(1/3) Excited to share our latest work using @depmap.org to uncover a new synthetic lethality in two distinct patient populations! We found that SKI complex inactivation through two independent genomic alterations creates a dependency on PELO #CancerResearch #SyntheticLethality #Genomics #DepMap

Exciting new synthetic lethal target emerging from #depmap data 🧪🧬 Frequent passenger mutations in genes involved in mRNA quality control lead to a dependency on PELO-HBS1L Congratulations to the DepMap team! @vazquezf.bsky.social #depmap #cancertarget #syntheticlethal

Exciting new synthetic lethal target emerging from #depmap data 🧪🧬 Frequent passenger mutations in genes involved in mRNA quality control lead to a dependency on PELO-HBS1L Congratulations to the DepMap team! @vazquezf.bsky.social #depmap #cancertarget #syntheticlethal

Exciting new synthetic lethal target emerging from #depmap data 🧪🧬 Frequent passenger mutations in genes involved in mRNA quality control lead to a dependency on PELO #depmap #cancertarget #syntheticlethal

📣Registration is now open for an exciting Gordon Conference on synthetic lethality organized by Ben Schwartz (GSK), Mathew Garnett (Sanger), and Francisca Vazquez (DepMap Director, Broad Institute) Highly recommended! Register here grc.org/synthetic-le...

DepMap keeps growing—and so does the portal! To help navigate the portal, new in 24Q4 we’ve launched a new resource page 🚀! Check it out and share your feedback.

We’re kicking off the first DepMap post with a bang! ⭐ 35 CRISPR screens ⭐ NEW data from our Pediatric Dependencies Accelerator Program (learn more at PedDep.org) ⭐ First 281 WES -> WGS ⭐ New Resources page 📣 DepMap is now on dbGaP (phs003444.v1.p1) Read our release notes for more info!