(@halaestephan.bsky.social)

Starting 2025 the right way ! Very delighted to share our work describing how hypoxia decreases MHC I expression and the immunopeptidome leading to immune evasion. A huge thank you to our collaborators and all the contributing authors! www.embopress.org/doi/full/10....

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Hypoxia promotes tumor immune evasion by suppressing MHC-I expression and antigen presentation | The EMBO Journal imageimageHypoxia contributes to cancer resistance to both standard therapies and immunotherapy. This work demonstrates that tumor hypoxia promotes immune evasion by autophagy-mediated downregulation ... https://www.embopress.org/doi/full/10.1038/s44318-024-00319-7