#PERTomics, the systematic functional perturbation of genes and quantification of subcellular, cellular, and organismal responses. To functionally annotate uncharacterized genes, build genetic interaction maps, identify drug dependencies and synergies, and understand polygenetic biology.

DNA guides instead of RNA?! A CRISPR-Cas12a system flips the script, using DNA guides to target RNA. 🔬 Enables direct RNA detection + knockdown 🧬 Reveals a distinct activation mechanism ⚙️ Expands the toolbox for programmable RNA control Big step for CRISPR versatility. www.nature.com/articles/s41...

Excited host @hohmannulrich.bsky.social from @imbmainz.bsky.social, along with @manuelkaulich.bsky.social Date: 07.04.2026 Time: 15:00 Venue: Haus 22 Seminar Room 1. (S22-1) Title: ‘Mechanistic insights into nuclear mRNA export and degradation’ @goetheuni.bsky.social @cpi-exstra.bsky.social

A fantastic line up of speakers. Hope to see many of you in wonderful Mainhatten (Frankfurt).

Happy to share another paper from the lab. While KEAP1 is often mutated in aggressive lung cancer, its loss can paradoxically suppress tumor growth in certain contexts by inducing Nrf2-driven reductive stress. link.springer.com/article/10.1...

How do immune disease-relevant variants rewire gene regulation in CD4+ T cells? In a collaboration led by Daniel Schraivogel and Lars Steinmetz at @embl.org, we combined two large-scale CRISPRi screens (4.1M cells) to map the downstream cascades of thousands of SNPs.

Out now on bioRxiv! 🧬🖥️ Dewi Moonen, @anniquec.bsky.social and a team led by Lars Steinmetz and Daniel Schraivogel at EMBL have mapped the downstream regulatory networks of thousands of immune disease-relevant variants in CD4+ T cells www.biorxiv.org/content/10.6...

Very proud to see this work out on bioRxiv. Using genome-scale TAP/Perturb-seq we mapped the function of immune-disease variants to target genes and regulatory cascades. Have a look at the 🧵from @anniquec.bsky.social for more info!

So great to this preprint out. It was/is such a pleasure to work with this fantastic team. Congratulations to all of you!

Our preprint is published in MSB! This time with the correct preprint post below! link.springer.com/article/10.1...

The public event "CRISPR Gene scissors in Dresden" is taking place March 26 to 29. The "CRISPR-Roadshow" is teaming up with partners @mpi-cbg.de, @tudresden.bsky.social, and @crtd-tud.bsky.social for a wide range of activities on the CRISPR/Cas method. www.crispr-whisper.de/2025/10/01/d...

Insights from the 2nd EuroDepMap Symposium are now out in FEBS Letters. Last November at Human Technopole researchers in cancer functional genomics and computational biology discussed challenges and future directions in mapping cancer vulnerabilities and building predictive frameworks. Link ⬇️

Our thoughts, impressions, and presentations of the "2nd EuroDepMap symposium" in Milan (Nov 2025) are online at @febsletters.bsky.social. febs.onlinelibrary.wiley.com/doi/10.1002/...

💫 Thank you to all participants and speakers who joined us at the 2nd @eurocancerdepmap.bsky.social Symposium! Together, we’re advancing #cancer functional genomics across Europe. youtu.be/Qt_ozbzM5js

The Synthetic Lethality and Innovations in CRISPR Screening session begins with @manuelkaulich.bsky.social telling us about exciting CRISPR libraries they have developed and how nuclear mRNA processing can mask the CRISPRko phenotypes @eurocancerdepmap.bsky.social

Our paper benchmarking foundation models for perturbation effect prediction is finally published 🎉🥳🎉 www.nature.com/articles/s41... We show that none of the available* models outperform simple linear baselines. Since the original preprint, we added more methods, metrics, and prettier figures! 🧵

In times when science must defend itself, the decision by the German Research Foundation (DFG) to significantly support German universities through the Excellence Initiative for the next seven years is a signal that stands unparalleled. www.dfg.de/en/news/news...

Such a wonderful example of what genetic screens can tell us about human patho/physiology. Cudos @mgarnett.bsky.social, Fiona Behan and many more.

Congratulations! & thanks for letting us contribute to this wonderful story.

A record low…. only 16% of Germans think that Germany can trust the US. A record fast…. never before lost a US president support for its political agenda that fast. www.spiegel.de/politik/deut...

If a team wished to include combinatorial gene perturbation and bioinformatics in their program, please reach out.

New Gordon Research Conference Alert: Synthetic Lethality Approaches in Oncology. www.grc.org/synthetic-le.... Join us 20-25th July 2025 for an intimate meeting with thought leaders in the field. Great for networking and opportunities for early career scientists to present their research.

80% of Germans (84% participation) voted for democracy. #TogetherAgainstPopulism

Interested in synthetic lethality or how functional genomics can be leveraged for clinical benefit? Then, this is the place to meet: www.grc.org/synthetic-le...

If you search for unexpected phenotypes (genetic interactions), aren't they expected when observed? 🤔

Which rate do you consider appropriate, 10% or 1% ?

Thinking about grant alternatives to fund basic research? Provocative thought - How about getting a royalty rate per accessed publication (per corresponding author)?

📣Registration is now open for an exciting Gordon Conference on synthetic lethality organized by Ben Schwartz (GSK), Mathew Garnett (Sanger), and Francisca Vazquez (DepMap Director, Broad Institute) Highly recommended! Register here grc.org/synthetic-le...

FYI 🔔The abstract deadline for #cshlnetworks is coming up - Jan. 27th! Register to submit your abstract here: bit.ly/40cIfSl @fritzroth.bsky.social @jsvanleeuwen.bsky.social @pedrobeltrao.bsky.social

The German Research Council, aka DFG, is on BlueSky. Welcome @dfgpublic.bsky.social

Make your mark on the future of #PrecisionMedicine at #CRISPR25! Showcase #CRISPR methods for modulating the genome at scale🧬 𝗦𝘂𝗯𝗺𝗶𝘁 𝗮𝗻 𝗮𝗯𝘀𝘁𝗿𝗮𝗰𝘁 𝗯𝘆 𝟰 𝗙𝗲𝗯𝗿𝘂𝗮𝗿𝘆 for a chance to build your professional profile at the forefront of a global community. 📎 bit.ly/3BDXOtP

Are you interested in how genes/proteins interact to regulate cellular and organismal physiology? If so, let's grab a coffee at the upcoming #CSHL Network Biology meeting. meetings.cshl.edu/meetings.asp...

I messed up my earlier message by using the wrong link/date. So here is the correction!! See you in Hinxton (2–4 April, 2025) coursesandconferences.wellcomeconnectingscience.org/event/crispr...

Wow ! Not only the topic, but look at this line up of speakers. How can one not go?

Look who's here @pnas.org ✔️ @science.org ✔️ @naturecellbiology.bsky.social ✔️ @natrevgenet.bsky.social ✔️ @naturebiotech.bsky.social ✔️ @naturemicrobiol.bsky.social ✔️ @naturechemistry.bsky.social ✔️ @genesdev.bsky.social ✔️ @cellchembiol.bsky.social ✔️ @genomeresearch.bsky.social ✔️ @jcellbiol.bsky.social ✔️

I’ll be pitching a Mosbacher Kolloquium at the next annual meeting of the German Society for Biochemistry and Molecular Biology (GBM). The topic will be „Advances in gene regulation, editing, and medicine“. Anything that you’d like to be highlighted? gbm-online.de/en/the-gbm-2...

Join us for the 6th CRISPR and Beyond Conference on 2-4 April 2025!🧬 A must-attend event for researchers in high-throughput screening and #GeneEditing, exploring emerging technologies and models. #CRISPR25 👉Programme and registration: bit.ly/3Amz34N

Incredibly proud of my PhD student @MartinWegner for receiving this year’s PhD award of the @GoetheUniversityFrankfurt. 🎉🎊🥳🍾 I guess with 11 papers, multiple patents, and a spinoff, it’s kind of deserved 🤔