Two alternative isoforms of PRC2 accessory subunit AEBP2 modulate developmental Polycomb functions in opposite ways - with broadly-expressed AEBP2L acting as an intrinsic inhibitor in somatic cells @adrianbracken.bsky.social @davidovichlab.bsky.social and colleagues www.embopress.org/doi/full/10....

We are delighted that @genesdev.bsky.social have selected our (w/ @adrianbracken.bsky.social) Weaver syndrome paper artwork as the November cover! This piece was made by my incredibly talented niece, Gina 'Dna Vinci' Ronan. @ucddublin.bsky.social @tcddublin.bsky.social @ucd-sbbs.bsky.social

1/ 🚀 AEBP2 isn’t what we thought. You were told that AEBP2 promotes PRC2 activity on chromatin. We found the opposite: the most prevalent AEBP2 isoform inhibits PRC2 activity. 👉 surl.li/cgwqcq A thread 🧵

Absolutely delighted to share our preprint, using functional genomics to uncover a novel dependency in lymphoma that can overcome resistance to targeted therapy. Grateful to co-first author @jamesnolan.bsky.social and co-senior authors @conwayer1.bsky.social and @adrianbracken.bsky.social see👇

🧵1/Exciting news in cancer epigenetics! Our latest research, "AEBP2-Directed H3K27me2 Defines a Specific Vulnerability in EZH2-mutant Lymphoma", is now available on www.biorxiv.org/content/10.1.... Here's a thread summarizing our findings!👇 #CancerResearch #Epigenetics #Chromatin #Lymphoma

2/ Firstly, this was a fantastic collaborative effort that would not have been possible without super-talented co-first author @dr-chromatin.bsky.social, and co-senior authors @conwayer1.bsky.social and @adrianbracken.bsky.social.

Delighted that our work on EZH2 dominant negativity in Weaver syndrome is now out in Genes & Development! This exciting work on chromatinopathies 🧬 was in collab with @adrianbracken.bsky.social and spearheaded by Orla Deevy. @ucddublin.bsky.social @ucd-sbbs.bsky.social www.ucd.ie/newsandopini...

Check out this 🧵 from @eimearlagan.bsky.social on our new Molecular Cell @cp-molcell.bsky.social paper! We show how the H3K27M Oncohistone reprograms chromatin in DMG, creating a specific dependency on CBX4/PCGF4-containing forms of cPRC1 👇

🧬🧪Exciting chromatin research conference hosted by @aicc-ireland.bsky.social in May! The deadline for poster/talk abstracts is April 28, see details in the post below.

We are very excited to launch the registration for our 2025 symposium on 'Chromatin, Epigenetics and Transcription' today! Join us at @tcddublin.bsky.social on May 28th for this event featuring keynote, new PI and PhD/postdoc talks and posters! allirelandchromatinconsortium.ie/annual-meeti...

1/ H3K27me3 mimicry has repeatedly emerged through evolution, but what's the physiological relevance? We show that JARID2 and PALI1 mimic H3K27me3 to antagonise PRC2 in vivo and restrict the spread of Polycomb domains. 🧵 www.biorxiv.org/content/10.1...

Looking forward to welcoming @peterlewislab.bsky.social from @uwmadison.bsky.social for our March webinar on 'Dissecting the Biochemical Complexes Governing Gene Silencing' on March 28th! Register here: us06web.zoom.us/webinar/regi... @activemotifusa.bsky.social

What a week it has been for our @uniofgalway.bsky.social committee members @jgahan.bsky.social and @thecocodium.bsky.social. Congrats on the grant successes from @researchireland.bsky.social and @wellcometrust.bsky.social respectively! Keep an eye out for job ads from them soon 👀

Coming up this month on Feb 28th- we will be joined by @arnausebe.bsky.social from the @crg.eu for his webinar on 'The origin and early evolution of animal regulatory genome architecture'. Registration details here: us06web.zoom.us/webinar/regi... @activemotifusa.bsky.social

Just a few days left to submit your abstract for our #Epigenetics2025 conference in Belfast! genetics.org.uk/events/epige...

Join us in Belfast for our #epigenetics meeting and hear from fantastic speakers. Submit an abstract until 26 Jan and register until 23 Feb! Don't miss this chance to share your research & network with experts in the field. genetics.org.uk/events/epige...

Congratulations to all authors on this very interesting work! Regarding EZH1, it aligns well with what our group and Danny Reinberg's group have proposed based on structural and functional data.

Please see 🧵by @evhealy.bsky.social about our new paper exploring the role of PRC1 and PRC2 in non-dividing cells 👇

Our first 2025 webinar is coming up in a few weeks - Jan 31st! Mark your calendars! @davidlabmsk.bsky.social will join us for her webinar on 'Turning back the clock: Targeting a new metabolism-epigenetic axis in T-cells.' Registration: us06web.zoom.us/webinar/regi... @activemotifusa.bsky.social

Join us for Luciano Di Croce’s webinar tomorrow. Registration links below 👇

Our final webinar before Christmas 🎅 is coming up! We will be joined by Luciano Di Croce for his webinar on 'Dissecting Dynamics of Chromatin Function in Cell Differentiation and Cancer'. Register here: us06web.zoom.us/webinar/regi... @activemotifusa.bsky.social

We've now filled one #Epigenetics, Chromatin and Gene regulation starter pack. Thanks for all the enthusiasm and support, if you'd like to be listed @raduzabet.bsky.social has been hard at work getting part II up and running: go.bsky.app/SqLa3aw

Of course, being new to bluesky we managed to forget to add the all important registration link 🤦‍♂️ Register here: us06web.zoom.us/webinar/regi...

How does PRC1 counteract transcription? See this preview from @adrianbracken.bsky.social and I on an exciting new study from @robklose.bsky.social lab where they show ncPRC1 blocks the early stages of transcription. www.sciencedirect.com/science/arti... @conwayer1.bsky.social for title inspo!