@genikhovich.bsky.social
📤 279
📥 178
📝 77
Evolution of developmental mechanisms, especially axial patterning. Experimental embryology. 🪸🪼
pinned post!
David’s
@davidmoersdorf.bsky.social
cool paper about the role of Chordin in BMP signaling in the sea anemone Nematostella is finally out
www.science.org/doi/10.1126/...
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Chordin-mediated BMP shuttling patterns the secondary body axis in a cnidarian
Chordin-mediated BMP shuttling is the candidate mechanism for generating bilateral symmetry in the cnidarian-bilaterian ancestor.
https://www.science.org/doi/10.1126/sciadv.adu6347
5 months ago
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45
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reposted by
A. Sánchez Alvarado
2 days ago
Metamorphosis in Schizocardium californicum drives dramatic reorganization of cell types, with adult structures forming through transcriptional reprogramming of larval cells rather than their wholesale replacement. @paul.bump.bsky.social
@lowelab.bsky.social
www.biorxiv.org/content/10.1...
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31
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reposted by
Arnone Lab
5 days ago
Our study, just published in
#ScienceAdvances
and funded by
@hfspo.bsky.social
, explores the post metamorphic cell composition of the sea urchin juvenile, revealing that its body is head-like. Long considered brainless creatures, they’re all brain instead!
www.science.org/doi/10.1126/...
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Single-nucleus profiling highlights the all-brain echinoderm nervous system
A sea urchin is a head with a brain-like organization and a vertebrate-type retinal signature.
https://www.science.org/doi/10.1126/sciadv.adx7753
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reposted by
Developmental Biology
17 days ago
#DBfeature
#EvoDevo
mRNA splicing variants of the transcription factor Blimp1 differentially regulate germline genes in echinoderms "Each Blimp1 isoform has distinct functions within & between species" by Gerardo Reyes, Nathalie Oulhen, Gary Wessel
www.sciencedirect.com/science/arti...
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reposted by
Harmit Singh Malik
16 days ago
More pictures of the brilliance that is (lab manager) Aida de la Cruz with her creation.
add a skeleton here at some point
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A nice survey of membrane tags in a variety of EvoDevo models (also featuring Nematostella). Thanks to
@michalis-averof.bsky.social
for the invitation.
add a skeleton here at some point
18 days ago
0
7
0
reposted by
Development
19 days ago
Signals from the head and germinative region differentially regulate regeneration competence of the tapeworm Hymenolepis diminuta Read this
#LifelongDevSI
#OA
Research Article by Elise McCollough Nanista, Tania Rozario & colleagues
@ugaresearch.bsky.social
:
journals.biologists.com/dev/article/...
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1
1
reposted by
Arnau Sebé-Pedrós
25 days ago
We are happy to share our latest work in
@nature.com
. We study the genomic and cellular basis of facultative symbiosis in Oculina patagonica - a Mediterranean coral remarkable for its ability to survive long periods without algal symbionts. Led by Shani Levy and
@xgrau.bsky.social
rdcu.be/eLbaZ
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Cool-cool-cool
add a skeleton here at some point
about 1 month ago
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Hi, can someone point me to good commercial polyclonal anti-FMRF amide antibody, which is not from rabbit? Ideally, tested on cnidarians. Thanks in advance!
about 1 month ago
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www.pnas.org/doi/10.1073/...
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Dual Bmp-negative feedback loops modulate function of both AER and ZPA to buffer and constrain postaxial digit number | PNAS
Several lines of evidence indicate that posterior (postaxial) digit number in tetrapod vertebrates is constrained to the pentadactyl state by inter...
https://www.pnas.org/doi/10.1073/pnas.2427249122
about 1 month ago
0
1
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Sanjay's amazing story is available on
www.biorxiv.org/content/10.1...
Congratulations to
@sanjay-n.bsky.social
,
@ulrichtechnau.bsky.social
and everyone else 🎉
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Notch coordinates self-organization of germ layers and axial polarity in cnidarian gastruloids
Dissociation and reaggregation experiments in several animal systems have revealed the stunning capacity of self-organization. Reaggregated early gastrula cells (here called gastruloids) of the sea an...
https://www.biorxiv.org/content/10.1101/2025.09.09.675057v1.full
about 2 months ago
1
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1
Congratulations to Dr. Paul Knabl
@paulknabl.bsky.social
Fantastic work and excellent defense!
about 2 months ago
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I don't know about "twice". My memory is crappier...
add a skeleton here at some point
2 months ago
0
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www.nature.com/articles/s41...
Cool paper by
@emmanuelhaillot.bsky.social
et al. from Uli Technau's group.
@tclebedeva.bsky.social
and I were also involved 🙃
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Segregation of endoderm and mesoderm germ layer identities in the diploblast Nematostella vectensis - Nature Communications
Recent work suggested that diploblast embryos (Cnidaria) may have germ layers that are similar to those seen in bilaterians, but how these are specified remained unclear. Here, they use scRNA-seq and ...
https://www.nature.com/articles/s41467-025-63287-4
2 months ago
0
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reposted by
Nature
3 months ago
Nature research paper: The genomic origin of the unique chaetognath body plan
go.nature.com/3HAsyyV
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The genomic origin of the unique chaetognath body plan - Nature
Genomic, single-cell transcriptomic and epigenetic analyses show that chaetognaths, following extensive gene loss in the gnathiferan lineage, relied on newly evolved genes and lineage-specific tandem duplications, not caused by a whole-genome duplication event, to shape their distinctive body plan.
https://go.nature.com/3HAsyyV
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www.biorxiv.org/content/10.1...
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Loss of Twist impairs tentacle development and induces epithelial neoplasia in the sea anemone Nematostella vectensis
The basic helix-loop helix transcription factor Twist plays diverse roles in mesodermal development across bilaterians, but its function in cnidarians remains unclear. Here, we investigate the role of...
https://www.biorxiv.org/content/10.1101/2025.08.09.669484v1
3 months ago
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0
www.biorxiv.org/content/10.1...
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Depletion of a neural cell adhesion molecule disrupts both epithelial and germ layer identity in sea anemone embryos
Assembly of cells into epithelial layers marks the early steps of tissue organization and embryonic development in most animals. Although several conserved proteins are known to be essential for epith...
https://www.biorxiv.org/content/10.1101/2025.08.03.668367v1#ref-27
3 months ago
0
5
0
reposted by
Pawel Burkhardt
3 months ago
Ctenophores possess a unique aboral organ that acts as a multisensory center, controlling complex behaviors. We’ve now created a ctenophore model integrated with our 3D volume EM data. Puts it into perspective. Check out our recent work here:
www.biorxiv.org/content/10.1...
#ctenophores
#volumeEM
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Gastruloids employ an alternative morphogenetic route to generate a posterior body axis on adherent substrates
Morphogenesis emerges from the integration of genetic programs with environmental signals, yet studying this interplay in embryos remains challenging due to the inherent complexity of embryonic system...
https://www.biorxiv.org/content/10.1101/2025.08.04.668470v1
3 months ago
0
0
0
reposted by
James Briscoe
3 months ago
A Summer reading recommendation: new primer in
@dev-journal.bsky.social
explains how dynamical systems theory unlocks the logic of developmental patterning Everything from bistable switches & oscillators to phase portraits & more with Python code to explore
journals.biologists.com/dev/article/...
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From genes to patterns: five key dynamical systems concepts to decode developmental regulatory mechanisms
Summary: Dynamical systems theory provides a powerful quantitative and intuitive framework to understand developmental processes. This Primer brings key concepts of this framework to the ever-growing ...
https://journals.biologists.com/dev/article/152/14/dev204617/368764/From-genes-to-patterns-five-key-dynamical-systems
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reposted by
Tiago Simões
4 months ago
A rare job opportunity for Invertebrate Zoology:
fieldmuseum.hrmdirect.com/employment/j...
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Assistant Curator of Invertebrate Zoology, Careers At Field Museum
Position Assistant Curator of Invertebrate Zoology FLSA Status Exempt Department Negaunee Integrative Research Center Our Mission Since the 1893 World Columbian Exposition our organization has aimed...
https://fieldmuseum.hrmdirect.com/employment/job-opening.php?req=3457892&req_loc=919166&&nohd&fbclid=IwQ0xDSwLs1GJjbGNrAuzUW2V4dG4DYWVtAjExAAEeUxM4o1aIW8pqi3sB59NxzXqG4n6hmvz7bw7FhnnkmHak6BZSkP0lVxS0PiA_aem_BP9m-FzUotCPySAj516YGA#job
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reposted by
Rebecca R Helm
4 months ago
BEHOLD! One of Earth's greatest lineages of life: the lil wiggle arm guys, Meteora. These single-celled critters, originally found in deep-sea sediments, are SO DIFFERENT from other lifeforms on Earth that they're likely in their own kingdom (as in, the Animal Kingdom, the Plant Kingdom etc). 🧪🌿
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Tsuyo's cool paper on Wnt3 being both a canonical and a PCP Wnt in Clytia is out
doi.org/10.7554/eLif...
Congratulations to everyone involved!
@biodev-vlfr.bsky.social
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Planar cell polarity coordination in a cnidarian embryo provides clues to animal body axis evolution
The jellyfish embryonic body axis is globally coordinated by conserved planar cell polarity (PCP) mechanisms and oriented by localised Wnt3 in two steps, highlighting PCP’s role in animal axis evoluti...
https://doi.org/10.7554/eLife.104508.3
4 months ago
0
0
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Uri does really cool stuff in Hydractinia
add a skeleton here at some point
5 months ago
0
2
0
David’s
@davidmoersdorf.bsky.social
cool paper about the role of Chordin in BMP signaling in the sea anemone Nematostella is finally out
www.science.org/doi/10.1126/...
loading . . .
Chordin-mediated BMP shuttling patterns the secondary body axis in a cnidarian
Chordin-mediated BMP shuttling is the candidate mechanism for generating bilateral symmetry in the cnidarian-bilaterian ancestor.
https://www.science.org/doi/10.1126/sciadv.adu6347
5 months ago
5
45
16
reposted by
Laurent Formery
5 months ago
Our brittle star patterning study is now out at EvoDevo! 🥳
doi.org/10.1186/s132...
@lowelab.bsky.social
add a skeleton here at some point
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The last part of
@paulknabl.bsky.social
's PhD is now available at
www.biorxiv.org/content/10.1...
Paul showed that BMP signaling is active in the diffuse nervous system of the sea anemone Nematostella and the box jellyfish Tripedalia. Moreover, suppression of BMP signaling in Nematostella leads...
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The anti-neural role of BMP signaling is a side effect of its global function in dorsoventral patterning
In Bilateria with centralized nervous systems (e.g. in vertebrates or arthropods), the minimum of the BMP signaling activity gradient defines the position of the central nervous system. BMP-dependent ...
https://www.biorxiv.org/content/10.1101/2025.06.08.658475v1
5 months ago
3
30
15
Cool paper! Congratulations to
@chemamd.bsky.social
, Emanuel Haillot and everyone else involved!
www.biorxiv.org/content/10.1...
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Developmental system drift in dorsoventral patterning is linked to transitions to autonomous development in Annelida
The Bone Morphogenetic Protein (BMP) pathway is the ancestral signalling system defining the dorsoventral axis in bilaterally symmetrical animals. However, Spiralia, a large bilaterian clade including...
https://www.biorxiv.org/content/10.1101/2025.05.29.656861v1
5 months ago
2
8
4
www.biorxiv.org/content/10.1...
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Mesoglea biogenesis reveals a cryptic aboral valve for pressure regulation in cnidarian morphogenesis
Cnidarians are classically defined by a single oral opening, a hallmark of the blind gut model in early animal evolution. Here, we identify a pressure-sensitive aboral valve in Nematostella vectensis ...
https://www.biorxiv.org/content/10.1101/2025.05.26.656114v1
6 months ago
0
3
1
reposted by
Neil Shubin
6 months ago
New paper from the lab: Our teeth arose as sensory organs on the outside of the body of ancient jawless fish.!! Congrats to Yara Haridy and the team! Background and video:
phys.org/news/2025-05...
Open Access Paper:
www.nature.com/articles/s41...
News and Views:
www.nature.com/articles/d41...
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Teeth first evolved as sensory tissue in the armored exoskeletons of ancient fish, fossil scans find
Anyone who has ever squirmed through a dental cleaning can tell you how sensitive teeth can be. This sensitivity gives important feedback about temperature, pressure—and yes, pain—as we bite and chew ...
https://phys.org/news/2025-05-teeth-evolved-sensory-tissue-armored.amp
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330
reposted by
Cnidarian developmental mechanisms group
6 months ago
"Aboral cell types of Clytia and coral larvae have shared features and link taurine to the regulation of settlement" Kudos to Julia Ramon-Mateu and Anna Ferraioli
@biodev-vlfr.bsky.social
, and thanks to our collaborators for their coral larva expertise
www.science.org/doi/10.1126/...
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Aboral cell types of Clytia and coral larvae have shared features and link taurine to the regulation of settlement
Larvae of jellyfish and corals have specialized sensory cells with shared features potentially linked to settlement regulation.
https://www.science.org/doi/10.1126/sciadv.adv1159
1
35
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reposted by
Iana V. Kim
6 months ago
It's a fantastic collaboration with
@alexdemendoza.bsky.social
,
@pawelburkhardt.bsky.social
,
@joanjsoto.bsky.social
, Sally Leys, Hiroshi Suga,
@crisnava.bsky.social
,
@xgrau.bsky.social
, Marta,
@aelek.bsky.social
,
@zolotarg.bsky.social
,
@seanamontgomery.bsky.social
, Ewa, Didac,
@encent.bsky.social
.
1
9
2
reposted by
Marios Chatzigeorgiou
7 months ago
Our latest peer-reviewed paper is out in
@cp-cellreports.bsky.social
. Zonglai &
@hoyerjorgen.bsky.social
show that the evolutionarily conserved proteins Anoctamin 5 and 6 are involved in sensing chemical and mechanical cues that mediate larval settlement and metamorphosis in Ciona.
add a skeleton here at some point
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Excellent thread 🙃
add a skeleton here at some point
7 months ago
0
2
0
reposted by
Patrick Steinmetz
7 months ago
🚨🧪Help us share: Registration deadline to the MBL
#Symbiosis
course got extended! Join us to get practical experience on a diversity of symbiotic organisms at the legendary MBL in Woods Hole.
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Molecular and Cell Biology of Symbiosis | Marine Biological Laboratory
This is an immersive research-based course designed to teach basic concepts, open research questions, and facilitate state-of-the-art experimental approaches in symbiosis research.
https://www.mbl.edu/education/advanced-research-training-courses/course-offerings/molecular-and-cell-biology-symbiosis
0
5
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reposted by
Thibaut Brunet
7 months ago
Striking new study from
@archaeon-alex.bsky.social
's lab just out in
@science.org
on multicellular development induced by compression in Archaea:
www.science.org/doi/10.1126/...
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Tissue-like multicellular development triggered by mechanical compression in archaea
The advent of clonal multicellularity is a critical evolutionary milestone, seen often in eukaryotes, rarely in bacteria, and only once in archaea. We show that uniaxial compression induces clonal mul...
https://www.science.org/doi/10.1126/science.adu0047
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reposted by
Pauli Group (posts by Andi Pauli)
7 months ago
Become our neighbor!! Check out this amazing opportunity
@imbavienna.bsky.social
- top-notch research environment with fantastic facilities, and all of that in a thriving international environment in beautiful Vienna!
add a skeleton here at some point
1
16
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www.biorxiv.org/content/10.1...
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The xenacoelomorph gonopore is homologous to the bilaterian anus
The bilaterian through gut with an anal opening is a key invention in animals, since it facilitates effective food processing, which allows animals to grow to a larger body size. However, because non-...
https://www.biorxiv.org/content/10.1101/2025.02.10.637358v1
8 months ago
1
3
1
reposted by
Kristina Stapornwongkul
8 months ago
Thrilled to announce that I am looking for a Research Technician/Assistant to join my lab
@imbavienna.bsky.social
. Please consider applying if you’re enthusiastic about
#devbio
#stemcells
#teamwork
and excited to help shaping a new lab! Thankful for any retweet! 🫶
imba.onlyfy.jobs/job/l6u2m980
add a skeleton here at some point
1
50
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reposted by
bioRxiv Developmental Biology
8 months ago
Wnt signaling restores evolutionary loss of regenerative potential in Hydra
https://www.biorxiv.org/content/10.1101/2025.03.18.643955v1
0
2
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Andi does amazing science. Let your Master students-about-to-finish know.
add a skeleton here at some point
8 months ago
0
2
0
Tanya's
@tclebedeva.bsky.social
paper on endomesoderm specification in the beta-catenin-negative area of the Nematostella embryo is out!
www.nature.com/articles/s41...
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β-catenin-driven endomesoderm specification is a Bilateria-specific novelty - Nature Communications
Lebedeva et al. show that unlike Bilateria, the embryo of the cnidarian Nematostella specifies its endomesoderm in the β-catenin-negative domain. In contrast, subsequent β-catenin-dependent axial patt...
https://www.nature.com/articles/s41467-025-57109-w
8 months ago
5
71
27
reposted by
Developmental Biology
8 months ago
#DBfeature
#SeaUrchin🌊
An RNA interference approach for functional studies in the sea urchin and its use in analysis of nodal signaling gradients by Keen Wilson, David R. McClay et al
www.sciencedirect.com/science/arti...
0
7
2
www.nature.com/articles/s41...
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The Hydractinia cell atlas reveals cellular and molecular principles of cnidarian coloniality - Nature Communications
Here they generate a cell type atlas of the colonial cnidarian Hydractinia symbiolongicarpus, which reveals that distinct colony parts are mostly made from unique combinations of shared cell types, an...
https://www.nature.com/articles/s41467-025-57168-z
8 months ago
0
6
1
reposted by
Patrick Steinmetz
8 months ago
Thrilled to share our new prepreprint on the nutritional control of
#Nematostella
Vasa+/Piwi+ cells. Prolonged starvation delays Tor activation & cell cycle re-entry indicating quiescence deepening!
tinyurl.com/2k9azd4y
@eudaldpascual.bsky.social
@ktgarschall.bsky.social
@msarscentre.bsky.social
0
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Our atlas of BMP signaling activity in adult Nematostella is finally out! Fantastic, meticulous work and beautiful illustrations by
@paulknabl.bsky.social
Thanks,
@fwf-at.bsky.social
for funding our work!
bmcbiol.biomedcentral.com/articles/10....
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A whole-body atlas of BMP signaling activity in an adult sea anemone - BMC Biology
Background BMP signaling is responsible for the second body axis patterning in Bilateria and in the bilaterally symmetric members of the bilaterian sister clade Cnidaria—corals and sea anemones. Howev...
https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-025-02150-w
9 months ago
2
63
22
www.biorxiv.org/content/10.1...
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Geometry-driven asymmetric cell divisions pattern cell cycles and zygotic genome activation in the zebrafish embryo
Synchrony in early embryonic cell cycles, followed by gradual desynchronization at the midblastula transition (MBT), is a widely conserved feature across animal phylogeny. Embryos that fail to maintai...
https://www.biorxiv.org/content/10.1101/2025.02.03.636134v1
9 months ago
0
1
0
www.nature.com/articles/s41...
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Regeneration in the absence of canonical neoblasts in an early branching flatworm - Nature Communications
Adult pluripotent stem cells, called neoblasts, are considered a defining feature of all flatworms. This manuscript shows that canonical neoblasts are absent in an early branching flatworm lineage, ra...
https://www.nature.com/articles/s41467-024-54716-x
9 months ago
0
4
0
reposted by
Uri Frank
10 months ago
Gonads and germ cells have an interdependent relationship in the cnidarian
#Hydractinia
. Germ cells secrete a TGF-beta ligand (called Gonadless) to induce and maintain the somatic gonad; gonads activate Tfap2 in pluripotent stem cells (i-cells) to commit them to germ fate
tinyurl.com/245rw699
2
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reposted by
Uri Frank
10 months ago
#Hydractinia
takes regeneration to the extreme¬in a new preprint, Curantz et al. show that dissociated, reaggregated cells can form a new individual. We also show how they do it and which cells types actually contribute to the new individual (tip: not many of them).
tinyurl.com/mr2s9zyf
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