Good morning from Generative Biology! @bernasozen.bsky.social starts by taking a closer look at metabolism in early embryogenesis. Learn more about stem cell-based embryo models in her recent @dev-journal.bsky.social Review: doi.org/10.1242/dev.... and interview: doi.org/10.1242/dev....

Really grateful to @bernasozen.bsky.social and @harrymcnamara.bsky.social for their thoughtful preview of our CRISPRa-programmed embryo model in @cp-cellstemcell.bsky.social. Love the title and the insight. means a lot to us!🙏🏾

In this Review, @bernasozen.bsky.social, Patrick Tam & Martin Pera summarize how recent studies of embryo models have advanced our understanding of cell state transitions of the pluripotent human epiblast and highlights some key remaining questions: doi.org/10.1242/dev....

a real pleasure to write this piece with Martin Pera and Patrick Tam, where we reflect on recent insights and open questions in early human development: doi.org/10.1242/dev....

Get ready for our next western/evening 🌙 session seminar on Thursday! with Loic Le-Goff @loic-legoff.bsky.social (buckling morphogenesis 🪰) and Berna Sozen @bernasozen.bsky.social (🐁 gastrulation) 🗓️ Thursday, March 06th at ⏰ 09:30 PST / 12:30 EST / 17:30 UTC / 17:30 GMT / 18:30 CET

🚨Why can’t mammals regenerate legs or arms like frog tadpoles or salamanders? Our preprint tackles (part of) this BIG question with surprising findings about oxygen sensing 🔗 www.biorxiv.org/content/10.1... Happy New Year, everyone! 🎉 🐭 vs 🐸 #evodevo #regenerative #cellbio 🧵👇

Metabolism is a key developmental regulator. In mammalian gastrulation, hexosamine biosynthetic pathway drives epiblast differentiation, while glycolysis guides mesoderm migration and lateral expansion. bsky.app/profile/epim...