Looking to start your lab in generative biology / AI? Come join us at the @sangerinstitute.bsky.social Sanger is core-funded so you can generate data at scale to train the next generation of models and understanding. Design/Engineering/Chemistry/Proteins/Pathways! pls RT tinyurl.com/GenGenFaculty

Announcing the Ascona Workshop "Statistical and AI methods for multi-modal multi-scale modeling of biological systems" on 28 June - 3 July 2026 in Ascona, CH www.huber.embl.de/group/events... Reserve the dates!

Enjoyed reading “AI for chemistry in 2025 is like AI for images in 2010” leashbio.substack.com/p/ai-for-che...

We can know more than we can tell, but now Al can capture it. Our multimodal agent analyzes lab videos to generate protocols & catch common lab errors. Preserving tacit knowledge in proteomics. Now in @molsystbiol.org @patiskowronek.bsky.social #Google link.springer.com/10.1038/s443...

Funny how LLM companies are spending millions to discover what students learn in the first year of business school. At least the employees are having lolz.

🎄 We’re hiring in Health AI at @HelmholtzMunich! 🔹 PIs in Health AI/AI Foundations 🔹 Health AI Fellows 🔹 Clinical AI Consultants Apply👇 PIs: jobs.helmholtz-muenchen.de/jobposting/8... Fellows: jobs.helmholtz-muenchen.de/jobposting/7... Consult: jobs.helmholtz-muenchen.de/jobposting/c...

🚨New preprint(1/2)! We show that RTK fusion oncoproteins broadly suppress EGFR signaling. How? Sequestration of adapters as the shared principle. Led by superb PhD student Carol Gao. www.biorxiv.org/content/10.1... Implications for drug tolerance/resistance, and includes one big surprise🫧.👇

🚨Preprint 2/2: Several studies implicate condensates in RTK fusion onco-signaling. So we were surprised to find that condensates are entirely dispensable😮(!). A study from proteins to mice, by dynamic duo @davidgonzmar.bsky.social and @trmumford.bsky.social. www.biorxiv.org/content/10.6... 👇

Here's another exciting doctoral project led by Research Group Leader Beatrice Ramm at the Friedrich Miescher Laboratory. Check the list of other available projects on our website: lnkd.in/gEMXNQY6 The application portal is open so apply now! #PhD #IMPRS #graduateprogram #maxplanck

Very excited to announce that MSc computational cancer is now open for applications! A new joint programme from UCL engineering & cancer institute. Teaching #cancer through a computational lens, integrating cutting edge research with taught components. Apply below! www.ucl.ac.uk/prospective-...

Great to see this published: Fitting dynamical landscape models to single-cell data, creating interpretable maps of cell decision making & developmental logic Applied to neural tube patterning, we show how morphogen signals reshape landscapes and drive fate decisions www.pnas.org/doi/10.1073/...

Anthony A. Hyman will become EMBL’s next Director General. He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999. www.embl.org/news/people-...

🧬 Kinase Inhibitors can do more than block their targets! A study by @cemm.oeaw.ac.at[email protected] and #IRBBarcelona reveals that many inhibitors also trigger the degradation of the kinases, uncovering an overlooked mechanism with therapeutic potential. Out in @nature.com ➡️ bit.ly/43SD9xj

Great post. “mentoring should be criteria for hiring tenure-track faculty! But alas, it rarely is.” Also how to measure? Everyone can write about how to be a good mentor on an application form but how can you assess if they actually are?

[so AI may be bad but probably no worse than your average pundit and definitely not as bad as WSJ 😆] 3/n

I tried the updated Gemini image generator on scientific related image prompts that have failed in the past and I am really impressed by the quality of the outputs. The first is drawing a diagram for a pocket prediction algorithm using Voronoi diagram, Delaunay triangulation and alpha shapes

I think almost all scientific projects should be planned carefully. And I think an app can dramatically improve that. So I wrote an app for that (free for now, if you can fund this let me know). I tested it quite a bit (>8000 users in beta so far). try it: planyourscience.com

This is wild - an open challenge on 'virtual cell' perturbation prediction falls on its face due to flawed metrics: gmdbioinformatics.substack.com/p/arc-virtua... Benchmarking is important. It's also difficult. It's not just an engineering challenge. Figuring out what "good performance"... ⬇️

Chemical proteomics decrypts the kinases that shape the dynamic human phosphoproteome https://www.biorxiv.org/content/10.1101/2025.11.18.689017v1

Ten days left to apply to be a @crick.ac.uk Early Career Group Leader Closing date 27th November www.crick.ac.uk/careers-stud...

New essay out today by me and @acjsissons.bsky.social - ‘Getting Britain out of the hole: a plan for the economy’. You can read the whole thing here getting-out-of-the-hole.uk A chart mega-thread follows 🧵

To the consumers of LLM tools and of their outputs: Is it really that hard to see that ideation/conception and implementation are distinct skills in writing (of text and code), and that while LLMs are strong at implementation, they continue to fall short on ideation?

Enthusiastic about connectomics and X-rays? Several positions in our group at Crick for postdocs and senior scientists (permanent!). DM me if interested – and let’s talk if you are at Sfn next days or at the NIH BRAIN CONNECTS meeting today! Please share!

Switzerland is joining Horizon Europe! We are uniting two research powerhouses. For cutting-edge innovation that will boost our energy security, digital transformation, health and so much more. Today is a good day for science, and for our EU-Switzerland partnership.

Haha, this from the New Yorker is getting passed around the math dork community. I did a comic about this kind of thought a few years ago: www.smbc-comics.com/comic/commut...

Excited to launch an openRxiv partnership with the scientist-run AI review service qed (@qedscience.bsky.social), the brainchild of @odedrechavi.bsky.social 1/n openrxiv.org/enabling-rev...

Crick group leaders work across disciplines, supported by core funding and mentoring to build ambitious, curiosity-driven research. Apply now to join us ➡️ www.crick.ac.uk/careers-stud...

Our latest: *Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding* For a summary & the digested highlights see thread🧵 from @giulia-boezio.bsky.social www.biorxiv.org/content/10.1...

Skeetorial on our BRAF preprint! tinyurl.com/asymmBRAF The RAS->RAF->MEK->ERK cascade carries mutations in most human cancers. Interestingly, although we have three RAF paralogues (A, B and C), it is the BRAF that is predominantly mutated in cancer patients. (1/10)

We just posted an impact story on policies at HHMI, Gates & Astera promoting #OpenAccess #OpenScience #OpenData. Powerful signals to other funders to accelerate discovery in science. Well done @madubs.bsky.social @openaccessmaven.bsky.social @pracheeac.bsky.social! sparcopen.org/impact-story...

We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions. Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research. Apply now ➡️ www.crick.ac.uk/careers-stud...

Opening my lab @crick.ac.uk two years ago has been a privilege, a delight and ultimately the most transformative experience of my sciencific career. Discovery science without boundaries, inspiring colleagues and infinite possibilities. Come join us!

Motivated graduates with backgrounds in biological or biomedical sciences, physics, chemistry, mathematics, engineering and/or computer science are invited to apply to our 4-year fully funded PhD programme. Apply by 05 November 2025 www.crick.ac.uk/careers-and-...

Omg nature is so weird and amazing

🚀 New talk! "Automated ML-guided lead optimization: surpassing human-level performance at protein engineering" ▶️ www.youtube.com/watch?v=mEhB... ✨🧪 This was a talk I gave at the recent AIxBIO conference in Cambridge UK. A 10-minute pitch for what we do at Cradle!

🌊 Signals intertwine, 🔬 cells tell hidden stories, 🤖✨ SciML maps their future. Come do a PhD with us www.crick.ac.uk/careers-stud...

Applications are now open for the @cruk-cityoflondon.bsky.social Black Leaders in Cancer PhD Programme. If you are interested in our project ‘Reprogramming Plasticity in Colorectal Cancer’ feel free to get in touch! www.colcc.ac.uk/2026-blic-ph...

First work on kinases from my lab! Working on this project, I often remembered the late Cyrus Chothia who said that if the data doesn’t fit a beautiful model, maybe it’s not the model, maybe you just need more data. :)

🚨New Preprint🚨 How do morphogens integrate dynamically with other modes of signalling+what can this do for pattern precision and robustness? We used the Drosophila visual system as our muse to dive into this question with the amazing Vil Fernandes @ucl.ac.uk 🧠🪰 👇 www.biorxiv.org/content/10.1...

Our article on human multidomain protein biogenesis is now published in @natsmb.nature.com www.nature.com/articles/s41...

The Garnett Lab is excited to launch DepMap Miner, a new tool to explore cancer dependency data! Built on the Sanger DepMap, the DepMap Miner brings together multi-omic and functional datasets for over 1300 cancer cell models. Start mining data now: dataminer.depmap.sanger.ac.uk

Fresh from the press💥 We asked what happens when you evolve gene regulatory networks computationally at scale. Do general principles of GRN evolution jump out? Is the process predictable? Read on to find out @prxlife.bsky.social @crick.ac.uk @ucl-ipls.bsky.social 👉 journals.aps.org/prxlife/abst...

@mariasecrier.bsky.social & I are looking for an enthusiastic & excellent data scientist for a 4-year postdoc to understand cell cycle dysregulation in cancer. Deadline 15th October. Get in touch if you have any questions. Please repost! More details: www.imperial.ac.uk/jobs/search-...

🥁 Check out our new preprint on OmniPath, the prior knowledge resource for #SystemsBiology, and its brand-new OmniPath Explorer web app! 🥳 📖 Preprint: www.biorxiv.org/content/10.1... 🔍 Explorer: explore.omnipathdb.org OmniPath integrates 160+ resources for multi-omics analysis & modeling. 🧶⬇️

💥 We are *also* organizing Machine Learning for Structural Biology @ EurIPS, Copenhagen!! Topics include anything in the ML+bio intersection. Submit your ML+bio short papers! Authors can even present in both locations if they have people in both locations 🚀

Studying cancer evolution needs multi-region or single cell seq for phylogenetics, right? Amazingly (I think!) we found single-sample bulk methylation suffices, via analysis of "fluctuating methylation". In @nature.com today led by brilliant @calumgabbutt.bsky.social www.nature.com/articles/s41...

The advert for the first of these positions (computational/mathematical synbio) is live! www.ucl.ac.uk/work-at-ucl/...

Edith Heard our new CEO shares ten lessons from her life in science, from curiosity, courage and coffee to the secrets of our genetic code. www.crick.ac.uk/news/2025-09...

1/7 Really happy to see my PhD work published in ✨Developmental Cell✨ today! We find human endoderm is specified by two developmental trajectories 🔀, and the choice between alternate routes is dictated by the combinatorial BMP4/Activin signalling. www.cell.com/developmenta...

Congratulations to @gregfindlay.bsky.social on being awarded a €1.5 million Starting Grant from the @erc.europa.eu to take a closer look at possible disease variants hiding in the dark genome. www.crick.ac.uk/news/2025-09...