If I may be allowed a moment of fatherly pride. Huge congratulations to Maddy Cesare on being selected for the New South Wales team competing at the Australian Youth Women’s Baseball Championship ⚾️🇦🇺 A big achievement, especially in her first year of eligibility. Baseball is awesome.

1/I’m proud to that our NHMRC Ideas Grant was successful and will support ongoing research in how DNA repair influences cancer cell fate. This project builds on pioneering work by @szmyd-radoslaw.bsky.social and @radoncdocgee.bsky.social, supported by @cmri.bsky.social and @sydney.edu.au

We are grateful to the National Health and Medical Research Council for granting four of our scientists highly sought after Ideas Grants. https://www.cmrijeansforgenes.org.au/news/cmri-researchers-awarded-four-nhmrc-grants Tony Cesare

New @natcomms.nature.com paper today from Tracy Bryan's lab @cmri.bsky.social: "Nuclear actin and DNA replication stress regulate telomere maintenance by telomerase". Happy our lab could play a small part. Congrats Tracy, Ash Harman, Noa Lamm and the whole team. www.nature.com/articles/s41...

One name appears on an award, but it truly reflects the collective effort of an exceptionally talented team. All credit to @radoncdocgee.bsky.social, @szmyd-radoslaw.bsky.social, @drmelaniew.bsky.social, @annagmanjon.bsky.social, Lucy French, Sienna Casolin, Scott Page, & our awesome collaborators.

Thank you @karimmekhail.bsky.social, @chiololab.bsky.social, and @altmeyerlab.bsky.social for organising @fusionconf.bsky.social #SGO25. Exciting science at a fantastic venue!

Delighted to be in beautiful Riviera Maya Mexico 🇲🇽 for @fusionconf.bsky.social #SGO25. www.fusion-conferences.com/conference/188

The first preprint from Noa Lamm’s team @cmri.bsky.social is now available: Anillin-dependent actin assembly at PML nuclear bodies protects genome stability www.biorxiv.org/content/10.1... Delighted our lab could play a role supporting Noa’s vision on this project.

Grateful that our lab was successful in two Australian Research Council Discovery Project grants last week. I’m the sole CI on one, while @hildapickett.bsky.social and Cesare-lab post-doc @scientistkate.bsky.social are CIs on the other. Both projects explore genome stability in human cells

The Cesare Lab had an excellent time at the Australian Cell Cycle, DNA Repair & Telomere Meeting in Melbourne. australiancellcycle.org A huge thank you to @genomestability.bsky.social and all the organisers for putting together such a fantastic and inspiring meeting. We're looking forward to 2027!

Delighted to be hosting Simon Boulton (@boultonlab.bsky.social) today for seminar at @cmri.bsky.social. Simon will present “Making T-loops to solve the end-protection problem”, sharing recent advances from his lab on how cells safeguard their chromosome ends.

Sharon Cantor (@cantorlab.bsky.social) is visiting @cmri.bsky.social tomorrow (Friday 17 October) to present her seminar -- "Defining and Targeting BRCAness". If you’re in the area, stop by the CMRI Seminar Room at 12:30 PM for what will be an excellent talk!

Happy that @drmelaniew.bsky.social and I could play a small role in this lovely work led by @ssegurabayona.bsky.social. Please do give the preprint a look.

📢Deadline extended! Our 2nd Spatial Genome Organisation Conference deadline has been extended to 25 Sep, dont miss out on joining our fantastic line up of speakers, alongside Karim, Matthias and Irene in what is set to be a fantastic meeting this October! #SGO25 Final slots ➡️https://bit.ly/3JJzYR4

A shout out to lab member @szmyd-radoslaw.bsky.social for his recent recognition by @sydney.edu.au. Well earned Radek!

We’re proud of our researcher Dr Radek Szmyd who has received a 2025 University of Sydney Faculty of Medicine and Health Mid-Career Research Outstanding Publication Award - for Radek’s extraordinary work to understand why cancer cells die in different ways following radiotherapy.

New from us in @natrevmcb.nature.com -- @szmyd-radoslaw.bsky.social & @radoncdocgee.bsky.social explore how DNA repair actively shapes cancer cell fate following DNA damage, reframing repair as both a protective process & a driver of treatment response and cell death. www.nature.com/articles/s41...

DNA replication and Cryo-EM star Jacob Lewis is visiting @cmri.bsky.social today to present seminar. If you happen to be in Westmead, talk is 12:30 pm local time. See you there.

Excited to speak at the Hunter Meeting next week, alongside @cmri.bsky.social colleagues Pragathi Masamsetti (postdoc with Patrick Tam, proud Cesare lab alum) and Pengyi Yang (Head, Computational Systems Biology Unit). Looking forward to great science and good company. www.huntermeeting.org.au

If you happen to be the the Oz Single Cell Conference this week in Sydney, check out @scientistkate.bsky.social's talk on Friday. Kate is a joint postdoc w/@piptaberlay.bsky.social and will present her work on 3D Genome architecture and replication stress. www.ozsinglecell.com

ACCM 2025! The Cesare lab will be there in force. Come join us in Melbourne for 3 days of amazing science.

I'm super excited to announce that registrations are now open for the 19th Australian Cell Cycle, DNA Repair and Telomere Workshop. Awesome international speaker line-up, with plenty of locals being invited! Book now to secure your earlybird rate. www.australiancellcycle.org

Fantastic opportunity in Melbourne.

Hosting Lee Wong from @monashuniversity.bsky.social tomorrow to present her seminar: "Onco-histone mutations in paediatric high-grade glioma: molecular mechanisms and implications for therapy." If you are around @cmri.bsky.social tomorrow at 12:30, come by for a great talk.

@genomestability.bsky.social (Andrew Deans) will be @cmri.bsky.social tomorrow to present seminar at 12:30; "The Multifaceted Role of FANCM enzyme in DNA Repair and Cancer Therapy". If you are in the area, please do come by for a great talk.

My and @telomerase-cmri.bsky.social’s annual attempt to bring a little bit of college baseketball culture down under. Go Tar Heels!

🚀 New Paper Alert! Our latest @natrevmcb.bsky.social explores how nuclear and genome organization drive DNA double-strand break repair! 🧬 📖 Free access: rdcu.be/edViW Please 🔄 ❤️

🧵 1/10 Excited to share our latest study in @naturecomms.bsky.social "A CPC-shelterin-BTR axis regulates mitotic telomere deprotection" t.co/VypPsLBJCR

1/Out today in @naturecomms.bsky.social, “A CPC-shelterin-BTR axis regulates mitotic telomere deprotection”. Here we identify the mechanism that unwinds telomere-loops (t-loops) during mitotic arrest to activate the DNA damage response and signal mitotic stress. www.nature.com/articles/s41....

Hosting the incomparable Paul Timpson from @garvaninstitute.bsky.social for seminar tomorrow (12:30, Friday 14 March) @cmri.bsky.social. “Imaging and improving drug targeting in pancreatic cancer using in vivo biosensors” Paul always gives a fantastic talk. Hope to see you there.

Review from our lab out today: "Roles for the 3D Genome In the cell cycle, DNA replication, and double strand break repair." Written by @scientistkate.bsky.social, with her co-supervisor @piptaberlay.bsky.social and collaborator Mat Jones. www.frontiersin.org/journals/cel...

A Big welcome to Clara Armon, who joined our lab this week as an undergraduate intern from @bostonu.bsky.social via an exchange program with @sydneyuni.bsky.social. Welcome to Australia, Clara!

Thanks for the shoutout @naturecellbiology.bsky.social.

Excellent opportunity in Copenhagen.

@hildapickett.bsky.social - Welcome to Blue Sky!

Thank you to Roger Greenberg and Hilda Pickett for organising a fantastic 2025 Mammalian DNA Repair GRC in Ventura, California. Looking forward to the next time.

Excited to present Social DNAing tomorrow. I’ll talk about our work led by @szmyd-radoslaw.bsky.social in collaboration with @radoncdocgee.bsky.social. 12 pm Eastern USA Thanks Shan Zha for the invite. www.cancer.columbia.edu/research/pro...

I think some people hear “grants” and think that without them, scientists and government workers just have less stuff to play with at work. But grants fund salaries for students, academics, researchers, and people who work in all areas of public service. “Pausing” grants means people don’t eat.

FYI for Australian scientists. Incredible resource for all things Australian Research Council. Highly recommended follow for those of us doing science down under.

Fascinating and thought-provoking new study by Tony Cesare's lab! It was a pleasure to write a News & Views about this work together with @villungerlab.bsky.social www.nature.com/articles/s41...

1/Delighted to announce the newest paper from our lab, “Homologous recombination promotes non-immunogenic mitotic cell death upon DNA damage”, is out today in @naturecellbiology.bsky.social, www.nature.com/articles/s41....

It makes a lab head proud to see their trainees doing good for the world. @annagmanjon.bsky.social followed her calling to work on the most pressing environmental issues of our time. This is an exciting initiative Anna. Good luck and enjoy the adventure!

Fortunate to see Max present this at a conference recently. Lovely work from all involved. www.biorxiv.org/content/10.1...

Well done Kate!

Delighted to publish my new molecular animation: DNA Break Repair by Homologous Recombination youtu.be/Xe-83tBcxhs

Always delightful to see former PhD students doing well. Great work Pragathi!

Dr Kate from the Cesare lab headed to Otago, NZ to present her work on chromatin and replication at AEpiA2024 www.aepia.org.au.

Happy Holliday Junction for those who celebrate

Thank you @tat1anamoiseeva.bsky.social for putting this together, very helpful!