📣Tomorrow: Closed Licences, Closed Doors webinar! Join us and @knowledgerights21.org to find out about open licensing, AI, and the future of research impact! 🗓️ 14 April | ⏰ 10:00 BST/11:00 CEST There's still time to register 👉 embl-org.zoom.us/meeting/regi... #OpenScience #AcademicSky 🧪

🧬🖥️ Introducing TRIPSO: a transformer network to help interpret single cell data analyses by learning multiple predefined or data-driven gene programme-specific embeddings Tripso was developed by a team across the Lotfollahi, Haniffa, Gottgens and Vento labs www.biorxiv.org/content/10.6...

The reveal is here! Meet your experts: 🎤 Presentations: Dr. David Hulcoop @opentargets.org Dr. Benjamin White @knowledgerights21.org Dr. Summer Rosonovski #EuropePMC 💬 Panel: Melissa Harrison #EuropePMC @ebi.embl.org Dr. Kiera McNeice Research Transparency Manager* Dr. Bastian Drees @embl.org

The Open Targets Platform spring 🌼 release is out — and this one marks the beginning of something we've been building towards for a while.

The Open Targets Platform spring (26.03) release is out now! 🌸 Find all the details of the updates on the blog: blog.opentargets.org/open-targets...

Closed licences, closed doors. We're hosting a webinar with @kr21.bsky.social exploring how licensing shapes real-world research impact, from @opentargets.org to pandemic response. Speaker panel reveal soon 👀 🗓️ 14 April ⏰ 10:00 BST 🔗 embl-org.zoom.us/meeting/regi... #OpenScience #AcademicSky 🧪

Introducing PerturbGen: a generative AI foundation model that predicts how genetic perturbations affect cellular trajectories www.biorxiv.org/content/10.6...

Out now on bioRxiv! 🧬🖥️ Dewi Moonen, @anniquec.bsky.social and a team led by Lars Steinmetz and Daniel Schraivogel at EMBL have mapped the downstream regulatory networks of thousands of immune disease-relevant variants in CD4+ T cells www.biorxiv.org/content/10.6...

Finally I can properly explore the mcp-ui pattern. Pretty interesting how the development of new components (especially complex ones) will change dramatically in how data is loaded into them. Exiting times🔥 building a demo using @opentargets.org components. Ref: mcpui.dev

What does game theory have to do with gene predictions? Irene Lopez explains how we apply Shapley value-based explanations for Locus-to-Gene scores in the Open Targets Platform, addressing a common concern of machine learning models: explainability 🧬🖥️ blog.opentargets.org/how-we-impro...

🧬🖥️ Our latest publication reveals a shift in strategies to discover novel drug targets over the past 20 years: after 2015, biomedical evidence supporting a target-disease indication increasingly appears before the approval year www.nature.com/articles/s41...

Open Targets Platform data is now available on @amazonwebservices.bsky.social through the Open Data Program! registry.opendata.aws/opentargets/

🔬New Perturbation Catalogue update! With a redesigned interface, richer datasets and powerful analysis workflows, it’s now easier than ever to explore genetic perturbation data. www.ebi.ac.uk/perturbation... #Bioinformatics #FunctionalGenomics @training.ebi.embl.org @opentargets.org

The Perturbation Catalogue is live! 🧬🔎🖥️ It aims to bring genetic perturbation data into one curated, harmonised, and discoverable platform. Take a look! www.ebi.ac.uk/perturbation...

🧬🖥️ "This integration is a great example of bringing leading AI to platforms and data that are already widely used across the industry.” — Jonah Cool, Head of Life Sciences Partnerships, Anthropic Find out more about the Open Targets Platform MCP server: blog.opentargets.org/official-ope...

The needle in the haystack problem: spotting novel drug targets among redundant evidence. Our solution? A time-series novelty metric for Open Targets Platform associations. Thanks to Coté Falaguera & @opentargets.org partners for making this happen.

Out now in Nature Communications! 🧬🖥️ An Open Targets team developed a metric for the novelty of a target in the context of a disease, according to current available knowledge. This allows drug discovery scientists to easily identify potentially novel targets www.nature.com/articles/s41...

Out now! 🧬 Loss of CHD1 and MAP3K7 creates an acquired cancer vulnerability, highlighting these genes as potential biomarkers of immune checkpoint blockade response Find out more: www.cell.com/cell-reports...

New biomarkers for cancer immunotherapy have been identified. 🔎 Researchers found that loss of two genes, CHD1 and MAP3K7, makes tumours more likely to respond to immunotherapy. The findings could help support more personalised cancer treatment 👇 bit.ly/4sMBTq2

We're recruiting 3 roles through @sangerinstitute.bsky.social 👩‍🔬🧬💻 NEW: ➡ Postdoc with @carlanderson.bsky.social ➡ Technical Specialist with @bayraktarlab.bsky.social ALSO: ➡ (Senior) Postdoc in Mo Lotfollahi’s lab More information in the thread See all available jobs: opentargets.org/jobs

🚀 Announcing the Official @opentargets.org MCP! We've partnered with @anthropic.com to give AI seamless access to high-quality genetic and target-discovery data. Open for the entire community to accelerate therapeutic development. Read more at blog.opentargets.org/official-ope...

Introducing the official Open Targets Platform Model Context Protocol 🧬🖥️ In partnership with @anthropic.com, we’ve created an MCP server making Open Targets Platform data accessible to AI-powered tools and agents Try it out and watch out for future releases: mcp.platform.opentargets.org/mcp

The Wellcome Genome Campus lit up for the holidays ✨ 📸 Helena Cornu

NEW: NLP data scientists/scientific data engineers at @ebi.embl.org Develop a comprehensive open source side effect resource and standardised AI/ML training sets to improve early identification of safety liabilities Apply by 11 January embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Open Targets Platform 25.12 is out now! Thanks to a GWAS Catalog update including 3 major studies using UK Biobank data, we now have over 1.4 million GWAS credible sets in the Platform. Discover the data, feature, and technical updates in this release: blog.opentargets.org/open-targets... 🧬🖥️

NEW: multiple (senior) postdoctoral fellow roles in Mo Lotfollahi's group at @sangerinstitute.bsky.social There are many research focus areas available, including Open Targets translational AI projects Apply now: sanger.wd103.myworkdayjobs.com/en-US/Wellco...

#OnThisDay 10 years ago, we launched the Open Targets Platform! 🎂 🧬🖥️

NEW: Technical Specialist @sangerinstitute.bsky.social Perform large-scale phenotypic CRISPR screens on human iPSC-derived microglia to identify modifiers of immune dysfunction relating to neurodegeneration 🧬 Apply by 11 January: sanger.wd103.myworkdayjobs.com/en-US/Wellco... #ScienceJobs

#Postdoc alert! We are looking for motivated individual with experience in computational systems biology to join our NetworkCommons initiative to benchmark and democratise network contextualisation methods across multiple applications. Deadline Dec 17th link here: tinyurl.com/yrrzxa94

Can we use #AI to revolutionise drug discovery? Meet Lit-OTAR, a deep learning framework built by Europe PMC and @opentargets.org It’s identified >48.5 million unique associations, accelerating the drug discovery process! Read the thread for a paper summary👇 #AI4Science #BioNLP #DrugDiscovery

NEW: Postdoc with @epetsalaki.bsky.social @juliosaezrod.bsky.social and Tamas Korcsmáros Benchmark and integrate state-of-the-art network contextualisation methods, combining large-scale transcriptomics, proteomics, and single-cell data Apply by 17 Dec embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

The recently-announced Open Psychiatry Project is the first initiative to jointly analyse UK mental health research data Findings from this project will be integrated into the Open Targets Platform to help identify and prioritise the most promising therapeutic targets.

Millions of people are affected by mental health conditions, yet progress in treatment has been slow. The Open Psychiatry Project aims to change that with a secure platform linking genetic and clinical mental health data. @cam.ac.uk @opentargets.org www.ebi.ac.uk/about/news/a...

And that's the Open Targets Hackathon done! 🧬🖥️ Thank you to everyone who joined in person and online, and who contributed to make this event a success Particular thanks to our sponsors: Gates Foundation, Google Cloud, and @thehyvenl.bsky.social 🎉

Open Targets Hackathon Day 1! Following our official kick off yesterday, there was some incredible energy and focus in the room Thanks to our sponsors Gates Foundation, Google Cloud, and @thehyvenl.bsky.social for making this possible!

The Open Targets Hackathon is today! 🎉 We're super excited to kick off this event celebrating 10 years of the Open Targets Platform Thank you to Google Cloud for sponsoring our compute and Hariprasad Radhakrishnan for mentoring our teams and sharing this video — made with Google Veo 3! 🖥️🧬

At #ASHG25 and want to find out more about the largest and most comprehensive systematic analysis of common variation in humans? Go find Daniel at poster board 1014T!

We're at #ASHG2025! Come say hello and find out more about Open Targets projects 👋

CLOSING: Postdoc in @francescoiorio.bsky.social's lab at @humantechnopole.bsky.social Apply through LinkedIn by 5 October: www.linkedin.com/jobs/view/43... #scienceJobs #AcademicSky #postdocJobs

Out now in Nature Comms: the largest trans-eQTL meta-analysis in a single cell type! An Open Targets team led by Krista Freimann and @kauralasoo.bsky.social analysed 3,734 lymphoblastoid cell line samples across nine cohorts, identifying four robust loci www.nature.com/articles/s41...

CLOSING: ➡️ Senior Bioinformatician with Roser Vento Tormo sanger.wd103.myworkdayjobs.com/en-US/Wellco... ➡️ Technical Specialist (neuro) with Omer Ali Bayraktar sanger.wd103.myworkdayjobs.com/en-US/Wellco... Both @sangerinstitute.bsky.social roles close on 2 October

Excited for a major milestone in our efforts to map enhancers and interpret variants in the human genome: The E2G Portal! e2g.stanford.edu This collates our predictions of enhancer-gene regulatory interactions across >1,600 cell types and tissues. Uses cases 👇 1/

The Open Targets Platform autumn release is out! 🍂 We have ingested the full dataset of over 13 million enhancer-gene regulatory interactions in the human genome across 1,458 DNase-seq experiments covering 369 cell types and tissues from the ENCODE-rE2G model blog.opentargets.org/open-targets...

🚩1 MILLION curated associations!!! 🚩 Launched in 2008, took us 15 years to reach 500K, and thanks to your research and collaboration, we doubled the number in less than 3 years! See some data insights tinyurl.com/mw53njbb #OpenAccess

Last call to submit a project for the Open Targets Hackathon! Submit a project by 12 September: docs.google.com/forms/d/e/1F... We will prioritise projects where the project leads have signed up to attend the hackathon. Registrations are currently full but you can sign up to the waiting list

Out now on bioRxiv! 🧬🖥️ A team from the Cowley, Bassett, and @gosiatrynka.bsky.social labs integrate pooled iPSC phenotyping, transcriptomics, and CRISPR perturbations to identify genetic drivers of molecular and cellular phenotypes in microglia www.biorxiv.org/content/10.1... #neuroskyence

Out now! 🧬 Lewis Evans and the team at @sangerinstitute.bsky.social and UCL define the pathways for tau entry into human neurons, a key mechanism for the progression of tauopathies associated with Parkinson’s and Alzheimer’s disease www.embopress.org/doi/full/10.... #neuroscience #neuroskyence

CLOSING: Front end developer for the Open Targets Platform Join @carcruz.dev's team and help us turn complex data into powerful discovery tools, working closely with our industry and academic partners Apply by 19 August embl.wd103.myworkdayjobs.com/EMBL/job/Hin... #ReactJobs #DevJobs

NEW: Front-End Web Dev @ebi.embl.org Join the Open Targets Platform team! Design and build this cloud-first, open-source application, used to explore and prioritise potential drug targets embl.wd103.myworkdayjobs.com/EMBL/job/Hin...

“It’s been a very collaborative experience.” @malloryfreeberg.bsky.social talks to us about developing the Perturbation Catalogue The beta version is available to explore now, and the team are keen to hear your feedback! www.ebi.ac.uk/perturbation... blog.opentargets.org/creating-a-p...