Our paper benchmarking foundation models for perturbation effect prediction is finally published 🎉🥳🎉 www.nature.com/articles/s41... We show that none of the available* models outperform simple linear baselines. Since the original preprint, we added more methods, metrics, and prettier figures! 🧵

In times when science must defend itself, the decision by the German Research Foundation (DFG) to significantly support German universities through the Excellence Initiative for the next seven years is a signal that stands unparalleled. www.dfg.de/en/news/news...

Such a wonderful example of what genetic screens can tell us about human patho/physiology. Cudos @mgarnett.bsky.social, Fiona Behan and many more.

Congratulations! & thanks for letting us contribute to this wonderful story.

A record low…. only 16% of Germans think that Germany can trust the US. A record fast…. never before lost a US president support for its political agenda that fast. www.spiegel.de/politik/deut...

If a team wished to include combinatorial gene perturbation and bioinformatics in their program, please reach out.

New Gordon Research Conference Alert: Synthetic Lethality Approaches in Oncology. www.grc.org/synthetic-le.... Join us 20-25th July 2025 for an intimate meeting with thought leaders in the field. Great for networking and opportunities for early career scientists to present their research.

80% of Germans (84% participation) voted for democracy. #TogetherAgainstPopulism

Interested in synthetic lethality or how functional genomics can be leveraged for clinical benefit? Then, this is the place to meet: www.grc.org/synthetic-le...

If you search for unexpected phenotypes (genetic interactions), aren't they expected when observed? 🤔

Which rate do you consider appropriate, 10% or 1% ?

Thinking about grant alternatives to fund basic research? Provocative thought - How about getting a royalty rate per accessed publication (per corresponding author)?

📣Registration is now open for an exciting Gordon Conference on synthetic lethality organized by Ben Schwartz (GSK), Mathew Garnett (Sanger), and Francisca Vazquez (DepMap Director, Broad Institute) Highly recommended! Register here grc.org/synthetic-le...

FYI 🔔The abstract deadline for #cshlnetworks is coming up - Jan. 27th! Register to submit your abstract here: bit.ly/40cIfSl @fritzroth.bsky.social @jsvanleeuwen.bsky.social @pedrobeltrao.bsky.social

The German Research Council, aka DFG, is on BlueSky. Welcome @dfgpublic.bsky.social

Make your mark on the future of #PrecisionMedicine at #CRISPR25! Showcase #CRISPR methods for modulating the genome at scale🧬 𝗦𝘂𝗯𝗺𝗶𝘁 𝗮𝗻 𝗮𝗯𝘀𝘁𝗿𝗮𝗰𝘁 𝗯𝘆 𝟰 𝗙𝗲𝗯𝗿𝘂𝗮𝗿𝘆 for a chance to build your professional profile at the forefront of a global community. 📎 bit.ly/3BDXOtP

Are you interested in how genes/proteins interact to regulate cellular and organismal physiology? If so, let's grab a coffee at the upcoming #CSHL Network Biology meeting. meetings.cshl.edu/meetings.asp...

I messed up my earlier message by using the wrong link/date. So here is the correction!! See you in Hinxton (2–4 April, 2025) coursesandconferences.wellcomeconnectingscience.org/event/crispr...

Wow ! Not only the topic, but look at this line up of speakers. How can one not go?

Look who's here @pnas.org ✔️ @science.org ✔️ @naturecellbiology.bsky.social ✔️ @natrevgenet.bsky.social ✔️ @naturebiotech.bsky.social ✔️ @naturemicrobiol.bsky.social ✔️ @naturechemistry.bsky.social ✔️ @genesdev.bsky.social ✔️ @cellchembiol.bsky.social ✔️ @genomeresearch.bsky.social ✔️ @jcellbiol.bsky.social ✔️

I’ll be pitching a Mosbacher Kolloquium at the next annual meeting of the German Society for Biochemistry and Molecular Biology (GBM). The topic will be „Advances in gene regulation, editing, and medicine“. Anything that you’d like to be highlighted? gbm-online.de/en/the-gbm-2...

Join us for the 6th CRISPR and Beyond Conference on 2-4 April 2025!🧬 A must-attend event for researchers in high-throughput screening and #GeneEditing, exploring emerging technologies and models. #CRISPR25 👉Programme and registration: bit.ly/3Amz34N

Incredibly proud of my PhD student @MartinWegner for receiving this year’s PhD award of the @GoetheUniversityFrankfurt. 🎉🎊🥳🍾 I guess with 11 papers, multiple patents, and a spinoff, it’s kind of deserved 🤔