Happy to share the Biodiversity Cell Atlas white paper, out today in @nature.com. We look at the possibilities, challenges, and potential impacts of molecularly mapping cells across the tree of life. www.nature.com/articles/s41...

Brown algae up to some interesting strategies regarding gene repression, losing all "traditional" pathways while expanding the DOT1 (H3K79me writer) protein family! I hope to learn more at the EMBO workshop next month in Barcelona!

Activity of most genes is controlled by multiple enhancers, but is there activation coordinated? We leveraged Nanopore to identify a specific set of elements that are simultaneously accessible on the same DNA molecules and are coordinated in their activation. www.biorxiv.org/content/10.1...

Evolution’s eye game is wild, but mollusks take it to another level CRISPR in apple snails gives us a new model to dissect how nature rebuilds complex organs like the camera-type eyes we humans possess It turns out Evolution doesn’t just innovate, it rewinds, remixes, & regenerates rdcu.be/ezw0t

Very happy to share our new paper where we develop CRISPR-Cas9 genome editing in our favorite unicellular relative of animals, Corallochytrium limacisporum! With @sebasn1.bsky.social @multicellgenome.bsky.social Elena and Claudio. Check it out: royalsocietypublishing.org/doi/10.1098/...

I just published: Academic poaching: when other PIs steal your trainees There are many toxic behaviors in academia, but one we rarely talk about is #AcademicPoaching. Have you ever been a victim? #AcademicChatter #AcademicSky #phdchat medium.com/p/academic-p...

And another opportunity! Any postdocs looking forward to start your lab on a tenure track? Supportive environment, great core facilities and an outstanding PhD program.

New Pre-print! A long-standing question for transcription factor biology is how their chromatin context dependency works in plants. In this collaboration with Fred Berger lab, we present some new ideas not only in Arabidopsis but also in Marchantia. www.biorxiv.org/content/10.1...

We are looking for new colleagues to come join us in Galway as group leaders (Junior and Senior). The Centre for Chromosome Biology is a great place and it is a good time to join. Please reach out if you want to chat about the opportunity! www.nature.com/naturecareer...

Pls. share widely Calling all transposon fans & lovers of genetic innovation MOBILE GENOME welcomes you in Heidelberg, Nov. 4–7 2025 → Vibrant & friendly community → Cutting-edge talks from mechanisms to physiology → Plenty of surprises (TEs never stop innovating) submit abstract by July 29

We are looking for a student to continue our work on chromatin evolution: www.nature.com/articles/s41... www.biorxiv.org/content/10.1... The project with @seanamontgomery.bsky.social will focus on chromatin state readers across eukaryotes. More info: recruitment.crg.eu/content/jobs...

We're looking for a potential PhD student to come explore the evolution of chromatin across eukaryotes in the @arnausebe.bsky.social lab! The project is flexible and a wide range of backgrounds will be considered! Please reach out if you have any questions. Link to application: shorturl.at/LlsJw

A single-cell ATACseq atlas of our favourite sea anemone, Nematostella vectensis! By @aelek.bsky.social @martaig.bsky.social

📖 Happy to share our recent preprint! www.biorxiv.org/content/10.1... We discovered how SINEs are kept silent: the ChAHP protein complex acts as a molecular brake on POL III transcription retrotransposons. A 🧵:

Transcription factors targeting RNA-directed DNA methylation machinery in Arabidopsis reproductive tissues. From: www.nature.com/articles/s41... I think I saw another preprint on this by another lab too.

How 🆒 is this?!? www.cell.com/cell/abstrac...

Updating my intro slides with this fantastic figure now! (And maybe I'll add an extra dashed line for my beloved bryophytes)

1 plant hormone receptor ☘️ 3,500 mutants, to single-site saturation 🧬 >45,000 binding and abundance measurements 📶 Very happy to present our latest work – where deep mutational scanning meets the world of small molecules.

 www.biorxiv.org/content/10.1...

 With @benlehner.bsky.social [1/7]

We’ve uncovered Asgard chromatin structures formed by a Hodarchaeal histone : closed hypernucleosome conserved in archaea and an open form resembling the H3-H4 eukaryotic octasome. Fantastic work by @harshranawat.bsky.social! www.biorxiv.org/content/10.1... #Chromatin #Asgard #Archaea #cryoEM

Our new study of chromatin ubiquitylation by variant PRC1 on the single-molecule scale: We visualize directly how vPRC1 ubiquitylates neighboring nucleosomes during a single binding event, showing a potential mechanism how H2Aub domains are established. www.science.org/doi/10.1126/...

Delighted that our work on positional memory is now published. We asked how axolotl cells 'know' which part of the limb to regenerate after injury. www.nature.com/articles/s41... A joy to work with super team Sarah Plattner, Yuka Sugiura, Francisco Falcon and Elly Tanaka. 🧵1/14

Delighted to see our work now published in @currentbiology.bsky.social. A great place for Bostrychia to stake its claim as an emerging red algal model system. Check it out here: www.cell.com/current-biol...

Check out this tremendous work from @ianakim.bsky.social! An enormous effort to gather micro-C data from 9 species and uncover insights into how animal genome organization evolved and diversified!

💥🥳 At long last, our latest paper is out! Gag proteins of endogenous retroviruses are required for zebrafish development www.pnas.org/doi/10.1073/... Led heroically by Sylvia Chang & @jonowells.bsky.social A study which has changed the way I think of #transposons! No less! 🧵 1/n

🧵 reprise: our paper on protein network evolution in the piRNA genome defence pathway has now been published at @embojournal.org 🥳 Very positive experience with fast and constructive reviewing (thank you, three secret people) and good journal communication. bsky.app/profile/embo...

Our preprint has now found a wonderful home in @molbioevol.bsky.social. Shout out to our collaborators in the Mozgova lab too 💚

In the silence of chromatin, Toxoplasma whispers change. TgSNF2h sculpts the genome - MORC in the backseat. Some genes wake. Others sleep. A dance of nucleosomes shaping space for life parasite stages to unfold. Now in Nature Microbiology: rdcu.be/ehkWp

Excited to see all the EvoChromo people again at this meeting! A fantastic collection of kind and curious researchers made the last edition the top meeting I've attended, and I expect v2 to be even better!

Fantastic study on so many levels, check it out! DNA methylation, chromatin accessibility, developmental biology, horizontal gene transfer, and my favourite, Marchantia! This paper has it all

My group is hiring a new Postdoc to work on gene regulation and chromatin in Nematostella. Please RT! For more information see here: gahanlab.com tinyurl.com/34xke35d

wow, telomeric transposons in bacteria with linear chromosomes! (of course this was first figured out in flies, inc by Bob Levis, who i was happy to see few days ago at the fly meeting). 🪰 www.science.org/doi/10.1126/... www.sciencedirect.com/science/arti... www.sciencedirect.com/science/arti...

Interested in photosynthetic organisms? Looking for a space to focus on research and kick-start your journey as a group leader? We’d love for you to join us. We offer an incredibly competitive package—on par with about 2 ERC grants for 8 years—and a collaborative environment unlike anywhere else 1/2

Relaxed DNA substrate specificity of transposases involved in programmed genome rearrangement 🤯 #TEsky www.biorxiv.org/content/10.1...

🔬 PhD Opportunity in Evolutionary Cell Biology! Interested in how cell types evolve? Join us to investigate placozoan cell types using advanced microscopy, single-cell omics, and functional assays! Apply here: euraxess.ec.europa.eu/jobs/323665 #PhDPosition #EvolutionaryBiology #CellBiology🧪

Excited to share this story from the “Chromatin Dream Team” in the @arnausebe.bsky.social lab on chromatin evo across eukaryotes! 12 histone mark profiles from 12 species, including rhizarians, discobans, and cryptomonads. Read on to see what we found! www.biorxiv.org/content/10.1... 1/n

1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬 But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯 Our new study reveals how retrotransposons invade the germline directly from somatic cells. www.biorxiv.org/content/10.1... A short thread 🧵👇

1/ H3K27me3 mimicry has repeatedly emerged through evolution, but what's the physiological relevance? We show that JARID2 and PALI1 mimic H3K27me3 to antagonise PRC2 in vivo and restrict the spread of Polycomb domains. 🧵 www.biorxiv.org/content/10.1...

After a lot of work, we are finally able to share this project about the cell cycle in Marchantia from the Haseloff lab. If you want to find out how cell division is controlled, you can’t miss out this one… #PlantScience #Synbio #EvoDevo www.biorxiv.org/content/10.1...

We offer three new positions to join BCA Phase 0: 1. A full-stack developer to work on the BCA database with @ebi.embl.org 2. A senior research technician to develop sc methods 3. A bioinformatician to analyze new atlases with @sangerinstitute.bsky.social Details below. Please, share and repost.

🚨Preprint Alert🚨 I'm really happy to finally share our exploits in red algae and introduce the wider community to Bostrychia, the new model system we have been developing to tackle the molecular biology of red algae. Isn't she a beauty? Thread below 🧵 1/8 www.biorxiv.org/content/10.1...

Our latest work: how can compartmentalization emerge in a eukaryotic genome lacking canonical heterochromatin? By investigating bacterial genomes put in yeast, we show that the presence or absence of transcription is sufficient! #chromatin #3Dgenome #generegulation www.science.org/doi/10.1126/... 👇

🔬Decoding Silencing: How Heterochromatin Transcribes to Silence Itself! 🧬 Discover how a pioneer transcription factor-like complex infiltrates repressive heterochromatin, producing transcripts with hidden introns that kickstart RNAi-mediated heterochromatin formation www.nature.com/articles/s41...

Intriguing work on an H3K27me3-reader protein leading to transcriptional activation: www.embopress.org/doi/full/10.... Ciliates continue to impress! The authors also draw nice parallels to Rhino (H3K9me3 reader) and piRNA cluster expression in Drosophila

By definition, enhancers can activate from a distance. But with increased distance between enhancer and promoter, the activation drops. To study this systematically, we build a synthetic locus: www.cell.com/molecular-ce... 1/12

The yeast genome is globally accessible in living cells [new from the group of David Clark] www.nature.com/articles/s41... ▶️Measured DNA accessibility in living budding yeast by inducible expression of methyltransferases ▶️The genome is globally accessible in living cells, unlike in isolated nuclei

behold our paper on Medusavirus nucleosomes. Fantastic work by Chelsea Toner, @nhoitsma.bsky.social, and Sashi Weerawarana This giant virus also encodes a linker histone, more about that in the paper 🧪👩‍🔬 🧵. www.nature.com/articles/s41...

Gene regulation involves thousands of proteins that bind DNA, yet comprehensively mapping these is challenging. Our paper in Nature Genetics describes ChIP-DIP, a method for genome-wide mapping of hundreds of DNA-protein interactions in a single experiment. www.nature.com/articles/s41...

Check out the lab website for more details on what we do! www.sebepedroslab.org

For my first post here, I am happy to share that our latest paper is out at #NAR. Thanks for the smooth and constructive reviewing process and the highlight #RNAbiology #TEsky #smallRNAs (1/8) doi.org/10.1093/nar/...

Very nice to see this work on silencers from the Stark lab! doi.org/10.1016/j.mo...