If you are interested in single-cell splicing QTL analysis, it will worth trying ISSAC. My talk at the Biology of Genomes 2026: youtu.be/ObWtjpYBie4 ISSAC Preprint: www.medrxiv.org/content/10.6...

Sharing our exciting single-cell splicing method ISSAC. Key features include: 1) ISSAC is 1.4 to 2.5-fold power increase over LeafCutter on single-cell sQTL discovery, and scalable to millions of cells 2) ISSAC is able to map cell-state-dependent sQTLs and intron-retention sQTLs.

Excited to share our new paper on Cell Genomics: We mapped how genetics shape the muscle transcriptome in response to exercise and diet intervention. 📄 www.cell.com/cell-genomic...

Collaborative work led by Zhihao and me finally online at Nature Communications! nature.com/articles/s41... Huge congratulations to Zhihao and his outstanding leadership. Also, to first author Foozhan Tahmasebinia, and key contributions from Yinglu Tang and Rushi Tang!

Exciting new benchmark for DNA language models!

This study is truly amazing.

The next Human Cell Atlas will be held in Singapore in June 2025. The early-bird registration is already open: 2025events.humancellatlas.org/2025GM I highly encourage single-cell folks to register. Many exciting talks ahead!

Our paper on single-cell splicing QTL is now published as a cover article in Nature Genetics. www.nature.com/articles/s41... Congratulations to co-first authors Chi Tian, Yihan Tong, and Yuntian Zhang! Huge thanks to AIDA leaders Shyam Prabhakar, @jayshin.bsky.social, Woong-Yang, and Kian Hong!

Very exciting work for biology and drug discovery!

QC is arguably the most important step in any single cell analysis. Low quality data can lead to incorrect conclusions.

HCA Asia 2024 off to a great start!

En route to HCA Hong Kong. Excited to reconnect with old friends and making new ones!

Comprehensive knockdown of 305 splicing-related proteins and their effect on splicing. Such a tour de force!!

Here is a starter pack for functional genomics on bluesky. Not sure if there is one already but do let me know if so. Let me know if you want to be added to the list. go.bsky.app/SvBtD4d

The SG Academies South-East Asia Fellowship Programme (2024 Round) application is now open and will close on 31 Jan 2025. snas.org.sg/saseaf.

Is there a starter pack for functional genomics? Should I start one?

Has anyone used Video Byte or Graphical Abstract service by Springer Nature? Is it worth it?