Sanjay Narayanaswamy
@sanjay-n.bsky.social
📤 229
📥 692
📝 16
Came for science. Staying for the memes. PhD student at
@ulrichtechnau.bsky.social
Lab, Uni Wien
pinned post!
Happy to be presenting our story on Nematostella self-organization :) tune in if you like to hear what organizes the organizer in cnidarian gastruloids!
www.biorxiv.org/cgi/content/...
add a skeleton here at some point
9 months ago
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reposted by
Sanjay Narayanaswamy
James Briscoe
5 days ago
Paying peer reviewers Interview with
@danielgorelick.bsky.social
about
@biologyopen.bsky.social
Fast & Fair trial in which peer reviewers were paid £220/review Spoiler: it works - fast, high quality reviews
www.nature.com/articles/d41...
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Why paying peer reviewers works, according to a journal’s editor-in-chief
A biology journal that paid peer reviewers found that the approach cut the time to a first editorial decision by 85% and maintained high-quality reviews.
https://www.nature.com/articles/d41586-026-01973-z
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reposted by
Sanjay Narayanaswamy
Anna Klompen, PhD
8 days ago
First postdoc paper and first Nematostella project! By using the dynamic expression pattern of minicollagens, we describe the transcriptional profile during biogenesis for two major stinging cell types: nematocytes and spirocytes
www.biorxiv.org/content/10.6...
#StunningStella
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Minicollagen expression dynamics reveal a transcriptional program for cnidogenesis in the sea anemone Nematostella vectensis
Cnidae are explosive harpoon-like organelles localized within stinging cells, or cnidocytes, of the phylum Cnidaria (jellyfish, hydroids, sea anemones, and corals). These unique Golgi-derived vesicula...
https://www.biorxiv.org/content/10.64898/2026.06.23.733813v1.article-metrics
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Sanjay Narayanaswamy
KLI
8 days ago
🌟📣 Check out the new publication of KLI fellow Sanjay Narayanaswamy (
@sanjay-n.bsky.social
) and colleagues: "Notch coordinates self-organization of germ layers and axial polarity in sea anemone gastruloids".
www.nature.com/articles/s41...
Congratulations to the authors! 💐
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Notch coordinates self-organization of germ layers and axial polarity in sea anemone gastruloids - Nature Communications
Here they show that gastruloids made of embryonic cells of the sea anemone Nematostella can robustly regenerate whole organisms. They show that Notch signaling is crucial to sort out the randomly disp...
https://www.nature.com/articles/s41467-026-74441-x
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reposted by
Sanjay Narayanaswamy
William DeWitt
10 days ago
Spectacular preprint led by
@sydsat.bsky.social
in
@ohnolog.bsky.social
lab,
@uwgenome.bsky.social
. Neutrophils precede gastrulation in killifish and rapidly patrol the yolk. (1/2)
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Early immune cell development precedes gastrulation in annual killifish
During embryogenesis, cell types arise in a predictable order because developmental regulators act sequentially. But how evolutionary changes in morphogenesis reshape the signaling environments that a...
https://doi.org/10.64898/2026.06.25.734555
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reposted by
Sanjay Narayanaswamy
19 days ago
Congratulations to
@kremnyovs.bsky.social
,
@tclebedeva.bsky.social
and
@hejnol.bsky.social
- this is a fantastic paper.
www.nature.com/articles/s41...
Very happy to have been part of this collaboration.
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A blastoporal organizer in a ctenophore - Nature
Experiments using the comb jelly Mnemiopsis leidyi and the sea anemone Nematostella vectensis reveal that the emergence of a core signalling pathway may have been a key innovation enabling the transit...
https://www.nature.com/articles/s41586-026-10643-z
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reposted by
Sanjay Narayanaswamy
about 2 months ago
Here’s the last major paper from the PhD of
@paulknabl.bsky.social
. We were trying to understand what BMP signaling does in the sea anemone Nematostella when it is not patterning its second body axis. Check out Part 1 in BMC Biol. 2025; and here's is our Part 2
journals.plos.org/plosbiology/...
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The anti-neural role of BMP signaling is a consequence of its ancestral function in dorsoventral patterning
Bilaterian animals with centralized nervous systems have patterns of BMP signaling activity gradient that suggest an “anti-neural” ancestral role, but the evidence for this remains unclear. This study...
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3003803
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reposted by
Sanjay Narayanaswamy
James Briscoe
about 1 month ago
Is this the future of peer review? New from
@biologyopen.bsky.social
: expanded Fast & Fair trial paying reviewers £220 per paper The result: rapid peer review with no drop in quality or change in acceptance rate Paying referees makes peer review faster & fairer
www.biorxiv.org/content/10.6...
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https://www.biorxiv.org/content/10.64898/2026.06.02.729548v1
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Sanjay Narayanaswamy
3 months ago
🚨 Why can’t mammals regenerate limbs like frog tadpoles or salamanders? In our new paper in
@science.org
, we show that species-specific oxygen sensing acts as a gatekeeper for initiating limb regeneration 🐭🐸 🔗
www.science.org/doi/10.1126/...
#EvoDevo
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Species-specific oxygen sensing governs the initiation of vertebrate limb regeneration
Why mammals cannot regenerate limbs like amphibians do presents a long-standing puzzle in biology. To uncover the underlying differences, we compared amputation responses of embryonic mouse (Mus musculus) and Xenopus laevis tadpole limbs. Lowering ...
https://www.science.org/doi/10.1126/science.adw8526
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reposted by
Sanjay Narayanaswamy
Joshua Frenster
4 months ago
The Frenster Lab is here! 🍾 I am so excited to start my
#EmmyNoether
funded group at
@uni-freiburg.de
this summer. Our group studies
#CellCompetition
dynamics during embryonic development using
#gastruloids
from multiple species. Thanks to the
@dfg.de
for creating this opportunity!
FrensterLab.com
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Frenster Lab | Cell Competition Dynamics
We study Cell Competition during Embryonic Development using 3D Gastruloids at the University of Freiburg. We view cells as interactive societies in development and cancer. Research, stem cells, Gastr...
https://FrensterLab.com
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reposted by
Sanjay Narayanaswamy
Gesellschaft für Entwicklungsbiologie e.V.
4 months ago
That's it:
#GfE2026
#GfESEBDDSDB2026
is over. Thanks for the science, talks, posters, chairing, discussions, helpers in back & front. See you latest at
#GfE2028
for more
#DevBio
& oidsks for all the fish, plants, mice, worm, flies, frogs, squids, brown algae, human, -oids, whatnots and you.
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Sanjay Narayanaswamy
Tatiana Lebedeva
4 months ago
Honored and very grateful to receive the GfE PhD Award 2026! Many thanks to GfE for the recognition of our work! This would not have been possible without the guidance of my supervisor
@genikhovich.bsky.social
and the many amazing collaborators and colleagues who contributed along the way ❤️.#GfE2026
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reposted by
Sanjay Narayanaswamy
Gesellschaft für Entwicklungsbiologie e.V.
4 months ago
The GfE PhD Award 2026 goes to Tatiana Lebedeva (
@tclebedeva.bsky.social
) for her outstanding contribution to developmental biology. She presents the topic of her thesis on the "Role of β-Catenin signaling in germ layer specification in Cnidaria".
#GfE2026
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reposted by
Sanjay Narayanaswamy
Alex Eve
4 months ago
#gfe2026
@gfeev.bsky.social
PhD Award goes to Tatiana Lebedeva 🎉 for Tatiana's thesis investigating the role of β-catenin in specifying germ layers in one of my favourite organisms, the starlet sea anemone, Nematostella.
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reposted by
Sanjay Narayanaswamy
Proceedings of the National Academy of Sciences
4 months ago
Opinion piece: Can space be democratized? India’s frugal #space innovation offers key lessons for #EmergingNations. In PNAS Front Matter:
https://ow.ly/QN1N50Yn1ps
#space
#EmergingNations
#ISRO
#India
#Chandrayaan3
#SpaceProgram
#NASA
#MAVENOrbiter
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reposted by
Sanjay Narayanaswamy
Matt Gibson
4 months ago
New preprint from Ruohan Zhong on the architecture of the Nematostella nervous system, check it out!
www.biorxiv.org/content/10.6...
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https://www.biorxiv.org/content/10.64898/2026.01.28.701697v1
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Sanjay Narayanaswamy
Michael Sars Centre
5 months ago
New paper out in
@bmc.springernature.com
🤩👏 A routine 5-ethynyl uridine (EU) RNA labeling experiment in a sea anemone turned into detective work for
@malinkjosavik.bsky.social
,
@ktgarschall.bsky.social
&
@prhsteinmetz.bsky.social
🕵️♀️
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A widely used RNA assay labels the wrong molecules in several model organisms
After a routine experiment raised suspicions, Steinmetz group researchers joined forces with collaborators to highlight the limitations of a commonly used RNA labeling product.
https://www.uib.no/en/michaelsarscentre/181287/widely-used-rna-assay-labels-wrong-molecules-several-model-organisms
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reposted by
Sanjay Narayanaswamy
Jakub Harnos lab
6 months ago
New Paper Alert! 1982: WNT discovered 1990s: NOTCH enters the stage 2000s: “Let’s study pathways separately.” 2025: “Actually, they talk to each other.” Welcome to the era of WNT-NOTCH crosstalk Great collaboration with Mašek lab (CZ) and G. Collu (US)
royalsocietypublishing.org/rsob/article...
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Decoding ‘Wntch’: the intertwined Wnt and Notch pathways in development and disease
Abstract. Multicellularity emerges from the ability of cells to undergo functional differentiation. One of the key mechanisms that enables this coordinatio
https://royalsocietypublishing.org/rsob/article/16/1/250282/479550/Decoding-Wntch-the-intertwined-Wnt-and-Notch
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reposted by
Sanjay Narayanaswamy
Inés Fournon Berodia
7 months ago
Thrilled to share the preprint from my PhD! 🥳 Where I characterised epithelial cell extrusion in a sea anemone 🔗
www.biorxiv.org/content/10.6...
Big thanks to my supervisor
@prhsteinmetz.bsky.social
and coauthors
@noahbruderer.bsky.social
@lionlchristiaen.bsky.social
at🇳🇴
@msarscentre.bsky.social
⬇️🧵
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Sanjay Narayanaswamy
Andy Baxevanis
7 months ago
A new Hydractinia single-cell atlas from the Schnitzler lab: >47K cells from feeding polyps and stolon tissue that refines major somatic cell lineages and recovers a novel population of putative immune cells – a valuable resource for the cnidarian research community and beyond!
tinyurl.com/hsymSC
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An updated and spatially validated somatic single-cell atlas of Hydractinia symbiolongicarpus - BMC Genomics
Single-cell RNA sequencing (scRNA-seq) has revolutionized transcriptomic research, enabling the creation of detailed tissue, organ, and species-level atlases for model organisms. In Hydractinia, a cni...
https://tinyurl.com/hsymSC
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reposted by
Sanjay Narayanaswamy
Paul Knabl
7 months ago
Congrats to Nadja and the
@tessmarraiblelabs.bsky.social
. Check out their cool new work (featuring a small sketch I made)!
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reposted by
Sanjay Narayanaswamy
Tessmar-Raible Labs
7 months ago
Freshly out at
@natcomms.nature.com
! Our
@univie.ac.at
@awi.de
@viennabiocenter.bsky.social
@ercgrantees.bsky.social
research into neurogenic plasticity of adult worm brains, and similarities in stem cells supporting growth of camera-type eyes.
www.nature.com/articles/s41...
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This is so cool :)
add a skeleton here at some point
7 months ago
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reposted by
Sanjay Narayanaswamy
Oded Rechavi
9 months ago
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
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Sanjay Narayanaswamy
Nat Clarke
9 months ago
🚨 My lab is hiring at all levels! Interested in animal origins & evolutionary cell biology? I'm recruiting a postdoc, PhD students & a research assistant to study the molecular evolution of cell adhesion using marine invertebrates + comparative genomics. 🔗:
clarkelab.com/join/
Please repost!
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reposted by
Sanjay Narayanaswamy
Kate Cavanaugh
9 months ago
See this? This = implanting mouse embryo. Usually this happens inside its mother and is invisible to us, but we can actually watch implantation ex vivo with the hope of understanding why implantation goes awry in embryos of older women. A 🧵...
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Sanjay Narayanaswamy
Arnau Sebé-Pedrós
10 months ago
Happy to share the Biodiversity Cell Atlas white paper, out today in
@nature.com
. We look at the possibilities, challenges, and potential impacts of molecularly mapping cells across the tree of life.
www.nature.com/articles/s41...
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reposted by
Sanjay Narayanaswamy
9 months ago
Just came back from a great meeting in Tutzing on the biology of basal Metazoa. Excellent talks, fantastic posters and very kind and vital community. Thanks also to our keynote speaker, Cassandra Extavour. She was the highlight of the meeting. Thanks everyone for contributing.
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Sanjay Narayanaswamy
Virtual Gastrulation Zoom Talks
9 months ago
We are excited to announce the first Western VGZT of Season 7! 🎉 🗓️ Thursday, October 2nd ⏰ 9:30 PDT / 12:30 EDT / 16:30 UTC / 17:30 BST / 18:30 CET Our speakers: 👉 Antonia Weberling (
@a-weberling.bsky.social
) 👉 Sanjay Narayanaswamy (
@sanjay-n.bsky.social
)
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Happy to be presenting our story on Nematostella self-organization :) tune in if you like to hear what organizes the organizer in cnidarian gastruloids!
www.biorxiv.org/cgi/content/...
add a skeleton here at some point
9 months ago
0
14
5
reposted by
Sanjay Narayanaswamy
Development
10 months ago
Hydra body axis balance: a fight between two transcription factors This Research Highlight showcases the work from Jaroslav Ferenc, Marylène Bonvin, Panagiotis Papasaikas, Jacqueline Ferralli, Clara Nuninger and Charisios D. Tsiairis:
journals.biologists.com/dev/article/...
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reposted by
Sanjay Narayanaswamy
10 months ago
We knew that cnidarians have stunning regenerative capacities. But the molecular and cellular mechanisms underlying the self-organization of gastruloids of Nematostella surprised us. A story of cell sorting and Notch signaling. Please check out the work of Sanjay's PhD work:
doi.org/10.1101/2025...
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🚨 Happy to share my PhD work! We set out to find what organizes the organizer in Nematostella gastruloids. While we knew Wnt1/3+ cells confer axial polarity, we identify the role of Notch signaling as partner in crime in polarising these organizers. How does it do it?
www.biorxiv.org/cgi/content/...
add a skeleton here at some point
10 months ago
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3
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reposted by
Sanjay Narayanaswamy
10 months ago
Finally, the excellent postdoc work of Emmanuel Haillot is out, where he dissected the integration of Wnt, MAPK and Notch signaling in defining mesoderm and endoderm identities in the diploblast Nematostella. Strikingly similar to sea urchins.
www.nature.com/articles/s41...
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reposted by
Sanjay Narayanaswamy
12 months ago
Great opportunity! The Uni Vienna has launched a call (APART) for 4-funding for outstanding postdocs from a US institution. The host lab has to nominate by 1 August a candidate for further selection. Anyone interested in our work please contact me by email with CV/motivation letter. Hurry up!
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Nematostella butt valve!
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about 1 year ago
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reposted by
Sanjay Narayanaswamy
Alfonso Martinez Arias
about 1 year ago
In which we discuss the homologies between amphibian and mammalian organizers from the perspective of
#gastruloids
with special relevance to recently described A and C gastruloids as containing Spemann/Mangold and Trunk/Tail organizers
www.sciencedirect.com/science/arti...
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We review self-organisation of organizers through the lens of Cnidarians (primarily Hydra and Nematostella) and propose an integrative Mechanochemical view for the same. Happy to be part of the 100 year Mangold-Spemann special edition
@cellsdev.bsky.social
@ulrichtechnau.bsky.social
add a skeleton here at some point
about 1 year ago
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reposted by
Sanjay Narayanaswamy
about 1 year ago
About 100 years the Mangold-Spemann organizer was published and this has been one of the most fruitful and inspiring concepts in Developmental Biology. But how can organizers self-organize? In this review we summarize the knowledge how cnidarians do that:
doi.org/10.1016/j.cd...
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Redirecting
https://doi.org/10.1016/j.cdev.2025.204024
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reposted by
Sanjay Narayanaswamy
Ste Tavano
over 1 year ago
Here our model of how LME animal migration ends. I am happy to see this work out! As for cell migration in vivo, the path of this journey hasn’t always been straightforward. It is the closing of a chapter, and I look forward to what the future will bring.
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Happy to have presented our evolving story at
#DevStem2025
. Exciting stuff on the way :)
add a skeleton here at some point
over 1 year ago
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0
reposted by
Sanjay Narayanaswamy
Tessmar-Raible Labs
over 1 year ago
Kick-off of the late afternoon session at the
#DevStem2025
meeting. Sanjay Narayanaswamy
@sanjay-n.bsky.social
from
@ulrichtechnau.bsky.social
lab discusses germ layer biology in
#Nematostella
, exploring a powerful gastruloid system. For a primer on gastruloids, see
doi.org/10.1016/j.cd...
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reposted by
Sanjay Narayanaswamy
Kristina Stapornwongkul
over 1 year ago
We’re looking for PhD students to join the lab! 🧫🧑🔬 Curious about how metabolic processes shape patterning and morphogenesis? Enthusiastic about stem cell models for human development? - Then apply through the VBC PhD program!
training.vbc.ac.at/phd-program/
‼️Deadline: April 15‼️
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PhD Program
Empowering Curious Researchers at the Vienna BioCenter PhD Program Are you a curious and motivated student looking to launch a successful scientific career? Look no further than the Vienna BioCenter P...
https://training.vbc.ac.at/phd-program/
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reposted by
Sanjay Narayanaswamy
the Node
over 1 year ago
Unexpected role of β-catenin signaling in germ layer specification In this 'Show and tell' post,
@genikhovich.bsky.social
and
@tclebedeva.bsky.social
tell us about their video of a GFP-β-catenin knock-in Nematostella embryo from their latest paper: 🎥
thenode.biologists.com/unexpected-r...
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Beautiful!
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over 1 year ago
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Arguably the most significant step forward in discovery dissemination.
add a skeleton here at some point
over 1 year ago
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reposted by
Sanjay Narayanaswamy
Biology Open
over 1 year ago
We are excited to be launching the next phase of our Fast & Fair peer review initiative: offering high-quality peer review within 7 working days.
#fastandfairpeerreview
Read the Editorial by EiC Daniel Gorelick
@danielgorelick.bsky.social
at:
bit.ly/4kYD1mL
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Sanjay Narayanaswamy
Eszter Posfai
over 1 year ago
How many cells do you need to establish PCP? The magic number is 3! Beautiful work by Lena Basta in Danelle Devenport's lab. Happy to have contributed.
www.science.org/doi/10.1126/...
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Epithelial polarization by the planar cell polarity complex is exclusively non–cell autonomous
For cells to polarize collectively along a tissue plane, asymmetrically localized planar cell polarity (PCP) complexes must form intercellular contacts between neighboring cells. Yet, it is unknown wh...
https://www.science.org/doi/10.1126/science.ads5704?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
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Had an amazing time presenting some of our work with
#Nematostella
at the
#gastruloids
meeting in beautiful Barcelona. Lots of science and cool breeze!
over 1 year ago
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reposted by
Sanjay Narayanaswamy
Richard Behringer
over 1 year ago
Developmental biology research leads to fundamental discoveries for biomedical research. Apoptosis. Ellis & Hovitz, 1986. PMID: 3955651. Worm image by Tokiko Furuta (Arur Lab)
@socdevbio.bsky.social
9/12
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Sanjay Narayanaswamy
Development
over 1 year ago
In preprints: the ins and outs of Cnidaria germ layers Lucas Leclère and Chiara Sinigaglia
@chisinig.bsky.social
(
@cnidevo.bsky.social
@biom-banyuls.bsky.social
) discuss 3 recent
#preprints
about the mechanisms that govern germ layer formation in Nematostella vectensis:
doi.org/10.1242/dev....
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