Merry Christmas, genetic interaction nerds: www.biorxiv.org/content/10.6...

🚨New preprint(1/2)! We show that RTK fusion oncoproteins broadly suppress EGFR signaling. How? Sequestration of adapters as the shared principle. Led by superb PhD student Carol Gao. www.biorxiv.org/content/10.1... Implications for drug tolerance/resistance, and includes one big surprise🫧.👇

Exciting stuff!

Probably explains why science is better when you do it do fun than when you do it to win.

Aneesa Shaikh, Maddy Parsons and colleagues investigate ligand- and integrin-independent mechano-sensitive EGFR activation in lung cancer cells. journals.biologists.com/jcs/article/...

Darwin's regrets: "If I had to live my life again I would have made a rule to read some poetry and listen to some music at least once every week.. The loss of these tastes is a loss of happiness, and may possibly be injurious to the intellect and more probably to the moral character"

The fact that 12% of federal judges are Black shows the corruption of DEI. The fact that 67% of Supreme Court Justices belong to a small legal cult called the Federalist Society shows the power of meritocracy.

Introduce yourself with 5 concerts you’ve seen: Radiohead The Rolling Stones Jack White Bob Dylan Hélène Grimaud

New paper “Proteome-wide model for human disease genetics” is now live at Nature Genetics: rdcu.be/eRu7K popEVE (pop.evemodel.org) finds the needles in the haystacks of human genetic variation:

This is bound to be a great place!

This.

May her memory be a blessing.

The amount of AI generated art in slides at this conference, primarily used by older scientists, is killing me. Scientists please. Don’t use these ai platforms to make your figures or slides. They look bad and I have yet to see them meaningfully improve the message of talks.

Oh, bloody brilliant! Guess what I’m replying next time I don’t care to review something!

The @nytimes.com decided last year what the story was; Trump II was the righteous punishment visited upon their interns and junior staffers and grandchildren for being so annoying about MeToo and BLM, and once they understood that and repented, they could have democracy back.

I wrote a blog post about the future of structural bioinformatics. Where to go after AlphaFold? How do we avoid the field becoming a load of half-baked LLMs? Let me know what you think. jgreener64.github.io/posts/struct...

Skeetorial on our BRAF preprint! tinyurl.com/asymmBRAF The RAS->RAF->MEK->ERK cascade carries mutations in most human cancers. Interestingly, although we have three RAF paralogues (A, B and C), it is the BRAF that is predominantly mutated in cancer patients. (1/10)

For every Nobel that goes to a criminally under-recognized woman scientist (Brunkow, Karikó), or fails to go (Candy Lee), a week of mourning and reform for an academic system wherein you can do Nobel-prize-worthy-work and still end up without a conceivable path to being a professor.

Seems like they also listen to Ghost at Science!

First work on kinases from my lab! Working on this project, I often remembered the late Cyrus Chothia who said that if the data doesn’t fit a beautiful model, maybe it’s not the model, maybe you just need more data. :)

In case you missed it: an essential piece from Olúfẹ́mi O. Táíwò from earlier this week: www.bostonreview.net/articles/how...

Mechanism of MEK1 phosphorylation by the N-terminal acidic motif mediated asymmetric BRAF dimer https://www.biorxiv.org/content/10.1101/2025.09.26.678760v1

Slightly diminish a book Windy Heights

Monumental effort from @maxbillmann.bsky.social and colleagues, quantifying genetic interactions among 4 million human gene pairs. Lots of features associated with genetic interaction & GI degree conserved from yeast. www.biorxiv.org/content/10.1...

I also really dislike that talking about AI in this way by journalists - and discrediting humans who actually worked on a paper in the process - is basically free advertising for the AI industry.

ECRs who probably did the bulk of the work go completely unmentioned in the piece, in lieu of putting all credit on some anonymous and benevolent AI force that's probably just a few tens of millions of weights in a PyTorch model

I really dislike how science has started calling almost any fancy computational technique AI. 🧪 The framing of this entire article makes it sound like a benevolent AI independently made these drugs. That is *pure fantasy*. Instead: a team of scientists made a machine learning model for a study.

We are excited to share our preprint describing DirectContacts2! Here we develop a machine learning model to discriminate between direct and indirect protein interactions. We use our model to construct a highly accurate wiring diagram of the human cell. www.biorxiv.org/content/10.1...

These NPG spinoff journals are out of control

This. It’s such a no-brainer, really

We are looking for a postdoctoral fellow to join us to explore telomerase regulation by histones. Please get in touch if this may interest you.

How can an individual protein show adaptation? The light- and temp-sensitive BcLOV4 gives a pulse of translocation during a step input of light. Answer in our preprint: *intra-molecular* feed-forward regulation. bit.ly/3Rg9veD A @bugajlab.bsky.social collab with @nmrkaygee.bsky.social 🧵

DOGE is a criminal conspiracy to defraud the people of the United States

Not to worry, it will all trickle down to the poor racists!

🧵

I just did a photo op at a US base in Greenland that I learned about last week. Here’s why we must destroy our alliances and hand over the Arctic to Russia. by JD Vance

The barrier is literally paper thin bsky.app/profile/reic...

No matter your station in life, there is astoundingly little separating you from those men in that cage behind Kristi Noem. No charges, no attorneys, no hearings, no trial. Just conjecture and brute force could be enough to justify completely dehumanizing you, too.

Agree. This piece was shockingly bad. Hobbes summarized main issues with the article well.

regarding Columbia University, I just learned about this (anonymous) account of negotiations of the Hitler regime in the 1930s with Frankfurt University -- Germany's most prestigious university at the time:

Oh wow! The WaPo has gone full propaganda

Truest, saddest truth ever said. Some people need a master, they will live and die as serfs.

Some science news to brighten up your timelines ☀️ Our latest work on the modifiers that cause changes in gene essentiality between genetic backgrounds, now on bioRxiv: www.biorxiv.org/content/10.1... So what did we find?

Second, women make terrific leaders. They tend to be organized and prepared. They also tend to be more empathic as they have often experienced more challenges and setbacks than men in similar positions. They tend to be more courageous, particularly when the stakes are high. 36/n

Happy Working Women‘s Day!

Interesting! @nytimes.com still hasn’t covered any of the Stand Up for Science protests today, but they made sure to put this important news front and center online. Powerful reporting…

It’s actually just racist because the NYT is co-signing the idea that he got his job because he is Black and there’s no evidence for this

Opinion | It's time to remake the military to put America First. We'll start by renaming bases for Confederate generals who waged war against the United States. by Pete Hegseth