New CRUK Post-doc position in our group. #mutationalorder #multiomics #cancer. my.corehr.com/pls/uoxrecru...

Excited to announce that this week I have officially started my lab at @oncology.ox.ac.uk. Grateful for all the support I received by colleagues and mentors Adam Mead, Irene Roberts, @bethpsaila.bsky.social, @houlstonlab-icr.bsky.social and many others without whom this would have not been possible.

New review on the importance of intestinal epithelial-mesenchymal crosstalk - from development and homeostasis through to regeneration to neoplasia. Excellent collaboration with Frances England, Manquiang Lin and Michael Sigal www.nature.com/articles/s41...

Studying cancer evolution needs multi-region or single cell seq for phylogenetics, right? Amazingly (I think!) we found single-sample bulk methylation suffices, via analysis of "fluctuating methylation". In @nature.com today led by brilliant @calumgabbutt.bsky.social www.nature.com/articles/s41...

A fantastic keynote lecture from @bethpsaila.bsky.social, Professor of Haematology @imm.ox.ac.uk @ox.ac.uk, for our final talk of the day. 💬

I am delighted to announce that I am starting my lab next month in @oncology.ox.ac.uk @ox.ac.uk It is such a privilege to be a part of this storied institution! Also, we are hiring - if chromosomal instability and cancer biology excite you, come join the fun! Job Specification: lnkd.in/e8-3hyfr

🚨 New paper alert! 🚨 I’m thrilled and proud to share that our latest work has just been published in @science.org! 🎉 🧽 📖 Read our paper here: doi.org/10.1126/sci... 🎬 Watch a summary: youtu.be/MttCA3GGWEM 🧵 Or keep reading for the key points! 🔑 1/19

Now online in Cancer Discovery @aacrjournals.bsky.social: Systematic Evaluation of GAPs & GEFs Identifies a Targetable Dependency for Hematopoietic Malignancies - by Pu Zhang, Zhendong Cao, Anthony Daniyan, Omar Abdel-Wahab, Junwei Shi, et al. doi.org/10.1158/2159...

Thrilled to share our latest work - we describe a novel and therapeutically relevant mechanism underlying dysregulation of innate immune receptor C5aR1 in the tumour microenvironment. Thanks and congratulations to all authors! www.nature.com/articles/s41...

We're recruiting a postdoc to join my lab at @oncology.ox.ac.uk & @oxcio.bsky.social to understand immune regulation in cancer and develop new approaches for cancer prevention and metastasis. Deadline: 11 August 2025 my.corehr.com/pls/uoxrecru... Lab info: www.oncology.ox.ac.uk/team/jie-yang

Exciting news!!! We are recruiting a RA to join my lab at ‪@oncology.ox.ac.uk‬ to study epigenetic reprogramming in stem cells and within the TME using colon organoids www.oncology.ox.ac.uk/team/giulia-... Deadline 2nd of July (my.corehr.com/pls/uoxrecru...) Re-post are very welcome!

🚨🚨Paper out! 🚨🚨 Delighted to share our work, now published in ‪@natgenet.nature.com‬ 🧬! shorturl.at/94s5S We identified a targetable, chromothripsis-associated genetic event in blast phase (BP) MPN, a particularly poor prognostic subtype of acute leukaemia. 1/n Illustration: Hratch Arbach 🧵👇

Lovely new paper from @leedham-simon.bsky.social dissecting epithelium-microenvironment crosstalk through BMP & wnt signalling in the intestine. Inhibition of BMP antagonist GREM1 may forestall polyp formation in Hereditary Mixed Polyposis Syndrome (HMPS). www.nature.com/articles/s41...

Different flavour of post from me today! A bunch of us in the lab at the @imm.ox.ac.uk are taking up Bone Cancer Research Trust (BCRT)'s June rowing challenge to both raise funds and awareness: www.justgiving.com/fundraising/... Please share/donate if you can!

The plasticity of cancer-associated fibroblasts

Excited to announce that thanks to securing a UKRI FLF follow-on award (mitchell.science/talk/566k-fo...) ✨We are hiring✨ 3-year systems biology (wet/dry) postdoc, to pioneer new approaches to personalised medicine. Learn more + apply (before 29 June): mitchell.science/talk/recruit... Plz share

Out @nature.com: Clonal tracing with somatic epimutations 🧬 Single cell methylome encodes cell state & clonal identity 🔨 EPI-Clone reads out both (+mutations, +RNA) at scale 🩸 Clonal expansions of HSCs are universal from age 50, not driven by CH mutations doi.org/10.1038/s415... 🧵

📣We’re hiring a Postdoc! Join my new lab at the University of Oxford to investigate therapy resistance in brain cancer. ⏰Deadline: 16 June 2025 Apply 👇 my.corehr.com/pls/uoxrecru... Boosts appreciated! #PostdocJobs #CancerResearch #BrainCancer

Huge thanks to our John Goldman Fellow, Dr Giulia Orlando, for giving some of our supporters a special tour of her lab @ox.ac.uk and sharing more about her research into juvenile myelomonocytic leukaemia (JMML). An incredibly inspiring day! 🔬

Delighted that our work describing a potential novel treatment approach for B-cell Acute Lymphoblastic Leukaemia is published today in @natcomms.nature.com‬. 🧵 www.nature.com/articles/s41...

Out in Cell @cp-cell.bsky.social: Design principles of cell-state-specific enhancers in hematopoiesis 🧬🩸 screen of fully synthetic enhancers in blood progenitors 🤖 AI that creates new cell state specific enhancers 🔍 negative synergies between TFs lead to specificity! www.cell.com/cell/fulltex... 🧵

Job Alert 🔊🔊 Looking for your first or next Postdoc position? Then don't look further, apply to this opportunity to join our lab to tackle the next big challenges in the Wnt signalling field. Experience in protein biochemistry and in vitro cell biology is essential for this post tinyurl.com/2p9rndfy

After decades of research on stem cells and their reprogramming, we're now seeing extensive clinical trial assessment, some with very encouraging results. This is a new @science.org outstanding review of the biology and ongoing research efforts www.science.org/doi/10.1126/...

Exciting job opportunities here for *TWO* computational researchers to contribute to a new collaborative effort between the @imm.ox.ac.uk and @ludwigcancer.bsky.social focussing on progression to high risk blood cancers and secondary leukaemia. Come join our brilliant team!

We are recruiting! Senior postdoc in computational cancer genomics/epigenomics @ludwigcancer.bsky.social @ox.ac.uk. Lead research into epigenetic drivers of secondary AML with rich omics data + strong clinical/wet-lab collaborations. cutt.cx/YUoB We look forward hearing from you! #epigenetics #jobs

So excited to get underway on CRC-STARS - a brilliant collaborative effort to improve therapies for colorectal cancer. Thanks to all the colleagues, patients and funders for helping us get here! news.cancerresearchuk.org/2025/03/31/5...

Congratulations to Professor Simon Leedham (@ndm.ox.ac.uk) and team! Cancer Research UK & partners have today committed £5.5m in funding to form a world-leading research team tasked with making personalised medicine a reality for people with bowel cancer. Read more ➡️

🚀 PhD Opportunity! 🚀 Join the GSK-Oxford GO-PREECISE Programme! We’re looking for a DPhil/PhD student to explore the pre-tumour microenvironment in colorectal polyps (Project 8). Work to help drive cancer prevention! 🔬✨ 📍 Apply now: lnkd.in/e8PNTAth #CancerResearch #PhDOpportunity #JoinUs

To conclude our #RareDiseaseDay series, we spoke with @ellouka.bsky.social, a clinician scientist researching Paediatric Myelodysplastic Syndromes (MDS) and Juvenile Myelomonocytic Leukaemia (JMML). These are incredibly rare childhood cancers, with no current treatment options available. 🧪

🔥 New Fraticelli lab publication🔥 “Pre-existing stem cell heterogeneity dictates clonal responses to the acquisition of leukemia driver mutations” Now at Cell Stem Cell, with two new figures, in vivo, and sequential mutagenesis data. Performed with the support of Cris Cancer and @erc.europa.eu

New to bluesky, but I’m excited to share my work over the last few years with @jbuenrostro.bsky.social! Chronic inflammation creates an epigenetic memory in colonic stem cells, priming them for tumor growth: tinyurl.com/ColitisNagar.... Here’s a walkthrough of what we found (🧵)

Good morning everyone, I'm pleased to share our latest advance in bone marrow in vitro modelling: www.biorxiv.org/content/10.1...

Massively parallel reporter assays (MPRAs) testing >680,000 sequences combined with machine learning to improve regulatory element & variant effect prediction. Amazing work by @vagar.bsky.social, Fumitaka Inoue, @jshendure.bsky.social and many others as part of ENCODE. www.nature.com/articles/s41...

Excited to share a major breakthrough from the lab! D&D-seq is a new technology that bridges a key gap in single-cell multi-omics/genomics : the ability to map DNA:Protein interactions (e.g., TFs or chromatin remodellers). Led by Ivan Raimondi, Wei-Yu Chi and Sang-Ho Yoon

🧪 Ready, set, degrade! So proud to share our work in the @jclinical-invest.bsky.social, establishing a versatile approach for creating transgenic dTAG mice to degrade oncoproteins. We showcase that KRAS G12V degradation triggers antitumor immunity in lung cancer. Link: www.jci.org/articles/vie...

On Radio 4 TODAY - Listen to Abs Khan, senior research fellow in the MRC MHU, talking about how organoid research could help develop better treatments on the latest episode of Best Medicine 🧫 🧪 6:30 pm on BBC Radio 4 or online now! www.bbc.co.uk/programmes/m...

1/ 🎄 What’s the best gift under the tree for a computational biologist? 🎁 A new experimental assay that refines our view of gene regulation: ACCESS-ATAC! This creative idea from Richard Sherwood was developed collaboratively between his lab and mine. #Genomics www.biorxiv.org/content/10.1...

Kick off the new year with cutting-edge science. Join the NIC, Prof. Christoph Klein and @abattacks.bsky.social for their webinar on "Organoids" happening on Wednesday, 8 January 2025! www.iseh.org/ISEHWebinars

"The academic structure … makes planning for a family feel like an impossible luxury." In this #ScienceWorkingLife, two postdocs share how, as women in academia, having children can feel impossible—and how talking about it makes them feel less alone. scim.ag/49BKZgp

Absolutely outstanding presentation by @ellouka.bsky.social at #ASH24 about the role of dendritic cells secreting GAS6 in maintaining LSCs in juvenile myelomonocytic leukemia #jmml #HemeSky

Excited to share a new pre-print led by the incredible PhD student Aimilia Vareli. biorxiv.org/content/10.1... She asked why drugs that kill cancer cells in blood don't kill them in lymph nodes? How we can fix that? 🧵🧪 @sussexcancer.org @bsmsmedschool.bsky.social @sussexuni.bsky.social

Just in time for #ASH24, our latest paper is out. We performed scRNA-seq on HSPCs over human development, maturation, and postnatal aging. We looked at dynamics of HSPC subsets, lineage biases, HSC level priming, and identified a developmentally restricted human HSC. www.nature.com/articles/s41...

🧪🧬A new review on epigenetic-targeted drugs - with a big focus on how epigenetic drugs are being explored for combination therapies across multiple types of cancer. www.nature.com/articles/s41...

Hello Bluesky! To introduce ourselves, we thought we'd share a video we made to celebrate turning 35 this year 🎂 Hear from some of our scientists, past & present, about a variety of our highlights and achievements since we were founded by Sir David Weatherall in 1989:

Check out our new review by the amazing @alexkschurer.bsky.social and @thehematopoet.bsky.social on chromatin modifiers in AML! Just in time for the first menin inhibitor FDA approval! 🧪🩸

two excellent papers on enhancer-promoter distance. Revisiting a classic unsolved problem. www.cell.com/molecular-ce... www.cell.com/molecular-ce... Wysocka and @chribue.bsky.social labs

I'm going to repost a #thread here about a recent #paper from my group together with the labs of Marketa Tomkova and Skirmantas Kriaucionis: nature.com/articles/s41588-024-01945-x In it, we show that epigenetic DNA methylation causes errors during DNA replication! #epigenetics #mutations 1/🧵

Excited for #ASH24 & thrilled that *3* brilliant folks from the team have oral presentations, travel awards and 2/3 nominated for **best of ASH**!! @imm.ox.ac.uk @ox.ac.uk @cancerresearchuk.org @ludwigcancer.bsky.social

Here it is! Congratuations to @jesskelley.bsky.social @edimitrova.bsky.social @neilblackledge.bsky.social @aleksszczurek.bsky.social and the rest of the team (Maciej, Amy, and Hieu). This was a fab collaboration with Arminja Kettenbach. Also see a lovely complementary paper from Fei Chen's group.