Cosmin Tudose
@cosmintudose.bsky.social
📤 54
📥 88
📝 17
Postdoctoral researcher @IBCII Perturbation Genomics Lab Omics | Bioinformatics | Cancer
pinned post!
Pleased that the 2nd part of my PhD is now available as a preprint! Here, we investigated the epigenomic and transcriptomic changes occurring upon PRC2 depletion in AML cells.
biorxiv.org/content/10.1...
. A thread🧵1/17
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Diverse epigenomic mechanisms underpin transcriptional dysregulation in Polycomb-altered acute myeloid leukemia
Background Polycomb Repressive Complex 2 (PRC2) modulates chromatin accessibility and architecture to direct tissue-specific gene expression. PRC2 function is frequently altered in cancer by loss-of-f...
https://biorxiv.org/content/10.1101/2025.08.28.672871v1
4 months ago
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reposted by
Cosmin Tudose
Colm Ryan
about 1 month ago
Great to see this out, collaboration with the Bond lab
@sysbioire.bsky.social
to understand consequences of EZH2 mutation in T-acute lymphoblastic leukaemia (T-ALL). Congrats to
@lefeivret.bsky.social
@cosmintudose.bsky.social
and other authors not on bluesky!
ashpublications.org/bloodadvance...
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Reduced PRC2 function causes asparaginase resistance in T-ALL by decreasing WNT pathway activity
Key Points. Reduced PRC2 function in T-ALL is associated with asparaginase resistance that is linked to reduced WNT/STOP pathway activity.Asparaginase resi
https://ashpublications.org/bloodadvances/article/doi/10.1182/bloodadvances.2024015408/556934/Reduced-PRC2-function-causes-asparaginase
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Pleased that the 2nd part of my PhD is now available as a preprint! Here, we investigated the epigenomic and transcriptomic changes occurring upon PRC2 depletion in AML cells.
biorxiv.org/content/10.1...
. A thread🧵1/17
loading . . .
Diverse epigenomic mechanisms underpin transcriptional dysregulation in Polycomb-altered acute myeloid leukemia
Background Polycomb Repressive Complex 2 (PRC2) modulates chromatin accessibility and architecture to direct tissue-specific gene expression. PRC2 function is frequently altered in cancer by loss-of-f...
https://biorxiv.org/content/10.1101/2025.08.28.672871v1
4 months ago
1
5
3
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