Voice deficits are common in Parkinson's disease & significantly impact quality of life. Now, Brooke Rodgers & Allison Schaser show that overexpression of alpha-synuclein alone does not result in significant vocalisation deficits. doi.org/10.1242/bio.... #Parkinsonism #AlphaSynuclein

Hymenopteran insects such as #honeybees show great potential as biosensors. Lorenzo Corsico & co assess this potential in detecting potato virus Y, exploring a cost-effective approach for monitoring plant health. doi.org/10.1242/bio....

Neha Jadhav Giridhar, Bita Hambrecht and colleagues build a miniature 3D ‘nerve–muscle’ system in the lab that closely reflects the structure and function of human connections between nerves and muscles – something no other animal model can fully replicate. doi.org/10.1242/bio....

Summer Paulson & co show that physical confinement enhances phagocytosis, and that phagocytosis induces persistent cell migration, or ‘phagocytic priming’. This response could be relevant for innate immune surveillance. doi.org/10.1242/bio.... #Microglia #ConfinedMotility

Aurélia Joly, @micro-megs.bsky.social & co show that stem cell-intrinsic NF-κB activity is crucial for preventing apoptosis and ensuring proper intestinal epithelial repair following injury in #Drosophila. 🪰 doi.org/10.1242/bio.... #StemCells #Intestine

Francis Letendre & co describe a strong positive correlation between dinoflagellate cell surface area & mechanically stimulated bioluminescence peak intensity, opening new methods for monitoring harmful algal blooms and dinoflagellate populations. doi.org/10.1242/bio.... #HABs #Bioluminescence

Thank you Adam Downie @adamdownunder.bsky.social for sharing your experience of fee-free #OA publishing in @biologyopen.bsky.social via our #ReadAndPublish agreement with The University of Queensland. Read Adam’s paper: bit.ly/4hA9vm1 See if your institution is participating too: bit.ly/3O7BxGi

Jimena Fernández & co reveal that pregnant Liolaemus pictus can physiologically compensate for experimentally induced thermal restrictions, maintaining offspring performance and highlighting the species’ potential resilience to warming. doi.org/10.1242/bio....

Allison Malay & co explore how landscape, immunity and hive management shape honey bee viral infections, offering new insights into pollinator health. 🐝 doi.org/10.1242/bio....

Chutima Chan & co reveal how a mitochondrial enzyme can be redirected to peroxisomes by associating with a related enzyme, providing a novel route to regulate #metabolism. doi.org/10.1242/bio.... #MalateDehydrogenase

Inner ear development involves epithelial cells from opposite sides fusing. Tamilkumar & co find that the epithelial cells that fuse during chick otic vesicle closure are not completely rigid and adapt a reversible, fluid-like trait that facilitates fusion. doi.org/10.1242/bio.... #EpithelialFusion

With mRNA-based labelling and light sheet fluorescence imaging in Perfluorodecalin, Oksana Netschitailo and colleagues reveal the dynamics of extra-embryonic membrane formation in honeybee embryos. doi.org/10.1242/bio.... #LiveImaging #Insects #Morphogenesis

We are highlighting Jane Francis, Director of the British Antarctic Survey, UK, who also delivered a plenary lecture at the Biologists @ 100 conference, as an extraordinary biologist. #100biologists @bas.ac.uk

You can read Jane's recent @biologyopen.bsky.social interview here: doi.org/10.1242/bio....

Toiba Mushtaq & co reveal that tricellulin is a stable component of tricellular tight junctions, crucial for maintaining epithelial barrier function & integrity. In addition to protein–protein interactions, monolayer mechanics control the proper localisation of tricellulin. doi.org/10.1242/bio....

Saanjbati Adhikari speaks with authors, @apaterlini.bsky.social, @wimvanderpoel.bsky.social & co, about their first impressions, their experiences with the peer-review process, their favourite aspects of publishing with BiO & how publishing in BiO has impacted their careers. doi.org/10.1242/bio....

Issue 9 is closed! Explore Issue 9: bit.ly/4710ChG Cover: Otic vesicle undergoing epithelial fusion, stained for Cdh1 (red), Laminin (magenta), F-actin (green) and Nucleus (cyan).

Md Tangigul Haque & co show that natural heatwaves reduce mating frequency in Australian damselflies but do not affect flight activity or abundance, highlighting potential long-term consequences, including population decline and biodiversity loss. doi.org/10.1242/bio....

The transcriptional regulators SOX2 and NR2F1 drive the development of the visual thalamus. Mutations in these genes cause visual impairment in humans, and now Linda Serra & co conduct genetic and molecular analyses on the SOX2 and NR2F1-coregulated genes. doi.org/10.1242/bio....

As part of our commitment to Open Access, we support libraries, consortia and researchers. For #OAWeek, we share a recent webinar that includes tips and recommendations for navigating the editorial process and publishing #OA youtu.be/PjD5QQ-p0Xg #OAWeek25

Tropomyosins form long chains, which makes it challenging to add fluorescent tags. Will Scott, @sporemohan.bsky.social & co use a clever strategy: by adding a long, flexible linker, they can visualize various tropomyosins in live human cells with minimal disruption. doi.org/10.1242/bio....

Vinoth S & Kirankumar Santhakumar present a drug-resistant pro-angiogenic #zebrafish model to test potential anti-angiogenic drugs for anti-cancer therapeutics. 🐟 doi.org/10.1242/bio....

Satheeja Santhi Velayudhan & co describe dynamic tension-dependent localisation of Diversin, a protein that regulates planar cell polarity signalling & apical constriction during Xenopus neurulation. 🐸 doi.org/10.1242/bio....

This week has been special for us, marking 100 years of supporting biologists and inspiring biology. We celebrated our achievements at @zoologymuseum.bsky.social last night. We want to thank all our staff, whose continual inspiration and daily support for one another make our work possible.

The next extraordinary biologist that we are featuring is Martha Susana Cruz-Xelhuantzi, a @biologyopen.bsky.social author who examined the cellular organisation & characteristics of the yeast, Debaryomyces hansenii, and interviewee in @biologyopen.bsky.social's 'First person' series. #100biologists

Blood stem and progenitor cells give rise to all blood cell types. Tim Petzold & co show that when Connexin 41.8 is present but impaired, it delays their initial formation and disrupts the timely activation of a key signalling pathway in #zebrafish embryos. doi.org/10.1242/bio....

2012: The first issue of Biology Open @biologyopen.bsky.social was published with the primary objective of publishing “good-quality, sound research, without attempting to judge impact or novelty”. Read the story of Biology Open: a conversation with past and present Editors-in-Chief. bit.ly/4gW1PtT

Looking to get involved in peer review? Check out the Fast & Fair initiative run by Biology Open. journals.biologists.com/bio/pages/fa... #PeerReview #PaidWork #Journals #Academia #Research #Biology #BiologyOpen

Justin Wheelan & co show that ubiquitin-resistant ICER mutant suppresses melanoma progression and prolongs survival in brafV600E zebrafish, revealing its potential as a tumour suppressor and therapeutic target in melanoma resistance. doi.org/10.1242/bio....

Duttenhefner & co reveal that GSTP1 depletion disrupts redox balance in pancreatic cancer, leading to metabolic adaptations. They perform multiomics analysis, revealing key stress response pathways and potential targets for improved treatment strategies. doi.org/10.1242/bio....

Lily Kelleher & @manuramalho.bsky.social show that important bacteria associated with Aphaenogaster ants change in warmer temperatures, with a depletion of important bacteria that help with their growth, development and vitamin B synthesis. doi.org/10.1242/bio....

We are delighted to support the 4th FEBS-IUBMB-ENABLE Conference titled "Bridging Minds: Interdisciplinary Research for the Future of Life Sciences". Congratulations to Julia Isakova @juliaisakova.bsky.social for winning the Flash Talk prize.

Andreas Ruser & co measure the hearing sensitivity of 2 grey seals and find that hearing thresholds at low frequencies were lower than predicted by the standard audiogram currently used to assess the impact of anthropogenic sound on marine mammal hearing. doi.org/10.1242/bio....

Moss, @hammofish.bsky.social & co establish #zebrafish as a viable model for dissecting LMX1B-related pathologies like Nail-patella syndrome (NPS). Zebrafish lmx1ba & lmx1bb knockout lines exhibit paralogue-specific roles in the development of tissues affected in NPS. 🐟 doi.org/10.1242/bio....

Bats perform flights with continual altitude changes rather than flying at a constant altitude. Gottfried Sachs provides an explanation for this by showing that flights with continual altitude changes constitute a fuel-saving flight mode in bats. 🦇 doi.org/10.1242/bio....

@adamdownunder.bsky.social, @craigefranklin.bsky.social & co expose clownfish embryos to UV radiation (UVR) corresponding to water depths reflective of their settlement; mimicking what could happen in a future coral reef with fewer structures shielding against UVR. doi.org/10.1242/bio....

Thomas & co present an open-source 3D Slicer extension that reduces photogrammetry error by ∼ 15% on delicate rodent skulls, providing a convenient interface for generating 3D models of biological specimens from photographs. doi.org/10.1242/bio....

Stinson & co show that macrophages migrate persistently after they transition from 2D adhesion to an adhesive confined environment. Migration is enhanced further if cells sense a fibronectin gradient. doi.org/10.1242/bio....

Debadas Sahoo & Sibakalyani Acharya reveal metabolic depression & suppression of the non-specific immune response in hibernating male common Asian toads, characterised by elevated oxidative stress markers in liver tissue, indicating a tissue-specific immune response. doi.org/10.1242/bio....

Our next extraordinary biologist is Mark Peifer, recent @biologists.bsky.social Director and a prolific author, having published in @dev-journal.bsky.social, @jcellsci.bsky.social and @biologyopen.bsky.social. #100biologists @peiferlabunc.bsky.social

Adapting gait to varying speeds and inclines is essential for navigating complex environments. Shizuku Terui & co investigate how critical kinematic variables, which reflect how the body manages momentum transfer between steps, adapt to changes in speed and incline. doi.org/10.1242/bio....

We are highlighting Cathy Jackson, @biologyopen.bsky.social Deputy Editor and an Editorial Advisory Board member at @jcellsci.bsky.social, as an extraordinary biologist this week. #100biologists @ijmonod.bsky.social

#Drosophila larvae have a lymph gland with hematopoietic progenitors & subsequently differentiated hemocytes, similar to blood cells. Ghosh, Iyer et al. induce inflammation stress in different lymph gland cell subsets to examine how these progenitor cells respond to stress. doi.org/10.1242/bio....

The brain is the most metabolically active organ in the body and has a high demand for iron. Mariam Duhaini & co identify new molecular signals released by brain astrocytes under iron deficiency. These findings offer crucial insights into brain iron control. 🧠🐭 doi.org/10.1242/bio....

Our Fast & Fair peer review initiative aims to provide authors with a first decision post review within 7 working days. Read articles handled through our Fast & Fair peer review in our collection. bit.ly/4fiAxNE #fastandfairpeerreview

Ashley Gendreau, Roger Hanlon & co @mblscience.bsky.social show that despite having a highly decentralised nervous system, octopuses exhibit specialised & repeatable patterns of arm use, offering new insights into sensorimotor control in animals with nontraditional anatomies. doi.org/10.1242/bio....

Angela Fan, @yoldasyildiz.bsky.social & co show the importance of studying alcohol effects in more realistic systems that reflect the complexity of the living brain, showing that alcohol during adolescence can affect RNA regulation in very specific ways. 🧠https://doi.org/10.1242/bio.062010

Arnon Pudgerd and colleagues show that ecdysteroid stimulated bursicon expression and improved the immune response against bacterial challenges. doi.org/10.1242/bio....

To know about Daisy's experience of publishing with @biologyopen.bsky.social, read this Editorial: doi.org/10.1242/bio....

We are featuring Daisy Pineda-Suazo, who was interviewed for @biologyopen.bsky.social's ‘First Person’ series in 2024 after her first-author publication in the journal, as an extraordinary biologist. #100biologists #NPAW2025