🚨New Preprint🚨 How do morphogens integrate dynamically with other modes of signalling+what can this do for pattern precision and robustness? We used the Drosophila visual system as our muse to dive into this question with the amazing Vil Fernandes @ucl.ac.uk 🧠🪰 👇 www.biorxiv.org/content/10.1...

Our article on human multidomain protein biogenesis is now published in @natsmb.nature.com www.nature.com/articles/s41...

The Garnett Lab is excited to launch DepMap Miner, a new tool to explore cancer dependency data! Built on the Sanger DepMap, the DepMap Miner brings together multi-omic and functional datasets for over 1300 cancer cell models. Start mining data now: dataminer.depmap.sanger.ac.uk

Fresh from the press💥 We asked what happens when you evolve gene regulatory networks computationally at scale. Do general principles of GRN evolution jump out? Is the process predictable? Read on to find out @prxlife.bsky.social @crick.ac.uk @ucl-ipls.bsky.social 👉 journals.aps.org/prxlife/abst...

@mariasecrier.bsky.social & I are looking for an enthusiastic & excellent data scientist for a 4-year postdoc to understand cell cycle dysregulation in cancer. Deadline 15th October. Get in touch if you have any questions. Please repost! More details: www.imperial.ac.uk/jobs/search-...

🥁 Check out our new preprint on OmniPath, the prior knowledge resource for #SystemsBiology, and its brand-new OmniPath Explorer web app! 🥳 📖 Preprint: www.biorxiv.org/content/10.1... 🔍 Explorer: explore.omnipathdb.org OmniPath integrates 160+ resources for multi-omics analysis & modeling. 🧶⬇️

💥 We are *also* organizing Machine Learning for Structural Biology @ EurIPS, Copenhagen!! Topics include anything in the ML+bio intersection. Submit your ML+bio short papers! Authors can even present in both locations if they have people in both locations 🚀

Studying cancer evolution needs multi-region or single cell seq for phylogenetics, right? Amazingly (I think!) we found single-sample bulk methylation suffices, via analysis of "fluctuating methylation". In @nature.com today led by brilliant @calumgabbutt.bsky.social www.nature.com/articles/s41...

The advert for the first of these positions (computational/mathematical synbio) is live! www.ucl.ac.uk/work-at-ucl/...

Edith Heard our new CEO shares ten lessons from her life in science, from curiosity, courage and coffee to the secrets of our genetic code. www.crick.ac.uk/news/2025-09...

1/7 Really happy to see my PhD work published in ✨Developmental Cell✨ today! We find human endoderm is specified by two developmental trajectories 🔀, and the choice between alternate routes is dictated by the combinatorial BMP4/Activin signalling. www.cell.com/developmenta...

Congratulations to @gregfindlay.bsky.social on being awarded a €1.5 million Starting Grant from the @erc.europa.eu to take a closer look at possible disease variants hiding in the dark genome. www.crick.ac.uk/news/2025-09...

Feeling very fortunate to be awarded a Programme Foundation Award from CRUK @cruk-si.bsky.social This is a new area for the lab & lets us team up with @mariasecrier.bsky.social to tackle a big problem of how different cancers lose control of proliferation

I like how the QWERTY keyboard mirrors evolution. Proteins and pathways adapted to a situation persist, even when the situation changes. So we end up with mysteriously complex Rube Goldberg machines across biology that only make sense if you know about clashing type bars in Victorian machines.

Exciting day for @crick.ac.uk today: Edith Heard takes over as Director We're looking forward to this new chapter in the story www.crick.ac.uk/about-us/lea...

Latest pre-print from our lab is out. Great work by @alexbendel.bsky.social and team. Full deep mutational scan of an entire human protein interaction domain family 2M quantitative measurement of protein-protein interaction -> deep learning model to predict PPI from sequence More details 👇

Our latest research is out today on ‪@medrxivpreprint.bsky.social: www.medrxiv.org/content/10.1... Saturation genome editing of BRCA1 across cell types accurately resolves cancer risk. Led by the amazing Phoebe Dace. This one’s packed full of data, so check out the paper. Quick highlights… 🧵 1/n

Open postdoc positions in the lab: Come work with us if you're interested in computational modelling of neural dynamics in the brain. www.kcl.ac.uk/jobs/121068-...

Out now! Our very first [email protected], an impressive feat by @tobyandrews.bsky.social where we show how a developing heart grows and scales up its morphological complexity to keep beating...an excellent summary below ⬇️ www.cell.com/developmenta...

An analysis shows that current deep learning models do not beat linear baselines in predicting gene perturbation effects, thus emphasizing the importance of further method development and evaluation. @const-ae.bsky.social @wkhuber.bsky.social @s-anders.bsky.social www.nature.com/articles/s41...

What a fantastic accomplishment -- and what a fantastic story! www.quantamagazine.org/at-17-hannah...

Excited to share our latest work published in #ScienceSignaling! 🚀 www.science.org/doi/10.1126/... (1/4)

This project has been in the making for quite some time. CORNETO not only integrates key concepts and methodologies in biological network inference, but also introduces a novel framework for multi-condition analysis. Congrats to the team, and especially to @pablormier.bsky.social for leading this.

How can we reform science? I have some ideas. But I am not sure you’ll like them, because they don’t promise much. elevanth.org/blog/2025/07...

I do not think you could invent Quantum Mechanics solely from 1900 data. And it could be very much architecture dependent : LLMs are not able to even infer Newton's laws from a massive number simulations arxiv.org/abs/2507.06952

Schmidt Fellowships for #AI in #cancer research 2025 round is now open. These are pathway to independence fellowships between @icr.ac.uk & @imperialcollegeldn.bsky.social that support fellows to be competitive for faculty jobs at the end of the 2 year funding. www.imperial.ac.uk/jobs/search-...

join us at ISMB iscb.bsky.social & @dreamchallenges.bsky.social - benchmarking foundation models w. @anshulkundaje.bsky.social @oldbap.bsky.social G. Stolovitzky @bowang87.bsky.social @mariabrbic.bsky.social K. Kalantar, J. Guinney supported by @ebi.embl.org @cziscience.bsky.social Tempus AI

🚨Job alert in theory/math devbio 🚨 I’m currently advertising postdoc positions to join my group. We’re building reaction-diffusion models to understand some of the crazy things embryos can do. We are based in a beautiful part of Scotland :). Please share! www.abdnjobs.co.uk/vacancy/rese...

Good news for all em-dash enthusiasts: ChatGPT now uses en dashes – with spaces, of course.

I remain sceptical about AI’s role in other aspects of science, but this strongly reinforces the idea that without an AI-first coding strategy (including appropriate training), one risks being left far behind in the coming years. www.microsoft.com/en-us/resear...

Novel Research in Biological Artificial Intelligence: Expressions of interest and nominations for a Max Planck Director to lead research in the field of Biological Artificial Intelligence @mpi-cbg.de and @csbdresden.bsky.social. More information: www.mpi-cbg.de/news-outreac...

In yeast, the CDK and cyclin proteins that drive cell division activate first in the nucleus — a different location in the cell from where was previously thought https://go.nature.com/3GdXuEz

Excited to launch our AlphaGenome API goo.gle/3ZPUeFX along with the preprint goo.gle/45AkUyc describing and evaluating our latest DNA sequence model powering the API. Looking forward to seeing how scientists use it! @googledeepmind

Congratulations to the Crick’s Samra Turajlić on her new appointment as Director of the @cruk-mi.bsky.social 🥂

Organoids in a dish are next to one another. Treatment stops some of them from growing but their neighbours just keep going. What’s the difference? Hint: it’s not genetic doi.org/10.1101/2025...

When do girls fall behind in maths? Gigantic study pinpoints the moment www.nature.com/articles/d41...

Our latest "Dynamic Landscape Analysis of Cell Fate Decisions: Predictive Models of Neural Development From Single-Cell Data" A rigorous mathematical foundation for Waddington's landscape to study cell fate decision making Applied to ventral neural tube development www.biorxiv.org/content/10.1...

We are recruiting! We're searching for a postdoctoral research fellow to study patient-specific regulators of plasticity in primary and metastatic CRC. Please reach out if you have any questions! www.ucl.ac.uk/work-at-ucl/...

Apparently, transcriptomics is not the only field struggling with overly optimistic results from new deep learning techniques. www.understandingai.org/p/i-got-fool...

You are a scientist or an engineer (with a PhD) and you want to upskill to learn about delivering scientific infrastructure for the lifesciences (experimental or computational)? You want to work in Europe, in an internationally excellent service delivery team? ARISE2 is for you!

New Faraday Fellowships for international applicants moving to the UK Up to £4 million per researcher over 5-10 years Fast-track option for mid-career researchers looking to relocate to the UK

Crick researchers have developed a new stem cell model of the mature amniotic sac development. The team is now exploring the potential for using these new 3D models in clinical applications, such as cornea reconstruction and treating ulcers. www.crick.ac.uk/news/2025-05...

Join us in London (12-13 November) for the 10th anniversary of SynBio UK, the premier conference for synthetic and engineering biology. Organised this year by @biochemsoc.bsky.social and colleagues at @ucl.ac.uk. www.eventsforce.net/biochemsoc/s... #synbio

Here it is! Bonsai. Now there is really no more excuse for using t-SNE/UMAP. Bonsai not only makes cool pictures of your data. It actually rigorously preserves its structure. No tunable parameters. Incredible work by @dhdegroot.bsky.social. I'm so excited about this! www.biorxiv.org/content/10.1...

The next session is focused on our @uclspeccoll.bsky.social team and their recent experiences of co-production! If you are interested in the practitioner view, the lessons they have learned and how they are embedding this into future practice, come and join us! buff.ly/4NIzRhq

Can using synthetic approaches to build biology help teach us the design principles of how embryos build themselves? 👷‍♀️🔧 If this is a question that interests you, come and share your thoughts at this Royal Society Workshop on Generative Biology www.royalsoc.ac.uk/science-even...

If you’re interested in GI organoids please join us for the first LION meeting at The Crick 09/06! 🦁

🔊 Pls repost: we (Membership/Elections & #OpenScience Implementation) are looking for a trainee with expertise in #datascience, #machinelearning, data visualization You can contact me or @tlemberger.bsky.social if you know anyone who is interested More info on project ➡️ www.embo.org/vacancy/ai-a...

Stoked to present our latest, superbly led by Chris et al & @torres-sanchez.bsky.social We tackled a fundamental problem – how tissues are patterned during development – found that geometry-constrained ECM fractures pattern the myocardium in the vertebrate heart 1/n www.biorxiv.org/content/10.1...