This is a masterpiece. Simply excellent www.instagram.com/reel/DMVGMIC...

Didn’t want to believe this was true. It’s true.

Good discussion & study-design recommendations in this new preprint by @mikelove.bsky.social @klmohlke.bsky.social & colleagues: Higher eQTL power reveals signals that boost GWAS colocalization 🧪🧬 www.biorxiv.org/content/10.1...

My first conference ever was at IPAM as an undergrad, bringing me into scientific research. When I branched out into new topics, my first conference as new faculty was also at IPAM. My R35 was suspended. A lot of personal feelings, but more I worry for the future of the country.

“There’s no better example of how [HIV and COVID were] different than to look at what happened to Tony Fauci. Celebrated for leading the response to HIV, pilloried for playing the same leading role with COVID, he eventually needed a security service to protect him and his family”

Nick Eagles on analyzing Visium HD at #GBCC2025

Stefano @stemang.bsky.social showing off #tidyomics at the #GBCC2025 !

Quote of the day from #GBCC2025 “It can fail. But, sometimes, it works”

Worth reading

I've seen folks talk about how "in four years" they'll be able to get back to their planned projects and I really don't think that's going to work out. People & projects losing funding now will not be able to hit pause and come back once funding is restored. Hard-won progress & capacity will be lost

I am at StatGen 2025 in Minneapolis. I would be happy to chat with students or postdocs about research or career questions. Send me a DM.

Apparently, transcriptomics is not the only field struggling with overly optimistic results from new deep learning techniques. www.understandingai.org/p/i-got-fool...

"I'm still in shock. I know that there have been political issues around Harvard in recent weeks, but antibiotic resistance isn't one of them." My conversation with Harvard microbiologist @baym.lol, one of many researchers there who just lost millions in fed. grants. www.wbur.org/news/2025/05...

Check this out - the company I co-founded is trying to figure out how to make this super easy product.synthesize.bio (and we have beta models out to AI generate new expression data based on experimental design!)

I received a surprising and disturbing request from NIH on Friday. They wrote to cancel a subaward to Hong Kong on one of my grants. (This was disturbing but not surprising.) They also ordered us not to interact with our collaborators in Hong Kong on any work under the award:

I wrote about how we must stand and fight against the threat of eugenics. Fueled by white nationalism and scientific racism, these beliefs are factually wrong and ethically abhorrent. This fight includes supporting efforts to diversify our workforce & science. To stop now would be a deep betrayal.

I miss when the biggest controversy about mRNA was whether it correlated with protein or not.

Schumer needs to go

Tenure clock extensions are a great deal for the institution. Not so much for the faculty member

Really excited to present in this fantastic seminar series this Wednesday. Will be sharing some of the insights we have gained into disease-associated epigenetic changes by studying the Mendelian developmental disorders of the epigenetic machinery.

UC Berkeley researcher pushes AI to the next level by comprehensively simulating the complex behavior of a complete organism.

Switching from internet to zoom phone so campus can save money. With new training, websites etc. How often do campuses think through: "we save $100,000, but use 1.5hrs of prof time with 5,000 profs getting paid $75/hr and.. oh shit we just spent $550K on salary to save $100K" .. I'm guessing never

Super huge congrats to postdoc in our group Bernie Mulvey and co-leads Kristen Maynard & @kasperdhansen.bsky.social on this absolute tour de force paper profiling sex differences in the human hypothalamus. Really important biological insight about gene expression differences in sex-biased disorders.

For #FluorescenceFriday - sneak peek from new preprint coming soon investigating spatially-resolved molecular sex differences in the human hypothalamus - spearheaded by postdoc in our group Bernie Mulvey, and led by Kristen Maynard and @kasperdhansen.bsky.social 🧠🔬🧪

@mikeschatz.bsky.social announcing that it will happen again in 2026! 🎉 This was terrific. Let's hope science stays legal 😘 and everyone fill the time in 2025 by attending gbcc2025.org, where @bioconductor.bsky.social and @galaxyproject.bsky.social will come together at CSHL for the first time.

At CSHL for Biological Data Science 2024

We had a great seminar at JHU from David Gorkin (Emory) on mechanisms that link chromatin remodelers (specifically BAF) to developmental disorders. I especially enjoyed how he contrasted - in the fetal mouse brain - the effect of heterozygous (more patient relevant) vs. homozygous LOF.

Read this if you’re interested in epigenome editing.

This whole thread is 🤯 full of great science

For all the new followers here: welcome! Here some recent highlights: (1/4) My eclectic and subjective list of scientific writing tips

Looks interesting!

I'm biased because Chris Lo is a close friend and Kasper Hansen is on my committee, but this will be a great resource for population transcriptomics. Trans-eQTL calling is limited by power with "only" hundreds of samples. This corpus has hundreds of thousands. doi.org/10.1101/2023...