I'd planned not to write about politics here but some things are too infuriating. Wes Streeting, who has lots of Mandelson connections, and -18% disapproval, plans an early power bid, just to prevent the only candidate with positive approval, Andy Burnham (+10%), from competing tinyurl.com/3j7jx2s7

If you are interested in PARP inhibitors and history, this might be of interest to you. www.nature.com/articles/s41.... An attempt to cover the work of thousands and their immense contributions to the development of a targeted approach to treating cancers.

Another classic from @albertociccia.bsky.social & @angelotaglialatela.bsky.social!

Excited to share our structural insights into how microtubules differentially guide phosphorylation of kinetochore-microtubule regulators, Ndc80 and MCAK, for chromosome segregation. Heroic efforts by Yiming Niu with a fun collaboration with Jennifer DeLuca lab! www.science.org/doi/10.1126/...

Microtubules have been viewed as passive structural supports, but a study from @hirofunabiki.bsky.social in @science.org Advances redefines microtubules as active regulators, helping to prevent abnormalities in the number of chromosomes, a hallmark of cancer. 🔗: https://bit.ly/4v8miCC

👋 To all aneuploidy and chromosome instability aficionados check out the Consequences of Aneuploidy FASEB conference (Florida-USA 🏖️) co-organised with @peterlylab.bsky.social, Mike Lampson, Alison Taylor and myself: events.faseb.org/event/Aneupl... 👉 Deadline for abstract submission: August 3rd.

You are interested in immunology and how nucleic acid structures contribute to their function and how this impacts disease development - Rayk Behrendt and myself have open PhD positions for a joint PhD program between Bonn and Osaka.

To kickstart this new Bluesky account: We're hiring! The Bertolin Lab @dundee.ac.uk is looking for a postdoc to work on DNA-end homeostasis & genome stability, funded by Wellcome Trust Award. Exciting science, fantastic environment, founding role in the lab. Details in the flyer — get in touch! 👇

NOW LIVE!: PhD opening joint with @drjonbaxter.bsky.social at @gdsc-sussex.bsky.social Get in touch and apply if you are interested in any and all of: Chromosomes, Genome Stability, Chromatin and DNA Topology in Mitosis and Meiosis. www.sussex.ac.uk/study/fees-f...

Delighted to share our new paper on LXR agonism pre-conditioning T cells to more readily adopt effector states, out in @jem.org today. This was a long project started in @sohailtavazoie.bsky.social's lab and completed across the atlantic here in Berlin at Charité.

If you're a physics researcher, please sign this letter. Anyone in the biomedical sciences know of a similar letter for our fields? Or anyone interested in putting one together? ecr-openletter-stfc.github.io#sign-form

Physics are hit worst, but it's not just physics. @ukri.org, it's not too late to reverse course. www.theguardian.com/science/2026...

2nd postdoc job alert in the Crick Institute in London. Project will examine the role of motors & the cytoskeleton (actin, septins and microtubules) during vaccinia virus egress using biochemical, structural & cellular approaches + live cell imaging. spread the word. crick.ac.uk/WayPostdoc20...

As I predicted, the cutting of @ukri.org funding is to provide "more emphasis on commercialisation". This is an absolutely terrible decision. Most startups fail, or are bought by larger competitors. In both cases, their research is frequently lost from the public domain www.bbc.co.uk/news/article...

Yes @ukri.org, please provide clarity and reasons for this chain of events. It would be a huge disadvantage to UK innovation if we went down a path of science funding that is similar to Trump's USA.

This is an absolute outrage that should be discussed as widely as possible. I expect that this failing government will try and use the MRC to divert funding from academic research into commercial enterprises, killing UK research in the process.

Excited to announce a new review article that Andreas Villunger @villungerlab.bsky.social, Dario Rizzotto (not on bsky) and I wrote. In this article, we discuss mitosis as a central cell cycle stage for integrating DNA damage, cell death and inflammatory responses. www.nature.com/articles/s41...

Parkes lab pre-print alert! ‘TMEM33 deletion potentiates anti-tumor CD8⁺ T cell immunity.’ Led by mtjackson101.bsky.social. Full bluetutorial follows! 1/10 www.biorxiv.org/content/10.6...

Our latest paper on the molecular mechanisms of XPF-ERCC1 recruitment to SLX4-dependent DNA repair pathways has been published! Congratulations to first author Junjie Feng, and a heartfelt thank you to all our collaborators for their contributions to this study! www.nature.com/articles/s41...

We are pleased to present our manuscript on the annotation of clear cell Renal Cell Carcinoma #GWAS risk loci, recently published in @commsbio.nature.com www.nature.com/articles/s42... #ccRCC #cancer #genetics #genomics #KidneyCancer

The 21st Course on Epigenetics which will take place from March 25th to April 1st, 2026 at the Institut Curie (Paris). The Course is open to M2 and PhD students. Application via the Advanced Training Office website before December 15th, 2025 at: minilien.curie.fr/3avv47

Happy to share the “International Symposium on Chromosome Dynamics: from Structure to Cellular Function” that will be held in Japan 31st of May 2026 www.fbs.osaka-u.ac.jp/labs/fukagaw.... Registrations will open on December 1st! Plenty of opportunities to present your work! Hope to seeing you

My lab at the University of Birmingham have a fully funded 4 year PhD position available, focusing on the molecular mechanisms of the Alternative Lengthening of Telomeres (ALT). Informal enquiries to [email protected] APPLICATION LINK: sits.bham.ac.uk/urd/sits.urd...

Congratulations to Lauren Davies, the lab's first PhD student, who defended her thesis with flying colours yesterday! Special thanks to Lauren's examiners @eileenparkes.bsky.social and @mcclellandlab.bsky.social! Lauren will stay for a few months to finalise a manuscript - so watch this space!

Deadline 18th Nov! Please write to express your support for continued funding for Jalview!

𝗖𝗮𝗻 𝗰𝗲𝗹𝗹𝘀 𝗲𝘃𝗲𝗿 𝘁𝗿𝘂𝗹𝘆 𝗿𝗲𝗰𝗼𝘃𝗲𝗿 𝗳𝗿𝗼𝗺 𝗗𝗡𝗔 𝗱𝗮𝗺𝗮𝗴𝗲?Excited to share our new study “Repair of DNA double-strand breaks leaves heritable impairment to genome function”, revealing DNA repair’s hidden cost, out now @science.org tinyurl.com/5n6zw3ye. Led by @sbantele.bsky.social and Jiri Lukas.🧵👇1/n

For everyone interested in art, my incredibly talented girlfriend Lara is auctioning one of her paintings to support @freedomfromtorture.bsky.social. The current bid is a bargain for her art, so snatch it up, and still get an incredibly good deal! artauction.freedomfromtorture.org/auction/item...

Interested in inherited chromosomal instability syndromes and DNA repair? We are looking for an enthusiastic person to join the Stewart lab at the University of Birmingham as a senior technician. Please checkout the job advert: www.jobs.ac.uk/job/DPH515/senior-research-technician

We are looking for a senior technician (can undertake PhD) at Uni of Birmingham (UK) to study chromatin replication and ubiquitylation using Xenopus egg extract. Deadline 28/10/25. Get in touch with me or @m-saponaro.bsky.social for informal inquiries. Please share. www.jobs.ac.uk/job/DOW912/s...

We're hiring ! Specifically....we are seeking to appoint a creative and motivated Postdoctoral Training Fellow to study how drug resistance emerges in homologous recombination defective (HRD) breast cancers and how this could be targeted. jobs.icr.ac.uk/vacancies/13...

#Jobalert 🚨: looking for a #computationalbiology expert with track record in analysis, integration and interpretation of #omics datasets, in particular #epigenomics, #singlecellgenomics, #proteomics data. uni-freiburg.de/stellenangeb... short deadline 30th September!

@mariasecrier.bsky.social & I are looking for an enthusiastic & excellent data scientist for a 4-year postdoc to understand cell cycle dysregulation in cancer. Deadline 15th October. Get in touch if you have any questions. Please repost! More details: www.imperial.ac.uk/jobs/search-...

Academic research generates almost all intellecutal innovation in the life sciences. With big pharma refusing to contribute, maybe it's time to stop giving them our research outputs cheaply, and instead having globally nationalised means of translating innovation? www.theguardian.com/business/202...

Great story from our fantastic neighbour Jörg Mansfeld!

Online Now: A redox switch in p21-CDK feedback during G2 phase controls the proliferation-cell cycle exit decision Online now:

Fantastic joint lab meeting day with @eileenparkes.bsky.social and Ben O'Leary plus our groups. Lots of cool science and discussions! And that fancy dinner at Lincoln College!

Postdoc positions open in my lab (Francis Crick Institute) to study 1. initiation of DNA replication. 2. chromatin replication/epigenetic inheritance. Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists. Deadline 3 August 2025. crick.wd3.myworkdayjobs.com/External/job...

We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms. Please get in touch with your CV if you are interested; closing date: 27th June 2025. More details here: candidate.hr-manager.net/ApplicationI...

Nice work by the Kurumizaka Lab in @natcomms.nature.com Multiple structures of RNA polymerase II isolated from human nuclei by ChIP-CryoEM analysis www.nature.com/articles/s41...

Happy to share our DNA Repair special issue on the replication stress response curated with @vindignilab.bsky.social. www.sciencedirect.com/special-issu...

Please repost! Post-doc studying novel mechanisms of post-replicative gap-filling available in my lab here in beautiful Snowdonia, between July 2025 to end Nov 2026. Generous travel budget. Lab is full of friendly and supportive colleagues. Link below, or DM me/email [email protected] for info

Such a cool story!

If you like chromatin remodellers and centromeres, this might be of interest. In it, we generated omics data from isogenic PBRM1 cell lines, which we hope is of use to the community, freely available (when evil forces aren't messing with the publicly funded websites 🙄) www.nature.com/articles/s41...

A new PhD position is available in my lab to explore DNA replication mechanisms using single-molecule approaches. Apply by 19th of March: www.crick.ac.uk/careers-stud...

Highly recommended!

Still a few days left to apply! I'm recruiting for two Postdoc positions in my lab at the University of Birmingham, investigating the Alternative Lengthening of Telomeres.

Are you interested to work in cancer drug discovery? Come and join us, we are recruiting a protein crystallographer to strengthen our structure-based drug discovery efforts. jobs.icr.ac.uk/vacancies/11...

We are recruiting a Higher Scientific Officer experienced in recombinant protein production and assay development to join an exciting collaboration to develop novel small molecule-controlled molecular switches to modulate CAR-T cell activity. jobs.icr.ac.uk/vacancies/11...

Interested in exploring epigenetic cell memory? Join us!! 6 PhD and postdoc positions available in our new center, EpiC.

Dear all, Postdoc positions are available to work on (1) the role of DNA strand break repair proteins during DNA replication and (2) the molecular/structural biology of XRCC1 protein complexes, as part of our work on genetic diseases & cancer. Contact me if interested: [email protected]