And that's the Open Targets Hackathon done! 🧬🖥️ Thank you to everyone who joined in person and online, and who contributed to make this event a success Particular thanks to our sponsors: Gates Foundation, Google Cloud, and @thehyvenl.bsky.social 🎉

Open Targets Hackathon Day 1! Following our official kick off yesterday, there was some incredible energy and focus in the room Thanks to our sponsors Gates Foundation, Google Cloud, and @thehyvenl.bsky.social for making this possible!

The Open Targets Hackathon is today! 🎉 We're super excited to kick off this event celebrating 10 years of the Open Targets Platform Thank you to Google Cloud for sponsoring our compute and Hariprasad Radhakrishnan for mentoring our teams and sharing this video — made with Google Veo 3! 🖥️🧬

At #ASHG25 and want to find out more about the largest and most comprehensive systematic analysis of common variation in humans? Go find Daniel at poster board 1014T!

We're at #ASHG2025! Come say hello and find out more about Open Targets projects 👋

CLOSING: Postdoc in @francescoiorio.bsky.social's lab at @humantechnopole.bsky.social Apply through LinkedIn by 5 October: www.linkedin.com/jobs/view/43... #scienceJobs #AcademicSky #postdocJobs

Out now in Nature Comms: the largest trans-eQTL meta-analysis in a single cell type! An Open Targets team led by Krista Freimann and @kauralasoo.bsky.social analysed 3,734 lymphoblastoid cell line samples across nine cohorts, identifying four robust loci www.nature.com/articles/s41...

CLOSING: ➡️ Senior Bioinformatician with Roser Vento Tormo sanger.wd103.myworkdayjobs.com/en-US/Wellco... ➡️ Technical Specialist (neuro) with Omer Ali Bayraktar sanger.wd103.myworkdayjobs.com/en-US/Wellco... Both @sangerinstitute.bsky.social roles close on 2 October

Excited for a major milestone in our efforts to map enhancers and interpret variants in the human genome: The E2G Portal! e2g.stanford.edu This collates our predictions of enhancer-gene regulatory interactions across >1,600 cell types and tissues. Uses cases 👇 1/

The Open Targets Platform autumn release is out! 🍂 We have ingested the full dataset of over 13 million enhancer-gene regulatory interactions in the human genome across 1,458 DNase-seq experiments covering 369 cell types and tissues from the ENCODE-rE2G model blog.opentargets.org/open-targets...

🚩1 MILLION curated associations!!! 🚩 Launched in 2008, took us 15 years to reach 500K, and thanks to your research and collaboration, we doubled the number in less than 3 years! See some data insights tinyurl.com/mw53njbb #OpenAccess

Last call to submit a project for the Open Targets Hackathon! Submit a project by 12 September: docs.google.com/forms/d/e/1F... We will prioritise projects where the project leads have signed up to attend the hackathon. Registrations are currently full but you can sign up to the waiting list

Out now on bioRxiv! 🧬🖥️ A team from the Cowley, Bassett, and @gosiatrynka.bsky.social labs integrate pooled iPSC phenotyping, transcriptomics, and CRISPR perturbations to identify genetic drivers of molecular and cellular phenotypes in microglia www.biorxiv.org/content/10.1... #neuroskyence

Out now! 🧬 Lewis Evans and the team at @sangerinstitute.bsky.social and UCL define the pathways for tau entry into human neurons, a key mechanism for the progression of tauopathies associated with Parkinson’s and Alzheimer’s disease www.embopress.org/doi/full/10.... #neuroscience #neuroskyence

CLOSING: Front end developer for the Open Targets Platform Join @carcruz.dev's team and help us turn complex data into powerful discovery tools, working closely with our industry and academic partners Apply by 19 August embl.wd103.myworkdayjobs.com/EMBL/job/Hin... #ReactJobs #DevJobs

NEW: Front-End Web Dev @ebi.embl.org Join the Open Targets Platform team! Design and build this cloud-first, open-source application, used to explore and prioritise potential drug targets embl.wd103.myworkdayjobs.com/EMBL/job/Hin...

“It’s been a very collaborative experience.” @malloryfreeberg.bsky.social talks to us about developing the Perturbation Catalogue The beta version is available to explore now, and the team are keen to hear your feedback! www.ebi.ac.uk/perturbation... blog.opentargets.org/creating-a-p...

Google Cloud is sponsoring the compute for the Open Targets hackathon! There is now a waiting list to attend the event in person, but project submissions and online registrations are still open. The two-day hackathon will explore data, analyses, and tools for target discovery

Meet Carlos Cruz! Carlos joined the Open Targets Platform team in 2021 🖥️🧬 @carcruz.dev, what is your role in Open Targets?

We're proud to play our part in diversifying genetic and genomic datasets by supporting this important work in Latin America co-led by Open Targets Science Director @gosiatrynka.bsky.social Greater genetic diversity improves discovery and brings us closer to better, more inclusive medicines

🧬 New @emblebi.bsky.social service beta launched: Perturbation Catalogue 🔎 Browse genetic perturbation datasets 🧠 Train models 🧬 Interpret variant function 🧭 Explore gene dependencies Search, test APIs, suggest datasets, send feedback! 🔗 www.ebi.ac.uk/perturbation... Funded by @opentargets.org

We have now deprecated Open Targets Genetics — it has been superseded by the Open Targets Platform The team said goodbye to Open Targets Genetics, through the medium of memes Enjoy!

Open licenses power discovery! Melissa Harrison shares a @opentargets.org use case: Open Targets identifies and prioritises drug targets using AI to extract gene, drug, and disease mentions and relationships to building drug development evidence #ChooseOpenWebinar for updates 💡 #MedLib #PhDsky

Open Targets Genetics has now been deprecated It has been superseded by the Open Targets Platform

Delighted to share the first preprint of my postdoc in the @carlanderson.bsky.social lab www.medrxiv.org/content/10.1...! 🚨 A super exciting study I co-led with the very talented @tobioinformatics.bsky.social . Stay tuned to see what we learned about genetic susceptibility to complex disease. 🧬🧵 1/

🚨New preprint just dropped 🚨 medrxiv.org/content/10.1101/2025.06.24.25330216 The main output from my PhD is finally public and we’re SUPER excited about the findings! If you’re interested in what we learnt about IBD with a massive 700+ sample sc-eQTL dataset of the gut, read on!

🧬 The latest Open Targets Platform release includes the first genetic evidence for ESR1 in osteoporosis ESR1 is a known target for osteoporosis, with approved drugs such as Estradiol, but this is the first time we have genetic evidence for this association platform.opentargets.org/disease/EFO_...

NEW: Technical specialist with @bayraktarlab.bsky.social Generate large-scale spatial transcriptomic datasets to create comparative cell atlases of ALS, Alzheimer’s disease and Parkinson’s disease #scienceJobs #neuroskyence sanger.wd103.myworkdayjobs.com/en-US/Wellco...

NEW: Postdoc in neurodegenerative disease spatial transcriptomics and ML with @bayraktarlab.bsky.social/Mo Lotfollahi Join a new project to create comparative cell atlases of ALS, Alzheimer’s disease and Parkinson’s disease #postdocJobs #neuroskyence sanger.wd103.myworkdayjobs.com/en-US/Wellco...

NEW: Postdoc with @saezlab.bsky.social Develop integrative computational pipelines to dissect immune-cell phenotypes and cell–cell interactions across Alzheimer’s, Parkinson’s, and ALS patient tissues Closes 20 July #postdocJobs #neuroskyence embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Postdoc position in our group at @ebi.embl.org about analyzing single cell data sets to better understand and treat neurodegen diseases, in collab with A Bassett, M Lotfollahi, @bayraktarlab.bsky.social, M Strauss and others within Open Targets. Deadline 20/07. Please share tinyurl.com/87wj466m

Hackathon registrations are now open! www.opentargets.org/hackathon Join us in person or online on October 21-22, 2025 to explore data, analyses, and tools for target discovery. Know someone who might be interested? Send this to them or tag them below!

Out now in iScience! @itreg.bsky.social in Annie Speak's lab created an in vitro model of T cell exhaustion to help identify and target new genes relevant to improving the immune response against cancer cells www.cell.com/iscience/ful...

Preprint out today! A team led by @tobioinformatics.bsky.social and Bradley Harris in @carlanderson.bsky.social ‘s lab has created the largest single-cell atlas of IBD tissues to date www.medrxiv.org/content/10.1...

A rundown of the new features and data in the Open Targets Platform 25.06 release! What are you most excited about?

We're recruiting three roles at @sangerinstitute.bsky.social! ➡️ Principal/senior data scientist and a (senior) postdoctoral fellow in the Lotfollahi group. Closes 6/8 July ➡️ Advanced Research Assistant to join Open-IBD with @carlanderson.bsky.social. Closes 25 June www.opentargets.org/jobs

🚀 The Summer ☀️ @opentargets.org Platform release is here! If you thought the last update was big… just wait till you see what’s inside. A quick thread on the highlights 👇

Open Targets Platform 25.06 is out now! 🌻 It includes 36% more GWAS credible sets (including from the VA Million Veteran Program study) and a new target interactors view to help nominate potential targets blog.opentargets.org/open-targets...

If EMBL-EBI managed data resources have ever saved you time & effort, this is your chance to give back! Fill in a 15-minute survey to help us: 🌍Demonstrate the real-world impact of our resources 🤓Understand your needs 🌟Secure continued funding Closes 16 July www.surveymonkey.com/r/QGFMBH8?ch...

👀 We're gearing up for the next release of the Open Targets Platform! The team will walk you through the latest updates in our LinkedIn Live on 19 June, 3pm UK time You'll then have the opportunity to ask us your questions about the Platform See you there! www.linkedin.com/events/25-06...

Open Targets Genetics will be deprecated on 9 July 2025 You will no longer be able to access genetics.opentargets.org. An archive of the data will be accessible through the EMBL-EBI FTP We are happy to help with questions or concerns on the Open Targets Community: community.opentargets.org

👇Join us this afternoon for a Q&A session on the Open Targets Platform!

“This work addresses a biological question of key importance with creative approaches" Diederik Laman Trip and @pedrobeltrao.bsky.social describe their new method to predict protein associations based on co-abundance in a research briefing, published today 🧬🖥️ www.nature.com/articles/s41...

Teamwork is crucial for proteins. Little is known, however, about which protein teams are actually active in which tissues. A new large-scale study by systems biologists at ETH Zurich is now redrawing the map. ethz.ch/en/news-and-...

🎂 The Open Targets Platform turns 10 this year! To celebrate this milestone, join us in person or online for a two-day hackathon exploring data, analyses, and tools for target discovery 🖥️🧬 You can already submit a project idea: www.opentargets.org/hackathon Registrations will open in June

Join us for a live Q&A on the Open Targets Platform, and the genetics data in our latest release! 🧬🖥️ We will review and prioritise questions submitted in advance: forms.gle/EA75gDdNwjxk... Register: embl-org.zoom.us/webinar/regi...

An atlas predicting protein interactions in 11 human tissues created by @pedrobeltrao.bsky.social's team at @imsb-eth.bsky.social will help uncover cell-type specific functions, elucidate disease mechanisms, and choose safer targets for drug discovery 🧬🖥️ blog.opentargets.org/an-atlas-of-...

A tissue-specific atlas of protein–protein associations enables prioritization of candidate disease genes - @pedrobeltrao.bsky.social @imsb-eth.bsky.social @opentargets.org go.nature.com/3Z1q0PM

Out today in Nature Biotechnology! This Open Targets project created an atlas of tissue-specific protein associations for 11 human tissues, furthering our understanding of cell-type and tissue-specific function, and helping to prioritise more specific—and potentially safer—drug targets 🧬🖥️

Out now! An Open Targets team reviewed the use of Natural Language Processing in drug discovery, exploring Named Entity Recognition, Knowledge Graphs, Large Language Models, and the strengths and weaknesses of different methods for NLP tasks 🧬🖥️ www.tandfonline.com/doi/full/10....