Skeetorial on our BRAF preprint! tinyurl.com/asymmBRAF The RAS->RAF->MEK->ERK cascade carries mutations in most human cancers. Interestingly, although we have three RAF paralogues (A, B and C), it is the BRAF that is predominantly mutated in cancer patients. (1/10)

For every Nobel that goes to a criminally under-recognized woman scientist (Brunkow, Karikó), or fails to go (Candy Lee), a week of mourning and reform for an academic system wherein you can do Nobel-prize-worthy-work and still end up without a conceivable path to being a professor.

Seems like they also listen to Ghost at Science!

First work on kinases from my lab! Working on this project, I often remembered the late Cyrus Chothia who said that if the data doesn’t fit a beautiful model, maybe it’s not the model, maybe you just need more data. :)

In case you missed it: an essential piece from Olúfẹ́mi O. Táíwò from earlier this week: www.bostonreview.net/articles/how...

Mechanism of MEK1 phosphorylation by the N-terminal acidic motif mediated asymmetric BRAF dimer https://www.biorxiv.org/content/10.1101/2025.09.26.678760v1

Slightly diminish a book Windy Heights

Monumental effort from @maxbillmann.bsky.social and colleagues, quantifying genetic interactions among 4 million human gene pairs. Lots of features associated with genetic interaction & GI degree conserved from yeast. www.biorxiv.org/content/10.1...

I also really dislike that talking about AI in this way by journalists - and discrediting humans who actually worked on a paper in the process - is basically free advertising for the AI industry.

ECRs who probably did the bulk of the work go completely unmentioned in the piece, in lieu of putting all credit on some anonymous and benevolent AI force that's probably just a few tens of millions of weights in a PyTorch model

I really dislike how science has started calling almost any fancy computational technique AI. 🧪 The framing of this entire article makes it sound like a benevolent AI independently made these drugs. That is *pure fantasy*. Instead: a team of scientists made a machine learning model for a study.

We are excited to share our preprint describing DirectContacts2! Here we develop a machine learning model to discriminate between direct and indirect protein interactions. We use our model to construct a highly accurate wiring diagram of the human cell. www.biorxiv.org/content/10.1...

When you’re so busy crowing about your political motivations that you forget to pretend you did it for the Jews.

These NPG spinoff journals are out of control

This. It’s such a no-brainer, really

We are looking for a postdoctoral fellow to join us to explore telomerase regulation by histones. Please get in touch if this may interest you.

How can an individual protein show adaptation? The light- and temp-sensitive BcLOV4 gives a pulse of translocation during a step input of light. Answer in our preprint: *intra-molecular* feed-forward regulation. bit.ly/3Rg9veD A @bugajlab.bsky.social collab with @nmrkaygee.bsky.social 🧵

DOGE is a criminal conspiracy to defraud the people of the United States

Not to worry, it will all trickle down to the poor racists!

🧵

I just did a photo op at a US base in Greenland that I learned about last week. Here’s why we must destroy our alliances and hand over the Arctic to Russia. by JD Vance

The barrier is literally paper thin bsky.app/profile/reic...

No matter your station in life, there is astoundingly little separating you from those men in that cage behind Kristi Noem. No charges, no attorneys, no hearings, no trial. Just conjecture and brute force could be enough to justify completely dehumanizing you, too.

Agree. This piece was shockingly bad. Hobbes summarized main issues with the article well.

regarding Columbia University, I just learned about this (anonymous) account of negotiations of the Hitler regime in the 1930s with Frankfurt University -- Germany's most prestigious university at the time:

Oh wow! The WaPo has gone full propaganda

Truest, saddest truth ever said. Some people need a master, they will live and die as serfs.

Some science news to brighten up your timelines ☀️ Our latest work on the modifiers that cause changes in gene essentiality between genetic backgrounds, now on bioRxiv: www.biorxiv.org/content/10.1... So what did we find?

Second, women make terrific leaders. They tend to be organized and prepared. They also tend to be more empathic as they have often experienced more challenges and setbacks than men in similar positions. They tend to be more courageous, particularly when the stakes are high. 36/n

Happy Working Women‘s Day!

Interesting! @nytimes.com still hasn’t covered any of the Stand Up for Science protests today, but they made sure to put this important news front and center online. Powerful reporting…

It’s actually just racist because the NYT is co-signing the idea that he got his job because he is Black and there’s no evidence for this

Opinion | It's time to remake the military to put America First. We'll start by renaming bases for Confederate generals who waged war against the United States. by Pete Hegseth

Opinion | On November 5th, voters gave Donald Trump an overwhelming mandate to seize Gaza, Greenland, and the Panama Canal while passing off domestic control to Elon Musk. Why is this so hard for the Left to understand?

🧵 from first hand experience

This headline is *chef's kiss* @jasonkoebler.bsky.social www.404media.co/openai-furio...

If you couldn’t catch it near the end

All I'm saying, @royalsociety.org, is that your one of your Fellows giving Nazi salutes is never going to be a good look for you.

“When and if fascism comes to America it will not be labeled ‘made in Germany’; it will not be marked with a swastika; it will not even be called fascism; it will be called, of course, ‘Americanism.'” — Halford E. Luccock, 1938

Nazis: "that's a nazi salute" Historians: "that's a nazi salute" Average person: "that's a nazi salute" The Media: "Elon Musk makes odd gesture throwing his heart to the crowd."

This is, or should be, a big deal -- Ann Telnaes, an absolute legend, quitting WaPo due to censorship of a cartoon criticizing billionaires anntelnaes.substack.com/p/why-im-qui...

my armchair psychological diagnosis is that the drive to accumulate as much wealth as possible eats away at the drive for self-improvement or the internal desire to cultivate any skills or tastes. these people build huge mounds of treasure and then essentially just sit around looking at it, empty.

🥳

Oh, Switzerland, you pretty.

Reading the pardon coverage...I don't think the significance of the Gaetz/Patel/Bondi nominations has sunk in. People still aren't getting what a politicized DOJ and FBI, with the power to arrest/bug/harass anyone for any reason, would be able to do.

Does my mutation have the same impact as yours? Population genetics 🤠 🥸 🤓 🤡 meets single cell CRISPRi ⚡ ! www.biorxiv.org/content/10.1... Led by Claudia Feng, Oliver Stegle, Britta Velten, @sangerinstitute.bsky.social .

Same is true about journal papers! Even within the review process for a single paper at a single journal!

We did this crazy project where we tried to see if proteins could interact with their mirror image ligand. Seems impossible when proteins need to form 3D structures to interact. But what about if the interaction remains disordered??? www.nature.com/articles/s41...

Since I suspect these might come up again... 1️⃣ It's "mass infection", not "focused protection". 2️⃣ It's "conspiracy theorist", not "critic". 3️⃣ It's "denier", not "skeptic". 4️⃣ It's "unevidenced", "misleading", or "false", not "disagreement". Bothsidesism and sanewashing are both widespread and 📈.