Hamda's paper is out: benchmarking different genetic interaction scoring methods for identifying synthetic lethal interactions from combinatorial CRISPR screens. academic.oup.com/nargab/artic...

Enjoyed writing this review of synthetic lethality in drug discovery with @emanuelvgo.bsky.social and @davidjadams.bsky.social rdcu.be/eFBmw

We're hiring ! Specifically....we are seeking to appoint a creative and motivated Postdoctoral Training Fellow to study how drug resistance emerges in homologous recombination defective (HRD) breast cancers and how this could be targeted. jobs.icr.ac.uk/vacancies/13...

📢 The 2nd European Cancer Dependency Map Symposium is coming! 🗓️ 20 Nov 2025 📍 Human Technopole, Milan Join us for a one-day dive into: 🔹 Cancer genomics 🔹 CRISPR screening 🔹 AI-driven target discovery With the patronage of AIRC 🔗 humantechnopole.it/en/trainings...

Join Us! @ioriolab.bsky.social

Pleased that the 2nd part of my PhD is now available as a preprint! Here, we investigated the epigenomic and transcriptomic changes occurring upon PRC2 depletion in AML cells. biorxiv.org/content/10.1.... A thread🧵1/17

Doomscrolling pause to chat CRISPR libraries! Preprint describes our new, data-driven approach to combine on-target and off-target predictions much more intelligently for *selecting* guides, which we use to develop our newest Cas9 knockout library, Jacquere. Thread: www.biorxiv.org/content/10.1...

just a month to go until the International Conference on Systems Biology #ICSB2025 kicks off in Dublin, still time to submit a poster abstract!

new from @cosmintudose.bsky.social What happens when tumor suppresor EZH2 is mutated in acute myeloid leukaemia? How does it change transcription, chromatin accessibility & drug response? The Bond lab created CRISPR mutants to find out & Cosmin put it all together www.biorxiv.org/content/10.1...

Article by Pádraig Cunningham and Barry Smyth in Communications of the ‪@acm.org‬ analyses the differences in quality and practices of new Open Access and traditional Computer Science journals. bit.ly/41KKQ7s

Delighted that our work on EZH2 dominant negativity in Weaver syndrome is now out in Genes & Development! This exciting work on chromatinopathies 🧬 was in collab with @adrianbracken.bsky.social and spearheaded by Orla Deevy. @ucddublin.bsky.social @ucd-sbbs.bsky.social www.ucd.ie/newsandopini...

Final year PhD students, I know you’re desperately trying to finish experiments/revisions/submissions/write a thesis & just survive - but please spare a few minutes to apply to your dream postdoc labs. It easily takes A YEAR from first contact, even if everything goes to plan on both sides.

Monumental effort from @maxbillmann.bsky.social and colleagues, quantifying genetic interactions among 4 million human gene pairs. Lots of features associated with genetic interaction & GI degree conserved from yeast. www.biorxiv.org/content/10.1...

With super Roman Chabanon and Sophie Postal Vinay, we show that inhibition of RNA editor ADAR1 causes a new form of BRCA synthetic lethality>autocrine inferferon poisoning. Relevant for ADAR1 drug discovery. Could provide a mechanistically different approach than PARPi. rdcu.be/eyo6t

This is one of those awesome "I always wanted to do that experiment" papers. And a great 🧵.

when an Irish funding agency launches a new grant call in July with a deadline in August it's hard to feel that researcher well-being is one of their priorities...

The final day of #ICSB2025 on Thurs, Oct 9, will finish with 3 more outstanding breakout sessions. ✨Clinical Decision Support Tools ✨Evolution & Development ✨AI/ML Approaches in Systems Biology For more info: bit.ly/4mPNfGQ @ucddublin.bsky.social @ucd-chas.bsky.social @precisiononcire.bsky.social

Unexpectedly, @jurgjn.bsky.social found that running Alphafold3 predictions for protein interactions can yield ipTM scores that are more predictive of true interactions when run in pools of proteins instead of pairwise predictions. Presumably, this reflects some sort of "competition effect".

School of Medicine @ucddublin.bsky.social are interested in expressions of interest. Note that the deadline is relatively tight – 28th August

Interested in moving your research to Ireland? Research Ireland have just launched a new call to recruit mid-career (5-15 year post PhD) and established researchers (>15 years post PhD).

Great to have an additional social option for #ICSB2025 – a walking tour of Dublin. It's a small city centre, so walking is the easiest way to see it! icsb2025.com/social-progr... #systemsbiology

A new drug target that has the potential to treat aggressive eye cancer has been discovered 👁️ This research may provide a hopeful outlook for eye cancer patients with very limited treatment options and has implications for a range of other cancers ⤵️ www.sanger.ac.uk/news_item/ne...

New work out in @natgenet.nature.com from @davidjadams.bsky.social Lab @sangerinstitute.bsky.social (with a contribution from us led by A.Vinceti): CDS2 is a cancer dependency in uveal melanomas with low CDS1 expression: a synthetic lethal axis with broad potential 🔗 www.nature.com/articles/s41...

Fantastic opportunity to launch your research group following the @embl.org model in a great environment with a solid startup package and access to state-of-the-art resources. Join us at the @ncmbm.bsky.social, part of the @nordicembl.bsky.social, at @uio.no Feel free to reach out if you have Qs.

At long last, Rosalind's paper on comparing methods for paralog synthetic lethality is online: genomebiology.biomedcentral.com/articles/10....

Do you have experience in mechanistic modelling of biological systems and want to do a postdoc with an interdisciplinary team on developing Digital Twins for rare disease? We have the job for you! Check it out below - deadline July 13th, online interviews 24th July.

New paper hot off the press www.nature.com/articles/s41... We analysed over 40,000 computer vision papers from CVPR (the longest standing CV conf) & associated patents tracing pathways from research to application. We found that 90% of papers & 86% of downstream patents power surveillance 1/

As scientists look for alternative homes for their research careers, will Ireland seize the opportunity? Perspective in @irishtimes.com today. www.irishtimes.com/opinion/2025...

One more day until abstract submission closes! We are particularly looking forward to learn about your advancements int the Metabolic Diseases area, so make sure you don't miss the opportunity to meet in person in Dublin for ICSB!

🧬 Excited to announce the 2nd Euro Cancer DepMap Symposium bringing together leading minds in functional genomics, cancer vulnerabilities, AI, CRISPR and anti-cancer target discovery.📍Join us in Milan for cutting-edge science, open discussion & collaboration. #EuroDepMap #CancerResearch #CRISPR

🔬 Join us in Milan for the 2nd European Cancer Dependency Map Symposium #ECDM25! A key event for scientists in functional genomics & target discovery. Talks, panels, AI & poster sessions await. Register now 👉 humantechnopole.it/en/trainings...

At #IACR2025 in Belfast Prof. Kerry Courneya gave an excellent talk on the relationship between exercise and cancer outcomes, highlighting the lack of controlled trials. He gave no details but promised a relevant study coming soon, this looks to be it! www.nejm.org/doi/full/10....

Just to remind people listening to RTÉ's report on the destruction of Irish sprat stocks (the basic food for many other fish) that most sprat go into fishmeal to feed farmed fish. Salmon farming is a major part of the problem. www.theguardian.com/world/2025/m...

Anjan's paper out in @molsystbiol.org. Main question: How are the molecular interaction networks inside cancer cells robust to the deletion of protein coding genes? One mechanism: increased protein abundance of a paralog (duplicate gene) www.embopress.org/doi/full/10....

"Government apathy and inaction towards fish conservation has led to parts of the ocean becoming lifeless marine deserts" www.irishexaminer.com/news/munster...

went for my first evening sea swim of the year yesterday and there was tons of people still in at 9pm. for those considering attending #ICSB2025, the water in Dublin will be even warmer by October!

nice work demonstrating a dosage sensitive compensatory relationship between paralogs journals.plos.org/plosgenetics...

congrats to @maxbillmann.bsky.social on making 'pertomics' an official published term www.embopress.org/doi/full/10....

Our work on deriving protein-protein (functional) associations across different human tissues from proteomics data is now published. There is quite a lot in this paper, so I will just touch on a few highlights: www.nature.com/articles/s41...

The Gulbenkian Institute of Molecular Medicine (GIMM) is one of the best research institutes in Portugal. It's currently recruiting for three Group Leaders (junior or senior) across different areas, including systems biology and bioinformatics. gimm.pt/jobs/open-ca...

speaker list is now expanded! sessions on cancer, evolution, metabolic disease, multi-omics, AI. speakers include @epetsalaki.bsky.social @ciriellolab.bsky.social @juliosaezrod.bsky.social @molsysbio.bsky.social @inesthiele.bsky.social @profjochen.bsky.social @renskevroomans.bsky.social +tons more

Olivier's paper out now! We find that similarity metrics derived from AlphaFold structures & PLM embeddings can help identify pairs of paralogs with shared functions. Not always better than sequence identity, but not redundant with it, so combining them works best. academic.oup.com/nargab/artic...

this week 20 years ago, Nature published two seminal papers showing for the first time that BRCA-mutant cells were selectively sensitive to PARP inhibitors, paving the way for clinical trials and approval of PARP inhibitors for patients with BRCA-mutant ovarian and breast cancers, and beyond.

our work on the molecular differences between transcription factor isoforms is out now in Molecular Cell! key point: 2/3rds of TF isos differ in properties like DNA binding & transcriptional activity many are "negative regulators" & misexpressed in cancer www.sciencedirect.com/science/arti...

disappointed to not be attending #CRISPR25 in person, but the lab will be well represented with Narod Kebabci giving a talk this afternoon and Metin Yazar presenting a poster this evening

new work led by Hamda Ajmal evaluating different genetic interaction scoring approaches to identify synthetic lethal interactions from combinatorial CRISPR screens www.biorxiv.org/content/10.1... #crispr

With Syed Haider we show that like BRCAness, phenocopies of Rb genomic defects (RBness) are common and in cancer and predict genetic dependencies. Work from @icr.ac.uk funded by @breastcancernow.bsky.social @cancerresearchuk.org www.science.org/doi/10.1126/...

this was a great meeting thanks to @francescoiorio.bsky.social @ciccarellilab.bsky.social and Freder for opening the biomedical sessions on Thursday morning!

on the (now hourly!) train to Belfast for the Irish Association of Cancer Research conference, looking forward to some great talks #IACRConference

We’ve put together an exciting lineup of short talks for #CRISPR25! Check out the full programme here: bit.ly/4bnAcqT 📅Don't miss out—register by 4 March to join our incredible speakers! bit.ly/3Amz34N @leopoldparts.bsky.social @durocher1.bsky.social @uweohler.bsky.social @erika-alden.bsky.social