Eimear Lagan
@eimearlagan.bsky.social
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📥 96
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Post-doc @ IGC, University of Edinburgh Epigenetics | Paediatric cancer | Functional genomics
pinned post!
Excited to share our new paper out today in
@cp-molcell.bsky.social
! We show that the H3K27M oncohistone rewires cPRC1, creating a unique dependency on CBX4/PCGF4-containing complexes, and also reveal a previously unknown function of CBX4. Highlights below (1/11).
6 months ago
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reposted by
Eimear Lagan
The Lewis Lab
4 months ago
We are excited to share our new preprint demonstrating that nucleic acid interactions with SUZ12 constrain PRC2 activity, establishing a kinetic buffer essential for targeted gene silencing and revealing vulnerabilities in diffuse midline gliomas.
www.biorxiv.org/content/10.1...
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reposted by
Eimear Lagan
Jongmin Kim
5 months ago
I find unstructured regions in proteins enigmatic and very interesting.
add a skeleton here at some point
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reposted by
Eimear Lagan
5 months ago
Great to see
@jongminkmg.bsky.social
’s preview of our work in
@cp-molcell.bsky.social
today!
www.cell.com/molecular-ce...
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Not all CBXs are created equal: A role for the disordered central region of CBX4 in pediatric glioma
In this issue, Lagan et al.1 apply genome-wide and tiling-scan CRISPR screens to uncover a key role for CBX4 and its central region in promoting the growth of diffuse midline glioma cells bearing the ...
https://www.cell.com/molecular-cell/abstract/S1097-2765(25)00455-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1097276525004551%3Fshowall%3Dtrue
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reposted by
Eimear Lagan
Institute of Genetics and Cancer
6 months ago
Congratulations to everyone involved in this collaborative effort. Read our web story here:
edin.ac/4jeAkLw
@cmvm-edinburghuni.bsky.social
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Researchers uncover key player behind gene repression in rare brain tumour
Researchers have discovered an important molecular mechanism underlying diffuse midline glioma - an aggressive and currently incurable brain tumour that mostly affects children.
https://edin.ac/4jeAkLw
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reposted by
Eimear Lagan
Molecular Cell
6 months ago
Online Now: A specific form of cPRC1 containing CBX4 is co-opted to mediate oncogenic gene repression in diffuse midline glioma Online now:
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A specific form of cPRC1 containing CBX4 is co-opted to mediate oncogenic gene repression in diffuse midline glioma
Lagan, Gannon, et al. reveal that H3K27M-DMGs depend on a specific form of cPRC1 containing CBX4 and PCGF4. H3K27M alters H3K27me3 distribution, causing increased binding of CBX4-PCGF4-cPRC1 and oncogenic gene repression. CBX4’s ability to read H3K27me3 and to form a specific cPRC1 complex with PCGF4 makes it essential in DMG.
http://dlvr.it/TKvbPC
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Excited to share our new paper out today in
@cp-molcell.bsky.social
! We show that the H3K27M oncohistone rewires cPRC1, creating a unique dependency on CBX4/PCGF4-containing complexes, and also reveal a previously unknown function of CBX4. Highlights below (1/11).
6 months ago
5
23
12
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