Nature suggests you use their "Manuscript Adviser" bot to get advice before submitting I uploaded the classic Watson & Crick paper about DNA structure, and the Adviser had this to say about one of the greatest paper endings of the century:

Chaetognaths have lost gene body methylation and shifted #5mC back to Transposable Elements. This reversion to the ancestral state is coupled with a simplification of DNMT3 architecture. We posit that trans-splicing might compensate. It is an honour to have contributed to this 20y struggle ⛰️.

We are excited to highlight our Rising Star Awardee, Dr. Can Aztekin @canaztekin.bsky.social whose work highlighting the importance of oxygen in regulating regeneration is inspiring. #Onetowatch

Announcing this year's Life Time Achievement Award. The one and only amazing Professor Brigette Galliot. Our inspiration with both her research and her service.

Cnidarian-Microbe Interactions Fully-funded postdoctoral position is available in the Gibson Lab at the Stowers Institute to investigate any aspect of cnidarian-microbe interactions. Strong background in coral symbiosis or eukaryotic microbiology preferred. Contact Matt Gibson: [email protected]

Happy to see our latest work out in @molbioevol.bsky.social. We revisit the evolution of 5-methylcytosine across neglected eukaryotic supergroups, establishing an ancestral repressive role silencing genome invaders, both transposons and viral elements👾: academic.oup.com/mbe/advance-... 🧵 1/7

Our study on a male-essential microRNA and the evolution of other dosage compensation mechanisms in birds is now out in Nature! www.nature.com/articles/s41...

't was lovely to host @julianolab.bsky.social here @uniofgalway.bsky.social. Great presentation and lots of fun later on a pint with @jgahan.bsky.social @rmacgabhann.bsky.social @hrhorkan.bsky.social and friends.

I am looking for a new postdoc to join the lab. Interested in pluripotency, germ cells, and in investigating these in a genetically tractable cnidarian? Get in touch! We offer a long-term contract, excellent research environment, and a lovely city #Galway. www.urifranklab.org

David’s @davidmoersdorf.bsky.social cool paper about the role of Chordin in BMP signaling in the sea anemone Nematostella is finally out www.science.org/doi/10.1126/...

Happy to share our genome paper now typeset. We sequenced and assembled the genome of Bougainvillia (jellyfish not the plant!) which has 28 eyes! doi.org/10.1093/g3jo...

"Aboral cell types of Clytia and coral larvae have shared features and link taurine to the regulation of settlement" Kudos to Julia Ramon-Mateu and Anna Ferraioli @biodev-vlfr.bsky.social, and thanks to our collaborators for their coral larva expertise www.science.org/doi/10.1126/...

Delighted to see this work from my lab published today, where we identify a population of ETV-1 positive glutamatergic neurons that are activated in the brain in response to a distant injury. www.nature.com/articles/s41...

Check out our latest work on the evolution of animal genome regulation out today in @nature.com. Nicely summarized below by @ianakim.bsky.social. www.nature.com/articles/s41... This is a major output from our ERC-StG project Evocellmap @erc.europa.eu at @crg.eu

Proud to present the peer-reviewed version of our Cell Type Allometry paper, out today in Science Advances! www.science.org/doi/10.1126/... Are animals of different sizes made of the same cell types? Here’s an update of the main points and revision items (with memes!) Thread 👇🧵

Just back from visiting @viennabiocenter.bsky.social where I met with colleagues @ulrichtechnau.bsky.social @genikhovich.bsky.social @tessmarraiblelabs.bsky.social Oleg Simakov and many others. Lovely weather and great science.

‼️ Attention non-bilaterian enthusiasts ‼️ Join us for the non-bilaterian satellite symposium at PASEDB 2025 this July! Come hear the latest in cnidarians, sponges, ctenophores & more! Talks will be selected from abstracts. Contact me with questions. Register at the link below:

Registrations are now open for the next @embo.org EvoChromo meeting in December. meetings.embo.org/event/24-evo... Join us in beautiful Costa Brava to discuss chromatin evolution! Co-organized with @tobiaswarnecke.bsky.social @sandraduharcourt.bsky.social @levine-lab.bsky.social and Nick Irwin

In this Review, @bernasozen.bsky.social, Patrick Tam & Martin Pera summarize how recent studies of embryo models have advanced our understanding of cell state transitions of the pluripotent human epiblast and highlights some key remaining questions: doi.org/10.1242/dev....

🧬🧪Exciting chromatin research conference hosted by @aicc-ireland.bsky.social in May! The deadline for poster/talk abstracts is April 28, see details in the post below.

Tanya's @tclebedeva.bsky.social paper on endomesoderm specification in the beta-catenin-negative area of the Nematostella embryo is out! www.nature.com/articles/s41...

Looking forward to welcoming @peterlewislab.bsky.social from @uwmadison.bsky.social for our March webinar on 'Dissecting the Biochemical Complexes Governing Gene Silencing' on March 28th! Register here: us06web.zoom.us/webinar/regi... @activemotifusa.bsky.social

🎉 bioRxiv & medRxiv are now managed by openRxiv, a new independent nonprofit. This transition allows for more flexibility and innovation. Our mission remains being a free service to authors ensuring rapid sharing of scientific information before peer review. ℹ️ openrxiv.org/introducing-...

🚨ISRB Webinar - Zone 2: Europe, West Asia & Africa on March 11th at 4pm Central European Time 📷 featuring Uri Frank and Stefano Tiozzo #ColonialRegeneration

The Hydractinia cell atlas is out. This remarkable animal has those cells, i-cells, that are pluripotent just like mammalian blastocyst inner cell mass. There is a difference, though––inner cell mass cells persist for only a few cell cycles before they differentiate; i-cells are adult cells.

Thrilled to receive a Discovery Award from @wellcometrust.bsky.social. We are working on adult, pluripotent stem cells in #Hydractinia. This animal is among the most regenerative creatures and does not succumb to age. Thanks to my team members and colleague at chromosome.ie @uniofgalway.bsky.social

Happy to formally announce I will be working on Nematostella again on the back of a recent @researchireland.bsky.social award! Also mazing to see 4/5 Frontiers for the Future awards to @uniofgalway.bsky.social announced today coming to PIs in the CCB (chromosome.ie)!

Our February webinar is coming up this Friday from @arnausebe.bsky.social at the @crg.eu. Join us for his talk on 'The origin and early evolution of animal regulatory genome architecture' Registration details below! @activemotifusa.bsky.social

Cycling in Ireland without mudguards is not a great idea. Fixed now 😎

Coming up this month on Feb 28th- we will be joined by @arnausebe.bsky.social from the @crg.eu for his webinar on 'The origin and early evolution of animal regulatory genome architecture'. Registration details here: us06web.zoom.us/webinar/regi... @activemotifusa.bsky.social

Answering the call of @haesleinhuepf.bsky.social, Christian Tischer, Pete Bankhead, @kbias.bsky.social @bethcimini.bsky.social My Fiji training notes are now FAIR. All online in an open format to download and use for teaching and training. All in Google Doc or PDF formats bit.ly/4hkfEBF

Looking forward to the allirelandchromatinconsortium.ie webinar by Aunau Sebe-Pedros @arnausebe.bsky.social on 28th February 4 pm (Dublin time). Register here us06web.zoom.us/webinar/regi...

New insight on gonad morphogenesis ! Our new paper reveals how germ & somatic cells interact through TGF-Beta feedback loop to drive gonad morphogenesis in Hydractinia. Check out the full paper in Science Advances ! tinyurl.com/245rw699

Check out our new preprint looking at regeneration from reaggregated cell suspensions in Hydractinia. Once again i-cells are flexing their capacities

Gonads and germ cells have an interdependent relationship in the cnidarian #Hydractinia. Germ cells secrete a TGF-beta ligand (called Gonadless) to induce and maintain the somatic gonad; gonads activate Tfap2 in pluripotent stem cells (i-cells) to commit them to germ fate tinyurl.com/245rw699

Our first 2025 webinar is coming up in a few weeks - Jan 31st! Mark your calendars! @davidlabmsk.bsky.social will join us for her webinar on 'Turning back the clock: Targeting a new metabolism-epigenetic axis in T-cells.' Registration: us06web.zoom.us/webinar/regi... @activemotifusa.bsky.social

#Hydractinia takes regeneration to the extreme¬in a new preprint, Curantz et al. show that dissociated, reaggregated cells can form a new individual. We also show how they do it and which cells types actually contribute to the new individual (tip: not many of them). tinyurl.com/mr2s9zyf

Delighted with my lab's contribution to this study. We show that this feature of #miRNA is a general cnidarian trait. It has implications for understanding the evolution of miRNAs in animals. Was great to work with @yehumoran.bsky.social and his team!

Our friendly 6-years old kitten

A PhD position in computational genomics is open in our group at Imperial/MRC LMS! 🌟 Join the DANIO-ReCODE Doctoral Network and work on gene regulation, evolution, development, and tissue regeneration. Open to all (except those residing in the UK in the past year). Deadline: 8 Jan 2025. t.ly/fDdDW

#DBfeature Apoptosis-dependent head development during metamorphosis of the cnidarian Hydractinia symbiolongicarpus by Gabriel Krasovec, Uri Frank @thecocodium.bsky.social www.sciencedirect.com/science/arti...

A conserved fertilization mechanism revealed. Conrats @yehumoran.bsky.social and colleagues! doi.org/10.1016/j.ce...

In Praise of Peer Review briscoelab.org/2024/12/11/i...

We are looking for a small-molecule inhibitor of Wnt/b-cat signaling, ideally one that was teasted in a marine invertebrate. Any idea?

Three must read papers for PhD students. #scisky #PhD #science #research #academicsky 1. The importance of stupidity in scientific research Open Access journals.biologists.com/jcs/article/...

A few days left to apply 🙌🏻

A very interesting issue of @devbiol.bsky.social www.sciencedirect.com/journal/deve...

How come PKA signalling has opposite roles for oocyte maturation in vertebrates compared to many other species? We unpicked this “cAMP paradox” in a cross-species collaboration, charting phosphorylation site evolution of the key regulator ARPP19. Meneau et al. DOI: 10.1242/dev.202655

Welcome to Bluesky, @danafrank.bsky.social

Our final webinar before Christmas 🎅 is coming up! We will be joined by Luciano Di Croce for his webinar on 'Dissecting Dynamics of Chromatin Function in Cell Differentiation and Cancer'. Register here: us06web.zoom.us/webinar/regi... @activemotifusa.bsky.social