Octopuses are fascinating animals with arms that can act almost independently of the brain. Ekaterina Gribkova & co explore a novel method for octopus ‘hypnosis’, which provides opportunities for advancing octopus neurobehavioral research. 🐙 doi.org/10.1242/bio.... #Octopus #Anesthesia

Andrew Boyce & co show that elevated extracellular ATP drives a macropinocytosis- and pannexin 1-mediated increase in neuroblastoma cell size. doi.org/10.1242/bio.... #Pannexin #PANX1 #Macropinocytosis #ATP

Fiona Mensching & co show the first functional data showing that Smc3 contributes to hair cell activities. doi.org/10.1242/bio.... #Smc3 #Hair cells #Zebrafish #Otoliths

Andrew Fraser & co from @jhu.edu reveal that #microtubules are essential for the collective migration of luminal cells and for mammary branching morphogenesis. doi.org/10.1242/bio.... #BranchingMorphogenesis #MammaryEpithelium

Throughout the year, our community has been sharing stories with us about how The Company of Biologists has supported you over time. Your stories were heartfelt, and we feel grateful and humbled that we have been able to be part of your journeys. bit.ly/4q7C0Ki

Microtubules are essential cellular structures & their malformation is often correlated with neurological diseases. Marinus Thein & co explore how different sets of modifications on the essential microtubule proteins correlate with and regulate each other. doi.org/10.1242/bio....

We are pleased to be a media partner for this upcoming symposium. Don't miss the deadline to register.

Craig Ashley Boys & co evaluate the effectiveness of modern fish screens in protecting drifting larvae under controlled hydraulic conditions 🐟 . doi.org/10.1242/bio.... #FishScreens #LarvalEntrainment

Paulina Swatowska & co identify compound inheritance of metabolic and immune gene variants that synergistically disrupt facial development, expanding our understanding of cleft lip genetics. doi.org/10.1242/bio.... #Zebrafish #CleftLip

Gülce Güralp & co investigate the wheat rhizosphere microbiome in Turkish soils and compare the results with other countries. doi.org/10.1242/bio.... #SoilMicrobiome #Rhizosphere

Taisuke Sato, Diana Bianchi and colleagues show alterations in RNA expression, protein expression and redox homeostasis in the placentas of four mouse models of Down syndrome 🐭 . doi.org/10.1242/bio.... #Trisomy21 #DownSyndrome #MouseModels #Transcriptomics

Myocyte fusion is essential for muscle development, and fusion defects cause myopathies in humans. Sunandan Dhar & co describe dynamic expression and function of the myocyte #fusogen, Myomixer, during #zebrafish #myogenesis. doi.org/10.1242/bio....

Muheng Liao & co show that a DNA methylation signature outperformed traditional clinical markers in predicting prostate #cancer progression, offering improved risk assessment for treatment decisions in intermediate-risk patients. doi.org/10.1242/bio.... #ProstateCancer #DNAmethylation

Brian Blais & co describe body temperature measurements of threatened narrow-headed gartersnakes in enclosures that mimic their natural habitat, providing insights to improve their conservation management and monitoring. doi.org/10.1242/bio....

With non-seed plant research gaining momentum and a vibrant community emerging, Karima El Mahboubi and Facundo Romani highlight the growing impact of diverse model systems on key questions in plant evolution. doi.org/10.1242/bio.... #MeetingReview #NonSeedPlants #EvoDevo

In this Editorial, we take the opportunity to look back on the activities and content BiO has published in 2025 to celebrate both our publishing and charitable efforts. doi.org/10.1242/bio....

Emily Fackler & co show that spring migratory timing in great reed warblers has a larger genetic contribution than autumn migratory timing, with genes associated with lipid hydrolysis and epigenetic processes playing a key role. doi.org/10.1242/bio....

@kpakari.bsky.social & co recapitulate the activity levels of hypomorphic mutations associated with human PMM2-congenital disorders of glycosylation in medaka. 🐟 doi.org/10.1242/bio.... #Degron #EndogenousGFPtagging #CRISPR

Emily Cordova Hurtado & co study generate and initially characterise a knockout mouse for a region of noncoding, regulatory DNA that was previously implicated in autism 🐭🧬. doi.org/10.1242/bio....

Carolyn Wheeler, Jodie Rummer @physiologyfish.bsky.social & co investigate the metabolic cost of egg production in tropical epaulette sharks. doi.org/10.1242/bio....

Issue 12 is complete! Cover: Members of BiO's community, including a founding Editor, past & present Editors-in-Chief, our academic Editors and some of the reviewers from BiO's Fast & Fair peer review initiative. We would like to thank them all. bit.ly/4piig6y

Bai-Lu Chen & co show that wolf spider mothers flexibly open egg sacs in response to embryonic cues and modulate escape speed under acute risks, illustrating a context-dependent trade-off during parental care. doi.org/10.1242/bio....

Radka Symonová & co provide a rare and robust evaluation of interactions among the environment, development and gene-expression timing in the brain of the pikeperch 🐟 , a key fish species in Europe. doi.org/10.1242/bio....

Sydney Roman, Gary Wessel & co test the role of the extracellular matrix in development & germ cell formation, revealing that germ cells fated by inheritance still read the collagenous ECM during fate determination & have plastic transcriptional responses. doi.org/10.1242/bio....

To accelerate the publication process, @biologyopen.bsky.social are testing an initiative that prioritises fast but fair peer review. This approach pays reviewers while requiring them to complete high-quality reviews in a set timeframe. Apply to be a reviewer www.biologists.com/bio-fast-and...

Transposon silencing is essential for germline development. Sophie Liddell et al. report the results of a genetic screen aimed at identifying genes required for gurken mRNA localization in the developing #Drosophila oocyte & uncover novel phenotypes of piRNA pathway mutants. doi.org/10.1242/bio....

Elizabeth Lawrence, @hammofish.bsky.social & co use #zebrafish to investigate the consequences of knocking out the long and short isoforms of TANGO1, a protein crucial for the export of large cargo from the endoplasmic reticulum (ER). doi.org/10.1242/bio....

Maryam Hekmatara & co identify the Golgi as a key regulatory node in maintaining photoreceptor polarity. doi.org/10.1242/bio....

Gillian Forbes & Pauline Schaap uncover developmentally important transcription factors by deleting candidate genes identified from phylogeny wide cell-type- and stage-specific RNA sequencing. doi.org/10.1242/bio.... #SocialAmoebas

Simon Loughran, @fmanfredini.bsky.social & co explore how natural deformed wing virus infections and cognitive ability shape brain gene expression in honey bee foragers. doi.org/10.1242/bio.... #Transcriptomics #HoneyBees

Takahiro Fujimoto & co investigate the consequences of overexpressing GFP fused to a nuclear export signal (NES-GFP) in fission yeast. doi.org/10.1242/bio....

Next, we are highlighting Renata Basto, a @jcellsci.bsky.social Editor who has published in @dev-journal.bsky.social, @jcellsci.bsky.social and @biologyopen.bsky.social, as an extraordinary biologist this week. #100biologists

#WntA is a crucial marker of stripe elements early in development for the Nymphalidae butterfly family. @jasminealqassar.bsky.social & co explore if WntA has maintained its role in stripe elements over 95 million years of evolution in the Hesperiidae family of butterflies. doi.org/10.1242/bio....

We are also featuring developmental biologist K. Vijayraghavan, a @dev-journal.bsky.social Advisory Board member and a Development and @biologyopen.bsky.social author, as an extraordinary biologist this week. #100biologists @kvijayraghavan.bsky.social

Issue 11 is now closed! Explore the issue here: bit.ly/48EfHqc On the cover: a female wolf spider brooding an egg sac, navigating on a water lily leaf as she ventures across a pool of water.

Julio Fierro Morales & co delve deeper into the biology of amoebal cell-substrate adhesions by asking how different cell-substrate adhesion compositions impact their lifetime and the stability of their components. doi.org/10.1242/bio....

As we reflect on the past 100 years, one thing becomes clear: the impact we have had on the communities we serve is only possible because of our inspiring and motivated staff. Read more about the people behind the Company here: bit.ly/44nyx2r

Looking forward to Friday's Non-seed plant meeting in Norwich. Together with @karimaelm.bsky.social, we wrote a Review about the last year meeting. We discuss about the latest advances and the importance of using in models. Thanks @biologists.bsky.social and @biologyopen.bsky.social. #PlantScience

Annabel Minard & co describe improved techniques to express genes robustly and engineer specific genotypes, such as heterozygous mutations, for more accurate modelling of genes involved in human health. doi.org/10.1242/bio....

Attending #CellBio2025? Have questions about publishing with Biology Open @biologyopen.bsky.social or our Fast & Fair peer review initiative? Meet Editor-in-Chief @danielgorelick.bsky.social on Tuesday, 9 December, 12:00 -13:00 pm at booth 1232.

Congratulations to Julia Enterria Rosales for winning first prize for the best talk at the 1st Advances in Extracellular Vesicle & Biomimetic Science Conference, hosted at @bcmhouston.bsky.social. We are delighted to have sponsored this award.

Our Editor-in-Chief Dan Gorelick will be attending #CellBio2025 @ascbiology.bsky.social @embo.org. Come and visit Dan @danielgorelick.bsky.social to discuss Biology Open, our Fast & Fair peer review initiative and other @biologists.bsky.social initiatives.

As part of our 100-year celebrations this year, we would like to hear stories from you about how @biologists.bsky.socialhas impacted your careers. bit.ly/3PL5CO6

Avik Banerjee & @MacrophysLab examine whether lizards cope with physiological stress by retaining more nutrients. doi.org/10.1242/bio.... #Carbon #Nitrogen #Nutrients #Reptile #Corticosterone

Sara Jiménez, @pancint.bsky.social, @molinalab.bsky.social & co use single-cell sequencing approaches to define the developmental differentiation of enteroendocrine cells, which has not yet been done in mice or humans. doi.org/10.1242/bio.... #StemCell #CellFate #Organoid

Kevin Adi Kurnia & co present a comparative analysis of #zebrafish fear responses to eight different fish species using 3D locomotion tracking assays. doi.org/10.1242/bio....

Moore, @birdbiomech.bsky.social & co discover that desert kangaroo rats don't all behave the same way when placed in the same outdoor enclosure. Some of these differences seemed linked to things like whether the animal was male or female, how big it was and moonlight. doi.org/10.1242/bio....

@biologyopen.bsky.social is compensating peer reviewers as part of the Fast & Fair peer review initiative. BiO’s Managing Editor Alejandra Clark recently joined reporter Geoff Marsh in a podcast that reviews the concept of paying peer reviewers more closely qspace.fqxi.org/podcasts/125....

Plant chemicals can impact the nervous system and behaviour of pollinators. Wade Pike & co find few effects of dietary plant chemicals on honey bee forager aggression and microbiome composition. doi.org/10.1242/bio....

Nimmy John and co find that #notch activation remains largely unchanged across temperatures, suggesting the presence of temperature-compensatory mechanisms that maintain robust Notch activation. doi.org/10.1242/bio....