"Liston, the cofounder of Cambridge spin-out Aila Biotech, is developing a Treg therapy for multiple sclerosis, a disease caused by immune cells attacking the nervous system by mistake. The therapy aims to boost Tregs in the brain to call the attack off." www.theguardian.com/science/2026...

Latest graduation hat - congratulations Dr Arman Ghodsinia!

"Liston, the cofounder of Cambridge spin-out Aila Biotech, is developing a Treg therapy for multiple sclerosis, a disease caused by immune cells attacking the nervous system by mistake. The therapy aims to boost Tregs in the brain to call the attack off." www.theguardian.com/science/2026...

In other words, don't let AI near your writing www.nature.com/articles/d41...

excellent advice!

Love this. Thanks to @labliston.bsky.social I include a slide in my “Pathway to Independence” talk about all the things I applied for & didn’t get But at least I tried and that’s the key thing

I'm officially an expert in failing! I was asked to give the opening keynote today for a @cruk-ci.bsky.social conference, speaking on the topic "Failing in Science" youtu.be/BdrTzYcT7MY?...

Oh this is wonderful- I love the "recognise the weirdness of our profession" message, and the idea of the wall of failure. Required watching for both established and aspiring scientists!

Excellent piece of advice, should be compulsory to all new students starting their research careers.

I'm officially an expert in failing! I was asked to give the opening keynote today for a @cruk-ci.bsky.social conference, speaking on the topic "Failing in Science" youtu.be/BdrTzYcT7MY?...

If this would be helpful to anyone, but you don't want to buy a copy, you can read it for free online: Link: heyzine.com/flip-book/a5... Password: BeKind

Now online! The 2026 volume of the Annual Review of Immunology. Take a look at the most read article "Tissue Regulatory T Cells" by Markus Feuerer, Daniel Gray, Lucille Rankin, Lisa Schmidleithner and @labliston.bsky.social @wehi-research.bsky.social

What if cytokine therapies could be delivered only where they’re needed? Using targeted gene delivery to the lung, we show it’s possible to locally control inflammation and limit pathology—without systemic effects. New research from @labliston.bsky.social www.science.org/doi/10.1126/...

If you want to learn more about cytokine delivery to modify the lung immune environment, but don't have time to read our full paper at @sciimmunology.bsky.social, here is a short (5 minute) explainer! youtu.be/fcIiIYNC-2s www.science.org/doi/10.1126/...

Anyone in Cambridge missing a tortoise?

Garden update

If you want to learn more about cytokine delivery to modify the lung immune environment, but don't have time to read our full paper at @sciimmunology.bsky.social, here is a short (5 minute) explainer! youtu.be/fcIiIYNC-2s www.science.org/doi/10.1126/...

Amazon alternative‼️ www.abebooks.com/servlet/Sear...

Sometimes science leads us to unexpected places. For example, work we started during the COVID lockdown, may help treating the "Curse of the Pharaohs". Read all about it at Science Immunology. PS, we don't support tomb-robbing of ancient Egyptian burial sites. www.science.org/doi/10.1126/...

The best part is, because we only altered the immunology of the lung tissue, the anti-viral responses generated in the LN were intact, so we could reduce lung inflammation without giving the infection a free-pass. This is why tissue immunology has such potential - only hit the site needed!

The system works great! AAV6.2.CC10 driving #IL2 production gives an expansion of #lung #Tregs without impacting other sites, even the draining LN of the lung. And it is not just IL2 - in the same way we can drive #IL10 or #IL1RA in the lung without altering systemic levels. Pick your own cargo!

We have an exciting new story out at @science.org's Science Immunology! It is all about using #AAV-mediated cytokine delivery to change the lung environment. We can boost #lung #Tregs or delivery anti-inflammatory #cytokines, preventing fatal respiratory collapse www.science.org/doi/10.1126/...

Morning squirrel visit

It took quite some trial and error, but eventually we found that intranasal delivery of AAV6.2 capsid with the CC10 promoter drove tight expression of our cargo by club cells, limited to the lung tissue. Gorgeous imaging from the team of @regisjoulia.bsky.social ia.bsky.social

Gene delivery of immunomodulatory cytokines to the lung preserves respiratory function during inflammatory challenge @labliston.bsky.social @sciimmunology.bsky.social @babrahaminst.bsky.social @drntombizodwa.bsky.social www.science.org/doi/10.1126/...

We have an exciting new story out at @science.org's Science Immunology! It is all about using #AAV-mediated cytokine delivery to change the lung environment. We can boost #lung #Tregs or delivery anti-inflammatory #cytokines, preventing fatal respiratory collapse www.science.org/doi/10.1126/...

Spring garden

Unfortunately, in my write up of our new paper, I committed the cardinal sin of science communication: I forgot to say we used #machinelearning! Clearly I should have led with "Hidden disease solved by #AI" www.nature.com/articles/s41...

Unfortunately, in my write up of our new paper, I committed the cardinal sin of science communication: I forgot to say we used #machinelearning! Clearly I should have led with "Hidden disease solved by #AI" www.nature.com/articles/s41...

We worked with the amazing Carine Wouters and clinicians across Europe to collect samples for a #systemsimmunology analysis together with the Humblet-Baron lab at @kuleuvenuniversity.bsky.social. Critically, we we able to access samples at the point of diagnosis, many still untreated.

Fast-forward a decade (!) of sample collection and analysis, and immune status distinguishes patients compared to healthy controls (AUC 0.83), with CD38+ #Tcells elevated and memory #Bcells way down. This shared phenotype suggests this *is* a distinct condition, not diverse undiagnosed patients

We have a new story out at @natcomms.nature.com! This time our lab tackled the enigmatic "autoinflammation of unknown origin". These #autoinflammatory patients don't fit the criteria of classical syndromes. It wasn't even clear they were a single group, to be honest www.nature.com/articles/s41...

We have a new story out at @natcomms.nature.com! This time our lab tackled the enigmatic "autoinflammation of unknown origin". These #autoinflammatory patients don't fit the criteria of classical syndromes. It wasn't even clear they were a single group, to be honest www.nature.com/articles/s41...

It's well established there is a spectrum of potential risk of polygenic autoimmunity in humans. We develop actual #autoimmunediseases either because of unknown inborn errors or due to environmental and lifestyle factors. We often share overlapping symptoms and / or similar inflammation traits...

A Fellow of St Catharine’s had led international research that revealed shared traits across the immune systems of patients with unexplained autoinflammation... www.caths.cam.ac.uk/unexplained-...

Adult patients with autoinflammation of unknown origin partially phenocopy the immune presentation of Still’s disease @natcomms.nature.com @labliston.bsky.social @campathology.bsky.social @kuleuvenuniversity.bsky.social www.nature.com/articles/s41...

A one minute primer on how #AutoSpectral improves spectral flow cytometry unmixing by using per-cell calculation of autofluroscence spectra. Use our R package and get higher quality spectral data, easy as that! www.biorxiv.org/content/10.1...

A one minute primer on how #AutoSpectral improves spectral flow cytometry unmixing by using per-cell calculation of autofluroscence spectra. Use our R package and get higher quality spectral data, easy as that! www.biorxiv.org/content/10.1...

Neat. Another challenge to the arbitrary division between life and non-life. Not a whole lot of difference between this and a giant virus

My garden feels very “Spring” today

If you know a scientist who is struggling with self-doubt, please send them these stories. "Simply realising that I am not alone has given me a profound sense of strength... reading your work has already helped more than I can express." - Dr Nicola-Maria Riley www.cam.ac.uk/stories/camb...

If you know a scientist who is struggling with self-doubt, please send them these stories. "Simply realising that I am not alone has given me a profound sense of strength... reading your work has already helped more than I can express." - Dr Nicola-Maria Riley www.cam.ac.uk/stories/camb...

Excited to organize @keystoneSymposia.bsky.social Tissue and Spatial Immunology with @leilaakkari.bsky.social and Hai Qi in February 2027! Join us to explore emerging research in Banff! keysym.us/KSSpatialImmune27 #KSSpatialImmune27

Dogs and toddlers try to help adults. Cats only help if it is in their own best interests. www.sciencedirect.com/science/arti...

Our latest review is out, a comprehensive synthesis of #tissue #Tregs. It has been a decade since @annualreviews.bsky.social #immunology last reviewed #TissueTregs, and there have been enormous advances and conceptual leaps forward in the field www.annualreviews.org/content/jour...

We also cover the increasingly promising attempts to exploit the properties of #tissueTregs in the clinic, and outline the key open questions for the field. We are really privileged to be tackling some of these questions in the lab right now, thanks to @erc.europa.eu and @wellcometrust.bsky.social.

The molecular cues that induce the #tissueTreg phenotype are only partially understood, but key external signals from the tissue environment seem to be important in upregulating a core transcription factor set, which remodels the epigenetic and transcriptional landscape.