot today! 💪

Well hey, I got new sunglasses as a belated birthday present for myself (•_•) ( •_•)>⌐□-□ (⌐□_□)

Instantly feel young again with this one simple trick: I asked my 3 year old nephew how old he thought I was, and he said 6. Then I asked how old my brother (his dad) was, and he said 100.

New episode of Hard Drugs! What if you could design a protein never seen in nature? Scientists are using new AI tools like RFDiffusion, AlphaFold & ProteinMPNN to hallucinate novel proteins to solve problems nature hasn't. @jacobtref.bsky.social & I talk about the art of protein design 🧑‍🎨

Our most practical episode yet for people who want to dabble in biotech As of 2022, you can hallucinate protein structures using AI similar to Midjourney (RFDiffusion) -> create amino acid strings for them (ProteinMPNN) -> validate with AlphaFold Biology becomes engineering…

New episode of Hard Drugs! What if you could design a protein never seen in nature? Scientists are using new AI tools like RFDiffusion, AlphaFold & ProteinMPNN to hallucinate novel proteins to solve problems nature hasn't. @jacobtref.bsky.social & I talk about the art of protein design 🧑‍🎨

New blog post! Let's say you have two measures meant to capture the same confounder. They're highly correlated. Can you still proceed with your regression analysis? (I admit, the title is a bit of a spoiler) www.the100.ci/2025/10/13/i...

OOOPS! UPDATE: Two HHS officials tell me that disease detectives, measles response officers, global health officials and the MMWR staff were laid off by mistake and will be reinstated. But Washington office is still RIFed

Cherish this type of translation before it disappears because of LLMs 😌

BREAKING: Friday night massacre underway at CDC. Doznes of "disease detectives," high-level scientists, entire Washington staff and editors of the MMWR (Morbidity and Mortality Weekly Report) have all been RIFed and received the following notice:

Biology is much more complicated than most non-biologists can imagine. And AI is not going to change this anytime soon. blog.genesmindsmachines.com/p/we-still-c...

🚨 The Economist has been telling you for years that polygamy causes civil war by locking men out of marriage. A new article with @rebeccasear.bsky.social and @anthrolog.bsky.social explains that the demography of marriage markets doesn't actually work that way. 🧵 www.pnas.org/doi/10.1073/...

Had quite a lot of doughnuts to eat for my birthday but I managed it 😮‍💨