Introducing openRxiv Labs! 🔬 Growing from the strong foundation of bioRxiv & medRxiv, Labs is an experimental space for working with collaborators to push the boundaries of open scientific communication. 👉 Check it out and learn more: openrxiv.org/openrxiv-lab... #OpenScience #Preprints #Scicomm

"Hypothesis generation: pretty good...data analysis: a super power...executing experiments: not so much" AI can help at every stage of the research cycle. Jonah Cool from @anthropic.com discuss the benefits of integrating frontier models and potential concerns youtu.be/sz1vQyBzSgw?...

The people who believe that generative AI development & adoption everywhere is the ultimate goal & the first order predictor of success are insufferable. So are the people who think that AI can't ever produce anything useful and that everything they do produce is "slop". I miss reasoned arguments.

An amazing list of speakers and lots of opportunity to give selected talks! Save the date and join us in Amsterdam next year!

Spurious correlation inflates performance in single-cell perturbation prediction www.biorxiv.org/content/10.6...

"a paper today is a Frankensteined-together patchwork of supplementary files that run longer than the manuscript, datasets in repositories...code posted to GitHub without documentation. The paper has been replaced....by a mess" www.thetransmitter.org/from-bench-t...

Excited to share our RegVelo paper in Cell www.cell.com/cell/fulltex... We unify RNA velocity + GRNs into one model → better OOD prediction of perturbations (e.g. gene KOs), with examples incl. neural crest KO predictions 🔬 Big thanks to W Wang, Z Hu & T Sauka-Spengler 🙏

But I suspect that we will see the idea that clear writing and concise articulation of ideas is some kind of quality differentiator die. And there are those who will say it was always a poor quality proxy, favoring only good writers not good scientists.

We're super excited to share MissAlignment: a new ML-based approach to reference-free tilt series alignment, spearheaded by @martenchaillet.bsky.social. We think it's going to make your cryo-ET life a lot better. Preprint: www.biorxiv.org/content/10.6... Code: github.com/warpem/miss-... 🧶 Thread:

A clear/significant finding derived from the single cell (sc) analysis of biological systems has been the realization that phenotypically homogeneous populations are heterogeneous at the level of gene expression (GE). www.cell.com/fulltext/S00... 🧵

How can we measure increased productivity of scientists, as a whole, whether from more AI, more funding or other measures, if the total number of Nature papers per week always stays the same?

Grant writing tips from a grumpy reviewer ploughing through grants. 1. Often your reviewers are going to come from a broad range disciplines adjacent but *not actually in* in your field. Help us get orientated in the summary with an analogy/sketch and go back to analogy / sketch throughout.

Does AlphaFold’s latent space encode only the native state or something like a distribution over conformations? We begin to answer this question with ConforNets, a mechanism for producing diverse states, or very specific ones, via inference-time adaption of OF3p’s latent space👇

I am giving a "Crash Course in Embryo Development" for the general public (no science background needed! pitched around GCSE-level) in London on 21st May www.crick.ac.uk/whats-on/cri... We'll dip into development, with a splash of embryo models, and a pinch of ethics. And it's free! Book online 👍

Good post by a history prof, in the genre “What most people don’t understand yet is …” — although, in my experience, a lot of the academics it’s addressing do grasp what’s happening with agents, and just really wish it would not happen.

Pay participants less than minimum wage and give no incentive for good performance. Sounds like AI actually increased peoples pay rate.

It’s official: the UK is rejoining Erasmus! 👏🇪🇺

A benchmark of 100 tasks in computational biology to evaluate agentic systems. The example questions seem narrow in scope but they don't include any bioinformatics skill definitions. Top models already solve 80% of these.

Scientists invented a fake disease. AI told people it was real www.nature.com/articles/d41... first author Lazljiv Izgubljenovic 👏🏽💀

Our heavily updated final version of ROCKET for experiment-guided structure modeling is out in @naturemethods! New frontiers like high-throughput fragment screening and mid-res tomography are forcing a rethink of how experiments are modeled. ROCKET+OpenFold proposes a solution👇

📢📢 join us for this edition of the “Quantitative biology to molecular mechanisms” EMBO workshop Gene regulation, cell dynamics & systems biology 17th - 20th November More info: s.embl.org/omx26-01-bl

Head of @crick.ac.uk worries about ‘shift from funding basic research’ Edith Heard tells @francesjones.bsky.social scientists have “duty to speak up” as discovery research comes under pressure www.researchprofessionalnews.com/rr-news-uk-c...

Professor Trey Ideker has been appointed as the new Director of the Big Data Institute. He has been recognised internationally for his contributions to biology, artificial intelligence, and cancer research. Learn more ➡https://buff.ly/YO3dCyx @medsci.ox.ac.uk

The Crick magazine spring edition is here, with our latest discoveries and science stories. Read about John Diffley’s mission to crack DNA replication and how a giraffe is helping scientists understand placenta evolution ➡️ www.crick.ac.uk/news-and-fea...

Honoured and overwhelmed to receive the 2026 Waddington Medal. Science is a team effort, and I've been fortunate to work alongside exceptional people asking hard questions. Thank you to the BSDB and to everyone who has been part of the journey. bsdb.org/2026/03/24/2...

Scientific publishing: Rethinking how research is reviewed and published Review of how the loss of impact factor affected submissions at eLife - uneven drop across countries, but generally holding up remarkably well and shows a new model is possible elifesciences.org/articles/110...

Blog post: transitioning to being a PI in the age of AI open.substack.com/pub/arjunraj...

Big congratulations to Sebastian from the lab and all other awardees, after barely not making the cut for MSCA the stars aligned this time.

This is brilliant. "Every minute, a new clock is displayed that has been generated by 12 different AI models." Some fare better than others! clocks.brianmoore.com

Great meeting with speakers in genomics, functional proteomics, quantitative imaging, microscopy, and theory. Plenty of talks selected from abstracts!

I am delighted to share that registration for the next @embo.org EMBO Cell cycle meeting is now open! meetings.embo.org/event/26-cel... . We have an outstanding lineup of speakers and several selected talks from submitted abstracts. Look forward to welcoming you in Portugal from 5–7 October 2026!

If you're analysing Cut&Run or Cut&Tag data here's a nf-core NextFlow pipeline to simplify and standardise data processing joss.theoj.org/papers/10.21...

New OpenFold3 preview out! (OF3p2) It closes the gap to AlphaFold3 for most modalities. Most critically, we're releasing everything, including training sets & configs, making OF3p2 the only current AF3-based model that is functionally trainable & reproducible from scratch🧵1/9

We’re recruiting new Research Group Leaders! Why join? 🌍Work across EMBL’s 6 sites 🎓Participate in @embl.org courses and seminars 🔬Lead discovery-driven research in a collaborative environment Apply by 11 April: embl.wd103.myworkdayjobs.com/en-US/EMBL/j... #ResearchCareers @epetsalaki.bsky.social

🚀 New in Communications Biology: Generative models of cell dynamics - from Neural ODEs to Flow Matching www.nature.com/articles/s42... We discuss modeling single-cell dynamics beyond snapshots: from cont-time Neural ODEs to simulation-free flow matching for scalable pop modeling.

Attending AI and Biology @ EMBL Heidelberg until Friday. If you’re around, feel free to come say hello and have a chat

New Perspective form Rory Maizels & me: "Gene regulatory networks: from correlative models to causal explanations" Gene regulatory networks are supposed to give us mechanistic explanations of development, so why are we drowning in 'hairballs' of statistical correlations? rdcu.be/e7zx7

No disciplinarity without interdisciplinarity!

In early-2025 I was reeling from a ‘scored fundable’ grant application that was not funded. I really believed in this grant and knew the ideas were good but the review panel just weren’t into the project and there nothing more I could do. That’s science, but it hurts. (1/8)

Congratulations to Prof Bart Vanhaesebroeck, Prof @christophertape.bsky.social & Team REWIRE-CAN on securing $25m in @cancergrand.bsky.social funding to take on the challenge of rewiring cancer cells. #CancerGrandChallenges @uclmedsci.bsky.social www.ucl.ac.uk/news/2026/ma...

Interested in joining a dynamic, interdisciplinary research department? A call is open for Group Leaders at the UCL Laboratory for Molecular Cell Biology. Please submit your expression of interest by April 13, 2026. Further details here: www.ucl.ac.uk/work-at-ucl/...

New from @dev-journal.bsky.social: we're launching a new initiative and hiring Preprint Editors to help navigate the growing world of preprints in developmental & stem cell biology Join our community & shape the future of research journals.biologists.com/dev/article/...

One of the main stories of my postdoc is finally out! It builds on an intuition from my early days in omics data analysis: our signaling pathways are simply too small, underrepresenting cellular complexity after stimulation. Something obvious, yet surprisingly hard to quantify.

“Helsinki hasn’t registered a single traffic-related fatality in the past year…Citing data that shows the risk of pedestrian fatality is cut in half by reducing a car’s speed from 40 to 30km/hr, city officials imposed the lower limit in most of Helsinki’s residential areas and city center in 2021.”

This spoof is fantastic, not least for the aging choices they’ve made for the tech broligarchs. youtu.be/zdkBUuWCZg4?...

This is such a great and timely survey on author's perception of peer review vs AI scientific review. A collaboration between @reviewcommons.org and @qedscience.bsky.social. The geek in me would have liked to see the distributions in the response scores ;). link.springer.com/article/10.1...

AMICI v1.0.0 is here. Big milestone release: 🧹 MATLAB interface officially retired ⚡ Brand-new JAX/diffrax interface 🧬 First support for PEtab v2 major step toward a cleaner, more future-proof ecosystem. github.com/AMICI-dev/AM...

Our internal organs are evolutionary marvels. New technologies are transforming our understanding of the evolution of vertebrate organs. You can find more by reading here: rdcu.be/e5EgU #EvoBio #EvoDevo 🐟🦎🐢🦇🐊🦜