(1/N) Thrilled to share that our paper HiPoNet (High dimensional Point cloud Network) to be presented at NeurIPS 2025! HiPoNet treats an entire high-dimensional point cloud as a datapoint! It captures multi-scale geometry and topology of the cloud perform classification and regression tasks.

Paul Nurse describing the main job of a PI (From ‘The Thinking Game’, 2024)

Important new paper from @batllelab.bsky.social showing how the KRAS-G12D inhibitor (RMC-9945) triggers rapid stem cell switching in CRC. This switch happens in just a few hours — similar to what we see with tumour cell responses to CAFs. aacrjournals.org/cancerdiscov...

Excited to share our new paper: ‘Phenoscaping Reveals Multimodal γδ T-cell Cytotoxicity as a Strategy to Overcome Cancer Cell–Mediated Immunomodulation’ led by Callum Nattress in collab. with Jonathan Fisher lab (1/13) aacrjournals.org/cancerres/ar...

Applications are now open for the @cruk-cityoflondon.bsky.social Black Leaders in Cancer PhD Programme. If you are interested in our project ‘Reprogramming Plasticity in Colorectal Cancer’ feel free to get in touch! www.colcc.ac.uk/2026-blic-ph...

Excited to be in Essen for @helloeacr.bsky.social Goodbye Flat Biology 🧫

A warm welcome to the newest member of the team: Lab-bubu

We are recruiting! Our lab is looking for a new mass cytometry technician to help study colorectal cancer organoid perturbation experiments at scale. Please feel free to contact me with any questions! Full job description and application details here: www.ucl.ac.uk/work-at-ucl/...

🚨 PhD Position available in our lab 🚨 exploring the power of blood immune multi-omics to detect lung cancer years prior to clinical diagnosis in a unique cohort of >10,000 CT screened individuals. ✅ Wet & dry lab ✅ September 2025 enrolment ✅ UK tuition fees only www.ucl.ac.uk/medical-scie...

Incredibly impressed by the student/postdoc run @bacell3d.bsky.social conference. Great talks, a vibrant community, and so well organised 👏

Very excited to have Prof. Chris Tape (University College London, UK) “Single-cell Phenoscaping of Tumour Microenvironment Organoids @christophertape.bsky.social What makes the phenotype of a cell?

Congrats to Rhianna O’Sullivan for winning a poster prize at the UCL Cancer Institute conference! 👏

Excited to be in Basel for BaCell3D @bacell3d.bsky.social

🏆 UCL is ranked 9th globally in the 2026 QS World University Rankings for the third year in a row. This marks our 14th year in the global top 10, reflecting the strength of our academic and employer reputation. 🔗 Learn more: www.ucl.ac.uk/news/2025/ju... #QSWUR

Excited to visit @nkinl.bsky.social today!

🧬 Excited to announce the 2nd Euro Cancer DepMap Symposium bringing together leading minds in functional genomics, cancer vulnerabilities, AI, CRISPR and anti-cancer target discovery.📍Join us in Milan for cutting-edge science, open discussion & collaboration. #EuroDepMap #CancerResearch #CRISPR

2 weeks left to apply for our new fully funded postdoc position studying plasticity regulators in metastatic CRC!

Happy to share details of this meeting and the exciting line-up of speakers. Hope to see you there. Please re-post www.crick.ac.uk/whats-on/5th...

We are recruiting! We're searching for a postdoctoral research fellow to study patient-specific regulators of plasticity in primary and metastatic CRC. Please reach out if you have any questions! www.ucl.ac.uk/work-at-ucl/...

Excited to arrive in Whistler for the @keystonesymposia.bsky.social on Organoids and Single Cells 🇨🇦 🐻

"We’re going to find a way to kill these cells,” says @christophertape.bsky.social “We won’t stop until we do.” Loved working on this piece with Chris & his team - and with Sharon, who donated her bowel tumour to Chris's @cancerresearchuk.org -funded lab. news.cancerresearchuk.org/2025/05/09/s...

Thanks to @cancerresearchuk.org for featuring our work on stem cell plasticity in CRC: news.cancerresearchuk.org/2025/05/09/s...

Congrats to Corinne Molyneux for winning a poster prize at the UCL Cancer Domain Symposium! 👏

If you’re interested in GI organoids please join us for the first LION meeting at The Crick 09/06! 🦁

Inspiring plenary talk from Prof Mariam Jamal-Hanjani #AACR25 speaking about former City of London Centre trainee Dr Sonya Hessey work and long term collaborations! 🤩🤩 #CRUKfunded

Upgrade to our single-cell organoid dissociation factory 💥

🎉Exciting news - @cancerresearchuk.org and partners have launched a £5.5m fund to research personalised treatments for bowel cancer. We're proud that our faculty member @christophertape.bsky.social and our Organoids facility are part of the international research team. bit.ly/3E3092H

April is #BowelCancerAwarenessMonth – here are the most common symptoms of bowel cancer 👇 It's important to know what's normal for your body. Talk to your GP if you notice anything unusual for you, or any changes that don’t go away. Share this to help us raise awareness 🔁

We are recruiting for a new Research Technician to join the @cruk-cityoflondon.bsky.social Organoid Platform! Full details at: www.ucl.ac.uk/work-at-ucl/...

🧪 Pipettes in a neat row. 🧫 Cells responding to a carefully measured symphony of perturbations. 🦾 Liquid handlers whirring softly. 📋 Protocols, pristine. We are seeking a detail-oriented protagonist to bring order to the world of intracellular signalling. crick.wd3.myworkdayjobs.com/External/job...

Excited to share today, a whole new chapter in my scientific journey. TAPELab( @christophertape.bsky.social) latest review on ‘High-dimensional signalling analysis of organoids’ is now online. Full review available here: www.sciencedirect.com/science/arti...

I see my job as making sure everyone in the team can go forward - some of it is long-term planning (building roads) but a lot of it is admin work (road maintenance) and short-term problem solving (highway patrol intervention). It's all necessary

If teams forming around the 'Rewiring Cancer Cells' or 'TME Dynamics' Grand Challenges would like to include our high-throughput organoid co-culture signalling technologies please get in touch!

I think the CRC field ‘may’ have too many gene signatures

"Genes are... the easy part" @philipcball.bsky.social argues biologists need to embrace complexity from the start, rather than beginning with oversimplified "one gene, one trait" models +1 www.cell.com/cell-systems...

Nice paper from @sleemmz.bsky.social et al underscoring the importance of stem cell transdetermination in CRC. RXR, YAP, and AP1 signalling collectively control access to revival stem cells and inhibition of these nodes limits plasticity to improve chemosensitivity. www.nature.com/articles/s41...

Academics get so jaded about institutions, when they reach a #leadership position many feel #researchculture is unactionable. Me and @deefitzgerald.bsky.social wrote a guide in @immunolcellbiol.bsky.social on leadership nurturing a positive culture 1/13 onlinelibrary.wiley.com/doi/10.1111/...

Our paper on nurturing a #PositiveResearchCulture within your #research #team published by @wellcometrust.bsky.social gives useful tips for your lab. As well as making you a good team leader, nurturing culture pays off in building your science: 1/11 wellcomeopenresearch.org/articles/9-3...

Some fantastic lab automation tips here 👇

(1/n) Excited to share our work on gene signal pattern analysis (GSPA)---our new method for analyzing gene expression over cellular manifolds! www.nature.com/articles/s43...

Wow, what a fantastic Christmas present to get - the main output of my @wellcometrust.bsky.social Henry Wellcome Fellowship is now out @molsystbiol.bsky.social and should be of interest to anybody who loves (PI3K) signalling and quantitative biology! www.embopress.org/doi/full/10....

A new CAR-T cell therapy has delivered promising results in treating patients with an aggressive blood cancer, in findings from a clinical trial led by Prof Martin Pule and Dr Claire Roddie from UCL Cancer Institute and @uclh.bsky.social www.ucl.ac.uk/news/2024/no...

Massive congrats to Shania, Svetlana & Noha (not on Bsky) identifying the mechanistic and phenotype cascades underpinning the anti-metastatic response triggered by viral mimicry TLDR; aggressive CMS4 tumours can be reprogrammed towards less aggressive CMS1 biorxiv.org/content/10.1... thread 👇

Annual lab curry and new karting tradition. Extremely proud to work alongside these wonderful people.

Excited to speak on the 'Single-cell Stage' at The Festival of Genomics & Biodata in London next month. Academic tickets are available free here: festivalofgenomics.com/london/en/pa...

Amazing work from UCL colleagues @ojlucas.bsky.social and @zaccasimo.bsky.social pairing proliferation rates with evolutionary dynamics from scDNA-seq data 🤩

Fantastic update on advances in single cell proteomics from @jesperolsenlab.bsky.social

The EMBL lift really embraces biological complexity

Despite a massive head start, BlueSky has now overtaken Threads in the US 👇

Excited to be in Heidelberg for the EMBL ‘Quantitative Biology to Molecular Mechanisms’ meeting www.embl.org/about/info/c...