Maryam Hekmatara & co identify the Golgi as a key regulatory node in maintaining photoreceptor polarity. doi.org/10.1242/bio....

Gillian Forbes & Pauline Schaap uncover developmentally important transcription factors by deleting candidate genes identified from phylogeny wide cell-type- and stage-specific RNA sequencing. doi.org/10.1242/bio.... #SocialAmoebas

Simon Loughran, @fmanfredini.bsky.social & co explore how natural deformed wing virus infections and cognitive ability shape brain gene expression in honey bee foragers. doi.org/10.1242/bio.... #Transcriptomics #HoneyBees

Takahiro Fujimoto & co investigate the consequences of overexpressing GFP fused to a nuclear export signal (NES-GFP) in fission yeast. doi.org/10.1242/bio....

Next, we are highlighting Renata Basto, a @jcellsci.bsky.social Editor who has published in @dev-journal.bsky.social, @jcellsci.bsky.social and @biologyopen.bsky.social, as an extraordinary biologist this week. #100biologists

#WntA is a crucial marker of stripe elements early in development for the Nymphalidae butterfly family. @jasminealqassar.bsky.social & co explore if WntA has maintained its role in stripe elements over 95 million years of evolution in the Hesperiidae family of butterflies. doi.org/10.1242/bio....

We are also featuring developmental biologist K. Vijayraghavan, a @dev-journal.bsky.social Advisory Board member and a Development and @biologyopen.bsky.social author, as an extraordinary biologist this week. #100biologists @kvijayraghavan.bsky.social

Issue 11 is now closed! Explore the issue here: bit.ly/48EfHqc On the cover: a female wolf spider brooding an egg sac, navigating on a water lily leaf as she ventures across a pool of water.

Julio Fierro Morales & co delve deeper into the biology of amoebal cell-substrate adhesions by asking how different cell-substrate adhesion compositions impact their lifetime and the stability of their components. doi.org/10.1242/bio....

As we reflect on the past 100 years, one thing becomes clear: the impact we have had on the communities we serve is only possible because of our inspiring and motivated staff. Read more about the people behind the Company here: bit.ly/44nyx2r

Looking forward to Friday's Non-seed plant meeting in Norwich. Together with @karimaelm.bsky.social, we wrote a Review about the last year meeting. We discuss about the latest advances and the importance of using in models. Thanks @biologists.bsky.social and @biologyopen.bsky.social. #PlantScience

Annabel Minard & co describe improved techniques to express genes robustly and engineer specific genotypes, such as heterozygous mutations, for more accurate modelling of genes involved in human health. doi.org/10.1242/bio....

Attending #CellBio2025? Have questions about publishing with Biology Open @biologyopen.bsky.social or our Fast & Fair peer review initiative? Meet Editor-in-Chief @danielgorelick.bsky.social on Tuesday, 9 December, 12:00 -13:00 pm at booth 1232.

Congratulations to Julia Enterria Rosales for winning first prize for the best talk at the 1st Advances in Extracellular Vesicle & Biomimetic Science Conference, hosted at @bcmhouston.bsky.social. We are delighted to have sponsored this award.

Our Editor-in-Chief Dan Gorelick will be attending #CellBio2025 @ascbiology.bsky.social @embo.org. Come and visit Dan @danielgorelick.bsky.social to discuss Biology Open, our Fast & Fair peer review initiative and other @biologists.bsky.social initiatives.

As part of our 100-year celebrations this year, we would like to hear stories from you about how @biologists.bsky.socialhas impacted your careers. bit.ly/3PL5CO6

Avik Banerjee & @MacrophysLab examine whether lizards cope with physiological stress by retaining more nutrients. doi.org/10.1242/bio.... #Carbon #Nitrogen #Nutrients #Reptile #Corticosterone

Sara Jiménez, @pancint.bsky.social, @molinalab.bsky.social & co use single-cell sequencing approaches to define the developmental differentiation of enteroendocrine cells, which has not yet been done in mice or humans. doi.org/10.1242/bio.... #StemCell #CellFate #Organoid

Kevin Adi Kurnia & co present a comparative analysis of #zebrafish fear responses to eight different fish species using 3D locomotion tracking assays. doi.org/10.1242/bio....

Moore, @birdbiomech.bsky.social & co discover that desert kangaroo rats don't all behave the same way when placed in the same outdoor enclosure. Some of these differences seemed linked to things like whether the animal was male or female, how big it was and moonlight. doi.org/10.1242/bio....

@biologyopen.bsky.social is compensating peer reviewers as part of the Fast & Fair peer review initiative. BiO’s Managing Editor Alejandra Clark recently joined reporter Geoff Marsh in a podcast that reviews the concept of paying peer reviewers more closely qspace.fqxi.org/podcasts/125....

Plant chemicals can impact the nervous system and behaviour of pollinators. Wade Pike & co find few effects of dietary plant chemicals on honey bee forager aggression and microbiome composition. doi.org/10.1242/bio....

Nimmy John and co find that #notch activation remains largely unchanged across temperatures, suggesting the presence of temperature-compensatory mechanisms that maintain robust Notch activation. doi.org/10.1242/bio....

Khatija Nishat and colleagues find that a tiny cellular structure called the primary cilium, which helps cells ‘talk’ to each other during development, depends on a protein called IFT139 to work properly, showing how defects in IFT139 can lead to ciliopathies.

It’s #PublicationIntegrityWeek, and we’d like to take this opportunity to thank all those who support us in our integrity work on the journals – helping to ensure the papers we publish can be trusted. 1/10

Nikita Jhaveri & co identify genetic & genomic hallmarks of the taxonomically restricted genes gon-14 and ivph-3 in #Caenorhabditis, highlighting changes that correlate when a new gene integrates into important biological processes. doi.org/10.1242/bio....

Little penguins undergo a catastrophic moult, replacing all feathers within a short timeframe while on land and not foraging. Wells & co examine the 2015 and 2016 moult seasons on Phillip Island, Australia, to explore factors influencing moult timing, duration and mass. doi.org/10.1242/bio....

We are pleased to be a media partner for @embo.org @embl.org Symposium - Collectivity in living systems: emergence, function, and evolution, 24 - 27 Feb 2026, EMBL Heidelberg & Virtual #EESCollectivity Abstract submission: 18 Nov 2025 Find out more bit.ly/3XzZzzy

#Fasting has become a widely adopted practice. Cesanelli & co show that prolonged fasting disrupts muscle force production & mechanical properties, indicating how energy demands influence the mechanical response of different muscles to metabolic stress. doi.org/10.1242/bio.... #MuscleMechanics

Samuele Sartori & co use a #zebrafish animal model to uncover the developmental roles of ADAMTS13, whose deficiency causes #congenitalthromboticthrombocytopenicpurpura, in vascular patterning and hematopoietic lineage balance. doi.org/10.1242/bio....

Katarzyna Hencel, @alperakay.bsky.social, @drsull.bsky.social & co demonstrate an accessible and affordable assay to measure #vitaminB12 in biological samples. doi.org/10.1242/bio....

Looking to publish your paper #OpenAccess? Check if your institution is signed up to our Read & Publish initiative and you can publish #OA for free: www.biologists.com/library-hub/...

Emily Barker & co generate and characterise mouse models of complete and partial HexA deficiency that are suitable for testing a broad range of therapies for Tay-Sachs disease. 🐭 doi.org/10.1242/bio.... #TaySachsDisease #MouseModel

Nazeefa Nashrah & co investigate how wild goldfish respond to rapid changes in temperatures by estimating their aerobic scope. They find that wild goldfish maintain a stable aerobic scope under short-term exposure to temperatures of 26 °C and 30°C. doi.org/10.1242/bio....

@sciencealyssa.bsky.social, @kourtidislab.bsky.social & co investigate the PIWI-piRNA pathway in #coloncancer using a nuanced bioinformatic and cell-based approach, linking the downregulation of PIWIL2 to disease progression, transposable element activation and DNA damage. doi.org/10.1242/bio....

Issue 10 is done and dusted! Explore here: bit.ly/4nP8CHQ. On the cover: An image of #zebrafish (prey) and a glass catfish (predator) interaction, from Kurnia et al., who use three-dimensional locomotion-tracking assays to observe fear responses in zebrafish.

David Klinke II & co provide evidence-based guidance for optimal preclinical model selection in #melanoma research. They show that two different melanoma mouse models exhibit distinct growth kinetics, immune infiltration patterns and therapeutic sensitivities. doi.org/10.1242/bio....

Irina Bacila & co from @sheffielduni.bsky.social define dysregulated molecular pathways induced by 21-hydroxylase deficiency in #zebrafish, highlighting its value as a model for adrenal disease. doi.org/10.1242/bio....

Voice deficits are common in Parkinson's disease & significantly impact quality of life. Now, Brooke Rodgers & Allison Schaser show that overexpression of alpha-synuclein alone does not result in significant vocalisation deficits. doi.org/10.1242/bio.... #Parkinsonism #AlphaSynuclein

Hymenopteran insects such as #honeybees show great potential as biosensors. Lorenzo Corsico & co assess this potential in detecting potato virus Y, exploring a cost-effective approach for monitoring plant health. doi.org/10.1242/bio....

Neha Jadhav Giridhar, Bita Hambrecht and colleagues build a miniature 3D ‘nerve–muscle’ system in the lab that closely reflects the structure and function of human connections between nerves and muscles – something no other animal model can fully replicate. doi.org/10.1242/bio....

Summer Paulson & co show that physical confinement enhances phagocytosis, and that phagocytosis induces persistent cell migration, or ‘phagocytic priming’. This response could be relevant for innate immune surveillance. doi.org/10.1242/bio.... #Microglia #ConfinedMotility

Aurélia Joly, @micro-megs.bsky.social & co show that stem cell-intrinsic NF-κB activity is crucial for preventing apoptosis and ensuring proper intestinal epithelial repair following injury in #Drosophila. 🪰 doi.org/10.1242/bio.... #StemCells #Intestine

Francis Letendre & co describe a strong positive correlation between dinoflagellate cell surface area & mechanically stimulated bioluminescence peak intensity, opening new methods for monitoring harmful algal blooms and dinoflagellate populations. doi.org/10.1242/bio.... #HABs #Bioluminescence

Thank you Adam Downie @adamdownunder.bsky.social for sharing your experience of fee-free #OA publishing in @biologyopen.bsky.social via our #ReadAndPublish agreement with The University of Queensland. Read Adam’s paper: bit.ly/4hA9vm1 See if your institution is participating too: bit.ly/3O7BxGi

Jimena Fernández & co reveal that pregnant Liolaemus pictus can physiologically compensate for experimentally induced thermal restrictions, maintaining offspring performance and highlighting the species’ potential resilience to warming. doi.org/10.1242/bio....

Allison Malay & co explore how landscape, immunity and hive management shape honey bee viral infections, offering new insights into pollinator health. 🐝 doi.org/10.1242/bio....

Chutima Chan & co reveal how a mitochondrial enzyme can be redirected to peroxisomes by associating with a related enzyme, providing a novel route to regulate #metabolism. doi.org/10.1242/bio.... #MalateDehydrogenase

Inner ear development involves epithelial cells from opposite sides fusing. Tamilkumar & co find that the epithelial cells that fuse during chick otic vesicle closure are not completely rigid and adapt a reversible, fluid-like trait that facilitates fusion. doi.org/10.1242/bio.... #EpithelialFusion

With mRNA-based labelling and light sheet fluorescence imaging in Perfluorodecalin, Oksana Netschitailo and colleagues reveal the dynamics of extra-embryonic membrane formation in honeybee embryos. doi.org/10.1242/bio.... #LiveImaging #Insects #Morphogenesis