Legube Lab Chromatin & DSB repair
@lablegube.bsky.social
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Studying the function of chromatin in DNA Double Strand break repair at the CBI in Toulouse
reposted by
Legube Lab Chromatin & DSB repair
Nature Cell Biology
5 months ago
💫NEW: Saur, Lesage et al. report that RNA:DNA hybrids arise at double-strand breaks in transcribed genes, independently of de novo recruitment of RNA polymerase II/III, as a result of DSB-induced transcriptional repression.
@lablegube.bsky.social
@cbitoulouse.bsky.social
bit.ly/4kFWGr1
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Transcriptional repression facilitates RNA:DNA hybrid accumulation at DNA double-strand breaks - Nature Cell Biology
Saur, Lesage et al. report that RNA:DNA hybrids arise at double-strand breaks in transcribed genes, independently of de novo recruitment of RNA polymerase II/III, as a result of DSB-induced transcript...
https://bit.ly/4kFWGr1
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Legube Lab Chromatin & DSB repair
Mekhail Lab at U. Toronto 🍁🇨🇦
8 months ago
🚀 New Paper Alert! Our latest
@natrevmcb.bsky.social
explores how nuclear and genome organization drive DNA double-strand break repair! 🧬 📖 Free access:
rdcu.be/edViW
Please 🔄 ❤️
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Nuclear and genome dynamics underlying DNA double-strand break repair
Nature Reviews Molecular Cell Biology - Changes in nuclear and genome organization promote the repair of DNA double-strand breaks and genome stability. Processes that are involved include the...
https://rdcu.be/edViW
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reposted by
Legube Lab Chromatin & DSB repair
altmeyerlab
8 months ago
How are chromosome breaks repaired and how is their repair influenced and facilitated by nuclear and genome dynamics? Fantastic initiative and collaboration with
@karimmekhail.bsky.social
,
@chiololab.bsky.social
, and
@lablegube.bsky.social
.
@natrevmcb.bsky.social
Link to article:
rdcu.be/edViW
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Nuclear and genome dynamics underlying DNA double-strand break repair
Nature Reviews Molecular Cell Biology - Changes in nuclear and genome organization promote the repair of DNA double-strand breaks and genome stability. Processes that are involved include the...
https://rdcu.be/edViW
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reposted by
Legube Lab Chromatin & DSB repair
10 months ago
#1 Happy to share our last work published in @NatureCellBio about a new cell cycle checkpoint that senses nuclear shape & mechanics to guarantee genome integrity
www.nature.com/articles/s41...
. Great work from
@sol-herve.bsky.social
& Andrea Scelfo in close collaboration with
@katemiro.bsky.social
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Chromosome mis-segregation triggers cell cycle arrest through a mechanosensitive nuclear envelope checkpoint - Nature Cell Biology
Hervé, Scelfo et al. show that chromosome mis-segregation induces mTORC2- and ATR-mediated p53 activation through a mechanosensitive checkpoint at the nuclear envelope triggered by altered heterochrom...
https://www.nature.com/articles/s41556-024-01565-x
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reposted by
Legube Lab Chromatin & DSB repair
Tony Cesare
10 months ago
1/Delighted to announce the newest paper from our lab, “Homologous recombination promotes non-immunogenic mitotic cell death upon DNA damage”, is out today in
@naturecellbiology.bsky.social
,
www.nature.com/articles/s41...
.
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Homologous recombination promotes non-immunogenic mitotic cell death upon DNA damage - Nature Cell Biology
Szmyd et al. show that DNA repair pathways impact whether cells with DNA lesions arrest in mitosis. The formation of homologous recombination-driven double Holliday junctions elicits mitotic cell deat...
https://www.nature.com/articles/s41556-024-01557-x
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