Bet your AI meets Rob Pike He'll wolf it down for tea tonight

(Nucleotide Transformer v3) A foundational model for joint sequence-function multi-species modeling at scale for long-range genomic prediction instadeep.com/wp-content/u... 🧬🖥️🧪 github.com/instadeepai/... (noncommercial)

Make a Bond movie academic YOLO or Not YOLO? Bimodal distribution of near-death experiences in the adult male mouse

This is such a cool story, we were nerding out about it this morning

Cries in Sony Walkman

Release the Jack Smith transcript.

Looks interesting, I am curious how this compares to Rasmussen & Kellis (2012)… and potentially more recent papers (have not surveyed this space for a while)

Deep deep organisms that might live for thousands of years aeon.co/essays/the-d...

I am aware that "the Die Hard Christmas joke is still funny" is a subjective statement. But hey. It is. The MOVIE ITSELF relies heavily on that joke and surely you will not risk offending its many sincere worshippers by denying that it was a force for good in the world, what is wrong with you

The true* meaning of Christmas is peace, love, and the celebration of a virtuous birth. That is why the Die Hard Christmas joke is still funny: it inverts that, to be about violence, marital strife and the celebration of an evil death. Anyway, I made a Christmas carol soundcloud.com/ian-holmes-2...

2025 Headline of the Year nominee (April)

These incompetent fascist idiots have no idea how rapidly samizdat spreads

here's the 60 minutes cecot video part 1 of 5 - recorded/uploaded by and all credit to @jasonparis.bsky.social I just reduced background noise, chopped the 14 minutes into 3 minute segments each compressed under 100 mb for bsky's limits, cropped and rotated a few degrees for easier viewing on here

I am so grateful to live in a town with a sci-fi bookstore like Dark Carnival. Obscure series you half finished in the 80s? Latest dungeon-crawling genre romp? Thought-provoking dystopias, guilty pleasures, experimental crossovers… all to be found in their labyrinth of piles www.darkcarnival.com

This whole thread is horrifying and contains MANY new details. This documentary needs to be torrented and played everywhere to the shame, vilification, and electoral destruction of Weiss, Miller, and all the collaborators and enablers

Electronic music production is a hobby I’ve given myself permission to be gloriously bad at. This year, I did (after being encouraged to by my very supportive partner) submit some terrible beginner tracks to @sfpubliclibrary.bsky.social’s Bay Beats platform: baybeats.sfpl.org/albums/wally...

💾 Prokka 1.15.6 is released! This is the last major release of Prokka. But don't be sad, because @oschwengers.bsky.social already has an excellent replacement called Bakta you can migrate to. #bioinformatics #microbiology #genomics github.com/tseemann/pro...

CBS didn't run the 60 Minutes segment on CECOT, but over here at @propublica.org we've been working on the story since March, including finding out who each and every man sent to that maximum security prison was. You can see our reporting here: www.propublica.org/series/depor...

People are dying inside American concentration camps right now. www.elpasotimes.com/story/news/i...

Hey, fellow evolutionary biologists: If you support trans rights, like, comment, or repost this. I want to show that transphobes like Richard Dawkins are a loud minority that does not represent our community

Apparently this was the 'year of the octopus'

once again plugging this amazing resource for anyone in the paediatric cancer space. so much data, so easily accessible

Now seems like a swell time to point out that Frontline just released this excellent 11-minute mini-documentary about what happened inside CECOT.

A lot of people on here angrily mocking someone for saying that academics may not have time to read every paper in their field, when those people would cheerfully acknowledge that truism in more relaxed circumstances, shows the extent to which polarization obliterates nuance in… certain debates.

Not sure if anyone has noticed but the honeymoon period of people trying to be kinder and gentler on this site may, possibly, have ended

I saw precursors of this numerous times in SF while I lived there. A Waymo unable to comprehend that a garbage truck was cutting through a one-way street as a shortcut, kept it plugged for half an hour. Another refused to pass a crosswalk while a wailing toddler sat on the curb, stalling the block

The story of Farage and Putin, told by British-Ukrainian soldier Shaun Pinner on a destroyed apartment block in Kyiv.

Clear evidence that at universities conservatives don't face higher obstacles than liberals to establish student groups + invite outside speakers. "These results fail to offer support for the view that conservative students encounter more difficulty in efforts to access campus resources."

Just unfriended a rampant terf on LinkedIn, a friendly acquaintance from grad school days and the spouse of a very close friend. Muting them seemed like a cop out

Can’t stop thinking about this. The Trump administration is essentially extorting hospitals into dropping gender-affirming care—without Medicare or Medicaid they’d go bankrupt. It’s akin to a backdoor ban even for people with private insurance, a proposal that wouldn’t pass Congress.

I wish a single journalist or leader would reach out to me I have the scientific expertise, lived experience of a trans person, and am literally a science communicator for my career I'm willing to explain this even though I know it will decrease my personal safety!! bsky.app/profile/jeym...

I get the intent of this statement. Students are way more than customers. They aren’t “always right”, shouldn’t dictate the curriculum, etc. And yet. It seems very complacent to say professors are fundamentally different from (say) freelance music teachers, who can’t afford NOT to think of customers

I can't believe this still needs to be said (and more loudly): Trans rights are human rights.

I mean you’d have to hike it *a lot* to make having a baby be the cheaper option

Vicente Gonzalez has a primary challenger, Etienne Rosas, whose donation page is here: secure.actblue.com/donate/rosas... Cuellar and Davis have no challengers. Yet.

Grateful to share our paper on gene-specific selective sweeps in human gut microbiomes, now out in Nature! It has been a joy to work with @rwolff.bsky.social, whose insights and hard work made this possible. www.nature.com/articles/s41...

Before the 1990s, plane crashes caused by microbursts used to kill planeloads of people fairly regularly. Dr. Ted Fujita and NCAR scientists figured out how to detect microbursts and warn pilots about them. Since then? Zero airliner crashes from microbursts.

here we fucking go www.npr.org/2025/12/15/n...

I keep saying this but no one is connecting the dots. The war is to satisfy legal preconditions for mass removal *domestically* of Latinos (i.e., suddenly a lot of people are going to be “Venezuelan” for purposes of removal). This is 100% Stephen Miller…oil claim is to make grandpa go along

My lab is recruiting postdocs in AI/ML for genetics & genomics through the Malone Postdoctoral Fellows program. Apply by Jan 30! Lots of other great labs across the Malone Center as well.

Conversational AI is great for retrieving knowledge, reformatting it, and (increasingly) putting it together. It does not have artistic judgment.“Knowledge” includes math, code, grammar, even established aesthetics; but as Debussy said, art doesn’t follow rules; it discovers them. Poetry ≠ grammar

youtu.be/ra0WKNhQZ0U Refreshingly, this pulls zero punches, and lands them squarely on the liars, grifters and frauds responsible for the lab leak hoax and the authoritarian persecution of science and scientists.

Enzyme Engineering Database (EnzEngDB): a platform for sharing and interpreting sequence–function relationships across protein engineering campaigns @francescazfl.bsky.social @jsunn-y.bsky.social @francesarnold.bsky.social @arianemora.bsky.social Paper: doi.org/10.1093/nar/... DB: enzengdb.org

I am an enthusiastic consumer of Tony’s Chocolonely and find their mission - to eliminate slavery in the cocoa supply chain - compelling. Their 2025 advent calendar contains some empty windows: “because the chocolate industry is unevenly divided, so is the calendar”. Guess they got me with that one

Wow!

Can't say I ever expected to see a "That Font was No Angel" headline. But here we are.

I like this. It hits the nail on the head. Partly because it does not mess around with distractions about water and energy use that have been roundly disproven, i.e. it avoids hitting the nail on the thumb

Why Grandma, what big emdashes you have

An energy-based model of protein conformational space can be used to predict structure from sequence, sample from the conformational landscape, rank structures, and predict mutation effects. @sokrypton.org www.biorxiv.org/content/10.6...

Cornetto v0.2.0 is now released for using programmable selective nanopore sequencing for genome assembly. GitHub: github.com/hasindu2008/... Paper: nature.com/articles/s41... Datasets: hasindu2008.github.io/cornetto/doc... ... and a banner made by Ira Deveson referring to ‘no boring bits’.