A benchmark of 100 tasks in computational biology to evaluate agentic systems. The example questions seem narrow in scope but they don't include any bioinformatics skill definitions. Top models already solve 80% of these.

Scientists invented a fake disease. AI told people it was real www.nature.com/articles/d41... first author Lazljiv Izgubljenovic 👏🏽💀

Our heavily updated final version of ROCKET for experiment-guided structure modeling is out in @naturemethods! New frontiers like high-throughput fragment screening and mid-res tomography are forcing a rethink of how experiments are modeled. ROCKET+OpenFold proposes a solution👇

📢📢 join us for this edition of the “Quantitative biology to molecular mechanisms” EMBO workshop Gene regulation, cell dynamics & systems biology 17th - 20th November More info: s.embl.org/omx26-01-bl

Head of @crick.ac.uk worries about ‘shift from funding basic research’ Edith Heard tells @francesjones.bsky.social scientists have “duty to speak up” as discovery research comes under pressure www.researchprofessionalnews.com/rr-news-uk-c...

Professor Trey Ideker has been appointed as the new Director of the Big Data Institute. He has been recognised internationally for his contributions to biology, artificial intelligence, and cancer research. Learn more ➡https://buff.ly/YO3dCyx @medsci.ox.ac.uk

The Crick magazine spring edition is here, with our latest discoveries and science stories. Read about John Diffley’s mission to crack DNA replication and how a giraffe is helping scientists understand placenta evolution ➡️ www.crick.ac.uk/news-and-fea...

Honoured and overwhelmed to receive the 2026 Waddington Medal. Science is a team effort, and I've been fortunate to work alongside exceptional people asking hard questions. Thank you to the BSDB and to everyone who has been part of the journey. bsdb.org/2026/03/24/2...

Scientific publishing: Rethinking how research is reviewed and published Review of how the loss of impact factor affected submissions at eLife - uneven drop across countries, but generally holding up remarkably well and shows a new model is possible elifesciences.org/articles/110...

Blog post: transitioning to being a PI in the age of AI open.substack.com/pub/arjunraj...

Big congratulations to Sebastian from the lab and all other awardees, after barely not making the cut for MSCA the stars aligned this time.

This is brilliant. "Every minute, a new clock is displayed that has been generated by 12 different AI models." Some fare better than others! clocks.brianmoore.com

Great meeting with speakers in genomics, functional proteomics, quantitative imaging, microscopy, and theory. Plenty of talks selected from abstracts!

I am delighted to share that registration for the next @embo.org EMBO Cell cycle meeting is now open! meetings.embo.org/event/26-cel... . We have an outstanding lineup of speakers and several selected talks from submitted abstracts. Look forward to welcoming you in Portugal from 5–7 October 2026!

If you're analysing Cut&Run or Cut&Tag data here's a nf-core NextFlow pipeline to simplify and standardise data processing joss.theoj.org/papers/10.21...

New OpenFold3 preview out! (OF3p2) It closes the gap to AlphaFold3 for most modalities. Most critically, we're releasing everything, including training sets & configs, making OF3p2 the only current AF3-based model that is functionally trainable & reproducible from scratch🧵1/9

We’re recruiting new Research Group Leaders! Why join? 🌍Work across EMBL’s 6 sites 🎓Participate in @embl.org courses and seminars 🔬Lead discovery-driven research in a collaborative environment Apply by 11 April: embl.wd103.myworkdayjobs.com/en-US/EMBL/j... #ResearchCareers @epetsalaki.bsky.social

🚀 New in Communications Biology: Generative models of cell dynamics - from Neural ODEs to Flow Matching www.nature.com/articles/s42... We discuss modeling single-cell dynamics beyond snapshots: from cont-time Neural ODEs to simulation-free flow matching for scalable pop modeling.

Attending AI and Biology @ EMBL Heidelberg until Friday. If you’re around, feel free to come say hello and have a chat

New Perspective form Rory Maizels & me: "Gene regulatory networks: from correlative models to causal explanations" Gene regulatory networks are supposed to give us mechanistic explanations of development, so why are we drowning in 'hairballs' of statistical correlations? rdcu.be/e7zx7

No disciplinarity without interdisciplinarity!

In early-2025 I was reeling from a ‘scored fundable’ grant application that was not funded. I really believed in this grant and knew the ideas were good but the review panel just weren’t into the project and there nothing more I could do. That’s science, but it hurts. (1/8)

Congratulations to Prof Bart Vanhaesebroeck, Prof @christophertape.bsky.social & Team REWIRE-CAN on securing $25m in @cancergrand.bsky.social funding to take on the challenge of rewiring cancer cells. #CancerGrandChallenges @uclmedsci.bsky.social www.ucl.ac.uk/news/2026/ma...

Interested in joining a dynamic, interdisciplinary research department? A call is open for Group Leaders at the UCL Laboratory for Molecular Cell Biology. Please submit your expression of interest by April 13, 2026. Further details here: www.ucl.ac.uk/work-at-ucl/...

New from @dev-journal.bsky.social: we're launching a new initiative and hiring Preprint Editors to help navigate the growing world of preprints in developmental & stem cell biology Join our community & shape the future of research journals.biologists.com/dev/article/...

One of the main stories of my postdoc is finally out! It builds on an intuition from my early days in omics data analysis: our signaling pathways are simply too small, underrepresenting cellular complexity after stimulation. Something obvious, yet surprisingly hard to quantify.

“Helsinki hasn’t registered a single traffic-related fatality in the past year…Citing data that shows the risk of pedestrian fatality is cut in half by reducing a car’s speed from 40 to 30km/hr, city officials imposed the lower limit in most of Helsinki’s residential areas and city center in 2021.”

This spoof is fantastic, not least for the aging choices they’ve made for the tech broligarchs. youtu.be/zdkBUuWCZg4?...

This is such a great and timely survey on author's perception of peer review vs AI scientific review. A collaboration between @reviewcommons.org and @qedscience.bsky.social. The geek in me would have liked to see the distributions in the response scores ;). link.springer.com/article/10.1...

AMICI v1.0.0 is here. Big milestone release: 🧹 MATLAB interface officially retired ⚡ Brand-new JAX/diffrax interface 🧬 First support for PEtab v2 major step toward a cleaner, more future-proof ecosystem. github.com/AMICI-dev/AM...

Our internal organs are evolutionary marvels. New technologies are transforming our understanding of the evolution of vertebrate organs. You can find more by reading here: rdcu.be/e5EgU #EvoBio #EvoDevo 🐟🦎🐢🦇🐊🦜

Some thoughts on AI and math, inspired by “First Proof”: www.daniellitt.com/blog/2026/2/...

Rewiring of oncogenic signaling in #DrugResistance is a moving target. In our new study, we used biophysical phosphoproteomics to investigate #BRAF mutant cancer, linking phosphorylation changes to protein function and #MolecularMechanisms through #Multi-Omics integration. tinyurl.com/funsignaling

Hey journals, if you want reviewers, reconsider the “no AI under any circumstances” policy. I’m happy not to paste unpublished work into the algorithmic equivalent of a public restroom wall, but broad technoskeptic edicts about how I manage my time are unlikely to inspire more volunteering.

Not all those who wander are lost.

AlphaGenome is out in @nature.com today along with model weights! 🧬 📄 Paper: www.nature.com/articles/s41... 💻 Weights: github.com/google-deepm... Getting here wasn’t a straight path. We discussed the story behind the model, paper & API in the following roundtable: youtu.be/V8lhUqKqzUc

“Everything we know about skin has been learned from so-called scientific studies funded by large corporations who have a financial stake in keeping our musculature covered in an unnecessary layer of man-made flesh,” said Health and Human Services Secretary Robert F. Kennedy Jr.

New paper alert!🤩Super proud that our story led by superstar postdocs @liujinghui.bsky.social and @nerlielisa.bsky.social is finally out! We found how electrical signals are key for promoting organ regenerative growth!!! A thread 🧵https://www.science.org/doi/10.1126/sciadv.aec0687

Our new paper: Entropy Sorting Feature Selection (ESFS) A computational framework for gene selection from single cell data that extracts biological signals in noisy data while avoiding artefacts from conventional dimensionality reduction A thread www.biorxiv.org/content/10.6...

Meet Leonie Johanna Lorenz 🇩🇪, a Predoctoral Fellow at EMBL-EBI who is bringing mathematical modelling to microbes. Find out more about how Leonie’s passion for modelling patterns extends from bacterial evolution to sewing 🧵 www.ebi.ac.uk/about/news/p...

We Are hiring!! 👨‍💻👩‍💻 CALM's new Data and Systems Steward Role is live 🎉https://crick.wd3.myworkdayjobs.com/External/job/London/Data-and-Systems-Steward_R2551 closing date 8th Feb!

One of the less advertised advantages of using LLMs for writing is that, when OneDrive decides your past few days of work were a mistake, the text still exists somewhere.

We are recruiting a Postdoc in computational biology, together with @mariasecrier.bsky.social 4yr, fully funded by @cancerresearchuk.org, ideal for Postdocs wanting to develop their independence Applications open now: www.imperial.ac.uk/jobs/search-...

Apply for the Ascona workshop "Statistical and AI methods for multi-modal multi-scale modeling of biological systems", 28 Jun-3 Jul 2026 on Monte Verità, Lago Maggiore at the foot of the Swiss Alps. ascona2026.sciencesconf.org

🚀 New preprint! Meet ORIGAMI: Mapping cancer cell state heterogeneity and plasticity, predicting and steering therapy-induced trajectories to rationalize genotype-agnostic combination strategies with only two physical metrics (cell surface area and volume) www.researchsquare.com/article/rs-8...

Looking to start your lab in generative biology / AI? Come join us at the @sangerinstitute.bsky.social Sanger is core-funded so you can generate data at scale to train the next generation of models and understanding. Design/Engineering/Chemistry/Proteins/Pathways! pls RT tinyurl.com/GenGenFaculty

Announcing the Ascona Workshop "Statistical and AI methods for multi-modal multi-scale modeling of biological systems" on 28 June - 3 July 2026 in Ascona, CH www.huber.embl.de/group/events... Reserve the dates!

Enjoyed reading “AI for chemistry in 2025 is like AI for images in 2010” leashbio.substack.com/p/ai-for-che...