The 2026 NCI Informatics Technology for Cancer Research (ITCR) Annual Meeting kicked off tonight with the pre-meeting workshops! #ITCR2026

We caught up with CSHL Fellows during the program's 40th anniversary celebration to reflect on how the program shaped the groundbreaking research they're leading today. https://www.cshl.edu/born-of-curiosity-cshl-fellows-program-marks-40-years/ #Research #InspiringDiscovery #ScienceMakesLifeBetter

📣There’s still time to submit your abstract for the 2026 Transposable Elements meeting! The deadline for submissions has just been extended to July 24. Learn more about #cshlcshlTE26 and register here: bit.ly/4vwizxw

Looking for a great @cshlmeetings.bsky.social CSHL meeting this Fall? Abstract submission is open for "Molecular Mechanisms of Neuronal Connectivity" until July 22nd. Join me, @dacolon.bsky.social, Elva Diaz and @schuldinerorenlab.bsky.social at the bar! meetings.cshl.edu/meetings.asp...

📣There’s still time to submit your abstract for the 2026 Mechanisms of Aging meeting! The deadline for submissions has just been extended to July 22nd. Learn more about #cshlaging and register here: bit.ly/4peJkVK

Registration is open for the CSHL Biological Data Science conference on Nov 4-7, 2026. Check out this awesome list of keynote speakers and session chairs. Learn more here: bit.ly/cshl-biodata26

A huge thanks to Elliot Hershberg for your incredible overview of our 90th Symposium! Read the full overview here: bit.ly/4oLflV7 An archive of the talks from #CSHLSYMP26 is available for viewing on a fee-basis through 8/14. Sign up here: bit.ly/43PZJWT

Day 2 at #CSHLSYMP26: AI in genomics & evolution insights from @Avsecz, @pkoo562, @deboramarks. Science on the lawn! #InspiringDiscovery #AIinBiology #ScienceMakesLifeBetter

Save the date 😎 #CSHL #BBB

The evening closed with a packed poster session: the real peer review, face to face. #InspiringDiscovery #CSHLSYMP26 #AIinBiology #ScienceMakesLifeBetter

Then the symposium did what only CSHL can do: moved the conversation to the lawn in front of the historic Carnegie Library. Wine, cheese, and the kind of unscheduled science that does not fit on any agenda.

The afternoon session closed with Debora Marks of @harvardmed.bsky.social reminding us that evolution is the longest-running optimization experiment in history and that language models trained on sequence diversity are finally letting us read what evolution has been writing for billions of years.

Peter Koo, CSHL's own, grounded the session with something every practitioner needed to hear: deep learning models are only as useful as our ability to interrogate them. Improving interpretability is not a footnote. It is the work.

The morning session on AI and Regulatory Genomics opened with @avsecz.bsky.social of Google DeepMind making the case for why the non-coding genome is no longer a black box. The tools to read regulatory logic at scale are here.

Day 2 at the 90th Cold Spring Harbor Laboratory Symposium on Quantitative Biology brought the science into sharper focus and the evening brought it onto the lawn.

Midway through the CSHL Symposium on AI in Biology and this far it's been a blast! Tomorrow I will be presenting our work on genomic foundation models for large-scale biomedical data analysis in poster session #3, 4:30 pm, poster #291. Come find me to connect and discuss :) #cshlsymp26

Made it to #cshlsymp26 Let me know if you’re around or come to my presentation, let’s connect! @cshlmeetings.bsky.social

My poster presentation today! "AI-based Meta-Analysis of Omics Data from Public Databases" #70 at 90th Cold Spring Harbor Laboratory Symposium on Quantitative Biology AI in Biology #cshlsymp26

Now to Anshul Kundaje @anshulkundaje.bsky.social - (another legend!) - on decoding regulatory DNA. He starts with the classic epigenomics roadmap cube (makes me nostalgic) but it's the same basic problem as AlphaGenome (editorial - Anshul is going to have a very different take on this) #cshlsymp26

Made it to #cshlsymp26 and will be doing some intermittent posting on the AI symposium here - starting with the wonderful Žiga Avsec from Google Deep Mind on AlphaGenome (editorial - it is rather great to see many Europeans - Londoners included! - at this meeting)

The 90th CSHL Symposium: AI in Biology starts tonight! #cshlsymp26

We are hosting the 51st annual meeting on Retroviruses this week! Use #cshlretro for all your posts!

Due to exceptionally strong interest, the 2026 CSHL Symposium: AI in Biology is oversubscribed. However, VIRTUAL REGISTRATION is still OPEN! Register here: bit.ly/4uYaHVN

Our brand new meeting Brain Body Physiology starts tonight! Use #cshlbrainbod for all your posts! 🧠

Alexis @alexisbattle.bsky.social did an awesome introduction for Jonathan’s @jkpritch.bsky.social for his #BoG2026 keynote! That was reaaaally good! 👏🏽 👏🏽 @cshlmeetings.bsky.social

En #BoG2026 hubo varixs mexicanxs 🇲🇽 o científicxs trabajando con datos de México🇲🇽 Me da gusto 😊 aprender de sus contribuciones a la ciencia. Esta vez hubo proyectos del Mexican Biobank doi.org/10.1038/s415... @cshlmeetings.bsky.social @valenomics.bsky.social Ana @xavierrocarada.bsky.social Irepan

Mohamed @mabuelanin.bsky.social included a super cute slide about microtus radiation (referring to new species not ☢️) 🦫🐀 They used #CiFi cifi.dennislab.org which they developed recently. Got chromosome-level scaffolds including several T2T genome 🧬 cases #BoG2026 @cshlmeetings.bsky.social

Arang Rhie from @aphillippy.bsky.social ’s lab told us about there is hidden structural variation on the human acrocentric chromosomes This project benefited from UK Biobank using all hg38 sequences (chrUn_…) More available at doi.org/10.64898/202... #BoG2026 @cshlmeetings.bsky.social

Winston @timp0.bsky.social is guiding us through a #DNAm journey starting with his paper with @kasperdhansen.bsky.social from 2011 Nowadays with @pacbio.bsky.social and @nanoporetech.com long read DNA data you get DNAm for free! 5mC, 5hmC, brain 🧠 etc 🐇 🕳️ #BoG2026 @cshlmeetings.bsky.social

Nilah Ioannidis kickstarted #BoG2026 ’s Friday by guiding us through their explorations of how DNA 🧬 sequence prediction models actually perform with unseen sequences Goal: use these models in the clinic for personal genomics to predict individual molecular changes @cshlmeetings.bsky.social

Megan D. Schertzer from @davidaknowles.bsky.social’s lab invites us to use « perplexity » from Ecology to measure isoform diversity (or other molecular units). Very thought provoking! 🤔 More at doi.org/10.1101/2025... #BoG2026 @cshlmeetings.bsky.social

🔬How do clinical exposures shape the gut microbiome, and how do longitudinal clinical–microbiome signatures predict patient outcomes? Come find out at my poster #194 today at 7:30 pm at @cshlmeetings.bsky.social Biology of Genomes 2026! #bog26 @blekhman.bsky.social

Boxiang @boxiangliu.bsky.social showcased #ISAAC for computing splicing QTLs #sQTLs using single cell data They applied it to DLPFC 🧠 data from 722 donors github.com/boxiangliula... #BoG2026 @cshlmeetings.bsky.social

Mateusz Garbulowski et al used custom #VisiumHD to study spatial host-microbiome (SHM-seq) interactions They also built #homic on top of #Kraken2 for accurate taxonomic classification of SHM-seq data QR code was deactivated, but go to github.com/mategarb/homic #BoG2026 @cshlmeetings.bsky.social

Brian Clearly’s work on « Fundamental errors in #RNAvelocity arising from the omission of cell growth » feels like a must read!! Brian shouted out the co-authors in the second slide 👏🏽 #BoG2026 @cshlmeetings.bsky.social doi.org/10.64898/202...

Did you miss #BoG2026 or want to share your work or want to keep learning about great computational biology? Mike @mikeschatz.bsky.social invites us to #BDS26 later this year in November Check bit.ly/cshl-biodata26 for all the details! @cshlmeetings.bsky.social

Mike @mikeschatz.bsky.social shared their latest swiss army knife for analyzing pangenome data QR code is broken but just go to github.com/kjenike/pana... to learn more ^^ It’s already been used by posters at #BoG2026!! @cshlmeetings.bsky.social

Alan @al-murphy.bsky.social gave a great talk on how to use “continual learning” as a principled training framework for genomic models: to go beyond #Enformer, #AlphaGenome, etc that were trained only on the reference genome 🧬 There’s lot to read on the QR codes #BoG2026 @cshlmeetings.bsky.social

I ❤️ @cshlmeetings.bsky.social @cshlnews.bsky.social! Beautiful place. One of those places that surrounds you with the feelings of wonder/purpose/etc that made you fall in love with science. And there’s a bar!

Mike @mikeschatz.bsky.social paid tribute to James P. Taylor who was one of the main champions of #OpenScience @jxtxfoundation.bsky.social carries on. Mike introduced the winners of the scholarship to attend #BoG2026 this year (sponsored by @pacbio.bsky.social this yr) 👏🏽 @cshlmeetings.bsky.social

Gabriel @gpreising.bsky.social #LFW shared work involving INECOL & Centro de Investigaciones Científicas de las Huastecas Aguazarca 🇲🇽 They studied swordtail fishes & their alternative reproductive tactics using long read data Earlier work doi.org/10.1093/evol... #BoG2026 @cshlmeetings.bsky.social

Time to learn about NIH (U.S. National Institutes of Health) and NHGRI National Human Genome Research Institute 🧬) at #BoG2026 @cshlmeetings.bsky.social

Delighted to be back at @cshlmeetings.bsky.social for Biology of Genomes, a historically important meeting w a really diverse and exciting lineup!

Aoxing @aoxing2.bsky.social gave a great talk at #BoG2026 (even more considering it was last minute promoted to a talk!) on studying sex chromosome dosage thanks to available biobank data from rare but tolerated sex chromosome trisomies Builds upon doi.org/10.1016/j.aj... @cshlmeetings.bsky.social

One of my favorite conferences of the year is happening now at @cshlnews.bsky.social! The Biology of Genomes always brings really exciting and thought-provoking research to campus.

Kyle K Farh is going to tell us about #PrimateAI-3D github.com/Illumina/Pri... which they’ve adapted to estimate S_het First talk with a GitHub link prominently displayed in several slides 🤩 I also liked the title slide with all co-authors listed ✅ #BoG2026 @cshlmeetings.bsky.social

Silvia Pérez-Lluch from @guigolab.bsky.social & #CRGenomica is the second #BoG2026 speaker We are learning what Alu repeats could be doing in the human genome 🧬 (10% of it!) through binding of CEBPA

Katarina Pavlovic is telling us about #Fiber-TEnCATS from the Boyle lab built on top of #nCATS, #Fiber-seq, et al. Long read data that tells us about DNAm and open chromatin in chunks long enough to study L1HS (about 17% of the human genome 🧬) #BoG2026 @cshlmeetings.bsky.social

Arbel @arbelharpak.bsky.social is teaching us about sign bias (the mean direction of allelic effects) across biobanks. This bias is explained by the trait’s skeweness (3rd central moment in statistics) doi.org/10.64898/202... #BoG2026 @cshlmeetings.bsky.social