Midway through the CSHL Symposium on AI in Biology and this far it's been a blast! Tomorrow I will be presenting our work on genomic foundation models for large-scale biomedical data analysis in poster session #3, 4:30 pm, poster #291. Come find me to connect and discuss :) #cshlsymp26

Made it to #cshlsymp26 Let me know if you’re around or come to my presentation, let’s connect! @cshlmeetings.bsky.social

My poster presentation today! "AI-based Meta-Analysis of Omics Data from Public Databases" #70 at 90th Cold Spring Harbor Laboratory Symposium on Quantitative Biology AI in Biology #cshlsymp26

Now to Anshul Kundaje @anshulkundaje.bsky.social - (another legend!) - on decoding regulatory DNA. He starts with the classic epigenomics roadmap cube (makes me nostalgic) but it's the same basic problem as AlphaGenome (editorial - Anshul is going to have a very different take on this) #cshlsymp26

Made it to #cshlsymp26 and will be doing some intermittent posting on the AI symposium here - starting with the wonderful Žiga Avsec from Google Deep Mind on AlphaGenome (editorial - it is rather great to see many Europeans - Londoners included! - at this meeting)

The 90th CSHL Symposium: AI in Biology starts tonight! #cshlsymp26

We are hosting the 51st annual meeting on Retroviruses this week! Use #cshlretro for all your posts!

Due to exceptionally strong interest, the 2026 CSHL Symposium: AI in Biology is oversubscribed. However, VIRTUAL REGISTRATION is still OPEN! Register here: bit.ly/4uYaHVN

Our brand new meeting Brain Body Physiology starts tonight! Use #cshlbrainbod for all your posts! 🧠

Alexis @alexisbattle.bsky.social did an awesome introduction for Jonathan’s @jkpritch.bsky.social for his #BoG2026 keynote! That was reaaaally good! 👏🏽 👏🏽 @cshlmeetings.bsky.social

En #BoG2026 hubo varixs mexicanxs 🇲🇽 o científicxs trabajando con datos de México🇲🇽 Me da gusto 😊 aprender de sus contribuciones a la ciencia. Esta vez hubo proyectos del Mexican Biobank doi.org/10.1038/s415... @cshlmeetings.bsky.social @valenomics.bsky.social Ana @xavierrocarada.bsky.social Irepan

Mohamed @mabuelanin.bsky.social included a super cute slide about microtus radiation (referring to new species not ☢️) 🦫🐀 They used #CiFi cifi.dennislab.org which they developed recently. Got chromosome-level scaffolds including several T2T genome 🧬 cases #BoG2026 @cshlmeetings.bsky.social

Arang Rhie from @aphillippy.bsky.social ’s lab told us about there is hidden structural variation on the human acrocentric chromosomes This project benefited from UK Biobank using all hg38 sequences (chrUn_…) More available at doi.org/10.64898/202... #BoG2026 @cshlmeetings.bsky.social

Winston @timp0.bsky.social is guiding us through a #DNAm journey starting with his paper with @kasperdhansen.bsky.social from 2011 Nowadays with @pacbio.bsky.social and @nanoporetech.com long read DNA data you get DNAm for free! 5mC, 5hmC, brain 🧠 etc 🐇 🕳️ #BoG2026 @cshlmeetings.bsky.social

Nilah Ioannidis kickstarted #BoG2026 ’s Friday by guiding us through their explorations of how DNA 🧬 sequence prediction models actually perform with unseen sequences Goal: use these models in the clinic for personal genomics to predict individual molecular changes @cshlmeetings.bsky.social

Megan D. Schertzer from @davidaknowles.bsky.social’s lab invites us to use « perplexity » from Ecology to measure isoform diversity (or other molecular units). Very thought provoking! 🤔 More at doi.org/10.1101/2025... #BoG2026 @cshlmeetings.bsky.social

🔬How do clinical exposures shape the gut microbiome, and how do longitudinal clinical–microbiome signatures predict patient outcomes? Come find out at my poster #194 today at 7:30 pm at @cshlmeetings.bsky.social Biology of Genomes 2026! #bog26 @blekhman.bsky.social

Boxiang @boxiangliu.bsky.social showcased #ISAAC for computing splicing QTLs #sQTLs using single cell data They applied it to DLPFC 🧠 data from 722 donors github.com/boxiangliula... #BoG2026 @cshlmeetings.bsky.social

Mateusz Garbulowski et al used custom #VisiumHD to study spatial host-microbiome (SHM-seq) interactions They also built #homic on top of #Kraken2 for accurate taxonomic classification of SHM-seq data QR code was deactivated, but go to github.com/mategarb/homic #BoG2026 @cshlmeetings.bsky.social

Brian Clearly’s work on « Fundamental errors in #RNAvelocity arising from the omission of cell growth » feels like a must read!! Brian shouted out the co-authors in the second slide 👏🏽 #BoG2026 @cshlmeetings.bsky.social doi.org/10.64898/202...

Did you miss #BoG2026 or want to share your work or want to keep learning about great computational biology? Mike @mikeschatz.bsky.social invites us to #BDS26 later this year in November Check bit.ly/cshl-biodata26 for all the details! @cshlmeetings.bsky.social

Mike @mikeschatz.bsky.social shared their latest swiss army knife for analyzing pangenome data QR code is broken but just go to github.com/kjenike/pana... to learn more ^^ It’s already been used by posters at #BoG2026!! @cshlmeetings.bsky.social

Alan @al-murphy.bsky.social gave a great talk on how to use “continual learning” as a principled training framework for genomic models: to go beyond #Enformer, #AlphaGenome, etc that were trained only on the reference genome 🧬 There’s lot to read on the QR codes #BoG2026 @cshlmeetings.bsky.social

I ❤️ @cshlmeetings.bsky.social @cshlnews.bsky.social! Beautiful place. One of those places that surrounds you with the feelings of wonder/purpose/etc that made you fall in love with science. And there’s a bar!

Mike @mikeschatz.bsky.social paid tribute to James P. Taylor who was one of the main champions of #OpenScience @jxtxfoundation.bsky.social carries on. Mike introduced the winners of the scholarship to attend #BoG2026 this year (sponsored by @pacbio.bsky.social this yr) 👏🏽 @cshlmeetings.bsky.social

Gabriel @gpreising.bsky.social #LFW shared work involving INECOL & Centro de Investigaciones Científicas de las Huastecas Aguazarca 🇲🇽 They studied swordtail fishes & their alternative reproductive tactics using long read data Earlier work doi.org/10.1093/evol... #BoG2026 @cshlmeetings.bsky.social

Time to learn about NIH (U.S. National Institutes of Health) and NHGRI National Human Genome Research Institute 🧬) at #BoG2026 @cshlmeetings.bsky.social

Delighted to be back at @cshlmeetings.bsky.social for Biology of Genomes, a historically important meeting w a really diverse and exciting lineup!

Aoxing @aoxing2.bsky.social gave a great talk at #BoG2026 (even more considering it was last minute promoted to a talk!) on studying sex chromosome dosage thanks to available biobank data from rare but tolerated sex chromosome trisomies Builds upon doi.org/10.1016/j.aj... @cshlmeetings.bsky.social

One of my favorite conferences of the year is happening now at @cshlnews.bsky.social! The Biology of Genomes always brings really exciting and thought-provoking research to campus.

Kyle K Farh is going to tell us about #PrimateAI-3D github.com/Illumina/Pri... which they’ve adapted to estimate S_het First talk with a GitHub link prominently displayed in several slides 🤩 I also liked the title slide with all co-authors listed ✅ #BoG2026 @cshlmeetings.bsky.social

Silvia Pérez-Lluch from @guigolab.bsky.social & #CRGenomica is the second #BoG2026 speaker We are learning what Alu repeats could be doing in the human genome 🧬 (10% of it!) through binding of CEBPA

Katarina Pavlovic is telling us about #Fiber-TEnCATS from the Boyle lab built on top of #nCATS, #Fiber-seq, et al. Long read data that tells us about DNAm and open chromatin in chunks long enough to study L1HS (about 17% of the human genome 🧬) #BoG2026 @cshlmeetings.bsky.social

Arbel @arbelharpak.bsky.social is teaching us about sign bias (the mean direction of allelic effects) across biobanks. This bias is explained by the trait’s skeweness (3rd central moment in statistics) doi.org/10.64898/202... #BoG2026 @cshlmeetings.bsky.social

Lifan Liang is going beyond eQTL to study brain 🧠 disorders Lots of single cell multiomic data from human iPSC-derived neurons. Leads to many chromatic accessibility (ca)QTLs upon neuron stimulation. Could help interpret non-coding 🧬 variation in 🧠 #BoG2026 @cshlmeetings.bsky.social

Sasha @sashagusevposts.bsky.social (author of #FUSION-TWAS and much more) gets the honor of starting day 2 of #BoG2026 @cshlmeetings.bsky.social Time to think about genetics 🧬, statistics, common variants, et al related to complex disorders

#TwINFER by Yogesh Goyal et al for analyzing recently divided cells (aka “twins”) seems interesting Gotta read later the preprint from doi.org/10.64898/202... #BoG2026 @cshlmeetings.bsky.social

Yoav @ygilad.bsky.social kickstarts #BoG2026 at @cshlmeetings.bsky.social by asking us to be open minded and think beyond biology defined by means. To think about the dispersion / variance.

#BOG26 begins tonight! 🧬

Thank you to everyone who came to the thirteenth in CSHL’s series of meetings on the History of Science—Five Decades of Nuclear Receptors: Physiology, Molecular Biology & Pharmacology! #cshhist26

At CSHL Fellows 40th Symposium, Bruce Stillman announced a multimillion-dollar endowment to fund future scientists. Congrats Fellows! https://www.newsday.com/news/health/cold-spring-harbor-lab-multimillion-endowment-nnf5yaob?utm_medium=web_share_api&utm_campaign=web_share_api

Thrilled to share that my abstract was selected for a 15-minute talk at #bog26 @cshlmeetings.bsky.social! I'll present our prairie & meadow vole assemblies using CiFi long reads, we built the first chromosome-scale diploid assemblies that fully resolve the Avpr1a duplication linked to pair bonding 🐭

Regulatory & ncRNA Meeting at Cold Spring Harbor Labs, amazing science and amazing people, will have to come back next time! #cshlregRNA @cshlmeetings.bsky.social

Regulatory & Non-Coding RNAs starts tonight! Share your moments from the meeting this week with us by using #cshlregrna

Hope everyone enjoyed The PARP Family and ADP-ribosylation meeting! #cshlparp

Thank you to all of our Neuronal Circuits participants! #cshlcircuits 🧠

Thank you to everyone who came to the Systems Biology: Global Regulation of Gene Expression meeting 🧬 #cshlsysbio

Welcome to all of our Systems Biology: Global Regulation of Gene Expression attendees! #cshlsysbio